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The role of AFAP1-AS1 in mitotic catastrophe and metastasis of triple-negative breast cancer cells by activating the PLK1 signaling pathway

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Oncology Research 2023年第3期31卷 375-388页

作者： SHUIZHONG CEN XIAOJIE PENG JIANWEN DENG haiyun jin ZHINAN DENG XIAOHUA LIN DI ZHU MING jin YANWEN ZHU PUSHENG ZHANG YUNFENG LUO HONGYAN HUANG Department of Spinal Surgery Orthopedic Medical CenterZhujiang HospitalSouthern Medical UniversityGuangzhou510280China Department of Critical Care Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou510515China Department of Breast Surgery Zhujiang HospitalSouthern Medical UniversityGuangzhou510280China Department of Gynecology and Obstetrics Southern Hospital Taihe BranchSouthern Medical UniversityGuangzhou510540China Department of Clinical Medicine Nanshan ClassGuangzhou Medical UniversityGuangzhou511436China Department of Gastroenterology Shenzhen HospitalSouthern Medical UniversityShenzhen518110China

Triple-negative breast cancer(TNBC)is characterized by fast growth,high metastasis,high invasion,and a lack of therapeutic targets.Mitosis and metastasis of TNBC cells are two important biological behaviors in TNBC malignant progression.It is well known that the long noncoding RNA AFAP1-AS1 plays a crucial role in various tumors,but whether AFAP1-AS1 is involved in the mitosis of TNBC cells remains unknown.In this study,we investigated the functional mechanism of AFAP1-AS1 in targeting Polo-like Kinase 1(PLK1)activation and participating in mitosis of TNBC cells.We detected the expression of AFAP1-AS1 in the TNBC patient cohort and primary cells by in situ hybridization(ISH),northern blot,fluorescent in situ hybridization(FISH)and cell nucleus/cytoplasm RNA fraction isolation.High AFAP1-AS1 expression was negatively correlated with overall survival(OS),disease-free survival(DFS),metastasis-free survival(MFS)and recurrence-free survival(RFS)in TNBC patients.We explored the function of AFAP1-AS1 by transwell,apoptosis,immunofluorescence(IF)and patient-derived xenograft(PDX)models in vitro and in vivo.We found that AFAP1-AS1 promoted TNBC primary cell survival by inhibiting mitotic catastrophe and increased TNBC primary cell growth,migration and invasion.Mechanistically,AFAP1-AS1 activated phosphorylation of the mitosis-associated kinase PLK1 protein.Elevated levels of AFAP1-AS1 in TNBC primary cells increased PLK1 pathway downstream gene expression,such as CDC25C,CDK1,BUB1 and TTK.More importantly,AFAP1-AS1 increased lung metastases in a mouse metastasis model.Taken together,AFAP1-AS1 functions as an oncogene that activates the PLK1 signaling pathway.AFAP1-AS1 could be used as a potential prognostic marker and therapeutic target for TNBC.

关键词： TNBC AFAP1-AS1 Mitotic catastrophe Metastasis PLK1

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Effect of Thermal Aging on Breakdown Strength of Epdm Rubber

Effect of Thermal Aging on Breakdown Strength of Epdm Rubber

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第三届材料科学应用与能源材料国际研讨会

作者： Ruocheng Wang Yunyi He Zhao Wang Hongwei Kang Jiawei Ma haiyun jin State Key Laboratory of Electrical Insulation and Power Equipment Xi'an Jiaotong University Wuxi power supply branch of state grid jiangsu electric power co.LTD

This paper takes the Ethylene Propylene Diene Monomer（EPDM） insulation layer of 220 kV integral prefabricated cable joint as the research object, performs accelerated thermal aging experiments at 130℃, 145℃, and 160℃, and then conducted Fourier Transform Infrared spectroscopy（FTIR）, Thermogravimetric Analysis（TGA） and power frequency breakdown strength test successively. The experimental results show that thermal aging results in long molecular chain degradation, bond breaking and oxidation of EPDM.The initial decomposition temperature decreases gradually with the aging time and the thermal stability decreases gradually under the action of thermal aging. The breakdown field strength decreased by 13.3%, 21.2% and 22.5% respectively at the end of thermal aging, and the decline rate increased with the aging temperature. The main reasons for the decrease of breakdown strength are the precipitation of crosslinking agent, the breaking down of molecular chain and the generation of oxygen-containing groups.

