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Relational Turkish Text Classification Using Distant Supervised Entities and Relations

Computers, Materials & Continua 2024年第5期79卷 2209-2228页

作者： halil ibrahim okur Kadir Tohma Ahmet Sertbas Department of Computer Engineering Faculty of Engineering and Natural SciencesIskenderun Technical UniversityHatay31200Turkey Department of Computer Engineering Faculty of EngineeringIstanbul University-CerrahpasaIstanbul34310Turkey

Text classification,by automatically categorizing texts,is one of the foundational elements of natural language processing *** study investigates how text classification performance can be improved through the integration of entity-relation information obtained from the Wikidata(Wikipedia database)database and BERTbased pre-trained Named Entity Recognition(NER)*** on a significant challenge in the field of natural language processing(NLP),the research evaluates the potential of using entity and relational information to extract deeper meaning from *** adopted methodology encompasses a comprehensive approach that includes text preprocessing,entity detection,and the integration of relational *** conducted on text datasets in both Turkish and English assess the performance of various classification algorithms,such as Support Vector Machine,Logistic Regression,Deep Neural Network,and Convolutional Neural *** results indicate that the integration of entity-relation information can significantly enhance algorithmperformance in text classification tasks and offer new perspectives for information extraction and semantic analysis in NLP *** of this work include the utilization of distant supervised entity-relation information in Turkish text classification,the development of a Turkish relational text classification approach,and the creation of a relational *** demonstrating potential performance improvements through the integration of distant supervised entity-relation information into Turkish text classification,this research aims to support the effectiveness of text-based artificial intelligence(AI)***,it makes significant contributions to the development ofmultilingual text classification systems by adding deeper meaning to text content,thereby providing a valuable addition to current NLP studies and setting an important reference point for future research.

关键词： Text classification relation extraction NER distant supervision deep learning machine learning

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Gastroesophageal reflux after per-oral endoscopic myotomy:Management literature

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World Journal of Gastroenterology 2024年第23期30卷 2947-2953页

作者： Ahmed Tawheed ibrahim halil Bahcecioglu Mehmet Yalniz Mohamed El-Kassas Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt Department of Gastroenterology Faculty of MedicineFirat UniversityElazig 23119Türkiye Liver Disease Research Center College of MedicineKing Saud UniversityRiyadh 7805Saudi Arabia

In this editorial,we respond to a review article by Nabi et al,in which the authors discussed gastroesophageal reflux(GER)following peroral endoscopic myotomy(POEM).POEM is presently the primary therapeutic option for achalasia,which is both safe and effective.A few adverse effects were documented after POEM,including *** diagnostic criteria were not clear enough because approximately 60%of patients have a long acid exposure time,while only 10%experience reflux *** predictors of high disease incidence have been identified,including old age,female sex,obesity,and a baseline lower esophageal sphincter pressure of less than 45 *** technical steps during the procedure,such as a lengthy or full-thickness myotomy,may further enhance the *** pump inhibitors are currently the first line of *** voices are increasingly advocating for the routine combining of POEM with an endoscopic fundoplication method,such as peroral endoscopic fundoplication or transoral incisionless ***,more research is necessary to determine the safety and effectiveness of these procedures in the long term for patients who have undergone them.

关键词： Achalasia Per-oral endoscopic myotomy Gastroesophageal reflux disease Transoral incisionless fundoplication Peroral endoscopic fundoplication

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Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy

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Cancer Communications 2024年第1期44卷 178-182页

作者： Okan Safak Shenghan Wang Carmen Mota Reyes ibrahim halil Gürcinar Sergey Tokalov Nedim Can Cevik Kivanc Görgülü Bengi Su Yilmaz Emre Erdogan Linhan Ye Qiaolin Li Elif Arik Sever SamedÖzer Güldal Süyen Helmut Friess Güralp Onur Ceyhan Rouzanna Istvanffy Hana Algül Ihsan Ekin Demir Department of Surgery Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of General Surgery HPB-UnitSchool of MedicineAcibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Comprehensive Cancer Center München Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of Hematology Oncology and Tumor ImmunologyCharitéUniversity Medicine BerlinCampus Virchow ClinicBerlinBerlinGermany Graduate School of Health Sciences Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Department of Physiology Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Else Kröner Clinician Scientist Professorship for Translational Pancreatic Surgery MunichGermany Neural Influences in Cancer(NIC)International Research Consortium MunichGermany

