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World Journal of Pediatrics 2022年第6期18卷 443-448页

作者： Eman R.Youness Sherien Mel-Daly Hanaa Reyad Abdallah hala T.el-Bassyouni Hisham Megahed Azzah A.Khedr Marwa elhady Walaa Alsharany Abuelhamd Medical Biochemistry Department Medical Research DivisionNational Research CentreGizaEgypt Biological Anthropology Department Medical Research DivisionNational Research CentreGizaEgypt Clinical Genetics Department Human Genetics and Genome Research DivisionNational Research CentreEl-Tahrir StreetPO:12622GizaEgypt Human Cytogenetics Department Human Genetics and Genome Research DivisionNational Research CentreGizaEgypt Pediatric Department Faculty of Medicine for GirlsAl-Azhar UniversityCairoEgypt Department of Pediatrics Faculty of MedicineCairo UniversityCairoEgypt

Down syndrome,Turner syndrome,and Klinefelter syndrome are the most common chromosomal disorders *** syndrome is caused by an extra copy of the 21st chromosome and has an incidence of 1 in 800 to 1000 live *** syndrom... 详细信息

关键词： chromosomal Turner Serum

Sustainable Industrial Community

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Journal of Environmental Protection 2017年第3期8卷 301-318页

作者： hala Omar Salah el-Haggar Mechanical Engineering The American University in Cairo Cairo Egypt

Nowadays, the style of living that significantly depends on consumption of resources and over consumption patterns, tremendous increase in population, urbanization and industrialization resulted into generation of huge amounts of industrial wastes. Many environmental problems are facing industrial areas, especially in developing countries, due to poor industrial hazardous waste management. In order to reduce the effect of industrial waste on the environment and to reach sustainable development, countries have developed and reinforced several environmental protection laws and regulations. Yet, the waste disposals via incineration and/or landfilling according to cradle-to-grave concept require high capital, high running costs and are seen by industries as a barrier for further industrial development. Most importantly, disposals of waste deplete natural resources causing them to be unsustainable. Hence, various concepts and strategies have been suggested to promote industrial sustainability. The aim of this paper is to present different concepts and practices including Cradle-to-Cradle approach, Cleaner Production, Industrial Ecology, Eco-Industrial Park and Environmentally Balanced Industrial Complex described in literature that help develop a successful sustainable industrial community and reach zero pollution. These concepts are illustrated via case studies. Moreover, this paper tackles the challenges facing industrial areas in Egypt and emphasis on the imperative need for considering sustainable industrial community.

关键词： Industrial Waste Sustainable Industrial Community Cradle-to-Cradle Cleaner Production Eco-Industrial Park Environmentally Balanced Industrial Complex Zero Pollution

Preliminary Study of a Hybrid Helicon-ECR Plasma Source

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Plasma Science and Technology 2016年第8期18卷 832-836页

作者： A.M.hala L.OKSUZ ZHU Ximing The National Center for Applied Physics Material Science Research InstituteKing Abdul Aziz City for Science and Technology(KACST) Süleyman Demirel University Science and Literature FacultyPhysics Department Institute for Plasma and Atomic Physics Ruhr University

A new type of hybrid discharge is experimentally investigated in this work. A helicon source and an electron cyclotron resonance（ECR） source were combined to produce plasma. As a preliminary study of this type of plasma, the optical emission spectroscopy（OES） method was used to obtain values of electron temperature and density under a series of typical conditions. Generally,it was observed that the electron temperature decreases and the electron density increases as the pressure increased. When increasing the applied power at a certain pressure, the average electron density at certain positions in the discharge does not increase significantly possibly due to the high degree of neutral depletion. electron temperature increased with power in the hybrid *** mechanisms of these preliminary observations are discussed.

