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Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen luo Xueran Kang Renwen Wan Fangqi Li Weiwei Lin Zhihua Han Beijie Qi Jinrong Lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

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Gear walk instability caused by brake-disc friction characteristics

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Chinese Journal of Aeronautics 2024年第2期37卷 343-359页

作者： Xiaoqiong DU Bin LI wen CAI Linyin luo School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Department of Mechanical Engineering University of MichiganAnn Arbor 48109USA AVIC General Huanan Aircraft Industry Co.Ltd. Zhuhai 519040China

A multi-body dynamic rigid-flexible coupling model of landing gear is established to study the gear walk instability caused by the friction characteristics of the brake *** validating the model with the experimental results,the influence of the landing gear structure and braking system parameters on gear walk is further *** the above factors,the slope of the graph for the friction coefficient of the brake disc and the relative velocity of brake stators and rotors is the most influential factor on gear walk *** trajectory analysis verifies that gear walk occurs when the coupling of multiple factors causes the system to exhibit an equivalent negative damping *** consider a more realistic braking case,a back propagation neural network method is employed to describe the nonlinear behavior of the friction coefficient of the brake *** the realistic nonlinear model of the friction coefficient,the maximum error in predicting the braking torque is less than 10%and the effect of the brake disc temperature on gear walk is *** results reveal that a more negative friction slope may contribute to a more severe unstable gear walk,and reducing the braking pressure is an effective approach to avoid gear walk,which provides help for future braking system design.

关键词： Gear walk Friction characteristics of brake disc Brake-induced vibration Negative damping Rigid-flexible coupling Negative slope of braking torque

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A strong and ductile medium Mn steel manufactured via ultrafast heating process

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Journal of Materials Science & Technology 2022年第2期97卷 54-68页

作者： Pengyu wen Bin Hu Jiansheng Han Haiwen luo State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingXue Yuan Lu 30Beijing 100083China School of Metallurgical and Ecological Engineering University of Science and Technology BeijingXue Yuan Lu 30Beijing 100083China

Ultrafast heating(UFH)at the rates of 10-300℃/s was employed as a new strategy to anneal a coldrolled 7 wt%Mn steel,followed by the immediate *** deformed strain-induced martensite and lightly-deformed thermal martensite,both had been already enriched with C and Mn before,transformed to fine and coarse austenite grains during the UFH,leading to the bimodal size *** with the long intercritical annealing(IA)process,the UFH processes produced larger fraction of RA grains(up to 37%)with a high density of dislocation,leading to the significant increase in yield strength by 270 MPa and the product of strength and elongation up to 55 GPa%due to the enormous work hardening *** a significant strengthening is first attributed to high density dislocations preserved after UFH and then to the microstructural refinement and the precipitation strengthening;whilst the sustainable work hardening is attributed to the successive TRIP effect during deformation,resulting from the large fraction of RA instantly formed with the bimodal size distribution during ***,the results on the microstructural characterization,thermodynamics calculation on the reverse transformation temperature and the kinetic simulations on the reverse transformation all suggest that the austenitization during UFH is displacive and involves the diffusion and partition of ***,we propose that it is a bainite-like transformation.

关键词： Ultrafast heating process Austenite reversion Medium Mn steel Mechanical properties Transformation-induced plasticity

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Numerical simulation of flow and heat transfer of n-decane in sub-millimeter spiral tube at supercritical pressure

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Chinese Journal of Chemical Engineering 2023年第8期60卷 173-185页

作者： Jiahao Xing Huaizhi Han Ruitian Yu wen luo School of Chemical Engineering Sichuan UniversityChengdu 610065China Engineering Research Center of Combustion and Cooling for Aerospace Power Ministry of EducationSichuan UniversityChengdu 610065China

The flow and heat transfer characteristics of n-decane in the sub-millimeter spiral tube(SMST) at supercritical pressure(p = 3 MPa) are studied by the RNG k-ε numerical model in this paper. The effects of various Reynolds numbers(Re) and structural parameters pitch(s) and spiral diameter(D) are *** indicate that the average Nusselt numberNu and friction factorNu increase with an increase in Re, and decrease with an increase in D/d(tube diameter). In terms of the structural parameter s/d, it is found that as s/d increases, the Nu first increase, and then decrease. and the critical structural parameter is s/d = 4. Compared with the straight tube, the SMST can improve Nu by 34.8% at best, while it can improve Nu by 102.1% at most. In addition, a comprehensive heat transfer coefficient is applied to analyze the thermodynamic properties of SMST. With the optimal structural parameters of D/d = 6 and s/d = 4, the comprehensive heat transfer factor of supercritical pressure hydrocarbon fuel in the SMST can reach 1.074. At last, correlations of the average Nusselt number and friction factor are developed to predict the flow and heat transfer of n-decane at supercritical pressure.