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Mechanical properties and microstructure of coordination toughened epoxy based composites

Mechanical properties and microstructure of coordination tou...

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第三届材料科学应用与能源材料国际研讨会

作者： Yunyi He Ruocheng Wang Zhao Wang Hongwei Kang Chenxi Zhang haiyun jin Naikui Gao State Key Laboratory of Electrical Insulation and Power Equipment Xi’an Jiaotong University

In this paper, toughening epoxy based composites were fabricated, the mechanical properties were measured and the microstructure was observed, the performance changes of epoxy casting system under different components were compared and analysed, coordination effect of multi-toughened was also investigated. Results showed that, the toughening agent and fumed silica as toughening fillers had the best strengthening and toughening effect on epoxy matrix with the addition of 4 wt.% and 3 wt.% respectively. Finally, by combining the different influence mechanism of the two fillers on the matrix, the comprehensive properties of the epoxy casting insulating materials were further improved. The results showed that the synergistic effect was obtained when the two fillers were blended with 3 wt.% toughener and 1 wt.% fumed silica. The tensile strength and impact strength were 67.42 MPa and 13.69 kJ/m, which were 67.51% and 37.15% higher than those of pure epoxy.

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Mechanical Behavior of Aged EPDM Insulation of High-Voltage Cable Joints in Thermal-Oxidative Environment

Mechanical Behavior of Aged EPDM Insulation of High-Voltage ...

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第三届材料科学应用与能源材料国际研讨会

作者： Jun Song Zhao Wang Hang Ji Ruocheng Wang Yunjie Zhou Yunyi He haiyun jin State Grid Shanghai Cable Company State Key Laboratory of Electrical Insulation and Power Equipment Xi'an Jiaotong University State Grid Shanghai Municipal Power Company

In this thesis, the thermal aging behaviour at 130℃, 145℃ and 160℃ for 220 kV cable joint EPDM insulation was investigated. The tensile strength and elongation of EPDM insulation both before and after the thermal-oxidative aging were measured, and the microstructure of materials was observed by SEM. The microstructure observation showed that pores formed and expanded into pieces inside the EPDM insulation with thermal aging course, the cracks would appear at the end of aging process. Both tensile strength and elongation of EPDM insulation decreased with aging process lasting, and decreased more gradually with increasing aging temperature. The tensile strength was more sensitive than elongation for aging process. The results can provide theoretical support for the fabrication, operating and maintenance for EPDM cable joint.

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数码印花与纺织品个性化定制C2B模式

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纺织学报 2015年第2期36卷 164-168页

作者：林虹 jin haiyun 国家数码喷印工程技术研究中心浙江杭州310052 杭州宏华数码科技股份有限公司浙江杭州310052

纺织业正处于深化转型升级与结构调整时期,数字化的数码印花技术与信息化的网络平台结合,创造出纺织品大批量个性化定制C2B商业模式,为传统纺织业注入新的活力。通过分析消费者个性化需求下的规模经济向范围经济转变,商业模式也随之由B2... 详细信息

纺织业正处于深化转型升级与结构调整时期,数字化的数码印花技术与信息化的网络平台结合,创造出纺织品大批量个性化定制C2B商业模式,为传统纺织业注入新的活力。通过分析消费者个性化需求下的规模经济向范围经济转变,商业模式也随之由B2C升级到C2B,来探求纺织品个性化定制C2B模式的市场背景。从3个方面论证了数码印花是支撑纺织品大批量个性化定制的关键技术:数码印花技术特点使纺织品个性化定制成为可能;数码印花技术进步将纺织品个性化定制推向规模化发展阶段;由众多数码印花机整合而成的工业互联网,在纺织品个性化定制中发挥更大的作用。

关键词：数码印花纺织品个性化大批量定制 C2B 工业互联网

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基于硅橡胶基可加工前驱体的低温烧结CaZnSi_(2)O_(6)玻璃陶瓷

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复合材料学报 2023年第8期40卷 4813-4820页

