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The Usefulness of Renal Doppler Parameters in Chronic Kidney Disease: Is There a Cut-Off Value to Estimate End Stage Kidney Disease?

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Open Journal of Radiology 2016年第1期6卷 18-23页

作者： Bozkurt Gulek Gokhan Soker Ertugrul Erken Fatma Ulku Adam halil Ibrahim Varan Sibel Ada Nazan Z. Alparslan Omer Kaya Eren Erken Behice Durgun Department of Radiology Numune Teaching and Research Hospital Adana Turkey Department of Nephrology Faculty of Medicine Gaziosmanpasa University Tokat Turkey Department of Nephrology Numune Teaching and Research Hospital Adana Turkey Department of Biostatistics Faculty of Medicine Cukurova University Adana Turkey Department of Rheumatology-Immunology Faculty of Medicine Cukurova University Adana Turkey Department of Anatomy Faculty of Medicine Cukurova University Adana Turkey

Aims: In this study, Doppler parameters were studied in patients with advanced stage renal disease, and the relationship between Doppler parameters and renal disease stage was investigated. Doppler values were evaluated for a cut-off value between normal and end-stage kidney disease group. Materials and methods: 50 patients with chronic kidney disease and 15 patients belonging to the same age group and with normal serum creatinine levels were comprised of the study and control groups. Resistivity and pulsatality indices were measured at the main renal arteries and interlobular arteries at both sides. Results: Statistically significant differences were found between the PI and RI values obtained from the main renal and interlobular arteries. PI sums were compared with those from the control group, and a cut-off value of 2.15 was found, with a sensitivity of 90% and a specificity of 86.7%. Conclusion: Any increase in the RI and PI values obtained from the main renal and interlobular arteries must bring to mind the possibility of advancing renal damage and interstitial fibrosis. Patients with and without renal parenchymal damage can be differentiated by means of comparing the total PI values obtained from the right and left main renal and interlobular arteries.

关键词： Ultrasonography Doppler Renal Insufficiency Chronic

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Combined metabolic activators improve cognitive functions in Alzheimer’s disease patients:a randomised,double-blinded,placebo-controlled phase-II trial

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Translational Neurodegeneration 2023年第1期12卷 849-871页

作者： Burak Yulug Ozlem Altay Xiangyu Li Lutfu Hanoglu Seyda Cankaya Simon Lam halil Aziz Velioglu Hong Yang Ebru Coskun Ezgi Idil Rahim Nogaylar Ahmet Ozsimsek Cemil Bayram Ismail Bolat Sena Oner Ozlem Ozdemir Tozlu Mehmet Enes Arslan Ahmet Hacimuftuoglu Serkan Yildirim Muhammad Arif Saeed Shoaie Cheng Zhang Jens Nielsen Hasan Turkez Jan Borén Mathias Uhlén Adil Mardinoglu Department of Neurology and Neuroscience Faculty of MedicineAlanya Alaaddin Keykubat UniversityAntalyaTurkey Science for Life Laboratory KTH-Royal Institute of TechnologyStockholmSweden Department of Neurology Faculty of MedicineIstanbul Medipol UniversityIstanbulTurkey Centre for Host-Microbiome Interaction’s Faculty of DentistryOral and Craniofacial SciencesKing’s College LondonLondonUK Department of Women’s and Children’s Health Karolinska InstituteStockholmSweden Functional Imaging and Cognitive-Affective Neuroscience Lab Istanbul Medipol Univer-sityIstanbulTurkey Department of Medical Pharmacology Faculty of Medi-cineAtatürk UniversityErzurumTurkey Department of Pathology Veterinary FacultyAtaturk UniversityErzurumTurkey Department of Molecular Biology and Genetics Faculty of ScienceErzurum Technical UniversityErzurumTur-key School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhouPeople’s Republic of China Department of Biology and Biological Engineering Chalmers University of TechnologyGothenburgSweden Department of Medical Biology Faculty of MedicineAtatürk UniversityErzurumTurkey Department of Molecular and Clinical Medicine University of Gothenburg and Sahlgrenska University HospitalGothenburgSweden.