关键词： Sub-millimeter spiral tube Supercritical pressure Numerical simulation Heat transfer performance

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Dramatical enhancement of circular dichroism in chiral hybrid perovskites via carboxylic hydrogen bond engineering

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Science China Chemistry 2025年

作者： Hang Li Xinling Li Peng Wang Tingting Zhu Ruiqing Li Huang Ye Yaru Geng Hongliang Dai Junhua luo State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences University of Chinese Academy of Sciences Fujian College University of Chinese Academy of Sciences College of Chemistry Fuzhou University College of Chemistry and Materials Key Laboratory of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of EducationJiangxi Normal University

Chiral hybrid perovskites （CHPs） have been regarded as promising candidates for developing chiroptoelectronics ***,circular dichroism （CD）,as one of the most important characteristics to evaluate the chiroptical activity,remains at a comparatively low level in CHPs compared to other chiral materials,which hinders the successful applications of CHPs in stateof-the-art ***,exploring new methods for enhancing CD in CHPs is urgently needed and remains ***,enhanced CD response has been successfully realized via constructing carboxylic hydrogen bonding in chiralachiral mixed cations perovskites （R/S-PPA）2（ABA）PbBr5（2R/2S）(PPA=1-phenylpropylamine,ABA=4-aminobutyric acid).Compared with the prototype （R/S-PPA）PbBr3（1R/1S）,2R/2S provide intimate connections between organic units and inorganic parts via carboxylic hydrogen bonding N–H···O bridge,contributing new chirality transfer paths.A larger inorganic skeletons’helicity in 2R/2S predicts a high degree of chirality ***,2R/2S exhibit significantly enhanced CD response with an anisotropy factor amplified by an order of ***,bright blue circularly polarized luminescence applications are achieved in 2R/*** work systematically investigates the correlation between CD and hydrogen bonding interaction in CHPs,meanwhile providing a new avenue to develop the application potential of chiral materials in chiroptoelectronics.

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A Novel Obstacle Avoidance Consensus Control for Multi-AUV Formation System

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IEEE/CAA Journal of Automatica Sinica 2023年第5期10卷 1304-1318页

作者： Linling Wang Daqi Zhu wen Pang Chaomin luo the Shanghai Engineering Research Center of Intelligent Maritime Search&Rescue and Underwater Vehicles Shanghai Maritime UniversityShanghai 201306China the Shanghai Maritime University Shanghai 201306China the School of Mechanical Engineering University of Shanghai for Science and TechnologyShanghai 200093China the Department of Electrical and Computer Engineering Mississippi State UniversityMississippi StateMS 39762 USA

In this paper, the fixed-time event-triggered obstacle avoidance consensus control for a multi-AUV time-varying formation system in a 3D environment is presented by using an improved artificial potential field and leader-follower strategy(IAPF-LF). Firstly, the proposed fixed-time control can achieve the desired multi-AUV formation within a fixed settling time in any initial system state. Secondly, an event-triggered communication strategy is developed to govern the communication among AUVs, and the communication energy consumption can be decremented. The time-varying formation obstacle avoidance control algorithm based on IAPF-LF is designed to avoid static and dynamic obstacles, the desired formation is maintained in the presence of external disturbances, and there is no Zeno behavior under the fixed-time event-triggered consensus control *** stability of the system is proved by the Lyapunov function and inequality scaling. Finally, simulation examples and water pool experiments are reported to verify the performance of the proposed theoretical algorithms.

关键词： Autonomous underwater vehicle(AUV) event-triggered control fixed-time consensus formation obstacle avoidance improved artificial potential field and leader-follower strategy(IAPF-LF)

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Calibration of the Solar X-ray Detector on-board the Macao Science Satellite-1B for Soft X-ray Detection

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Science China Earth Sciences 2025年第1期68卷 11-26页

作者： Man-Hei NG Xiaoping ZHANG Jianwu CHEN Yongqiang SHI Fuchang ZUO wenxi PENG Weichun FU Liansheng LI Pengwei luo Chi-Long TANG Guozheng ZHANG Zhiwu MEI Li WANG Cunhui LI Jiaming OU Yanyan XU State Key Laboratory of Lunar and Planetary Sciences Macau University of Science and Technology China National Space Administration (CNSA) Macau Center for Space Exploration and Science Space Optoelectronic Measurement and Perception Laboratory Beijing Institute of Control Engineering Institute of High Energy Physics Chinese Academy of Sciences Science and Technology on Vacuum Technology and Physics Laboratory Lanzhou Institute of Physics