作者：李鹏虎金海云刘怀东王昭高乃奎西安交通大学电力设备电气绝缘国家重点实验室西安710049

陶瓷材料的应用由于其烧结温度高、加工性能差而受到限制。以斜方硅钙石作为成瓷填料,低熔点玻璃粉作为助熔剂,纳米SiO_(2)作为补强剂,制备了硅橡胶基可陶瓷化复合材料。将这种复合材料作为可加工前驱体,在1000℃进行CaZnSi_(2)O_(6)玻... 详细信息

陶瓷材料的应用由于其烧结温度高、加工性能差而受到限制。以斜方硅钙石作为成瓷填料,低熔点玻璃粉作为助熔剂,纳米SiO_(2)作为补强剂,制备了硅橡胶基可陶瓷化复合材料。将这种复合材料作为可加工前驱体,在1000℃进行CaZnSi_(2)O_(6)玻璃陶瓷的烧结。研究了硅橡胶的质量分数和玻璃粉的含量对陶瓷材料力学性能的影响,研究了Bi_(2)O_(3)作为辅助助熔剂对陶瓷材料显微形貌、弯曲强度和介电性能的影响。结果表明:随着硅橡胶质量分数的减小或者玻璃粉含量的增加,陶瓷试样的弯曲强度先增大后减小。不加入Bi_(2)O_(3)时,经过1000℃烧结形成的陶瓷材料弯曲强度可以达到90.54 MPa,线性收缩率仅为15%。而适量的Bi_(2)O_(3)不仅可以提高显微形貌的致密度,使弯曲强度提高至110.48 MPa,还能够显著降低陶瓷材料在高温环境下的工频损耗,并且提高材料的工频击穿场强。本文制备的前驱体具有良好的加工性能,可以完成不同尺寸、不同形状的陶瓷材料的烧结。

关键词：可陶瓷化复合材料可加工前驱体玻璃陶瓷显微形貌介电性能

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Pattern Scan Laser Photocoagulator on Retinopathy: an annual clinical application summary

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Eye Science 2011年第2期26卷 70-74页

作者： haiyun Ye Chenjin jin Xiaoqing Zhong Zhen Tian Wanyi Lin Laser Laboratory of Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 China

Purpose:To evaluate the clinical efficacy of Pattern Scan Laser Photocoagulator (PASCAL) by observing the efficacy of PASCAL on retinopathy.Methods:A total of 92 patients with retinopathy (121 eyes) who underwent PASCAL between December 2008 and February 2009 in our center were retrospectively analyzed to evaluate the visual acuity changes and recovery conditions of the patients from baseline to posterior to the treatment.The retinopathy included:diabetic retinopathy,ischemic retinal vein occlusion.(IRVO),central serous chorioretinopathy (CSC),retinal periphlebitis (Eales disease) and retinal degeneration /holes.Results:The patients were subject to a 12-month follow up after PASCAL.The visual acuity findings were stated as below:for diabetic retinopathy.(73 eyes),10 eyes had improved visual acuity;55 eyes were stabilized and 8 eyes progressed;for IRVO (13 eyes),4 eyes showed improvement,6 eyes were stabilized and 3 eyes progressed;for CSC (9 eyes),6 eyes were alleviated and 3 eyes progressed;for retinal periphlebitis (5 eyes),2 eyes had enhanced visual acuity and 3 eyes showed stable visual acuity;for retinal degeneration /holes (21 eyes),5 eyes presented improved visu-al acuity,16 eyes were stabilized and no eye progressed.Indirect ophthalmoscopic reexamination confirmed secured blockage by laser spots and favorable absorption of the retinal edema and newborn capillaries.No obvious leakage was observed during fundus fluorescein angiography and no laser-related ocular adverse effect was reported.Conclusion:PASCAL is accurate,effective and well-tolerated.The duration of short laser pulse falls within the safety range,ensuring the stabilization and improvement in the pa-tient's visual acuity.The parameters,long-term efficacy and complications of PASCAL should be further demonstrated by performing long-term clinical trials with larger sample size.