Dear Editor,Targeting the immune compartment in pancreatic duc-tal adenocarcinoma(PDAC)holds promise for prognostic improvement,yet our knowledge on the spatial and tem-poral dynamics and the molecular modulators of t... 详细信息

关键词： immune adenocarcinoma immunotherapy

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Effect of surfactant on the dielectric and electrorheological properties of zinc borate/silicone oil dispersions

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International Journal of Minerals,Metallurgy and Materials 2019年第12期26卷 1523-1530页

作者： Omer Yunus Gumus halil ibrahim Unal Bursa Technical University Engineering and Natural Sciences FacultyFiber and Polymer Engineering DepartmentBursa 16310Turkey Gazi University Science FacultyChemistry DepartmentSmart Materials Research Lab.Ankara 06500Turkey

Zinc borate(ZB)particles dispersed in silicone oil(SO)at concentrations of φ=5vol%-20vol% were subjected to dielectric analysis to elucidate their polarization strength,time,and *** revealed that all virgin dispersions lacked *** X-100,a non-ionic surfactant,was added to ZB/SO dispersions to enhance the polarizability of ZB *** addition of 1vol% Triton X-100 enhanced the polarizability of ZB/SO dispersions,and the 15vol% ZB/SO system provided the highest dielectric difference Δε′(the difference in ε′values at zero and infinite frequency,Δε′=ε0–ε∝)of *** electrorheological(ER)activities of the ZB/SO/Triton-X dispersion system were determined through the ER response test,and viscoelastic behaviors were investigated via oscillation tests.A recoverable deformation of 36% under an applied electrical field strength of 1.5 kV/mm was detected through creep and creep recovery tests.

关键词： zinc borate electrorheological fluids dielectric analysis surfactant

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Wear Behavior of Aluminum Matrix Hybrid Composites Fabricated through Friction Stir Welding Process

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Journal of Iron and Steel Research International 2016年第10期23卷 1119-1126页

作者： halil ibrahim KURT Murat ODUNCUOGLU Ramazan ASMATULU Department of Mechanical and Metal Technologies Technical SciencesGaziantep University Department of Mechanical Engineering Wichita State University

Effects of friction stir processing（FSP）parameters and reinforcements on the wear behavior of 6061-T6 based hybrid composites were investigated.A mathematical formulation was derived to calculate the wear volume loss of the *** experimental results were contrasted with the results of the proposed *** influences of sliding distance,tool traverse and rotational speeds,as well as graphite（Gr）and titanium carbide（TiC）volume fractions on the wear volume loss of the composites were also investigated using the prepared *** results demonstrated that the wear volume loss of the composites significantly increased with increasing sliding distance,tool traverse speed,and rotational speed;while the wear volume loss decreased with increasing volume fraction of the reinforcements.A minimum wear volume loss for the hybrid composites with complex reinforcements was specified at the inclusion ratio of 50% TiC＋50% Al2O3 because of improved lubricant ability,as well as resistance to brittleness and *** possibilities to develop wear-resistant aluminum-based composites for different industrial applications were proposed.

关键词： aluminum alloy friction stir processing wear hybrid composite modeling

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Stability evaluation of the Gümüshane-Akcakale cave by numerical analysis method

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Journal of Mountain Science 2019年第9期16卷 2150-2158页

作者： ALEMDAG Selcuk ZEYBEK halil ibrahim KULEKCI Gokhan Department of Geological Engineering Gumushane UniversityGumushane 29100Turkey Department of Geography Ondokuz Mayis UniversitySamsun 55105Turkey Department of Mining Engineering Gumushane UniversityGumushane 29100Turkey