关键词： helicon plasma ECR hybrid discharge

Nucleotide Sequence Assessment of Four ORFs of Citrus Tristeza Virus: Evidence of Recombination

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Phyton-International Journal of Experimental Botany 2023年第3期92卷 691-705页

作者： Adel A.Rezk hala A.Amin Department of Agricultural Biotechnology College of Agricultural and Food ScienceKing Faisal UniversityAl-Ahsa31982Saudi Arabia Virus and Phytoplasma Research Department Plant Pathology Research InstituteAgricultural Research Center(ARC)Giza12619Egypt

Citrus Tristeza Virus(CTV),usually occurs in nature as a mixture of *** naturally infected citrus(Citrus sinensis)trees grafted on sour orange rootstock were collected from three citrus growing governorates in Egypt(Sharqia,Qalyubia and Garbia).In this study,RT-PCR,Single-Strand Conformation Polymorphism(SSCP)and nucleotide sequence analysis were used for four independent CTV genomic regions(p65,p18,p20,and p23)to detect and assess the sequence and genetic variabilities among CTV Egyptian *** products(650 bp)for the CTV p23 gene obtained from the selected isolates were used for the SSCP analysis and DNA *** patterns of p23 gene for individual isolates yielded different complex haplotype *** sequence analysis of p23 region amplified from six isolates under study revealed that p23 shared high nucleotide identity 98.7%with T36 isolate from USA,*** analysis of p23 gene indicated a close evolutionary relationship between all examined isolates and Qaha isolate(T36 isolate group),suggesting that they may have originated from closely related *** sequence analysis of the three genes located on CTV 3′-coterminal overhang,p18,p20 and p65,amplified from isolate A3,Sharqia governorate,revealed that the p18,p65,and p20 genes were related to the T3-KB isolate from South Africa with 99%–100%sequence *** relationship analysis for p65,p18 and p20 ORFs clustered the current A3 isolate with T3 genotype *** recombination analysis identified three of six isolates from Sharqia,and Garbia as potential recombinant for p23 *** isolates T36 and T3 were identified as major donors for recombination events in isolate *** results concluded that p23 ORF likely to be as a hotspot region for recombination and originated through recombination *** current study indicated that recombination is an important factor for the origin of CTV strains in Egypt.

关键词： Citrus Tristeza Virus hotspot region phylogenetic relationship analysis sequence comparison SSCP analysis

Anatomical and Molecular Identification of Ornamental Plant Ficus ***

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Phyton-International Journal of Experimental Botany 2023年第5期92卷 1329-1347页

作者： Abtisam Binnoubah Rim Hamdy Osama G.Ragab Ahmed M.el-Taher Ahmed Abou el-Yazied Fatmah A.Safhi hala A.elzilal Ashwaq T.Althobaiti Salha M.ALshamrani Diaa Abd el Moneim Ahmed el-Banhawy Department of Botany Faculty of ScienceUniversity of SabrathaSabratha999116Libya Department of Botany Faculty of ScienceCairo UniversityGiza12111Egypt Department of Botany and Microbiology Faculty of Science(Boys Branch)Al-Azhar UniversityCairo11884Egypt Department of Agricultural Botany Faculty of AgricultureAl-Azhar UniversityCairo11884Egypt Department of Horticulture Faculty of AgricultureAin Shams UniversityCairo11566Egypt Department of Biology College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia Department of Science and Technology College of RanyahTaif UniversityTaif21944Saudi Arabia Department of Biology College of ScienceTaif UniversityTaif21944Saudi Arabia Department of Biology College of ScienceUniversity of JeddahJeddah21959Saudi Arabia Department of Plant Production(Genetic Branch) Faculty of Environmental Agricultural SciencesArish UniversityEl-Arish45511Egypt Department of Botany and Microbiology Faculty of ScienceSuez Canal UniversityIsmailia41522Egypt

This present study includes twelve species that represent the Ficus genus,namely;aspera,carica,tinctoria ***,hirta,hispida,neriifolia,palmata,pumila,racemosa,septica,sur,and sycomorus,belonging to the Moraceae *** species samples were collected from various locations in *** study focused on the anatomical and molecular characteristics of mature foliage *** the identification and classification of taxa are highly dependent on the anatomical features of leaves,the anatomical characteristics were recorded in the form of a comparison between the examined plants in the data *** study aims to contribute to the identification of the studied species based on the anatomical details of the matured *** characterization includes the variations in upper and lower epidermal layers that are covered by a thin or thick cuticle;the number of palisade and spongy layers;crystals;secretory elements;lithocysts;the midrib zone has parenchyma associated with mechanical tissue,vascular system,and investigation of trichomes;on the other hand,in the current study,the phylogenetic analysis was conducted by using the ITS and 5.8 S *** the analysis of all the available data,it could be stated that there is an overall agreement with the anatomical character dendrogram.

