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Early diagenetic growth of carbonate concretions in the upper Doushantuo Formation in South China and their significance for the assessment of hydrocarbon source rock

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Science China Earth Sciences 2008年第9期51卷 1330-1339页

作者： DONG Jin ZHANG ShiHong JIANG GanQing ZHAO QingLe li haiyan SHI XiaoYing liU JunLai State Key Laboratory of Geological Process and Mineral Resources China University of GeosciencesBeijing 100083China Department of Geoscience University of NevadaLas VegasNV 89154-4010USA

Mineralogical and textural characteristics and organic carbon composition of the carbonate concretions from the upper Doushantuo Formation (ca. 551 Ma) in the eastern Yangtze Gorge area reveal their early diagenetic (shallow) growth in organic-rich shale. High organic carbon content (up to 10%) and abundance of framboidal pyrites in the hosting shale suggest an anoxic or euxinic depositional environment. Well-preserved cardhouse clay fabrics in the concretions suggest their formation at 0-3 m burial depth, likely associated with microbial decomposition of organic matter and anaerobic oxidation of methane. Gases through decomposition of organic matter and/or from methanogenesis created bubbles and cavities, and anaerobic methane oxidation at the sulfate reduction zone resulted in carbonate precipitation, filling in bubbles and cavities to form spherical structures of the concretions. Rock pyrolysis analyses show that the carbonate concretions have lower total organic carbon (TOC) content but higher effective carbon than those in the host rocks. This may be caused by enclosed organic matter in pores of the concretions so that organic matter was protected from further modification during deep burial and maintained high hydrocarbon generating potential even in over-matured source rock. As a microbialite sensu latu, concretions have special growth conditions and may provide important information on the microbial activities in depositional and early burial environments.

关键词： Doushantuo Formation carbonate concretion sedimentary environment hydrocarbon source rock

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Review of the Research of the 2011 Mw9.0 Tohoku-Oki Earthquake

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Earthquake Research in China 2017年第3期31卷 309-333页

作者： Shao Zhigang Wang Peng li haiyan Institute of Earthquake Science China Earthquake AdministrationBeijing 100036China

On March 11,2011, a M_W9.0 earthquake occurred in the Japan Trench, causing tremendous casualties,and attracting extensive concern. Based on the results of related research,this paper analyzes the observations,phenomena and understandings of the earthquake from varied aspects,and obtains four main conclusions.(1) The earthquake,occurring in the subduction zone in the Japan Trench located in the northwest boundary of the pacific plate has two zones of concentrated coseismic slip at different depths,and the slip in the deep zone is relatively small. Though there have been many M7. 0 historical earthquakes,slips in the shallow zone are large,but there have been few historical strong earthquakes.(2) Constrained by GPS data,the study of fault movement shows that fault movement in the Japan Trench has a background of widely distributed stability and locking( the locking zone is equivalent that of coseismic rupture zone). Perturbation occurred after the 2008 M8. 0 Hokkaido earthquake,several M7. 0 events had after slips larger than the coseismic slip,and two obvious slow slip events were recorded in 2008 and2011. Eventually,the March 9,2011 M7. 0 foreshock and the March 11,2011 M_W9.0 mainshock occurred. The pre-earthquake changing of the fault movement in the Japan Trench is quite clear.(3) Traditional precursory observation show no obvious anomaly,possibly due to monitoring reason. Anomaly before earthquake consists of high stress state in focal zone reflected by some seismic activity parameters,short period anomaly in regional ground motion,etc.(4) The analysis of physical property in focal zone aroused more scientific issues,for example,is there obvious difference between physical property in focal zone and its vicinity? Does frictional property of fault determine seismogenic ability and rupture process? Whether pre-earthquake fault movement include pre-slips? Could deep fluid affect fault movement in focal zone? Experience is the best teacher,and authors hope this pap

关键词： The 2011 Mw9.0 Japan earthquake Earthquake prediction Seismic monitoring Earthquake research

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liquid metal as energy transportation medium or coolant under harsh environment with temperature below zero centigrade

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Frontiers in Energy 2014年第1期8卷 49-61页

