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Differentiation of Exophytic Renal Masses with Determination of the Angular Interface with Renal Parenchyma in US and CT

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Open Journal of Medical Imaging 2012年第2期2卷 80-83页

作者： Duzgun Yildirim halil bozkurt Abdullah Cirakoglu Mutlu Sahin Bengi Gurses Baki Ekci Department of Radiology Iskenderun Military Hospital Hatay Turkey Department of Radiology Yeditepe Unversity Hospital Istanbul Turkey Department of Surgery University of Washington Seattle USA Department of Surgery Yeditepe Unversity Hospital Istanbul Turkey Department of Urology Karaman Public Hospital Karaman Turkey Department of Urology Kasimpasa Military Hospital Istanbul Turkey

Purpose: To determine whether benign exophytic renal masses can be distinguished from malignant lesions by using the angular interface sign in ultrasonography (US) and computerized tomography (CT). Materials and Methods: A total of 71 cases with exophytic renal mass (2 cm or greater) were examined on the basis of angular interface in US (n = 23), CT (n = 21) and US + CT (n = 16) between January 2008 and June 2010 were included in this study. The renal interface relationships were examined by 2 radiologists and classified as having angular or wide interface. Results: No statistically significant difference was found between the findings of two readers. There was almost perfect interobserver agreement for the interface sign. For cystic lesions, the angular interface sign was determined in all but two Bosniak category 1 cases. Also, the angular interface sign was positive in all but one Bosniak category 2 - 3. For cystic lesions with solid component and pure solid lesions, in the benign group, the angular interface sign was positive in all except three cases (vascular malformation, oncocytoma and Xanthogranulomatous pyelonephritis). In the malignant group, the angular interface sign was determined in only two RCC cases;in other primary or metastatic malignant lesions there was a wide interface sign. Conclusion: Exophytic renal masses can be differentiated as malignant or benign with 87% accuracy using only the angular interface sign in US or CT and also in opposition to dynamic-contrast examinations. This method entails a lack of additional radiation or contrast media exposure, time-saving, and costeffectivity.

关键词： Renal Neoplasms Differential Diagnosis Ultrasonography Computed Tomography Sign

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Relational Turkish Text Classification Using Distant Supervised Entities and Relations

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Computers, Materials & Continua 2024年第5期79卷 2209-2228页

作者： halil Ibrahim Okur Kadir Tohma Ahmet Sertbas Department of Computer Engineering Faculty of Engineering and Natural SciencesIskenderun Technical UniversityHatay31200Turkey Department of Computer Engineering Faculty of EngineeringIstanbul University-CerrahpasaIstanbul34310Turkey

Text classification,by automatically categorizing texts,is one of the foundational elements of natural language processing *** study investigates how text classification performance can be improved through the integration of entity-relation information obtained from the Wikidata(Wikipedia database)database and BERTbased pre-trained Named Entity Recognition(NER)*** on a significant challenge in the field of natural language processing(NLP),the research evaluates the potential of using entity and relational information to extract deeper meaning from *** adopted methodology encompasses a comprehensive approach that includes text preprocessing,entity detection,and the integration of relational *** conducted on text datasets in both Turkish and English assess the performance of various classification algorithms,such as Support Vector Machine,Logistic Regression,Deep Neural Network,and Convolutional Neural *** results indicate that the integration of entity-relation information can significantly enhance algorithmperformance in text classification tasks and offer new perspectives for information extraction and semantic analysis in NLP *** of this work include the utilization of distant supervised entity-relation information in Turkish text classification,the development of a Turkish relational text classification approach,and the creation of a relational *** demonstrating potential performance improvements through the integration of distant supervised entity-relation information into Turkish text classification,this research aims to support the effectiveness of text-based artificial intelligence(AI)***,it makes significant contributions to the development ofmultilingual text classification systems by adding deeper meaning to text content,thereby providing a valuable addition to current NLP studies and setting an important reference point for future research.

关键词： Text classification relation extraction NER distant supervision deep learning machine learning

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Can serum tumor marker densities according to tumor volume and testicle size be used to predict progression in patients with testicular cancer?