关键词： ITS trichomes leaf anatomy Ficus moraceae

Sensitivity Enhancement of Nonlinear Waveguide Sensors With Conducting Graphene Layer： TE Mode

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Photonic Sensors 2018年第1期8卷 29-33页

作者： hala J. el-KHOZONDAR Mohammed M. SHABAT Rana KHLIFA electrical Engineering department lslamic University of Gaza P.O.Box 108 Gaza Palestine Physics department lslamic University of Gaza P.O.Box 108 Gaza Palestine

We propose a three-layer waveguide sensor. The proposed sensor consists of a graphene thin layer with constant conductivity at the interface between air and dielectric media with thickness d sitting above a nonlinear layer. The sensitivity of the sensor is derived from the dispersion equation. The sensitivity is calculated for both TE0 and TE1. Results show that the sensitivity of the proposed sensor depends on the conductivity of the graphene layer, the angular frequency, and the thickness of the dielectric layer.

关键词： Graphene nonlinear Kerr like materials optical sensor waveguide sensor

Chlorine as an integrated approach for environmental health and hygiene:A case study on evaluation of the performance of waste stabilization ponds located at 11 governorates in Egypt

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Emerging Contaminants 2022年第1期8卷 243-253页

作者： Sayeda M.Abdo Mohamed Azab el-Liethy hala S.Doma Gamila E.el Taweel Gamila H.Ali Water Pollution Research Department National Research Centre12662DokkiGizaEgypt

The current study summarizes the current status of wastewater stabilization ponds(WSPs)treatment plants that have already been built in 11 governorates throughout ***,this study aims to determine the most appropriate chlorine dose for waste stabilization ponds(WSPs)effluents to ensure the treated effluents are suitable for reuse in unrestricted irrigation and to comply with the current legislation on direct discharge onto water *** to the findings,the chlorine doses used as a disinfectant in the treated effluents of the majority of WSP treatment plants ranged from 3 to 13 mg/***,two of the WSPs treatment plants effluents,the Qus WSPs treatment plant in Qena governorate and the Al Zarabii WSPs treatment plant in Asyut governorate used high chlorine doses reached to 17 and 19 mg/L,*** is due to the fact that both the Qus and Al Zarabii WSPs treatment plants have a high organic load,which necessitated the use of more chlorine to achieve the optimum chlorine dose at 13 mg/L for Qus and 11mg/L for Al *** findings demonstrated that chlorine has a powerful effect in completely removing ***,in most chlorine-treated wastewater final effluents,as the chlorine doses increased,the chlorophyll-a reading *** amount of trihalomethanes(THMs)produced as disinfectant byproduct was *** results proved that the water can be used in unrestricted irrigation,and after adding chlorine,it can be dumped on water bodies without health risks.

关键词： Waste stabilization ponds Microbial pathogens Chlorine doses Trihalomethanes(THMs)

Effect of Egyptian propolis on cryptosporidiosis in immunosuppressed rats with special emphasis on oocysts shedding,leukogram,protein profile and ileum histopathology

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Asian Pacific Journal of Tropical Medicine 2017年第3期10卷 240-248页

作者： Hamdy Soufy Nadia M.el-Beih Soad M.Nasr Tamer H.Abd el-Aziz Fathia A.M.Khalil Youssef F.Ahmed hala A.A.Abou Zeina Department of Parasitology and Animal Diseases National Research Centre Department of Zoology Faculty of ScienceAin Shams University Department of Reproduction and Artificial Insemination National Research Centre

Objective:To investigate the activity of Egyptian propolis extracts(ethanol and water)on cryptosporidiosis in experimentally infected dexamethasone-immunosuppressed ***:A total of 180 male rats(190-220)g BWt were randomly divided into 9 equal groups(G1-G9).Groups of rats were kept as(G1):normal control,(G2-G9):immunosuppressed with dexamethasone and(G3-G9):infected with Cryptosporidium *** from(G4to G9)were given orally ethanol and water extract of propolis(at a dose of 50 mg/kg BWt)and nitazoxanide(standard anti-cryptosporidial drug at a dose of 100 mg/kg BWt)to infected rats with different *** pellets were collected from all groups to monitor oocysts shedding from the 2nd to the 15th day post *** the end of the experiment,blood was collected from all groups for determination of leukogram and serum *** specimens were also examined ***:The highest reduction of oocysts shedding in faecal samples was 88%in rats prophylactically treated with propolis ethanol extract at the 4th dpi,and in rats prophylactically treated with water extract of propolis,was91%at the 6th *** was a marked increase in neutrophils count and α_2-andβ-globulins levels in infected rats treated with both extracts,while a significant decrease was detected in lymphocytes compared to the infected non treated group.β-globulin level markedly increased in the rats administered *** changes were observed in the ileum of rats infected with ***:Egyptian propolis extracts have an activity on cryptosporidiosis in ***,propolis modulated the immunity in dexamethasone-immunosuppressed rats.

