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World Journal of Pediatrics 2022年第6期18卷 443-448页

作者： Eman R.Youness Sherien Mel-Daly Hanaa Reyad Abdallah hala T.el-Bassyouni Hisham Megahed Azzah A.Khedr Marwa elhady Walaa Alsharany Abuelhamd Medical Biochemistry Department Medical Research DivisionNational Research CentreGizaEgypt Biological Anthropology Department Medical Research DivisionNational Research CentreGizaEgypt Clinical Genetics Department Human Genetics and Genome Research DivisionNational Research CentreEl-Tahrir StreetPO:12622GizaEgypt Human Cytogenetics Department Human Genetics and Genome Research DivisionNational Research CentreGizaEgypt Pediatric Department Faculty of Medicine for GirlsAl-Azhar UniversityCairoEgypt Department of Pediatrics Faculty of MedicineCairo UniversityCairoEgypt

Down syndrome,Turner syndrome,and Klinefelter syndrome are the most common chromosomal disorders *** syndrome is caused by an extra copy of the 21st chromosome and has an incidence of 1 in 800 to 1000 live *** syndrom... 详细信息

关键词： chromosomal Turner Serum

Sustainable Industrial Community

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Journal of Environmental Protection 2017年第3期8卷 301-318页

作者： hala Omar Salah el-Haggar Mechanical Engineering The American University in Cairo Cairo Egypt

Nowadays, the style of living that significantly depends on consumption of resources and over consumption patterns, tremendous increase in population, urbanization and industrialization resulted into generation of huge amounts of industrial wastes. Many environmental problems are facing industrial areas, especially in developing countries, due to poor industrial hazardous waste management. In order to reduce the effect of industrial waste on the environment and to reach sustainable development, countries have developed and reinforced several environmental protection laws and regulations. Yet, the waste disposals via incineration and/or landfilling according to cradle-to-grave concept require high capital, high running costs and are seen by industries as a barrier for further industrial development. Most importantly, disposals of waste deplete natural resources causing them to be unsustainable. Hence, various concepts and strategies have been suggested to promote industrial sustainability. The aim of this paper is to present different concepts and practices including Cradle-to-Cradle approach, Cleaner Production, Industrial Ecology, Eco-Industrial Park and Environmentally Balanced Industrial Complex described in literature that help develop a successful sustainable industrial community and reach zero pollution. These concepts are illustrated via case studies. Moreover, this paper tackles the challenges facing industrial areas in Egypt and emphasis on the imperative need for considering sustainable industrial community.

关键词： Industrial Waste Sustainable Industrial Community Cradle-to-Cradle Cleaner Production Eco-Industrial Park Environmentally Balanced Industrial Complex Zero Pollution

Anatomical and Molecular Identification of Ornamental Plant Ficus ***

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Phyton-International Journal of Experimental Botany 2023年第5期92卷 1329-1347页

作者： Abtisam Binnoubah Rim Hamdy Osama G.Ragab Ahmed M.el-Taher Ahmed Abou el-Yazied Fatmah A.Safhi hala A.elzilal Ashwaq T.Althobaiti Salha M.ALshamrani Diaa Abd el Moneim Ahmed el-Banhawy Department of Botany Faculty of ScienceUniversity of SabrathaSabratha999116Libya Department of Botany Faculty of ScienceCairo UniversityGiza12111Egypt Department of Botany and Microbiology Faculty of Science(Boys Branch)Al-Azhar UniversityCairo11884Egypt Department of Agricultural Botany Faculty of AgricultureAl-Azhar UniversityCairo11884Egypt Department of Horticulture Faculty of AgricultureAin Shams UniversityCairo11566Egypt Department of Biology College of SciencePrincess Nourah bint Abdulrahman UniversityRiyadh11671Saudi Arabia Department of Science and Technology College of RanyahTaif UniversityTaif21944Saudi Arabia Department of Biology College of ScienceTaif UniversityTaif21944Saudi Arabia Department of Biology College of ScienceUniversity of JeddahJeddah21959Saudi Arabia Department of Plant Production(Genetic Branch) Faculty of Environmental Agricultural SciencesArish UniversityEl-Arish45511Egypt Department of Botany and Microbiology Faculty of ScienceSuez Canal UniversityIsmailia41522Egypt