The Solar X-ray Detector(SXD) on-board the Macao Science Satellite-1B(MSS-1B) was successfully launched via the Chinese Long March-2C rocket on 21 May 2023, and commenced operations in early June of the same year. The MSS-1B/Soft X-ray Detection Units(SXDUs) employ two silicon drift detectors(SDDs), providing a wide range of energy spectra spanning from 0.7 to 24 keV. Notably, the SXDUs deliver a high-resolution capability of 0.14 keV@5.9 keV and operate with a time cadence of 1 second. Here, we perform thorough calibrations of the MSS-1B/SXDUs, employing a combination of ground experiments and simulations. In addition, quantitative analysis comparing the flux measurements obtained by the MSS-1B/SXDUs to the data collected by the Geostationary Operational Environmental Satellite(GOES), provides compelling evidence of their consistency. Furthermore, the preliminary spectral analysis results showcase the robustness and expected performance of the MSS-1B/SXDUs, unlocking their potential for facilitating the study of dynamic evolution of solar flares. Moreover, the innovative MSS-1B/Solar X-ray Detector facilitates concurrent observations of solar soft and hard X-rays, thereby making valuable contributions to the advancements in solar research.

关键词： Macao Science Satellite-1B (MSS-1B) Calibration Solar X-Ray Detector Spectrometer Soft X-rays Solar flares Solar abundances

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Comparison of nonclassicality between photon-added and photon-subtracted squeezed vacuum states

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Chinese Physics B 2012年第2期21卷 301-308页

作者： Ma Shan-Jun luo wen-Wei College of Physics and Communication Electronics Jiangxi Normal UniversityNanchang 330022China

In this paper, we introduce photon-added and photon-subtracted squeezed vacuum state （PASV and PSSV） and obtain their normalized factors, which have the similar forms involved in Lengendre polynomials. Moreover, we give the compact expressions of Wigner function, which are related to single-variable Hermite polynomials. Especially, we compare their nonclassicality in terms of Mandel Q-factor and the negativity of Wigner function.

关键词： photon-added and photon-subtracted squeezed vacuum state nonclassicality Wigner function

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Effect of flash processing on recrystallization behavior and mechanical performance of cold-rolled IF steel

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International Journal of Minerals,Metallurgy and Materials 2020年第9期27卷 1234-1243页

作者： Peng-yu wen Jian-sheng Han Hai-wen luo Xin-ping Mao State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China Department of Ferrous Metallurgy University of Science and Technology BeijingBeijing 100083China

Flash processing(FP)has attracted considerable attention due to its high efficiency,economic advantages,and the extraordinary opportunity if offers to improve the mechanical properties of *** this study,we investigated the influences of FP on the recrystallization(REX)behavior and mechanical performance of cold-rolled IF *** a thermomechanical simulator,we performed both single-stage FPs,at heating rates of 200℃/s and 500℃/s,and two-stage FP,with an initial preheating to 400℃ at a rate of 5℃/s and then to peak temperatures at a rate of 200℃/*** comparison to continuous annealing(CA),single-stage FP can effectively refine the recrystallized grain sizes and produce a similar or even sharperγ(ND(normal direction)//{111})texture *** particular,the heating rate of 500℃/s led to an increase in the yield strength of about 23.2%and a similar *** contrast,the two-stage FP resulted in a higher REX temperature as well as a certain grain refinement due to the stored strain energy,i.e.,the driving force of REX,which was largely consumed during ***,both stronger{110}and weakerγtexture components appeared in the two-stage FP and were believed to be responsible for the early necking and deterioration in ductility.

关键词： flash processing interstitial-free steel recrystallization mechanical properties texture

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MicroRNAs Involved in Skeletal Muscle Differentiation

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Journal of Genetics and Genomics 2013年第3期40卷 107-116页

作者： wen luo Qinghua Nie Xiquan Zhang Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding and Key Lab of Chicken Genetics Breeding and Reproduction Ministry ofAgriculture South China Agricultural University

MicroRNAs （miRNAs） negatively regulate gene expression by promoting degradation of target mRNAs or inhibiting their translation. Previous studies have expanded our understanding that miRNAs play an important role in myogenesis and have a big impact on muscle mass, muscle fiber type and muscle-related diseases. The muscle-specific miRNAs, miR-206, miR-1 and miR-133, are among the most studied and best characterized miRNAs in skeletal muscle differentiation. They have a profound influence on multiple muscle differ- entiation processes, such as alternative splicing, DNA synthesis, and cell apoptosis. Many non-muscle-specific miRNAs are also required for the differentiation of muscle through interaction with myogenic factors. Studying the regulatory mechanisms of these miRNAs in muscle differentiation will extend our knowledge of miRNAs in muscle biology and will improve our understanding of the myogenesis regulation.

关键词： MicroRNAs Skeletal muscle Differentiation Regulation

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