关键词： Cryptosporidiosis Propolis Rat model Leukogram Serum proteins Histopathology

Novel CYP1B1 mutations and a possible prognostic use for surgical management of congenital glaucoma

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International Journal of Ophthalmology(English edition) 2019年第4期12卷 607-614页

作者： Mohamed M.Khafagy Nadia el-Guendy Marwa A Tantawy Mohamed A.eldaly hala M.elhilali Abdel Hady A.Abdel Wahab Ophthalmology Department Faculty of Medicine Cairo University Cancer Biology Department National Cancer Institute Cairo University Research Department Children's Cancer Hospital

AIM: To identify CYP1B1 gene mutations and evaluate their possible role as a prognostic factor for success rates in the surgical management of Egyptian congenital glaucoma ***: Totally 42 eyes of 29 primary congenital glaucoma patients were operated on with combined trabeculotomy/trabeculectomy with mitomycin-C and followed up at 1 d, 1 wk, 1, 6 and 12 mo postoperatively. Genomic DNA was extracted from peripheral blood leukocytes. Coding regions of CYP1B1 gene were amplified using 13 pairs of primers, screened for mutations using single-strand conformation polymorphism followed by sequencing of both strands. Efficacy of the operation was graded as either a success [maintaining intraocular pressure(IOP) less than 21 mm Hg with or without antiglaucoma medication], or a failure(IOP more than 21 mm Hg with topical antiglaucoma medications). RESULTS: Seven novel mutations out of a total of 15 different mutations were found in the CYP1B1 genes of 14 patients(48.2%). The presence of CYP1B1 gene mutations did not correlate with the failure of the surgery(P=0.156, odds ratio=3.611, 95%CI, 0.56 to 22.89); while the positive consanguinity strongly correlated with failure of the initial procedure(P=0.016, odds ratio=11.25, 95%CI, 1.57 to 80.30). However, the Kaplan-Meier survival analysis revealed a significantly lower time of IOP control in the subgroup with mutations in CYP1B1 versus the congenital primary glaucoma group without mutations(log rank test, P=0.015).CONCLUSION: Seven new CYP1B1 mutations are identified in Egyptian patients. Patients harboring confirmed mutations suffered from early failure of the initial surgery. CYP1B1 mutations could be considered as a prognostic factor for surgery in primary congenital glaucoma.

关键词： CYP1B1 mutations primary congenital glaucoma intraocular pressure trabeculotomy/trabeculectomy with mitomycin-C.

Emerging role of biosimilars in the clinical care of inflammatory bowel disease patients

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World Journal of Clinical Cases 2022年第14期10卷 4327-4333页

作者： hala Najeeb Farah Yasmin Salim Surani Department of Internal Medicine Dow University of Health SciencesKarachi 74200Pakistan Department of Medicine Texas A&M UniversityCollege StationTX 77843United States Department of Anesthesiology Mayo ClinicRochesterMN 55905United States

The increasing incidence of inflammatory bowel disease(IBD)globally has redirected the healthcare system's focus towards safe and affordable pharmacological *** inception of anti-tumor necrosis factor-α(TNF-α)had resulted in a trend shift from surgical ***,as the patents of approved anti-TNF-αdrugs expire,biological copies of the many approved products are in the *** most commonly used biosimilar for IBD has been infliximab,followed by Adalimumab biosimilars which have been approved in major countries across the *** biosimilars are approved on the basis of similarity of their reference product,the lack of real-world evidence of its safety in ulcerative colitis and Crohn’s disease patients has contributed to physicians’***,biosimilars are expected to reduce treatment costs and provide economic benefits.

关键词： Inflammatory bowel disease Biosimilars Anti-tumor necrosis factor Infliximab Adalimumab Ulcerative colitis Chrons disease