This present study includes twelve species that represent the Ficus genus,namely;aspera,carica,tinctoria ***,hirta,hispida,neriifolia,palmata,pumila,racemosa,septica,sur,and sycomorus,belonging to the Moraceae *** species samples were collected from various locations in *** study focused on the anatomical and molecular characteristics of mature foliage *** the identification and classification of taxa are highly dependent on the anatomical features of leaves,the anatomical characteristics were recorded in the form of a comparison between the examined plants in the data *** study aims to contribute to the identification of the studied species based on the anatomical details of the matured *** characterization includes the variations in upper and lower epidermal layers that are covered by a thin or thick cuticle;the number of palisade and spongy layers;crystals;secretory elements;lithocysts;the midrib zone has parenchyma associated with mechanical tissue,vascular system,and investigation of trichomes;on the other hand,in the current study,the phylogenetic analysis was conducted by using the ITS and 5.8 S *** the analysis of all the available data,it could be stated that there is an overall agreement with the anatomical character dendrogram.

关键词： ITS trichomes leaf anatomy Ficus moraceae

Sensitivity Enhancement of Nonlinear Waveguide Sensors With Conducting Graphene Layer： TE Mode

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Photonic Sensors 2018年第1期8卷 29-33页

作者： hala J. el-KHOZONDAR Mohammed M. SHABAT Rana KHLIFA electrical Engineering department lslamic University of Gaza P.O.Box 108 Gaza Palestine Physics department lslamic University of Gaza P.O.Box 108 Gaza Palestine

We propose a three-layer waveguide sensor. The proposed sensor consists of a graphene thin layer with constant conductivity at the interface between air and dielectric media with thickness d sitting above a nonlinear layer. The sensitivity of the sensor is derived from the dispersion equation. The sensitivity is calculated for both TE0 and TE1. Results show that the sensitivity of the proposed sensor depends on the conductivity of the graphene layer, the angular frequency, and the thickness of the dielectric layer.

关键词： Graphene nonlinear Kerr like materials optical sensor waveguide sensor

Chlorine as an integrated approach for environmental health and hygiene:A case study on evaluation of the performance of waste stabilization ponds located at 11 governorates in Egypt

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Emerging Contaminants 2022年第1期8卷 243-253页

作者： Sayeda M.Abdo Mohamed Azab el-Liethy hala S.Doma Gamila E.el Taweel Gamila H.Ali Water Pollution Research Department National Research Centre12662DokkiGizaEgypt

The current study summarizes the current status of wastewater stabilization ponds(WSPs)treatment plants that have already been built in 11 governorates throughout ***,this study aims to determine the most appropriate chlorine dose for waste stabilization ponds(WSPs)effluents to ensure the treated effluents are suitable for reuse in unrestricted irrigation and to comply with the current legislation on direct discharge onto water *** to the findings,the chlorine doses used as a disinfectant in the treated effluents of the majority of WSP treatment plants ranged from 3 to 13 mg/***,two of the WSPs treatment plants effluents,the Qus WSPs treatment plant in Qena governorate and the Al Zarabii WSPs treatment plant in Asyut governorate used high chlorine doses reached to 17 and 19 mg/L,*** is due to the fact that both the Qus and Al Zarabii WSPs treatment plants have a high organic load,which necessitated the use of more chlorine to achieve the optimum chlorine dose at 13 mg/L for Qus and 11mg/L for Al *** findings demonstrated that chlorine has a powerful effect in completely removing ***,in most chlorine-treated wastewater final effluents,as the chlorine doses increased,the chlorophyll-a reading *** amount of trihalomethanes(THMs)produced as disinfectant byproduct was *** results proved that the water can be used in unrestricted irrigation,and after adding chlorine,it can be dumped on water bodies without health risks.

关键词： Waste stabilization ponds Microbial pathogens Chlorine doses Trihalomethanes(THMs)

Effect of Egyptian propolis on cryptosporidiosis in immunosuppressed rats with special emphasis on oocysts shedding,leukogram,protein profile and ileum histopathology

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Asian Pacific Journal of Tropical Medicine 2017年第3期10卷 240-248页

作者： Hamdy Soufy Nadia M.el-Beih Soad M.Nasr Tamer H.Abd el-Aziz Fathia A.M.Khalil Youssef F.Ahmed hala A.A.Abou Zeina Department of Parasitology and Animal Diseases National Research Centre Department of Zoology Faculty of ScienceAin Shams University Department of Reproduction and Artificial Insemination National Research Centre