作者： Yunxia GA0 Lei WANG haiyan li Jing liU Key Lab of Cryogenics and Beijing Key Lab of CryoBiomedicalEngineering Technical Institute of Physics and Chemistry ChineseAcademy of Sciences Beijing 100190 China Department of Biomedical Engineering School of Medicine TsinghuaUniversity Beijing 100084 China

The current highly integrated electronics and energy systems are raising a growing demand for more sophisticated thermal management in harsh environments such as in space or some other cryogenic environment. Recently, it was found that room temperature liquid metals （RTLM） such as gallium or its alloys could significantly reduce the electronics temperature compared with the conventional coolant, like water, oil or more organic fluid. However, most of the works were focused on RTLM which may subject to freeze under low temperature. So far, a systematic interpretation on the preparation and thermal properties of liquid metals under low temperature （here defined as lower than O^C） has not yet been available and related applications in cryogenic field have been scarce. In this paper, to promote the research along this important direction and to overcome the deficiency of RTLM, a comprehensive evaluation was proposed on the concept of liquid metal with a low melting point below zero centigrade, such as mercury, alkali metal and more additional alloy candidates. With many unique virtues, such liquid metal coolants are expected to open a new technical frontier for heat transfer enhancement, especially in low temperature engineering. Some innovative ways for making low melting temperature liquid metal were outlined to provide a clear theoretical guideline and perform further experiments to discover new materials. Further, a few promising applied situations where low melting temperature liquid metals could play irreplaceableroles were detailed. Finally, some main factors for optimization of low temperature coolant were summarized. Overall, with their evident merits to meet various critical requirements in modem advanced energy and power industries, liquid metals with a low melting temperature below zero centigrade are expected to be the next- generation high-performance heat transfer medium in thermal managements, especially in harsh environment in space.

关键词： liquid metal cryogenics low melting point,thermal management aircraft liquid cooling spaceexploration

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Research Progress and Analysis of Moxibustion in Prevention and Treatment of Acute Infectious Diseases

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Chinese Medicine and Culture 2019年第3期2卷 169-174页

作者： haiyan li Chao Zhang 张淑娜(翻译) Department of Acupuncture-Moxibustion literature Acupuncture-Moxibustion and Tuina SchoolShanghai University of Traditional Chinese MedicineShanghaiChina 不详

To introduce and evaluate current research progress of moxibustion in the prevention and treatment of acute infectious diseases,related literature in CNKI,Wanfang Data,and SinoMed was retrieved and analyzed by the present *** showed abundant studies on the mechanism of action of moxibustion in the prevention and treatment of acute infectious diseases with remarkable clinical *** present study also summarizes the commonly-occurring problems and found out the deficiencies in existing studies in hope of providing more reference for further research.

关键词： Acute infectious diseases Chinese medicine experimental research literature research mechanism of moxibustion

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A Floating Astronomical Time Scale for the Early Late Cretaceous Continental Strata in the Songliao Basin, Northeastern China

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Acta Geologica Sinica(English Edition) 2020年第1期94卷 27-37页

作者： MA Xiaojuan WU Huaichun FANG Qiang SHI Meinan ZHANG Shihong YANG Tianshui li haiyan WANG Chengshan Schoolof Ocean Sciences China University of GeosciencesBeijing 100083China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing 100083China

A continuous terrestrial succession was recovered from the Songke-2(SK-2)borehole in the Songliao Basin,Northeastern *** borehole provides a unique material for further research on the continental paleoclimate during Cretaceous greenhouse period,following a series of achievements of the Songke-1(SK-1)*** this study,thorium(Th)logging data were chosen as a paleoclimate proxy to conduct a detailed cyclostratigraphic *** Th series varies quasi-periodically;power spectra and evolutionary fast Fourier transformation(FFT)analysis reveal significant cycles in the Quantou(K2 q),Qingshankou(K2 qn),Yaojia(K2 y)and Nenjiang(K2 n)*** ratio of cycle wavelengths in these stratigraphic units is approximately 20:5:2:1,corresponding to long orbital eccentricity(405 kyr),short orbital eccentricity(100 kyr),obliquity(37 kyr),and precession cycles(22.5 kyr and 18.4 kyr).The durations of the K2 n,K2 y,K2 qn and K2 q are estimated as 6.97,1.83,5.30 and 4.52 Myr,respectively,based on the constructed^18.62 Myr"floating"astronomical time scale(ATS).Comparison of the durations between the SK-1 s and SK-2 boreholes exhibits a slight difference of 0.06 Myr and 0.459 Myr for K2 qn and K2 ***,our ATS of K2 n supports the chronostratigraphic frame constructed by the CA-ID-TIMS data of the SK-1 s *** new"floating"ATS provides precise numerical ages for stratigraphic boundaries,biozones and geological events in the Songliao Basin,and can serve as a basis for correlation of strata and events between marine and terrestrial systems.