Background Alzheimer’s disease(AD)is associated with metabolic abnormalities linked to critical elements of *** recently administered combined metabolic activators(CMA)to the AD rat model and observed that CMA improves the AD-associated histological parameters in the *** promotes mitochondrial fatty acid uptake from the cytosol,facilitates fatty acid oxidation in the mitochondria,and alleviates oxidative *** Here,we designed a randomised,double-blinded,placebo-controlled phase-II clinical trial and studied the effect of CMA administration on the global metabolism of AD ***-dose CMA included 12.35 g L-serine(61.75%),1 g nicotinamide riboside(5%),2.55 g N-acetyl-L-cysteine(12.75%),and 3.73 g L-carnitine tartrate(18.65%).AD patients received one dose of CMA or placebo daily during the first 28 days and twice daily between day 28 and day *** primary endpoint was the difference in the cognitive function and daily living activity scores between the placebo and the treatment *** secondary aim of this study was to evaluate the safety and tolerability of CMA.A comprehensive plasma metabolome and proteome analysis was also performed to evaluate the efficacy of the CMA in AD *** We showed a significant decrease of AD Assessment Scale-cognitive subscale(ADAS-Cog)score on day 84 vs day 0(P=0.00001,29%improvement)in the CMA ***,there was a significant decline(P=0.0073)in ADAS-Cog scores(improvement of cognitive functions)in the CMA compared to the placebo group in patients with higher ADAS-Cog *** cognitive functions in AD patients were supported by the relevant alterations in the hippocampal volumes and cortical thickness based on imaging ***,the plasma levels of proteins and metabolites associated with NAD+and glutathione metabolism were significantly improved after CMA *** Our results indicate that treatment of AD patients with CMA can lead to enhanced cognit

关键词： Alzheimer’s disease Combined metabolic activators Multi-omics Systems biology Systems medicine

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野生杏种子对外源赤霉素的生理响应

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干旱区研究 2009年第5期26卷 708-713页

作者：王蕾海利力.库尔班萨拉木.艾尼瓦尔新疆农业大学林学与园艺学院新疆乌鲁木齐830052 伊犁哈萨克自治州园艺技术推广总站新疆伊宁835000

以甜杏仁和苦杏仁天山野生杏种子为对象,观察赤霉素处理对种子打破休眠的影响、淀粉含量的动态变化、可溶性糖含量以及淀粉酶活性等生理指标。结果表明:赤霉素可以提高天山野杏的发芽率,其中对甜杏仁的作用更显著。种子吸水之后子叶中... 详细信息

以甜杏仁和苦杏仁天山野生杏种子为对象,观察赤霉素处理对种子打破休眠的影响、淀粉含量的动态变化、可溶性糖含量以及淀粉酶活性等生理指标。结果表明:赤霉素可以提高天山野杏的发芽率,其中对甜杏仁的作用更显著。种子吸水之后子叶中可溶性糖含量增高,其中苦杏仁的增幅大于甜杏仁,萌发之后2种杏仁可溶性糖含量均迅速下降。野杏干种子有较高的α-和β-淀粉酶活性,萌发种子中α-淀粉酶的活性比未萌发的种子活性高。可溶性糖含量与α-淀粉酶的活性成反比,说明可溶性糖对α-淀粉酶的活性有反馈抑制作用。种子萌发之前具有较高的β-淀粉酶活性,并且未受高浓度可溶性糖的抑制,萌发之后活性显著下降。表明较高的β-淀粉酶活性对野杏种子打破休眠是必要的。

关键词：野生杏种子种子休眠赤霉素处理淀粉酶活性

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沙棘NaCl胁迫下差异表达基因的转录组分析

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新疆农业大学学报 2017年第2期40卷 92-98页

作者：宋彬胡安鸿海利力.库尔班新疆农业大学林学与园艺学院乌鲁木齐830052 阿克苏地区林业科学研究所阿克苏843000

通过测定盐胁迫下沙棘生理指标的变化,利用生物信息学方法分析沙棘在盐胁迫下转录组数据,挖掘沙棘盐胁迫下差异表达基因,为沙棘在土壤盐渍化区域的开发及其利用提供理论依据。生理指标测定结果表明,在300mmol/L的盐胁迫下,丙二醛含量呈... 详细信息