Objective:To investigate the activity of Egyptian propolis extracts(ethanol and water)on cryptosporidiosis in experimentally infected dexamethasone-immunosuppressed ***:A total of 180 male rats(190-220)g BWt were randomly divided into 9 equal groups(G1-G9).Groups of rats were kept as(G1):normal control,(G2-G9):immunosuppressed with dexamethasone and(G3-G9):infected with Cryptosporidium *** from(G4to G9)were given orally ethanol and water extract of propolis(at a dose of 50 mg/kg BWt)and nitazoxanide(standard anti-cryptosporidial drug at a dose of 100 mg/kg BWt)to infected rats with different *** pellets were collected from all groups to monitor oocysts shedding from the 2nd to the 15th day post *** the end of the experiment,blood was collected from all groups for determination of leukogram and serum *** specimens were also examined ***:The highest reduction of oocysts shedding in faecal samples was 88%in rats prophylactically treated with propolis ethanol extract at the 4th dpi,and in rats prophylactically treated with water extract of propolis,was91%at the 6th *** was a marked increase in neutrophils count and α_2-andβ-globulins levels in infected rats treated with both extracts,while a significant decrease was detected in lymphocytes compared to the infected non treated group.β-globulin level markedly increased in the rats administered *** changes were observed in the ileum of rats infected with ***:Egyptian propolis extracts have an activity on cryptosporidiosis in ***,propolis modulated the immunity in dexamethasone-immunosuppressed rats.

关键词： Cryptosporidiosis Propolis Rat model Leukogram Serum proteins Histopathology

Novel CYP1B1 mutations and a possible prognostic use for surgical management of congenital glaucoma

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International Journal of Ophthalmology(English edition) 2019年第4期12卷 607-614页

作者： Mohamed M.Khafagy Nadia el-Guendy Marwa A Tantawy Mohamed A.eldaly hala M.elhilali Abdel Hady A.Abdel Wahab Ophthalmology Department Faculty of Medicine Cairo University Cancer Biology Department National Cancer Institute Cairo University Research Department Children's Cancer Hospital

AIM: To identify CYP1B1 gene mutations and evaluate their possible role as a prognostic factor for success rates in the surgical management of Egyptian congenital glaucoma ***: Totally 42 eyes of 29 primary congenital glaucoma patients were operated on with combined trabeculotomy/trabeculectomy with mitomycin-C and followed up at 1 d, 1 wk, 1, 6 and 12 mo postoperatively. Genomic DNA was extracted from peripheral blood leukocytes. Coding regions of CYP1B1 gene were amplified using 13 pairs of primers, screened for mutations using single-strand conformation polymorphism followed by sequencing of both strands. Efficacy of the operation was graded as either a success [maintaining intraocular pressure(IOP) less than 21 mm Hg with or without antiglaucoma medication], or a failure(IOP more than 21 mm Hg with topical antiglaucoma medications). RESULTS: Seven novel mutations out of a total of 15 different mutations were found in the CYP1B1 genes of 14 patients(48.2%). The presence of CYP1B1 gene mutations did not correlate with the failure of the surgery(P=0.156, odds ratio=3.611, 95%CI, 0.56 to 22.89); while the positive consanguinity strongly correlated with failure of the initial procedure(P=0.016, odds ratio=11.25, 95%CI, 1.57 to 80.30). However, the Kaplan-Meier survival analysis revealed a significantly lower time of IOP control in the subgroup with mutations in CYP1B1 versus the congenital primary glaucoma group without mutations(log rank test, P=0.015).CONCLUSION: Seven new CYP1B1 mutations are identified in Egyptian patients. Patients harboring confirmed mutations suffered from early failure of the initial surgery. CYP1B1 mutations could be considered as a prognostic factor for surgery in primary congenital glaucoma.

关键词： CYP1B1 mutations primary congenital glaucoma intraocular pressure trabeculotomy/trabeculectomy with mitomycin-C.

