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Polyphyllin I inhibits proliferation and metastasis of ovarian cancer cell line HO-8910PM invitro

Journal of Traditional Chinese Medicine 2013年第3期33卷 325-333页

作者： Linhui Gu Jianguo Feng Haiyan Xu Min luo Dan Su Cancer Research Institute Zhejiang Cancer Hospital

OBJECTIVE： To study the anticancer mechanism of polyphyllin I （PPI）, a Traditional Chinese Medicine, on the ovarian cancer cell line HO-8910PM in vitro. METHODS： Transwell chamber invasive assays were used to investigate the inhibitory capacity of PPI on HO-8910PM metastasis. Gene expression profiling chips was used to screen differentially ex- pressed genes between experiment group and con- trol group. Reverse transcription PCR and Western blotting were used to determine mRNA and pro- tein levels. RESULTS： With increasing PPI concentration, the metastatic capacity of cells decreased, with signifi- cance differences between the experimental and control groups （P〈0.01） as well as between two concentration groups. Gene expression profiling identified 123 differentially expressed genes, of which 70 were downregulated and 53 were upregu- lated. The genes were involved in multiple signal transduction pathways, including apoptosis, prolif- eration and metastasis. Real-time PCR （RT-PCR） showed that differential genes PIK3C2B, Caspase 9and WntSA were downregulated with increasing PPI, showing an evident dose-effect relationship. The c-Jun was an exception. As the PPI dosage in- creased and the exposure time was extended, c-Jun relative expression showed an upward trend. There were significant differences between the ex- periment and control （P〈0.05）. Western blot analy- ses showed that PPI treatment decreased levels of Caspase 9, WntSA and PIK3C2B and increased acti- vated Caspase 9,c-Jun and p-c-Jun expression levels. CONCLUSION＂ PPI has strong antitumor and anti transfer activity. It can activate c-Jun expression and the JNK signaling pathway, elicit cell apoptosis via the mitochondrial-mediated Caspase activation pathway, and finally inhibit tumor growth and mi- gration in vitro. The downregulation of PIK3C2B and Wnt5A jointly inhibit the proliferation and me- tastasis of HO-8910PM. PPI may be a novel treat- ment for ovarian cancer.

关键词： Chonglou Saponin I, Ovarian Neo-plasms Apoptosis Cell Movement

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A metamaterial-free fluid-flow cloak

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National Science Review 2022年第9期9卷 212-218页

作者： Fuyang Tay Youming Zhang Hongyi Xu Honghui Goh Yu luo Baile Zhang Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University School of Electrical and Electronic Engineering Nanyang Technological University Centre for Disruptive Photonic Technologies Nanyang Technological University

The model of ide al fluid flow around a cylindrical obstacle exhibits a long-established physical picture,where originally straight streamlines are deflected over the whole space by the *** by transformation optics and metamaterials,recent theories have proposed the concept of fluid cloaking,which is able to recover the straight streamlines,as if the obstacle did not ***,such a cloak,similar to all previous transformation-optics-based devices,relies on complex metamaterials with inhomogeneous parameters and is difficult to *** we deploy the theory of scattering cancellation and report on the experimental realization of a fluid-flow cloak without *** clo ak is realized by engineering the geometry of the fluid channel,which effectively cancels the dipole-like scattering of the *** clo aking effect is demonstrated through the direct observation of recovered straight streamlines in the fluid *** work sheds new light on conventional fluid control and may find application in microfluidic devices.

关键词： invisibility cloaks metamaterials fluid-flow control

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Impact of individual acid flue gas components on mercury capture by heat-treated activated carbon

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第9期13卷 700-708页

作者： Jian-ming ZHENG Jin-song ZHOU Zhong-yang luo Ke-fa CEN State Key Laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou 310027China School of Mechanical Engineering Jimei UniversityXiamen 361021China

Elemental mercury capture on heat-treated activated carbon （TAC） was studied using a laboratory-scale fixed bed reactor. The capability of TAC to perform Hg0 capture under both N2 and baseline gas atmospheres was studied and the effects of common acid gas constituents were evaluated individually to avoid complications resulting from the coexistence of multiple components. The results suggest that surface functional groups （SFGs） on activated carbon （AC） are vital to Hg0 capture in the absence of acid gases. Meanwhile, the presence of acid gas components coupled with defective graphitic lattices on TAC plays an important role in effective Hg0 capture. The presence of HC1, NO2, and NO individually in basic gases markedly enhances Hg0 capture on TAC due to the heterogeneous oxidation of Hg0 on acidic sites created on the carbon surface and catalysis by the defective graphitic lattices on TAC. Similarly, the presence of SO2 improves Hg0 capture by about 20%. This improvement likely results from the deposition of sulfur groups on the AC surface and oxidation of the elemental mercury by SO2 due to catalysis on the carbon surface. Furthermore, O2 exhibits a synergistic effect on Hg0 oxidation and capture when acid gases are present in the flue gases.