The Ak?akale Cave is located in the vicinity of the Arsa neighborhood within the boundaries of the Ak?akale village, Gümü?hane, Turkey. The cave is rich in cave formations(stalactite, stalagmite, cave pearl, cave flower, wall travertines). Thus, the appropriateness of opening the cave to visitors to boost tourism is of importance for the local and national economy. This study analyzes the stability of the Ak?akale Cave using a numerical analysis method. According to the results of the total displacement analysis, there are displacements in the entrance, ceiling, and sidewalls of the cave ranging from 1 mm to 48 mm. It seems that the entrance, ceiling, and sidewalls of the cave face a high risk of local or sudden collapse. According to the deformation analysis of the length section of the cave examined, local collapses may occur especially in the first 75 m from the entrance of the cave. We believe that this situation would not carry a risk for the Arsa neighborhood for now. In conclusion, the results of the stability analysis and in-situ observations showed clear evidence of former and ongoing cave-ins(collapses) and the Ak?akale Cave faces a high risk of local or sudden collapse. Thus, although the Ak?akale Cave is one of the most prominent karst caves in Turkey, it seems to be not appropriate to open the cave to tourist visits.

关键词： Akcakale Cave Dripstone Finite element method Karst caves Numerical analysis

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The tumor microenvironment of pancreatic adenocarcinoma and immune checkpoint inhibitor resistance: a perplex relationship

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Cancer Drug Resistance 2020年第4期3卷 699-709页

作者： Irem Sahin Sevda Turen Pranav Santapuram ibrahim halil Sahin Baskent University School of Medicine Department of Medicine AnkaraAnkara 06810Turkey TC Istanbul Kültür University Faculty of Health SciencesDepartment of NursingIstanbul 34158Turkey Emory University School of Medicine Department of MedicineAtlantaGA 30322USA Moffitt Cancer Center Department of Gastrointestinal OncologyTampaFL 33612USA

Pancreatic cancer is one of the most aggressive cancers with a high mortality rate even among patients with early-stage *** recent studies with novel therapeutic approaches have led to modest improvement in survival outcomes,limited progress is achieved for the use of immunotherapeutics in this challenging *** checkpoint inhibitors,thus far,single-agent or in combination,have not yielded significant improvement in survival outcomes except in mismatch repair-deficient pancreatic *** tumor microenvironment of pancreatic cancer has been considered as an attractive target for over a decade based on preclinical studies that suggested it may adversely affect drug delivery and antitumor *** this review article,we elaborate on the biology of pancreatic cancer microenvironment,its highly complicated interaction with cancer cells,and the immune *** also discuss plausible explanations that led to the failure of immune checkpoint inhibitors as therapeutic agents and the potential impacts of pancreatic cancer stroma on these negative studies.

关键词： Pancreatic adenocarcinoma durvalumab nivolumab ipilimumab pembrolizumab immune checkpoint inhibitors immunotherapy resistance mismatch repair deficient microsatellite instability high microsatellite stable tumor-associated macrophages myeloid-derived suppressor cells T regs T cells

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Effects of phacoemulsification surgery on ocular hemodynamics

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International Journal of Ophthalmology(English edition) 2013年第4期6卷 537-541页

作者： Adem Turk Suleyman Mollamehmetoglu halil ibrahim Imamoglu Mehmet Kola Hidayet Erdol Nurettin Akyol Department of Ophthalmology School of MedicineKaradeniz Technical University

AIM:To evaluate the possible effects of phacoemulsification cataract surgery on ocular hemodynamics.·METHODS:In this prospective study,intraocular pressure(IOP),pulsatile ocular blood flow(POBF),and ocular pulse amplitude(OPA) were measured pre-operatively(baseline) and at 1 week and 3 weeks postoperation in 52 eyes of 26 patients(mean age 63.15±10.25 years) scheduled for unilateral phacoemulsification cataract surgery with intraocular lens *** all of the eyes,a blood flow analyzer(Paradigm DICON;Paradigm Medical Industries Inc.;USA) was used to obtain measurements of IOP,POBF,and *** data obtained from operated eyes were compared statistically to untreated fellow phakic eyes of the patients.·RESULTS:For operated eyes,the mean baseline IOP,POBF,and OPA values were 15.9±4.64mmHg,17.41±4.84μL/s,and 2.91 ±1.12mmHg,*** IOP,POBF,and OPA values were 17.19 ±4.34mmHg,17.56 ±6.46μL/s,and3.12 ±1.1mmHg,respectively,in the nonoperated control *** significant differences from baseline measurements were not observed 1 week and 3 weeks postoperation for the operated or nonoperated *** were also no statistically significant differences in any measurements between the operated and nonoperated eyes in all the examination periods(P >0.05for all).·CONCLUSION:Uncomplicated phacoemulsification surgery does not affect ocular hemodynamics in normotensive eyes with cataracts.

