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A comparative study of liquid and solid inner contact roxatidine acetate ion-selective electrode membranes

Chinese Chemical Letters 2015年第6期26卷 714-720页

作者： Mohamed K.Abd el-Rahman hala E.Zaazaa Samah S.Abbas Badr el-Zeany Zeinab A.el-Sherif Dalia A.el-Haddad Analytical Chemistry Department Faculty of PharmacyCairo University National Organization for Drug Control and Research

A comparative study was conducted using two designs of a roxatidine acetate （ROX）-selective electrode; a conventional liquid inner contact called electrode A and a graphite-coated solid contact called electrode 13. The fabrication of electrodes was based on roxatidine-tetraphenylborate （ROX-TPB） as an ion-association complex in a PVC matrix using different plasticizers. electrode A has a linear dynamic range of 2.2 ×10^-5 mol/L to 1.0 ×10^-2 mol/L, with a Nernstian slope of 54.7 mV/decade and a detection limit of 1.4 ×10^-6 mol/L. electrode B shows linearity over the concentration range of 1.0×10^-6 mol/L to 1.0×10^-2 tool/L, with a Nernstian slope of 51.2 mV/decade and a limit of detection of 1.1×10^7 mol/L which is remarkably improved as a result of diminishing ion fluxes in this solid contact, ion-selective electrode. The proposed sensors display useful analytical characteristics for the determination of ROX in bulk powder and its pharmaceutical formulation. The present electrodes show clear discrimination of ROX from several inorganic, organic ions, sugars, some common drug excipients and the degradation product （3-[3-（1-piperidinyl methyl） phenoxy] propyl amine） of ROX. Furthermore, the proposed electrodes were utilized for the determination of ROX in human plasma, where electrode B covers drug Cmax which indicated its applicability to pharmacokinetic, bioavailability and bioequivalent studies. The results obtained by the proposed electrodes were statistically analyzed and compared with those obtained by a reported HPLC method. No significant difference for either accuracy or precision was observed.

关键词： Comparative study Roxatidine acetate Liquid inner contact electrode Solid contact electrode Degradation product Plasma

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Mineralogy and geochemistry of fine-grained Dahab stream sediments, Southeastern Sinai, Egypt: emphasis on the intergrowths of Fe–Ti oxides

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Acta Geochimica 2021年第6期40卷 871-894页

作者： Adel A.Surour Ahmed.M.A.el-Kammar Ebtisam H.Arafa hala M.Korany Petroleum and Mining Geology Faculty of SciencesGalala University43511 New Galala CityEgypt Department of Geology Faculty of ScienceCairo UniversityGiza 12613Egypt

Mineralogical and geochemical characteristics of stream sediments collected from 30 stations in the Dahab-Wadi Kid area(southeastern Sinai,Egypt)are *** studied sediments contain considerable amounts of heavy minerals,including abundant Fe–Ti oxides,with up to 25.94%index figure that measures the relative abundance of heavy minerals to light *** of the sediments and nature of Fe–Ti oxide intergrowths,in addition to some non-opaque heavy minerals,indicate multiple provenances with contributions from a variety of Neoproterozoic mafic to felsic *** amounts of heavy minerals are derived from schists that belong to the so-called Wadi Kid volcanosedimentary *** to the considerable contribution of the felsic intrusions represented by within-plate granites,the sediments are enriched in REE-bearing minerals(e.g.,monazite,cerianite,La-cerianite and allanite),V-bearing thorite,zircon,and a ZrO_(2) *** majority of Fe–Ti oxides are derived from the mafic intrusions,and they show evidence of pre-,syn-and post-depositional phases of alteration and formation of *** to the geochemical signature of the bulk silt fraction,there is remarkable enrichment of LREEs with distinct negative Eu anomaly,and this supports dominance of a provenance dominated by felsic intrusions(i.e.,the A-type within-plate granite and associated pegmatites).Also,the felsic provenance is responsible for slight abnormality of ∑PU+Th content(up to~37 ppm)and few anomalous samples bear uraniferous zircon and Ce-type *** present paper sheds light on the fertility of the Dahab stream sediments in some economic minerals for possible future exploitation,not for gold only,but for potential REEbearing minerals that are needed for a wide spectrum of modern technological industries.