关键词： Flue gases Mercury Activated carbon (AC)

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铁氧化物氧同位素示踪原理及其在铁矿成因研究中的应用

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岩石矿物学杂志 2019年第1期38卷 121-130页

作者：骆文娟孙剑中国地质科学院矿产资源研究所自然资源部成矿作用与资源评价重点实验室北京100037 中国地质科学院地质研究所自然资源部同位素地质重点实验室自然资源部深地动力学重点实验室北京100037

铁氧化物(以磁铁矿和赤铁矿最为常见)是铁矿床中最主要的含铁矿物,其氧同位素地球化学对于铁矿的成因研究具有重要意义。本文在总结了铁氧化物氧同位素分馏理论、不同成因类型铁矿形成过程的基础上,对世界主要类型铁矿铁氧化物的氧同位... 详细信息

铁氧化物(以磁铁矿和赤铁矿最为常见)是铁矿床中最主要的含铁矿物,其氧同位素地球化学对于铁矿的成因研究具有重要意义。本文在总结了铁氧化物氧同位素分馏理论、不同成因类型铁矿形成过程的基础上,对世界主要类型铁矿铁氧化物的氧同位素组成特征和分馏规律进行了总结,并以新疆智博、查岗诺尔、备战海相火山岩型铁矿为例,开展了磁铁矿氧同位素地球化学研究。结果发现,这些铁矿中磁铁矿氧同位素组成δ18OSMOW集中在1‰～3‰之间,表明其形成于岩浆作用主导的高温岩浆/岩浆-热液环境,后期低温热液作用对铁的成矿作用影响有限。

关键词：氧同位素磁铁矿赤铁矿铁矿地球化学

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Designing DNA cage-based immuno-fluorescence strategy for rapid diagnosis of clinical cervical cancer tissues

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Chinese Chemical Letters 2022年第2期33卷 788-792页

作者： Juanjuan Li Hongjie luo Xueqiong Zhu Jianfu Zhao Tianfeng Chen Department of Oncology The First Affiliated Hospitaland Department of ChemistryJinan UniversityGuangzhou 510632China Department of Obstetrics and Gynecology The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325000China

Exploiting a tissue diagnosis method to abstain the involuted operating and consume valuable reagents while realizing high-speed and inexpensive pathological grading technology to supply a better scheme for cancer therapy is a significant method of cancers detection. A promising immuno-fluorescence strategy was rationally designed and synthesized by loading ruthenium complex into cervical cancer-targeted DNA-cage, which was well used to realize high-speed and inexpensive diagnosis of clinical cervical cancer tumor tissues avoiding the traditional multi-stage process, thus demonstrating high application potential in clinical pathological grading and surgical judgment. Moreover, it has been finding that Apts-DNA@Ru can enrichment in the tumor region, interestingly, no enrichment in normal cervical cancer tissue. It has the potential to realize the integration of in vivo diagnose and further synchronous treatment in the near future. Thence, this study demonstrates a strategy for integration of cancer-targeted DNA-cage and fluorescent Ru POP as alternative IHC reagents for next-generation more rapid convenient cancer detection.

关键词： Rapid diagnostic Pathological grading Cervical cancer Immuno-fluorescence Cancer-targeted DNA-cage

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薄膜润滑与润滑状态图

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机械工程学报 2000年第7期36卷 5-10页

作者：雒建斌沈明武史兵温诗铸清华大学摩擦学国家重点实验室北京100084

讨论了速度、固体表面能、滑动比、润滑剂粘度和化学性能对薄膜润滑状态下油膜厚度的影响 ,以及弹流润滑向薄膜润滑转化条件和液体膜失效条件。

关键词：薄膜润滑液体膜失效润滑状态图

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The compatibly large nonlinear optical effect and high laser-induced damage threshold in a thiophosphate CsInP_(2)S_(7)constructed with[P_(2)S_(7)]^(4-)and[InS_(6)]^(9-)

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Chinese Chemical Letters 2024年第1期35卷 533-536页

作者： Mengjia luo Xiaohui Li Xingxing Jiang Zheshuai Lin Zhengyang Zhou Nanchang Key Laboratory of Photoelectric Conversion and Energy Storage Materials Nanchang Institute of TechnologyNanchang 330099China Shanghai Institute of Ceramics Chinese Academy of SciencesShanghai 200050China Functional Crystals Lab Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Institute of Experimental Physics Free University BerlinBerlin D-14195Germany

It is challenging to cooperatively improve the nonlinear optical(NLO)efficiency and the laser-induced damage threshold(LIDT).This work reports a novel IR NLO materials CsInP_(2)S_(7)(CIPS)designed by combination the strategies of alkali metals substitution and microscopic NLO units PS4 introduction based on AgGaS_(2).CIPS was composed of strongly distorted[InS_(6)]^(9-)octahedra and[P_(2)S_(7)]4-dimers constructed by corner-sharing[PS_(4)]^(3-),which increase the NLO efficiency and decrease thermal expansion anisotropy *** with AgGaS_(2),CIPS exhibited strong phase matchable NLO response ca.1.1×AGS@2.1μm,high LIDT ca.20.8×AgGaS_(2),and IR transparency up to 15.3μ*** analysis and theoretical investigation confirmed that large SHG effect and ultrahigh LIDT of CIPS originated from the synergistic contribution of[InS_(6)]^(9-)octahedra and[P_(2)S_(7)]*** results indicate that CIPS is a promising NLO candidate in the mid-IR region,and this study provides a new approach for developing potential NLO-LIDT compatible materials.