关键词：扫描激光视网膜临床应用病变 Pascal 花样疗效观察超短激光脉冲

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评价多孔Si_3N_4陶瓷断裂韧性的新方法——单向压缩试验

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稀有金属材料与工程 2017年第10期46卷 2883-2888页

作者：陈猛金海云潘希德王红洁金志浩西安交通大学电气设备电气绝缘国家重点实验室陕西西安710049

人们常用单边梁切口法(SENB)评价多孔陶瓷的断裂韧性(K_(IC)),K_(IC)随孔隙率增加而不断下降。SENB测试结果表明,多孔陶瓷中的微气孔、微裂纹不仅没有起到增韧作用阻止裂纹扩展,反而加速了扩展。而评价多孔陶瓷热震损伤抗力(R'''')时发... 详细信息

人们常用单边梁切口法(SENB)评价多孔陶瓷的断裂韧性(K_(IC)),K_(IC)随孔隙率增加而不断下降。SENB测试结果表明,多孔陶瓷中的微气孔、微裂纹不仅没有起到增韧作用阻止裂纹扩展,反而加速了扩展。而评价多孔陶瓷热震损伤抗力(R'''')时发现,多孔陶瓷R''''随孔隙率增加而增大,该理论表明孔隙率增加阻止了裂纹扩展。很显然,采用SENB法测定的K_(IC)值与微裂纹增韧以及热震损伤理论相矛盾。多孔陶瓷的单向压缩试验表明,其σ-ε曲线可明显分为两部分,即弹性变形部分和非线性部分。非线性部分出现是由于众多微裂纹亚稳扩展所致,最终发生失稳断裂。用该法测出的断裂能,可量化微裂纹增韧效应,完善了多孔陶瓷断裂韧性的测试方法。

关键词：多孔陶瓷断裂韧性(KIC) 单边梁切口法单向压缩试验热震损伤抗力(R'''')

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复合助剂对低温常压烧结AlN性能的影响

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稀有金属材料与工程 2006年第10期35卷 1616-1619页

作者：金海云王雯高积强乔冠军金志浩西安交通大学材料强度国家重点实验室陕西西安710049

研究了Y2O3,LiO2,CaO烧结助剂对AlN陶瓷常压烧结致密度和性能的影响。结果发现,同时添加Y2O3,LiO2,CaO作为助剂,在1600℃低温烧结就能获得具有高致密度、较小的晶粒尺寸(1μm^4μm)、较高的抗弯强度(331MPa)、断裂韧性(3.8MPa·m1/2)及... 详细信息

研究了Y2O3,LiO2,CaO烧结助剂对AlN陶瓷常压烧结致密度和性能的影响。结果发现,同时添加Y2O3,LiO2,CaO作为助剂,在1600℃低温烧结就能获得具有高致密度、较小的晶粒尺寸(1μm^4μm)、较高的抗弯强度(331MPa)、断裂韧性(3.8MPa·m1/2)及导热率(118W·m-1·K-1)的AlN陶瓷。

关键词：氮化铝烧结助剂力学性能热导率显微机构

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基于电学性能的发电机线棒主绝缘热老化特性研究

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绝缘材料 2023年第8期56卷 45-50页

作者：李育林刘向东韩佳轩王韦玉金海云南方电网储能股份有限公司广东广州510000 南方电网调峰调频发电有限公司检修试验分公司广东广州511400 西安交通大学电力设备电气绝缘国家重点实验室陕西西安710000 国网浙江省电力有限公司杭州供电公司浙江杭州310000

抽水蓄能发电机组长期运行过程中的热效应会对定子线棒主绝缘性能造成不利影响。本文以18kV抽水蓄能机组发电机VPI定子线棒为研究目标,制备试样并设计热老化方案,通过介电性能测试、电导测试及击穿特性测试,探究定子绝缘在不同热老化温... 详细信息

抽水蓄能发电机组长期运行过程中的热效应会对定子线棒主绝缘性能造成不利影响。本文以18kV抽水蓄能机组发电机VPI定子线棒为研究目标,制备试样并设计热老化方案,通过介电性能测试、电导测试及击穿特性测试,探究定子绝缘在不同热老化温度、不同热老化周期下的电学性能变化规律。结果表明:定子线棒弯曲段试样出现了较为明显且完整的损耗峰,在热老化过程中,绝缘材料的介电常数频谱整体随着老化周期的增加呈现增大趋势,其中弯曲段试样的介电常数随频率升高出现阶梯性下降趋势。随着老化的进行,试样的电导率逐渐上升,吸收比与极化指数均呈下降趋势,直线段试样和弯曲段试样的击穿强度均不断降低,其中弯曲段试样的击穿强度下降更为明显。

关键词：发电机线棒电学性能热老化

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