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Sepsis patient evaluation emergency department (SPEED) score & mortality in emergency department sepsis (MEDS) score in predicting 28-day mortality of emergency sepsis patients

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Chinese Journal of Traumatology 2019年第6期22卷 316-322页

作者： Adel hamed Elbaih Zaynab Mohammed elsayed Rasha Mahmoud Ahmed Sara Ahmed Abd-elwahed Department of Emergency Medicine Faculty of MedicineSuez Canal UniversityIsmailiaEgypt Department of Emergency Medicine Sulaiman Al-Rajhi CollegesFaculty of MedicineSaudi Arabia

Purpose:Sepsis is a common acute life-threatening condition that emergency physicians routinely *** options within the Emergency Department(ED)are limited due to lack of infrastructure,consequently limiting the use of invasive hemodynamic monitoring or imaging *** mortality rate due to sepsis can be assessed via multiple scoring systems,for example,mortality in emergency department sepsis(MEDS)score and sepsis patient evaluation in the emergency department(SPEED)score,both of which quantify the variation of mortality rates according to clinical findings,laboratory data,or therapeutic *** study aims to improve the management processes of sepsis patients by comparing SPEED score and MEDS score for predicting the 28-day mortality in cases of emergency ***:The study is a cross-sectional,prospective study including 61 sepsis patients in ED in Suez Canal University Hospital,Egypt,from August 2017 to June *** were selected by two steps:(1)suspected septic patients presenting with at least one of the following abnormal clinical findings:(a)body temperature higher than 38℃ or lower than 36℃,(b)heart rate higher than 90 beats/min,(c)hyperventilation evidenced by respiratory rate higher than 20 breaths/min or PaCO2 lower than 32 mmHg,and(d)white blood cell count higher than 12,000/μL or lower than 4000/μL;(2)confirmed septic patients with at least a 2-point increase from the baseline total sequential organ failure assessment(SOFA)score following *** inclusion criteria included adult patients with an age≥18 years regardless of gender and those who had either systemic inflammatory response syndrome or suspected/confirmed *** were shortly follow-up for the 28-day *** patient was subject to SPEED score and MEDS score and then the results were compared to detect which of them was more effective in predicting *** receiver operating characteristic curves were also done for MEDS and SPE

关键词： Sepsis Sepsis patient evaluation emergency department score Mortality in emergency department sepsis score Mortality

The Influence of Polyurethane Foam on the Insulation Characteristics of Mortar Pastes

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Journal of Minerals and Materials Characterization and Engineering 2017年第2期5卷 49-61页

作者： Ahmed Adel Mahmoud elsayed Abdel Ader Nasr Ahmed Abdel hamed Maamoun Department of Physics and Mathematics Faculty of Engineering Ain Shams University Cairo Egypt Department of Structural Engineering Ain Shams University Cairo Egypt

Rigid polyurethane foam is found virtually everywhere in our modern world and is used in sound and thermal insulation applications such as refrigerators, insulated buildings, thermosets. Organometallic compounds are used as polyurethane catalysts since they are very highly selective towards the isocyanate-polyol reaction. Also, amine catalysts are used to balance both the gelling reaction and the gas-forming or foaming reaction responsible for foam formation. In this work, the effect of a tin octoate catalyst on the mechanical properties and morphology of polyurethane foam were investigated. Also, the thermal conductivity and sound absorption coefficient for polyurethane foam mortar formulations were measured. The morphological properties of polyurethane foam were investigated using scanning electron microscope to determine the influence of varying the concentration of tin octoate. It was clear from the results that polyurethane foam has good thermal and sound insulation capabilities.

关键词： Polyurethane Foam Organometallic Catalyst Compressive Strength Thermal Conductivity Sound Absorption Coefficient

The Prognostic and Curative Benefits of Primary Tumor Resection versus No Resection in Stage IV Colorectal Cancer: A Comparative Study

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Surgical Science 2020年第3期11卷 39-49页

作者： Ibtsam Shehta Harera Taha A. Baiomy Ahmed A. Obaya Shady E. Shaker Amr Samir Ahmed M. elsayed Enas Mahmoud hamed Loay M. Gertallah Department of General Surgery Faculty of Medicine Zagazig University Zagazig Egypt Department of Clinical Oncology and Nuclear Medicine Faculty of Medicine Zagazig University Zagazig Egypt Department of Internal Medicine Faculty of Medicine Zagazig University Zagazig Egypt Department of Tropical Medicine Faculty of Medicine Zagazig University Zagazig Egypt Department of Radiology Faculty of Medicine Zagazig University Zagazig Egypt