关键词： Dahab stream sediments Silt fraction Fe-Ti oxides Textural variations Rees enrichment

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Chronic ocular GVHD:limbal and conjunctival stem cell allografts from the same hematopoietic stem cell donor

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International Journal of Ophthalmology(English edition) 2018年第9期11卷 1569-1572页

作者： elias F Jarade hala el Rami Youssef Abdelmassih Mazen Amro Beirut Eye and ENT Specialist Hospital Beirut 116-5311Lebanon

Dear Editor,I am *** F Jarade from the Beirut Eye and ENT Specialist Hospital, Beirut, Lebanon. I write to describe a novel surgical technique in the management of chronic ocular graft-versus-host disease（GVHD）.

关键词： Chronic ocular GVHD limbal and conjunctival stem cell allografts from the same hematopoietic stem cell donor

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Improved RC6 Block Cipher Based on Data Dependent Rotations

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Computers, Materials & Continua 2022年第1期70卷 1921-1934页

作者： Osama S.Faragallah Ibrahim F.elashry Ahmed AlGhamdi Walid el-Shafai S.el-Rabaie Fathi E.Abd el-Samie hala S.el-sayed Mohamed A.elaskily Department of Information Technology College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of electrical Communications Faculty of EngineeringKafrelsheikh UniversityKafrelsheikhEgypt Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of electronics and electrical Communications Faculty of Electronic EngineeringMenoufia UniversityMenouf32952Egypt Department of electrical Engineering Faculty of EngineeringMenoufia UniversityShebin El-Kom32511Egypt Department of Informatics Electronic Research Institute(ERI)CairoEgypt

This paper introduces an Improved RC6(IRC6)cipher for data encryption based on data-dependent *** proposed scheme is designed with the potential of meeting the needs of the Advanced Encryption Standard(AES).Four parameters are used to characterize the proposed *** parameters are the size of the word(w)in bits,the number of rounds(r),the length of the secret key(b)in bytes,and the size of the block(L)in *** main feature of IRC6 is the variable number of working registers instead of just four registers as in RC6,resulting in a variable block size for plaintext and *** IRC6 cipher is designed to improve the robustness against attacks by increasing the diffusion for each round and providing greater security with fewer *** effectiveness of the proposed IRC6 scheme is verified against theoretical *** proposed IRC6 scheme depends on full diffusion and confusion mechanisms regardless of the utilized block *** proposed IRC6 scheme saves 70%of the encryption time and 64%of the decryption time of *** simulation results prove that the IRC6 achieves a better encryption/decryption time compared to the ***,the proposed IRC6 is anticipated to fulfill the market needs and system security requirements.

关键词： Cryptography block cipher RC6,IRC6,AES

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Intelligent Multiclass Skin Cancer Detection Using Convolution Neural Networks

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Computers, Materials & Continua 2021年第10期69卷 831-847页

作者： Reham Alabduljabbar hala Alshamlan Department of Information Technology College of Computer and Information SciencesKing Saud UniversityRiyadhSaudi Arabia