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Current Urology 2024年第3期18卷 218-224页

作者： Aykut Demirci halil Basar Department of Urology Dr.Abdurrahman Yurtaslan Ankara Oncology Training and Research HospitalAnkaraTurkey

Background The objective of this study is to determine the role of tumor marker density(TMD)values such as alpha-fetoprotein tumor volume ratio(ATVR),beta-human chorionic gonadotropin tumor volume ratio(βTVR),alpha-fetoprotein testicle size ratio(ATSR),beta-human chorionic gonadotropin testicle size ratio(βTSR),lactate dehydrogenase tumor volume ratio(LTVR),and lactate dehydrogenase testicle size ratio(LTSR)in the determination of progression-free survival(PFS)in patients with testicular *** and methods A retrospective study was conducted of 95 patients followed-up in our clinic with a diagnosis of testicular cancer between January 2015 and August *** were grouped according to clinical stage,as either early stage(n=50)or advanced stage(n=45).Clinical and pathological data and TMD values for all patients were *** The median age of patients was 35 years(21–63 years).All TMDs except LTVR in advanced stage patients were found to be significantly higher than those of early stage patients(p<0.05).Median ATVR(2.58 vs.0.0),ATSR(0.63 vs.0.03),βTVR(0.9 vs.0.009),andβTSR(0.18 vs.0.007)of the nonseminoma patients were found to be significantly higher than those of the seminoma patients,respectively(p<0.001).Progression-free survival(months)was decreased in seminoma patients with high values ofβTVR(11.3±1.9 vs.35.2±0.7),βTSR(16.2±3.4 vs.35.2±0.75),LTVR(17.7±3.4 vs.35.2±0.7),and LTSR(21.5±3.13 vs.35.09±0.8)(p<0.001).Decreased PFS(months)was associated with higher values of ATVR(5.37±0.7 vs.35.05±0.93),βTVR(7.4±1.5 vs.34.6±1.3),ATSR(5.37±0.75 vs.35.05±0.9),βTSR(7±1.5 vs.34.6±1.3),and LTSR(7.9±1.2 vs.34.3±1.5)in nonseminoma patients(p<0.001).Based on multivariate analysis,βTVR-LTVR and ATVR-ATSR were determined to be independent risk factors for reduced PFS in seminoma and nonseminoma patients,respectively(p<0.05).Conclusions The results of this study suggest that the calculation of TMDs could be a promising and simple method for prediction of PF

关键词： Testicular cancer Progression Tumor marker density Prognostic factors

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Gastroesophageal reflux after per-oral endoscopic myotomy:Management literature

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World Journal of Gastroenterology 2024年第23期30卷 2947-2953页

作者： Ahmed Tawheed Ibrahim halil Bahcecioglu Mehmet Yalniz Mohamed El-Kassas Department of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt Department of Gastroenterology Faculty of MedicineFirat UniversityElazig 23119Türkiye Liver Disease Research Center College of MedicineKing Saud UniversityRiyadh 7805Saudi Arabia

In this editorial,we respond to a review article by Nabi et al,in which the authors discussed gastroesophageal reflux(GER)following peroral endoscopic myotomy(POEM).POEM is presently the primary therapeutic option for achalasia,which is both safe and effective.A few adverse effects were documented after POEM,including *** diagnostic criteria were not clear enough because approximately 60%of patients have a long acid exposure time,while only 10%experience reflux *** predictors of high disease incidence have been identified,including old age,female sex,obesity,and a baseline lower esophageal sphincter pressure of less than 45 *** technical steps during the procedure,such as a lengthy or full-thickness myotomy,may further enhance the *** pump inhibitors are currently the first line of *** voices are increasingly advocating for the routine combining of POEM with an endoscopic fundoplication method,such as peroral endoscopic fundoplication or transoral incisionless ***,more research is necessary to determine the safety and effectiveness of these procedures in the long term for patients who have undergone them.

关键词： Achalasia Per-oral endoscopic myotomy Gastroesophageal reflux disease Transoral incisionless fundoplication Peroral endoscopic fundoplication

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A case of asymptomatic fungal and bacterial colonization of an intragastric balloon

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World Journal of Gastroenterology 2009年第45期15卷 5751-5753页

作者： halil Coskun Suleyman bozkurt Department of General Surgery Goztepe Training and Research Hospital

Intragastric balloon therapy, as a part of a multidisciplinary weight management program, is an effective short-term intervention for weight loss. Although the insertion procedure is easy and generally well tolerated by patients, a few complications can occur. We report here a heavy smoker with intragastric balloon inser-tion complicated by colonization with opportunistic organisms. The 27-year-old female, body mass index 35.5 kg/m2, had a BioEnterics Intragastric Balloon inserted under conscious sedation without any perioperative complications. Six months later, when the standard removal time arrived, the balloon was seen to be covered with a necrotic white-gray material. Microbiological examination revealed Enterobacter cloacae and Candida species yeast colonies. We recommend that asymptomatic fungal and/or bacterial colonization should be considered among the complications of the intragastric balloon procedure, despite its rarity.