关键词： Infrared nonlinear optics materials A novel thiophosphate Structure design Structure-activity relationship High laser-induced damage threshold

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Calculation Method for Commutation Failure Fault Level in LCC-HVDC System Under Single-line-to-ground Faults Considering DC Current Variation

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Journal of Modern Power Systems and Clean Energy 2023年第6期11卷 1995-2002页

作者： Renlong Zhu Xiaoping Zhou Hanhang Yin Lerong Hong An luo Yandong Chen Hanting Peng College of Electrical and Information Engineering Hunan UniversityChangsha 410082China School of Electrical and Information Engineering Changsha University of Science and TechnologyChangsha 410114China

Earlier studies have reported some calculation methods for commutation failure fault level(CFFL) in line-commutated-converter based high-voltage direct current(LCCHVDC) system under single-line-to-ground(SLG) faults. The accuracy of earlier methods is limited because they only consider the commutating voltage drop and phase shift, while neglecting the DC current variation. Hence, this paper proposes a CFFL calculation method under SLG faults considering DC current variation, for better planning and designing of LCC-HVDC systems. First, the fault commutating voltage magnitude and phase shift are calculated. Then, the fault DC voltage during different commutation processes is deduced. Based on the commutating voltage magnitude and phase shift, and DC voltage during different commutation processes under SLG faults, the characteristics of CFFL with different fault time are demonstrated and analyzed. Next, the transient time-domain response of the DC current after the fault is obtained based on the DC transmission line model. Discrete commutation processes are constructed based on the commutation voltage-time area rule to solve the extinction angle under different fault levels and fault time. Finally, the CFFL is calculated considering the fault time, commutating voltage drop, phase shift, and DC current variation. The accuracy of the proposed method compared with the traditional method is validated based on the CIGRE benchmark model in PSCAD/EMTDC.

关键词： Commutation failure(CF) commutation failure fault level(CFFL) line-commutated-converter-based highvoltage direct current(LCC-HVDC) single-line-to-ground(SLG)fault

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Palladium-Catalyzed Oxidative C=C Triple Bond Cleavage of 2-Alkynyl Carbonyl Compounds Toward 1,2-Dicarbonyl Compounds

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Chinese Journal of Chemistry 2020年第6期38卷 553-558页

作者： Ming-Bo Zhou Mu-Jia luo Ming Hu Jin-Heng Li Key Laboratory of Chemical Biology&Traditional Chinese Medicine Research(Ministry of Education) Hunan Normal UniversityChangshaHunan 410081China Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle Nanchang Hangkong UniversityNanchangJiangxi 330063China State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan UniversityChangshaHunan 410082China

A new,gen era I palladium-catalyzed oxidative strategy for the cleavage of the C=C triple bond is *** employing PdCI2/CuBr2/TEMPO and air as the catalytic system and H2O as the carbonyl oxygen atom source,a wide range of 2-alkynyl carbonyl compounds,including 1,3-disubstituted prop-2-yn-l-ones,propiolamides and propiolates,lost an alkynyl carbon to access various 1,2-dicarbonyl compounds,e.g.,1,2-diones,2-keto amides and 2-keto esters,through Wacker oxidation,intramolecular cyclization and C—C bond cleavage cascades.

关键词： 1,2 carbonyl cleavage

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Inorganic–organic halide perovskites for new photovoltaic technology

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National Science Review 2018年第4期5卷 559-576页

作者： Dongmei Li Jiangjian Shi Yuzhuan Xu Yanhong luo Huijue Wu Qingbo Meng Key Laboratory for Renewable Energy (CAS) Beijing Key Laboratory for New Energy Materials and Devices Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences School of Physical Sciences University of Chinese Academy of Sciences

Perovskite solar cells(PSCs) have received worldwide attention due to excellent power-to-electricity conversion efficiency(PCE). Currently, a PCE record of as high as 22.1% has been achieved, comparative to those of copper indium gallium selenide and Cd Te solar cells. However, there are still some critical issues to solve, especially the stability issue at the current state, in order to promote PSC commercialization. In this respect, various device architectures and the working principle are briefly introduced. Then, key features of inorganic–organic hybrid perovskites and related film deposition methods are ***, experimental and theoretical efforts to reveal the physical issues of the device are emphasized as well as the cell stability. Finally, a short summary, challenge and prospect are given.

关键词： inorganic–organic hybrid perovskite materials perovskite solar cells heterojunction photophysics stability

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