关键词： cataract cataract extraction intraocular pressure phacoemulsification regional blood flow

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Natural Walls of Anatolia: formation and development of Diş Kayalıkları as a structural landform (Sivas, Türkiye)

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Journal of Mountain Science 2023年第7期20卷 1807-1823页

作者： UZUN Ali AYLAR Faruk ZEYBEK halil ibrahim GÜRGÖZE Serkan BAHADIR Muhammet ALEMDAĞ Selçuk Geography Department Ondokuz Mayis UniversitySamsun 55100Turkey Geological Engineering Department Gümüşhane UniversityGümüşhane 29100Turkey

The Diş Kayalıkları is one of the largest and most striking examples of crests in the world and is located between Eskidere and Boğazören villages of the İmranlı district of the Sivas province in Turkey. The crests, which resemble castle walls when viewed from afar, have a real wall pattern due to the right-angled crack system of the bedrock when viewed closely. This study aims at investigating the geomorphological features of the Diş Kayalıkları and determining how the geological and geomorphological evolution of the Diş Kayalıkları took place and how the current formation mechanism continues. In the region, the mid-latitude continental climate prevails with cold humid winters and warm dry summers. The bedrock consists of Miocene bedded deposits of different resistance, folded by young tectonic movements. Diş Kayalıkları was formed by selective erosion of less resistant terrain around a pack of resistant rock on the steeper southern slope of an asymmetrical anticline. It has a length of 4750 m in the approximately northwest-southeast direction, a maximum height of 30 m, and a width varying between 5 and 8 m. In the present morphological appearance of the Diş Kayalıkları, it can be stated that the structure formed after the tectonic formation process was eroded under the control of the local climate and crest formation was realized. In the following process, the crest experienced a polycyclic process where different landforms were formed. There are smaller landforms such as karren, cave and rock window on Diş Kayalıkları, and macrofossil beds in some places. This highly attractive geomorphosite, unknown to wider public, should be investigated from various scientific aspects and should be brought to regional tourism by making the necessary infrastructure and promotion studies.

关键词： Structural landform Crest Geosite DişKayalıkları Sivas

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Oncogenic fingerprint of epidermal growth factor receptor pathway and emerging epidermal growth factor receptor blockade resistance in colorectal cancer

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World Journal of Clinical Oncology 2016年第5期7卷 340-351页

作者： Zain A Sobani Ashwin Sawant Mikram Jafri Amit Keith Correa ibrahim halil Sahin Department of Medicine Maimonides Medical Center Department of Medicine Icahn School of Medicine at Mount Sinai St Luke’s Roosevelt Hospital Center Department of Medicine Albany Stratton Veterans Hospital

Epidermal growth factor receptor(EGFR) has been an attractive target for treatment of epithelial cancers, including colorectal cancer(CRC). Evidence from clinical trials indicates that cetuximab and panitumumab(antiEGFR monoclonal antibodies) have clinical activity in patients with metastatic CRC. The discovery of intrinsic EGFR blockade resistance in Kirsten RAS(KRAS)-mutant patients led to the restriction of anti-EGFR antibodies to KRAS wild-type patients by Food and Drug Administration and European Medicine Agency. Studies have since focused on the evaluation of biomarkers to identify appropriate patient populations that may benefit from EGFR blockade. Accumulating evidence suggests that patients with mutations in EGFR downstream signaling pathways including KRAS, BRAF, PIK3CA and PTEN could be intrinsically resistant to EGFR blockade. Recent whole genome studies also suggest that dynamic alterations in signaling pathways downstream of EGFR leads to distinct oncogenic signatures and subclones which might have some impact on emerging resistance in KRAS wild-type patients. While anti-EGFR monoclonal antibodies have a clear potential in the management of a subset of patients with metastatic CRC, further studies are warranted to uncover exact mechanisms related to acquired resistance to EGFR blockade.

关键词： Epidermal growth factor receptor Oncogenic signature Kirsten RAS BRAF Cetuximab Panitumumab Epidermal growth factor receptor blockade resistance

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