关键词： Gastric balloon Obesity, Complications Infection

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Neuroprotective effects of daidzein on focal cerebral ischemia injury in rats

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Neural Regeneration Research 2015年第1期10卷 146-152页

作者： Adem bozkurt Aras Mustafa Guven Tar?k Akman Adile Ozkan halil Murat Sen Ugur Duz Y?ld?ray Kalkan Coskun Silan Murat Cosar Department of Neurosurgery Canakkale Onsekiz Mart University Department of Neurology Canakkale Onsekiz Mart University Department of Medical Biochemistry Ministry of HealthAdministration of Public Health Deparment of Histology and Embryology Recep Tayyip Erdo?an UniversityFaculty of Medicine Department of Pharmacology Canakkale Onsekiz Mart University

Daidzein, a plant extract, has antioxidant activity. It is hypothesized, in this study, that daidzein exhibits neuroprotective effects on cerebral ischemia. Rat models of middle cerebral artery oc- clusion were intraperitoneally administered daidzein. Biochemical and immunohistochemical tests showed that superoxide dismutase and nuclear respiratory factor 1 expression levels in the brain tissue decreased after ischemia and they increased obviously after daidzein administra- tion; malondialdehyde level and apoptosis-related cysteine peptidase caspase-3 and caspase-9 immunoreactivity in the brain tissue increased after ischemia and they decreased obviously after daidzein administration. Hematoxylin-eosin staining and luxol fast blue staining results showed that intraperitoneal administration of daidzein markedly alleviated neuronal damage in the ischemic brain tissue. These findings suggest that daidzein exhibits neuroprotective effects on ischemic brain tissue by decreasing oxygen free radical production, which validates the afore- mentioned hypothesis.

关键词： nerve regeneration brain ischemia stroke daidzein oxidative stress apoptosis superoxidedismutase malondialdehyde nuclear respiratory factor 1 neural regeneration

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Dynamics and cytokinic regulation of immune cell infiltration in genetically engineered mouse models of pancreatic cancer dictate the sensitivity to immunotherapy

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Cancer Communications 2024年第1期44卷 178-182页

作者： Okan Safak Shenghan Wang Carmen Mota Reyes Ibrahim halil Gürcinar Sergey Tokalov Nedim Can Cevik Kivanc Görgülü Bengi Su Yilmaz Emre Erdogan Linhan Ye Qiaolin Li Elif Arik Sever SamedÖzer Güldal Süyen Helmut Friess Güralp Onur Ceyhan Rouzanna Istvanffy Hana Algül Ihsan Ekin Demir Department of Surgery Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of General Surgery HPB-UnitSchool of MedicineAcibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Comprehensive Cancer Center München Klinikum rechts der IsarTechnical University of MunichSchool of MedicineMunichBavariaGermany Department of Hematology Oncology and Tumor ImmunologyCharitéUniversity Medicine BerlinCampus Virchow ClinicBerlinBerlinGermany Graduate School of Health Sciences Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Department of Physiology Acibadem Mehmet Ali Aydinlar UniversityIstanbulIstanbulTurkey Else Kröner Clinician Scientist Professorship for Translational Pancreatic Surgery MunichGermany Neural Influences in Cancer(NIC)International Research Consortium MunichGermany

Dear Editor,Targeting the immune compartment in pancreatic duc-tal adenocarcinoma(PDAC)holds promise for prognostic improvement,yet our knowledge on the spatial and tem-poral dynamics and the molecular modulators of t... 详细信息

关键词： immune adenocarcinoma immunotherapy

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Syringaldehyde exerts neuroprotective effect on cerebral ischemia injury in rats through anti-oxidative and anti-apoptotic properties

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Neural Regeneration Research 2014年第21期9卷 1884-1890页