通过测定盐胁迫下沙棘生理指标的变化,利用生物信息学方法分析沙棘在盐胁迫下转录组数据,挖掘沙棘盐胁迫下差异表达基因,为沙棘在土壤盐渍化区域的开发及其利用提供理论依据。生理指标测定结果表明,在300mmol/L的盐胁迫下,丙二醛含量呈平稳上升的趋势。分析300mmol/L NaCl胁迫14d的沙棘叶片与对照总RNA,发现差异表达基因富集在光合作用、光合生物固碳、丙酮酸代谢、苯丙醇合成、乙醛酸盐代谢及丝氨酸、甘氨酸和苏氨酸代谢通路这6大通路中。其中,与光合作用通路相关的差异表达基因达到了27个,是所有代理通路中差异表达基因最多的。在gene ontology(GO)功能数据库中,差异表达基因主要富集在催化活性、氧化还原过程和氧化还原酶活性三大功能中。由于光合作用的影响,造成丙酮酸、苯丙醇、乙醛酸和氨基酸代谢的差异,有可能是沙棘抗盐胁迫的重要原因。

关键词：沙棘转录组基因耐盐光合作用

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患有1型糖尿病儿童和青少年生活质量的调查（英文）

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International Journal of Nursing Sciences 2017年第2期 94-98页

作者： Nurcan ?zyaz?c?o?lu Elif ünsal Avdal halil Sa?lam Department of Pediatric Nursing Faculty of Health SciencesUluda? University Department of Internal Medicine Nursing Faculty of Health ScienceKatip ?elebi University Department of Pediatrics Pediatric Endocrinology DivisionFaculty of MedicineUluda? University

Objective:Type 1 diabetes is a chronic illness which can have a negative effect on the health care and development of children and can put their lives in *** descriptive study aimed to determine the quality of life and the factors affecting it of children and adolescents with type 1 diabetes using the Pediatric Quality of Life Inventory(PedsQL).Methods:The study was conducted in the Child Endocrinology Unit of a University Hospital in Bursa,*** 64 children eight-12 years and 85 adolescents aged 13-18 with type 1 diabetes and their parents were *** measurements were obtained from the records of the endocrinology clinicare,which were made once every three months,and the average of the last three measurements was taken in the *** PedsQL was used to measure quality of life of the children and *** data was analyzed using SPSS version 20.0 and P <0.05 was considered *** demographic data of the children and parents were analyzed using means and ***'s correlation analysis was used to assess the relationship between two ***:Of the sub-groups on the scale,affective and school function scores were somewhat low,and social function scores were *** quality of life scores of the children and adolescents were found to correlate with those of their parents.A negative correlation was found between HbAlc levels and adolescent quality of life,a positive correlation was found between the child's age and the quality of life of the child and parents,and a negative correlation was found between the number of children in the family and the quality of life of the child and ***:An evaluation of the quality of life after a diagnosis of diabetes can be used to assess the problems which may be faced by children and adolescents and to combat these problems.

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Stray Dogs Problem and Right Approach to Prevent Attack

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Journal of Environmental Science and Engineering(A) 2023年第3期12卷 106-115页

作者： halil Ecel Serap Göncü Department of Work Safety the University ofÇukurovaAdana 01330Türkiye Department of Animal Science the University ofÇukurovaAdana 01330Türkiye

In this study,it is aimed to examine the knowledge level of reading stray dogs’behavior and the correct *** the aggression of dogs and understanding their behavior is very important for stray dogs and dog owners in social *** prepared online were shared with 279 people of different ages and genders working in different fields in 50 provinces located in different regions,and the feedback obtained by answering voluntarily was taken into *** a result of the study,when a dangerous-looking dog is encountered,it is necessary to stay as calm as possible and start to walk away slowly,without losing sight of the dog,with short steps,and without running under any *** without turning your back,because turning your back on the dog is a sign of weakness and an invitation to *** 36%left unanswered the question of what should be done at the time of the dog attack,20.1%replied by saying that they would stand calmly and shout and scare,and 20.9%would shout and *** results of the survey show that there are inaccuracies and deficiencies in both the body language of the dogs and the way they approach the *** participants answered the frequency of encountering stray animals by saying 75.9%daily.A safe approach to dogs or knowing the suitable approaches to calm a dangerous dog is very important in eliminating the *** results show that there is a need for correct,informative activities on dog behavior and the right approach.

