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Evaluation of 3D-CRT and VMAT Radiotherapy Plans for Left Breast Cancer with Regional Lymph Nodes Irradiation

Journal of Cancer Therapy 2023年第8期14卷 345-352页

作者： Houda Benmessaoud Hasnae Bouhia halima ahmut Sanaa El Majjaoui Hanane El Kacemi Khalid Hassouni Tayeb Kebdani Department of Radiotherapy National Institute of Oncology of Rabat Faculty of Medicine and Pharmacy of Rabat Rabat Morocco

Introduction: Radiation therapy after breast surgery is an integral part of the treatment of early breast cancer. The goal of radiation therapy is to achieve the best possible coverage of the planning target volume (PTV), while reducing the dose to organs at risk (OARs) which are normal tissues whose sensitivity to irradiation could cause damage that can lead to modification of the treatment plan. In the last decade, radiation oncologist started to use the Intensity Modulated Radiotherapy (IMRT) and Volumetric Modulated Arc Therapy (VMAT) for irradiating the breast, in order to achieve better dose distribution and target dose to the PTV and OAR. The aim of this study is to compare 2 external radiotherapy techniques (VMAT vs 3D) for patients with node-positive left breast cancer. Patients and Methods: We randomly selected 10 cases of postoperative radiotherapy for breast cancer in our hospital. The patients are all female, the average age was 45.4 years old, and the primary lesions are left breast. The ANOVA test was used to compare the mean difference between subgroups, and the p value Results: Dose volume histogram (DVH) was used to analyze each evaluation dose of clinical target volume (CTV) and organs at risk (OARs). Compared to 3DCRT plans, VMAT provided more uniform coverage to the breast and regional lymph nodes. The max point dose for tVMAT was lower on average (106.4% for VMAT versus 109% for 3DCRT). OAR sparing was improved with tVMAT, with a lower average V17Gy for the left lung (27.91% for VMAT versus 30.04% for 3DCRT, p and lower for V28Gy (13.75% for VMAT versus 22.34% for 3DCRT, p = 0.01). We also found a lower V35Gy for the heart on VMAT plan (p = 0.02). On the contrary, dose of contralateral breast was lower in 3DCRT than VMAT (0.59 Gy vs 3.65 Gy, p = 0.00). Conclusion: The both types of plans can meet the clinical dosimetry demands of postoperative radiotherapy for left breast cancer. The VMAT plan has a better conformity, but 3CDRT can provide a lo

关键词： Volumetric-Modulated arc Therapy 3D-Conformal Radiation Therapy Left Breast Cancer Target Volumes Treatment Plan

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Impact of the COVID-19 Pandemic Lockdown on Radiotherapy Patients: A Retrospective Cohort Study

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Journal of Cancer Therapy 2022年第3期13卷 155-167页

作者： Kenza Benali Houda Benmessaoud halima ahmut Sanaa El Majjaoui Tayeb Kebdani Khalid Hassouni Hanan El Kacemi Noureddine Benjaafar Department of Radiation Oncology National Institute of Oncology Rabat Morocco Faculty of Medicine Mohammed V University Rabat Morocco

Background: The coronavirus disease 2019 (COVID-19) pandemic has led to the imposition of a strict nationwide lockdown, which has affected all aspects of healthcare, including the delivery of standard care to cancer patients. Objective: The aim of this study was to report the impact of the COVID-19 pandemic on patient attendance at a radiotherapy department during the lockdown period. Methods: This is a retrospective analysis of all patients planned for radiotherapy at the National Institute of Oncology in Rabat. Patient compliance to radiotherapy during the lockdown period was measured and compared with that during the same period in 2019. Data regarding age, sex, tumor site and treatment-related factors were analyzed and compared with those during the same period in 2019. Results: We included a total of 650 patients, 348 patients in Group A (control period) and 302 in Group B (lockdown period). Patients were aged between 30 and 70 years in about 85%, with a female predominance in both groups. The most common sites of occurrence of cancer were breast, female reproductive organs and the head and neck. A 13.2% reduction in the number of treated patients and a 16.9% reduction in the number of sessions was observed. There was a significant decrease in the proportion of breast cancers treated (P = 0.03). The proportion of patients receiving palliative radiotherapy increased significantly (P = 0.03), with a significant increase in the use of single-fraction palliative radiation therapy (P = 0.006). There was a significant difference in the compliance to radiotherapy during the lockdown period (92.3% versus 86.4%, P = 0.01);delays and interruptions were due to travel restrictions (58.5%) and fear of contamination (29.2%). No patient was tested positive for COVID-19 during radiotherapy during the study period. Conclusion: We observed a decrease in the number of treated patients during the lockdown despite our efforts to maintain the treatment routine. A significant decreas

关键词： Cancer COVID-19 Pandemic Lockdown Radiotherapy Compliance

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