The worldwide mortality rate due to cancer is second only to cardiovascular *** discovery of image processing,latest artificial intelligence techniques,and upcoming algorithms can be used to effectively diagnose and prognose cancer faster and reduce the mortality *** applying these latest techniques has increased the survival chances during recent *** research community is making significant continuous progress in developing automated tools to assist dermatologists in decision *** datasets used for the experimentation and analysis are ISBI 2016,ISBI 2017,and HAM *** this work pertained models are used to extract the efficient *** pertained models applied are ResNet,InceptionV3,and classical feature extraction *** that,efficient preprocessing is conducted on dermoscopic images by applying various data augmentation ***,for classification,convolution neural networks were *** classify dermoscopic images on HAM 1000 Dataset,the maximum attained accuracy is 89.30%for the proposed *** other parameters for measuring the performance attained 87.34%(Sen),86.33%(Pre),88.44%(F1-S),and 11.30%false-negative rate(FNR).The class with the highest TP rate is 97.6%for Melanoma;whereas,the lowest TP rate was for the Dermatofibroma *** dataset ISBI2016,the accuracy achieved is 97.0%with the proposed classifier,whereas the other parameters for validation are 96.12%(Sen),97.01%(Pre),96.3%(F1-S),and further 3.7%(FNR).For the experiment with the ISBI2017 dataset,Sen,Pre,F1-S,and FNR were 93.9%,94.9%,93.9%,and 5.2%,respectively.

关键词： Convolution neural networks skin cancer artificial intelligence dermoscopy feature extraction classification

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Association of vitamin D receptor gene polymorphism(VDR)with vitamin D deficiency,metabolic and inflammatory markers in Egyptian obese women

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Genes & Diseases 2017年第3期4卷 176-182页

作者： Moushira Zaki Sanaa Kamal Walaa ABasha Eman Youness Wafaa Ezzat hala el-Bassyouni Khalda Amr Biological Anthropology Department National Research CentreGizaEgypt Medical Biochemistry Department National Research CentreGizaEgypt Internal Medicine Department National Research CentreGizaEgypt Clinical Genetics Department National Research CentreCairoEgypt Medical Molecular Genetics Department National Research CentreEgypt

Vitamin D deficiency might contribute to the pathogenesis of metabolic syndrome and could cause immune *** aim of this study is to analyze the associations between Vitamin D receptor(VDR)gene polymorphism,serum 25-hydroxy vitamin D,metabolic and inflammatory biomarkers in Egyptian obese *** study included 201 obese women with vitamin D deficiency and 249 obese matched age healthy controls with sufficient vitamin D *** age ranged between 25 and 35 *** biomarkers(interleukin-6 and C-reactive protein)and serum 25(OH)D were measured by enzyme-linked immunosorbent *** resistance(IR)was determined by the homeostasis model assessment of insulin resistance(HOMA-IR).Vitamin D receptor(VDR)gene polymorphisms of FokI,ApaI,and TaqI were studied by PCR using the restriction fragment length polymorphism(RFLP)*** women with vitamin D deficiency had significant higher values of inflammatory and metabolic parameters compared to ***-logistic regression showed associations between 25(OH)D deficiency and metabolic components when comparing cases with ***,cases carrying polymorphic alleles showed significant lower levels of serum 25(OH)D and higher HOMA-IR,blood pressure levels and lipid parameters compared to those with the wild type homozygote in obese cases with vitamin D *** D deficiency in Egyptian obese women with vitamin D deficiency is associated with abnormal metabolic components and abnormal inflammatory ***,VDR polymorphisms play important role in immune and inflammation status.

关键词： Inflammatory biomarkers Obese women Vitamin D deficiency Vitamin D receptor(VDR)gene polymorphism Egyptian

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Information security through controlled quantum teleportation networks

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Digital Communications and Networks 2020年第4期6卷 463-470页

作者： hala Hamdoun Alaa Sagheer Center for Artificial Intelligence and RObotics(CAIRO) Department of Computer ScienceAswan UniversityAswanEgypt Department of Computer Science College of Computer Science and Information TechnologyKing Faisal UniversitySaudi Arabia

Information security is the backbone of current intelligent systems,such as the Internet of Things(IoT),smart grids,and Machine-to-Machine(M2M)*** increasing threat of information security requires new models to ensure the safe transmission of information through such ***,quantum systems have drawn much attention since they are expected to have a significant impact on the research in information *** paper proposes a quantum teleportation scheme based on controlled multi-users to ensure the secure information transmission among *** teleportation is an original key element in a variety of quantum information tasks as well as quantum-based technologies,which plays a pivotal role in the current progress of quantum computing and *** the proposed scheme,the sender transmits the information to the receiver under the control of a third user or ***,we show that the efficiency of the proposed scheme depends on the properties of the transmission channel and the honesty of the *** with various teleportation scheme presented recently in the literature,the most important difference in the proposed scheme is the possibility of suspicion about the honesty of the controller and,consequently,taking proper precautions.