关键词： Stray dogs problem approach knowledge

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温度及盐胁迫对新疆两种沙棘种子萌发的影响

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江西农业大学学报 2017年第6期39卷 1196-1204页

作者：宋彬胡安鸿海利力.库尔班新疆农业大学林学与园艺学院新疆乌鲁木齐830052 阿克苏地区林业科学研究所新疆阿克苏843000

以两种沙棘属种子为研究对象,分析不同变温条件下种子萌发特点和不同盐浓度下种子的耐受性,为该属植物的种子繁殖、开发利用和植被恢复中的应用提供基础理论依据和技术参考。结果表明:5/2℃低温完全抑制了种子的萌发,温度的升高对种子... 详细信息

以两种沙棘属种子为研究对象,分析不同变温条件下种子萌发特点和不同盐浓度下种子的耐受性,为该属植物的种子繁殖、开发利用和植被恢复中的应用提供基础理论依据和技术参考。结果表明:5/2℃低温完全抑制了种子的萌发,温度的升高对种子萌发具有明显的促进作用,俄罗斯沙棘与中亚沙棘种子萌发的最适变温均为30/15℃。盐胁迫条件下,两种沙棘种子发芽率、发芽指数与盐浓度之间存在着显著的负相关关系,低于0.15 mol/L的NaCl溶液对俄罗斯沙棘、中亚沙棘种子萌发的影响不显著,大于0.15 mol/L时发芽率显著下降。当NaCl溶液大于0.30 mol/L时,沙棘种子萌发表现为全部抑制,转移至蒸馏水后,种子仍具有一定的萌发能力,恢复萌发率表现为随盐溶液前处理浓度的升高而降低的趋势。分析表明中亚沙棘种子萌发期耐盐性强于俄罗斯沙棘,种子萌发期的耐盐能力与生境土壤盐分含量的高低表现出一致性,这可能与两种沙棘所处的环境相关。

关键词：俄罗斯沙棘中亚沙棘种子萌发耐盐性

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沙尘胁迫对阿月浑子光合作用及叶绿素荧光特性的影响

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生态学报 2014年第22期34卷 6450-6459页

作者：帕提古力.麦麦提巴特尔.巴克海利力.库尔班新疆农业大学草业与环境科学学院乌鲁木齐830052 新疆农业大学林业与园艺学院乌鲁木齐830052

为了探讨长期沙尘胁迫下阿月浑子叶片光合性能的变化机制,以室内盆栽阿月浑子为材料,对叶片进行覆盖厚度为2mg/cm2(轻度),9 mg/cm2(重度)的沙尘处理,无沙尘覆盖为对照,并分别在处理后第7天、14天、28天和42天,测定叶片光合CO2同化速率,... 详细信息