关键词： Late Cretaceous SK-2 borehole cyclostratigraphy astronomical time scale Songliao Basin northeastern China

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Generation of male-sterile soybean lines with the CRISPR/Cas9 system

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The Crop Journal 2021年第6期9卷 1270-1277页

作者： Xiao Chen Suxin Yang Yaohua Zhang Xiaobin Zhu Xinjing Yang Chunbao Zhang haiyan li Xianzhong Feng Key Laboratory of Soybean Molecular Design Breeding Northeast Institute of Geography and AgroecologyThe Innovative Academy of Seed DesignChinese Academy of SciencesChangchun 130102JilinChina University of Chinese Academy of Sciences Beijing 100049China School of life Science Jilin Agricultural UniversityChangchun 130118JilinChina Jilin Academy of Agricultural Sciences Changchun 130000JilinChina

Soybean [Glycine max(L.) Merr.] provides a rich source of plant protein and oil worldwide. The commercial use of transgenic technology in soybean has become a classical example of the application of biotechnology to crop improvement. Although genetically modified soybeans have achieved commercial success,hybrid soybean breeding is also a potential way to increase soybean yield. Soybean cytoplasmic malesterile(CMS) lines have been used in three-line hybrid breeding systems, but their application to exploiting soybean heterosis has been limited by rare germplasm resource of sterile lines. The generation of various genetic diversity male-sterile soybean lines will help to overcome the shortcoming. In this study,we used targeted editing of AMS homologs in soybean by CRISPR/Cas9 technology for the first time to generate stable male-sterile lines. Targeted editing of GmAMS1 resulted in a male-sterile phenotype,while editing of GmAMS2 failed to produce male-sterile lines. GmAMS1 functions not only in the formation of the pollen wall but also in the controlling the degradation of the soybean ***/Cas9 technology could be used to rapidly produce stable male-sterile lines, providing new sterile-line materials for soybean hybrid breeding systems.

关键词： CRISPR/Cas9 Soybean Tapetum Gmams Male sterility

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Effects of catalyst mass loading on electrocatalytic activity:An example of oxygen evolution reaction

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Fundamental Research 2021年第4期1卷 448-452页

作者： linghui Yu Shengnan Suna haiyan li Zhichuan JXu School of Materials Science and Engineering Nanyang Technological UniversityBlock N4.150 Nanyang Avenue639798Singapore Singapore-HUJ Alliance for Research and Enterprise Campus for Research Excellence and Technological Enterprise(CREATE)NEW-CREATE Phase II138602Singapore Beijing Innovation Center for Engineering Science and Advanced Technology(BIC-ESAT) Beijing Key Laboratory for Magnetoelectric Materials and Devices(BKL-MMD)School of Materials Science and EngineeringCollege of EngineeringPeking UniversityBeijing 100871China Energy Research Institute@NTU ERI@NInterdisciplinary Graduate SchoolNanyang Technological University639798Singapore

The evaluation of the intrinsic activity of catalysts is the most basic in searching energy-and cost-efficient catalyst materials for various *** accurate determination of the intrinsic activity is essential for identifying efficient *** a huge number of studies of electrocatalysis for various applications have been reported,the effects of electrode loading on the apparent intrinsic activity obtained experimentally have been rarely *** a high mass loading on the electrode,not all the catalyst surfaces can be electrochemically active because not all the surfaces can be wetted by the *** loading also affects the transport of electrons over the electrode as well as the transport of ions in the electrolyte,and thus affects the *** lead to the derivations of the apparent intrinsic activity from the real intrinsic ***,for better understanding the derivations,we evaluate and discuss the effects of electrode mass loading using oxygen evolution reaction as an example.