Molecular analysis and anticancer properties of two identified isolates,Fusarium solani and Emericella nidulans isolated from Wady el-Natron soil in Egypt against Caco-2(ATCC) cell line

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Asian Pacific Journal of Tropical Biomedicine 2012年第11期2卷 863-869页

作者： hala F Mohamed University of Al-Azhar Faculty of Science(Girls Branch)Department of Botany and MicrobiologyYoussef Abbas Street

Objective:To characterize,identify and investigate the anticancer properties of two new soil fungal isolates,Emericella nidulansand Fusarium solani isolated from Wady el-Natron in Egypt against colon cancer Caco-2(ATCCj cell ***:Soil sample was cultured and two strains were chosen for morphological and phenotypical *** sequences of the 18s rRNA gene and the internal transcribed spacer region ITS of the two isolates were amplified by *** tree construction and analysis of the resulted multiple sequences from the two fugal isolates were also carried *** vitro anticancer activity of the two strains was done against colon Caco-2 cancer cell *** transcription — PCR was carried out to detect level of expression of p53 in Caco-2 cell ***:HF.I displayed morphological and genotypic characteristics most similar to that of Fusarium solani while HF.2 was most similar to Emericella nidulans with high similarity of 99%and 97%*** multiple sequence alignment of the two fungal isolates showed that,the maximum identical conserved domains in the 18s rRNA genes were identified with the nucleotide regions of Slst to 399th base pairs,88th to 525th base pairs *** those in the ITS genes were identified with the nucleotide regions of 88th to 463rd and Slst to *** two isolates showed ICsub>50 value with（6.24±5.21） and（9.84±0.36） μ g/mL) concentrations respectively at *** transcription- PCR indicated that these cells showed high level of expression for p53 ***:The morphology and molecular analysis identified HF.1 and HF.2 to be Fusarium solani and Emericella nidulans;new isolates of anticancer producing fungi from Wady el-Natroon city in *** with the two isolates caused P53 expression in Caco-2 cell *** two isolates can be used as an anticancer agents.

关键词： Fungi Colon cancer Caco-2 Phylogenetic tree Anticancer property Multiple sequence analysis Anticancer agent Cell line

Acute diseases:An epidemiologic perspective

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Journal of Acute Disease 2023年第1期12卷 1-9页

作者： Abdel-Hady el-Gilany hala Abou-elWafa Public Health and Preventive Medicine Public Health and Community Medicine DepartmentFaculty of MedicineMansoura UniversityMansouraEgypt Industrial Medicine and Occupational Health Public Health&Community Medicine DepartmentFaculty of MedicineMansoura UniversityMansouraEgypt

Many underdeveloped countries still struggle with the public health issue of acute illnesses,especially with the emergence of injuries as a major category of acute *** of the acute disease is challenging particularly when it occurs as an outbreak,either in isolation or as part of a wider *** narrative review summarizes the definition,epidemiologic transition,pattern and modes of spread,classification,epidemiologic measures,community burden,prevention,control,and future challenges of acute *** review is to provide a reference for epidemiologists,clinicians,researchers,and policymakers.

关键词： Acute disease Spread Transition Classification Burden

Validated stability indicating methods for determination of nitazoxanide in presence of its degradation products

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Journal of Pharmaceutical Analysis 2012年第2期2卷 105-116页

作者： Nouruddin W.Ali Samah Sayed Abbas hala el-Sayed Zaazaa Maha Mohamed Abdelrahman Mohamed Abdelkawy Analytical Chemistry Department Faculty of PharmacyBeni-Suef UniversityHussin El-Shafey StreetBeni-Suef CityEgypt Analytical Chemistry Department Faculty of PharmacyCairo UniversityKasr El-Aini Street11562CairoEgypt

Three sensitive,selective and reproducible stability-indicating methods are presented for determination of nitazoxanide (NTZ),a new anti-protozoal drug,in presence of its degradation *** A utilizes the first derivative of ratio spectra spectrophotometry by measurement of the amplitude at 364.4 nm using one of the degradation products as a *** B is a chemometric-assisted spectrophotometry,where principal component regression (PCR) and partial least squares (PLS) were *** two approaches were successfully applied to quantify NTZ in presence of degradation products using the information included in the absorption spectra in the range 260-360 *** C is based on the separation of NTZ from its degradation products followed by densitometric measurement of the bands at 254 *** separation was carried out on silica gel 60F 254,using chloroform-methanol-ammonia solution-glacial acetic acid (95:5:1:1 by volume,pH=5.80) as a developing *** methods are suitable as stability-indicating methods for the determination of NTZ in presence of its degradation products either in bulk powder or in pharmaceutical *** analysis of the results has been carried out revealing high accuracy and good precision.

关键词： Nitazoxanide Degradation Derivative spectrophotometry Chemometrics TLC-densitometry Stability-indicating methods