作者： Aras Adem bozkurt Guven Mustafa Akman Tar?k Ozkan Adile Sen halil Murat K?l?coglu Mesut Kalkan Y?ld?ray Silan Coskun Cosar Murat Department of Neurosurgery ?anakkale Onsekiz Mart UniversityCanakkaleTurkey Department of Neurology ?anakkale Onsekiz Mart UniversityCanakkaleTurkey Department of Medical Biochemistry Ondokuz May?s UniversitySamsunTurkey Deparment of Histology and Embryology Faculty of MedicineRecep Tayyip Erdo?an UniversityRizeTurkey Department of Pharmacology ?anakkale Onsekiz Mart UniversityCanakkaleTurkey

There are few studies on the neuroprotective effects of syringaldehyde in a rat model of cerebral ischemia. The study aimed to elucidate the mechanisms underlying the neuroprotective effects of syringaldehyde on ischemic brain cells. Rat models of cerebral ischemia were intraperitoneally administered syringaldehyde. At 6 and 24 hours after syringaldehyde administration, cell damage in the brain of cerebral ischemia rats was obviously reduced, superoxide dismutase activity and nuclear respiratory factor 1 expression in the brain tissue were markedly increased, malondi-adehyde level was obviously decreased, apoptosis-related cysteine peptidase caspase-3 and -9 immunoreactivity was obviously decreased, and neurological function was markedly improved. These ifndings suggest that syringaldehyde exerts neuroprotective effects on cerebral ischemia injury through anti-oxidation and anti-apoptosis.

关键词： nerve regeneration syringaldehyde brain ischemia neuroprotective effects inflammatory oxidative stress apoptosis neural regeneration

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REKF and RUKF for pico satellite attitude estimation in the presence of measurement faults

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Journal of Systems Engineering and Electronics 2014年第2期25卷 288-297页

作者： halil Ersin Sken Chingiz Hajiyev Department of Space and Astronautical Science The Graduate University for Advanced Studies (Sokendai) Aeronautics and Astronautics Faculty Istanbul Technical University

When a pico satellite is under normal operational condi- tions, whether it is extended or unscented, a conventional Kalman filter gives sufficiently good estimation results. However, if the measurements are not reliable because of any kind of malfunc- tions in the estimation system, the Kalman filter gives inaccurate results and diverges by time. This study compares two different robust Kalman filtering algorithms, robust extended Kalman filter （REKF） and robust unscented Kalman filter （RUKF）, for the case of measurement malfunctions. In both filters, by the use of de- fined variables named as the measurement noise scale factor, the faulty measurements are taken into the consideration with a small weight, and the estimations are corrected without affecting the characteristic of the accurate ones. The proposed robust Kalman filters are applied for the attitude estimation process of a pico satel- lite, and the results are compared.

关键词： pico satellite attitude estimation robust Kalman filter-ing extended Kalman filter (EKF) unscented Kalman filter (UKF).

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Effect of surfactant on the dielectric and electrorheological properties of zinc borate/silicone oil dispersions

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International Journal of Minerals,Metallurgy and Materials 2019年第12期26卷 1523-1530页

作者： Omer Yunus Gumus halil Ibrahim Unal Bursa Technical University Engineering and Natural Sciences FacultyFiber and Polymer Engineering DepartmentBursa 16310Turkey Gazi University Science FacultyChemistry DepartmentSmart Materials Research Lab.Ankara 06500Turkey

Zinc borate(ZB)particles dispersed in silicone oil(SO)at concentrations of φ=5vol%-20vol% were subjected to dielectric analysis to elucidate their polarization strength,time,and *** revealed that all virgin dispersions lacked *** X-100,a non-ionic surfactant,was added to ZB/SO dispersions to enhance the polarizability of ZB *** addition of 1vol% Triton X-100 enhanced the polarizability of ZB/SO dispersions,and the 15vol% ZB/SO system provided the highest dielectric difference Δε′(the difference in ε′values at zero and infinite frequency,Δε′=ε0–ε∝)of *** electrorheological(ER)activities of the ZB/SO/Triton-X dispersion system were determined through the ER response test,and viscoelastic behaviors were investigated via oscillation tests.A recoverable deformation of 36% under an applied electrical field strength of 1.5 kV/mm was detected through creep and creep recovery tests.

关键词： zinc borate electrorheological fluids dielectric analysis surfactant

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