关键词： Information security Machine-to-machine communication Intelligent secure systems Quantum teleportation Quantum networks

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Mathematical analysis of corneal remodelling after intracorneal ring surgery in keratoconus

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International Journal of Ophthalmology(English edition) 2017年第3期10卷 348-354页

作者： elias F.Jarade elise Slim Carole Cherfan hala el Rami Toufic Hassan elias Chelala Beirut Eye Specialist Hospital Beirut P.O box 116-5311 Lebanon Mediclinic Dubai Mall Dubai P.O box 282890 United Arab Emirates Saint-Joseph University Faculty of Medicine Beirut EO Box 11-5076 Lebanon

AIM：To represent mathematically the intersection between the ectatic corneal geometry and the plane of intracorneal ring implants（ICRS）in order to determine the corneal response to ICRS surgery in keratoconus（KC）.Thereafter,to present the concept and early results of a newly derived topography-guided nomogram for ICRS surgery for the treatment of keratectasia. METHODS：The corneal rings plane intersection was modelled to a conic section. Ring effect was the result of：the ring size,position（steep vs flat）,location（distance from the geometric centre of the cornea）,and the discrepancy between the ring＇s curvature and the tunnel＇s *** laser was used to create the tunnels and the incision sites were chosen according to the nomogram in order to place the thickest ring in the steepest portion of the cornea regardless of the astigmatism axis of ***：The conic section had a more prolate shape in the steep area of the cornea than in the flat area,depending on the corneal sagittal curvature. Equal ring size had more flattening effect in the steep area than in the flat area. Thick segment should be implanted under the steep portion of the cornea regardless of the cylinder axis of refraction. Single segment in the steep area was sufficient in early and moderate cases of KC. The new nomogram provided more topographic regularity with significant reduction of astigmatism and better improvement in uncorrected visual acuity（UCVA）and best-corrected visual acuity（BCVA）than the conventional nomogram. CONCLUSION：The newly derived nomogram can produce better results than the conventional nomogram. Moreover,based on this concept,a new nomogram can be integrated into the femtosecond laser software to create topography-guided,customized,elliptical tunnels with modified focal asphericity that allows for customized focal flattening of the irregularly steepened ectatic cornea.

关键词： keratoconus intracorneal ring mathematical model cornea topography guided nomogram

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Bitter gourd extract improves glucose homeostasis and lipid profile via enhancing insulin signaling in the liver and skeletal muscles of diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2021年第8期11卷 344-352页

作者： Saber Mohamed Eweda Mennatallah Ahmed Ali hala Mohamed Abd el-Bary Nahed Hussein el-Sokkary Madiha Hassan Helmy Maher Abdel-Nabi Kamel Department of Biochemistry Faculty of ScienceAlexandria UniversityAlexandriaEgypt Department of Pharmacology&Therapeutics Faculty of Pharmacy and Drug ManufacturingPharos University in AlexandriaAlexandriaEgypt Department of Biochemistry Medical Research InstituteAlexandria UniversityAlexandriaEgypt Department of Physiology Faculty of MedicineAlexandria UniversityAlexandriaEgypt Medical Laboratories Technology College of Applied Medical SciencesTaibah UniversityMadinahKSA