为了探讨长期沙尘胁迫下阿月浑子叶片光合性能的变化机制,以室内盆栽阿月浑子为材料,对叶片进行覆盖厚度为2mg/cm2(轻度),9 mg/cm2(重度)的沙尘处理,无沙尘覆盖为对照,并分别在处理后第7天、14天、28天和42天,测定叶片光合CO2同化速率,叶绿素含量以及叶绿素荧光特性等参数。结果表明,阿月浑子叶片的净光合速率(Pn)和气孔导度(Gs)随沙尘处理时间延长而下降,重度沙尘处理下Pn和Gs下降幅度比轻度大,胞间CO2浓度(Ci)处理前期增加而后期下降,重度沙尘处理下Ci增幅比轻度小;叶绿素a(Chl-a)、叶绿素b(Chl-b)和总叶绿素含量均随处理时间的延长而下降,在重度沙尘处理下下降幅度比轻度沙尘处理大,Chl-a的下降速率大于Chl-b,叶绿素a和b的比值(Chl-a/Chl-b)在重度沙尘处理下逐渐下降,而在轻度沙尘处理下呈升-降-升趋势;PSⅡ最大光化学效率(Fv/Fm)不同程度下降,在重度沙尘处理下下降幅度比轻度沙尘处理大;轻度沙尘覆盖下实际光化学效率(ΦPSⅡ)及非环式电子传递效率(ETR)在处理第42天显著下降,而重度覆盖处理先急剧下降,后期逐渐恢复;非光化学荧光猝灭(NPQ)在轻度胁迫下先下降而后逐步上升,在重度处理下则在处理前期就迅速上升。从而得出结论,阿月浑子轻度沙尘胁迫条件下前期其光合作用非气孔限制贡献率大于气孔限制,随胁迫时间气孔限制逐渐占优势,并且随处理时间的延长其吸收的光能用于保护性耗散量逐渐增加,使其光合CO2同化效率下降。

关键词：阿月浑子沙尘胁迫光合特性叶绿素荧光特性

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Effect of Concentration on Polyacrylonitrile （PAN） Nanofibers

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材料科学与工程（中英文版） 2011年第3期5卷 277-280页

作者： Umran Ozkoc halil ibrahim icoglu Ali Kirecci Textile Engineering Department Gaziantep University27310 Gaziantep Turkey

The study investigates the effect of solution concentration on the morphology of polyacrylonitrile (PAN) nanofibers. PAN electrospun nanofibers are produced from PAN/DMF solutions at six different concentrations (6%-16%). The morphology of the nanofibers is analyzed by scanning electron microscope. The experimental results show that the fiber diameter increases and the bead formation decreases as the concentration increases. On the other hand, the nanofiber diameter becomes finer but less uniform as the concentration decreases.

关键词：聚丙烯腈纤维纤维含量 PAN 纳米扫描电子显微镜溶液浓度作者纤维直径

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沙棘PEPCK基因的克隆及表达研究

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西北植物学报 2017年第10期37卷 1934-1940页

作者：宋彬胡安鸿田永芝黄俊华海利力.库尔班新疆农业大学林学与园艺学院乌鲁木齐830052 阿克苏地区林业科学研究所新疆阿克苏843000 新疆师范大学乌鲁木齐830054

以沙棘为研究对象,通过RACE、基因克隆和定量PCR技术,克隆并分析沙棘磷酸烯醇式丙酮酸羧激酶基因(PEPCK)的序列信息,以及进化树构建和氨基酸的二级结构分析,比较NaCl胁迫后PEPCK基因的表达变化,为揭示PEPCK基因在沙棘抗性方面的功能研... 详细信息

以沙棘为研究对象,通过RACE、基因克隆和定量PCR技术,克隆并分析沙棘磷酸烯醇式丙酮酸羧激酶基因(PEPCK)的序列信息,以及进化树构建和氨基酸的二级结构分析,比较NaCl胁迫后PEPCK基因的表达变化,为揭示PEPCK基因在沙棘抗性方面的功能研究奠定基础。结果显示:(1)成功克隆了沙棘PEPCK基因,该基因开放阅读框(ORF)为2 001bp,编码666个氨基酸。(2)序列分析表明,沙棘PEPCK与蓖麻、黄顶菊、核桃等序列一致性高达85%以上;进化上沙棘PEPCK基因与蓖麻和狭叶羽扇豆较近,与烟草、拟南芥进化关系较远。(3)在300mmol·L^(-1) NaCl盐胁迫下,沙棘PEPCK基因表达在胁迫组中显著上升,胁迫后7d时为未处理的2.5倍,15d时达到未处理的3.2倍。研究表明,沙棘PEPCK基因在沙棘适应外源盐胁迫的过程中可能发挥了重要作用。

关键词：沙棘进EPCK基因克隆序列分析表达

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