Background: Colorectal cancer (CRC) who is initially diagnosed with single or multiple synchronous distant metastases has an incidence of about 20% of all CRC patients. There is a controversy regarding the role of resection of the primary tumors in those patients. The aim of this study was to explore the prognostic roles and survival advantages of surgical excision of the primary colonic tumor in patients with CRC who are primarily diagnosed with distant metastases. Patients and Methods: We included forty patients who were diagnosed initially with stage IV CRC. We have divided the included patients into two categories the first one included 20 patients that underwent surgical excision of the primary cancer followed by administration of chemotherapy and the remaining 20 patients were initially given chemotherapy without excision of the cancer. We followed patients for 24 months to detect progression, response to chemotherapy, recurrence free survival and overall survival rates. Results: There is statistically significant difference between patients underwent different initial management techniques regarding N stage of the tumor (p = 0.039), response to chemotherapy (p = 0.048), occurrence of relapse (p = 0.022), disease free survival (DFS) (p = 0.027) or overall survival (OS) rates (p = 0.001) (DFS and OS were significantly higher among patients who received initial surgical management. Primary surgical removal of the tumor improved OS rate by 8 months (p = 0.001). Conclusion: Surgical removal of the primary malignancy in mCRC patients before chemotherapy administration improves patients’ survival rates and response to chemotherapy that lead to a better prognosis.

关键词： Metastatic CRC (mCRC) Surgical Resection Chemotherapy Survival

Prediction of Response to Neoadjuvant Chemotherapy in Egyptian Patients with Locally Advanced Breast Cancer: The Evolving Role of Tumour Infiltrating Lymphocytes (TILs)

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Journal of Cancer Therapy 2020年第4期11卷 206-219页

作者： Manal M. El-Mahdy Riham A. Ibrahim Radwa M. hamed Mohamaad S. Elkady Walid A. Bayoumy Zeinab M. elsayed Mai M. Ezz-El-Din Department of Pathology Ain Shams University Cairo Egypt International Medical Center Cairo Egypt Department of Clinical Oncology Faculty of Medicine Ain Shams University Cairo Egypt

Background & objectives:?Presence of TILs in breast cancer indicates better therapeutic responses to neoadjuvant chemotherapy (NAC), increased pCR and improved outcome. We aim at evaluation of TILs in breast cancer biopsies in correlation with pathological response after NAC in locally advanced breast cancer Methods. This study was conducted at Ain Shams university hospital and Maadi Military hospital in Egypt. 45 Female patients with locally advanced breast cancer were treated with NAC;?pathological response was assessed. Tumours were categorized into: luminal A, luminal B, Her2 enriched and TNBC. Assessment of TILs (CD4 and CD8 lymphocytes) was based on Immuno-Oncology Biomarker Working Group guidelines.?Results:?Tumours were classified into high and low TIL groups using the interquartile range cutoff (29%). High CD4 group showed increased pCR (p?= 0.003) and smaller residual tumours (p?= 0.04). High CD8 group showed a significant association with smaller residual tumours (p?= 0.003). At follow-up of 24-months, CD4 and CD8 high groups showed significantly higher 2-years DFS. The difference between CD4 high and low groups was significant in regards to estrogen receptor status, showing higher levels in hormone-negative tumors (p = 0.029). Patients with Her2 subtype showed higher CD4 (p = 0.007) and CD8 expression (p = 0.018). In CD4 & CD8 low groups, more patients developed local recurrence and distant metastasis (p = 0.025). Conclusion:?We concluded that TILs may predict response to NAC and overall prognosis of breast cancer. The evaluation of TILs in correlation with morphological or genomics-based parameters helps to stratify patients of breast cancer.

关键词： Breast Cancer Lymphocytes Neoadjuvant Chemotherapy

Pancreatic injury in patients with septic shock: A literature review

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World Journal of Gastrointestinal Oncology 2016年第7期8卷 526-531页

作者： Anis Chaari Karim Abdel Hakim Kamel Bousselmi Mahmoud Etman Mohamed El Bahr Ahmed El Saka Eman Hamza Mohamed Ismail elsayed Mahmoud Khalil Vipin Kauts William Francis Casey Department of Intensive Care King Hamed University Hospital

Sepsis and septic shock are life threatening condition associated with high mortality rate in critically-ill patients. This high mortality is mainly related to the inadequacy between oxygen delivery and cellular demand leading to the onset of multiorgan dysfunction. Whether this multiorgan failure affect the pancreas is not fully investigated. In fact, pancreatic injury may occur because of ischemia, overwhelming inflammatory response, oxidative stress, cellular apoptosis and/or metabolic derangement. Increased serum amylase and/or lipase levels are common in patients with septic shock. However, imaging test rarely reveal significant pancreatic damage. Whether pancreatic dysfunction does affect the prognosis of patients with septic shock or not is still a matter of debate. In fact, only few studies with limited sample size assessed the clinical relevance of the pancreatic injury in this group of patients. In this review, we aimed to describe the epidemiology and the physiopathology of pancreatic injury in septic shock patients, to clarify whether it requires specific management and to assess its prognostic value. Our main finding is that pancreatic injury does not significantly affect the outcome in septic shock patients. Hence, increased serum pancreatic enzymes without clinical features of acute pancreatitis do not require further imaging investigations and specific therapeutic intervention.

关键词： Septic shock Pancreas Lipase Amylase Prognosis