Objective:To investigate the modulatory effects of bitter gourd extract on the insulin signaling pathway in the liver and skeletal muscle tissues of diabetic ***:The ethanolic extract of bitter gourd was prepared and its contents of total polyphenols and flavonoids were assayed.A neonatal streptozotocin-induced diabetic rat model was established and the diabetic rats were assigned into different groups and were treated with different doses of bitter gourd extract(100,200,400,or 600 mg/kg)or with glibenclamide(0.1 mg/kg)for 30 *** blood glucose,insulin,and lipid profile were evaluated and the insulin signaling pathway in the liver and skeletal muscle of rats was *** correlations between homeostasis model assessment(HOMA)and the components of insulin signaling pathway were also ***:Different doses of bitter gourd extract significantly ameliorated fasting blood glucose level and HOMA index for insulin ***,bitter gourd extract increased serum insulin and improved disrupted serum lipid *** levels of insulin receptor substrate-1(IRS-1),p-insulin receptorβ(p-IR-β),protein kinase C(PKC),GLUT2,and GLUT4 were improved by treatment with bitter gourd *** best results were obtained with 400 mg/kg dose of the extract,the effect of which was equivalent to that of *** in the bitter gourd treated rats was negatively correlated with p-IR-β,IRS-1 and PKC in hepatic and skeletal *** was also negatively correlated with skeletal muscle ***:Bitter gourd extract improves glucose homeostasis and lipid profile in diabetic rats via enhancement of insulin secretion and ***,bitter gourd can be used as a potential pharmacological agent for the treatment of type 2 diabetes mellitus.

关键词： Neonatal Streptozotocin Diabetic Sulfonylurea Bitter gourd Phosphorylated insulin receptor Protein kinase C IRS-1 GLUT2/GLUT4 Insulin signaling

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Reviving Fertility:Phytochemicals as Natural Allies in the Fight against Non-genetic Male Infertility

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Clinical Complementary Medicine and Pharmacology 2024年第1期4卷 112-128页

作者： Vivek P.Chavda Shreya S Sonak Pankti C.Balar Krupa Vyas Pranali Palandurkar Komal Mule Krishna Patel Vivek hala Dixa A.Vaghela Devarshi Acharya Akta Vaishnav Jimil Gandhi Vasso Apostolopoulos Department of Pharmaceutics and Pharmaceutical Technology L M College of PharmacyAhmedabadGujarat 380008India Bharati Vidyapeeth University’s Poona College of Pharmacy ErandwaneKothrudPune 411038India Pharmacy section L M College of PharmacyAhmedabadGujarat 380008India University Department of Pharmaceutical Sciences R.T.M Nagpur 440033India Department of Pharmaceutics Khyati College of PharmacyAhmedabad 380009India IICISST Sardar Patel UniversityVallabh Vidyanagar 388120India Institute for Health and Sport Immunology and Translational ResearchVictoria UniversityMelbourneVIC 3030Australia Immunology Program Australian Institute for Musculoskeletal ScienceMelbourneVIC 3021Australia

Background:Male infertility poses a growing challenge to the healthcare system,with its prevalence on the *** lifestyle,food,and addictions such as smoking,alcoholism,*** the *** several approaches are being investigated to prevent and treat this condition,each therapeutic approach has its *** medications continue to play a crucial role in the healthcare *** recent years,there has been a shift towards determining the efficacy of phytochemicals(or,herbal drugs)as ***:To evaluate the effect of various herbs,plant,metabolites,or a part of plant in management of non-genetic male ***:The male infertility-associated keywords were searched in PubMed,excluding those non-English writen papers.A total of 146 pertinent and closely connected records were included for full reading and inclusion in the systemic ***:The manuscript focuses on individual herbal drug components,their active ingredients,their role in improving the condition and quality of life,and decreasing the prevalence of male ***:Herbal medicinal plants show promising outcomes to treat male *** alternatives are appealing and have regained *** future holds promise for some of these herbal treatments to advance with many showing improved outcomes in males with infertility issues.

关键词： Male infertility Plant-based management Phytochemical Herbal drug Traditional Chinese medicine

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