关键词： Electrocatalysis Water splitting Oxygen reduction reaction Electrode loading

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一种新能源车专用轮胎的设计

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橡塑技术与装备 2025年第1期51卷 25-29页

作者：张宁陈海龙蒋婷婷李海艳山东丰源轮胎制造股份有限公司山东枣庄277300

文章介绍了一款新能源车专用轮胎,规格型号为255/45R18。结构设计:充气外直径703 mm、行驶面宽220 mm、充气断面宽255 mm;花纹设计:变宽度纵向沟槽,可提升湿地抓着力;内外侧采用静音变节距设计,降低噪声;独特的消音槽和消音窗搭配设计,... 详细信息

文章介绍了一款新能源车专用轮胎,规格型号为255/45R18。结构设计:充气外直径703 mm、行驶面宽220 mm、充气断面宽255 mm;花纹设计:变宽度纵向沟槽,可提升湿地抓着力;内外侧采用静音变节距设计,降低噪声;独特的消音槽和消音窗搭配设计,降低行驶噪声;互锁式胎肩花纹块,可提高操控丝滑度;施工设计:胎面采用新能源电动汽车轮胎专用配方,具备优异的湿抓地、滚动阻力、防静电性能;胎侧为双复合设计,带束包含1#和2#两层钢丝帘线使用2+2×0.30HT钢丝,钢丝圈设计为斜六角形;成型使用荷兰VMI一次法成型机,硫化工艺为氮气硫化。新能源车专用轮胎成品检测的各项性能符合研发标准。

关键词：施工设计新能源车专用轮胎结构设计导静电预口型

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Small extracellular vesicles secreted by urine-derived stem cells enhanced wound healing in aged mice by ameliorating cellular senescence

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Journal of Materials Science & Technology 2021年第4期63卷 216-227页

作者： Yongjin Sun Juntao Zhang Bi Chen Yunlong Yang haiyan li Xin Niu Qing li Weidong Wu Zongping Xie Yunfeng Chen Fuyue Wu Yang Wang Department of Orthopedic Surgery Institute of Microsurgery on ExtremitiesShanghai Jiao Tong University Affiliated Sixth People’s HospitalShanghai 200233China Med-X Research Institute School of Biomedical EngineeringShanghai Jiao Tong UniversityShanghai 200030China Ruitai Biotechnology Co. LtdShanghai 201114China

Regeneration of chronic skin wounds in tissue is still a key challenge in regenerative medicine because of the accumulation of senescent cells and increasing secretion of s¨enescence-associated secretory phenotype(SASP)in the wound ***,some studies have reported that small extracellular vesicles(sEVs)derived from stem cells can alleviate cellular senescence with very low risk of tumorigenesis and immune *** our previous studies have shown that urine-derived stem cells(USCs)can be obtained easily and noninvasively and sEVs derived from USCs(USC-sEVs)have capabilities of regenerating tissue injuries,using USC-sEVs to enhance chronic skin wound healing in aged tissue might be a feasible and efficient ***,in this study,the USC-sEVs were collected and firstly loaded in a human acellular amniotic membrane(HAAM)for controlled releasing and locating the USC-sEVs in the wound site before they were implanted into a chronic skin wound in aged *** vivo results showed that the USC-sEVs in HAAM could effectively accelerate the wound healing by ameliorating cellular senescence and reducing the secretion of SASP in the aged skin *** elucidate the mechanism,USC-sEVs were used to in vitro culture human dermal fibroblasts(HDFs)and results showed that USC-sEVs could rejuvenate senescent fibroblasts by reversing the aging phenotypes of senescent HDFs and efficiently reducing the secretion of SASP after they activated the Sirt1 ***,USC-sEVs are efficient for enhancing wound healing in aged mice by ameliorating cellular senescence.

关键词： wound urine healing

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Design and Synthesis of Proteolysis Targeting Chimeras for Inducing BRD4 Protein Degradation

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Chemical Research in Chinese Universities 2018年第2期34卷 221-228页

作者： WANG Shihui li haiyan WANG Yue GAO Yang YU Shanshan ZHAO Qianqian JIN Xiangqun LU Haibin College of Pharmacy Jilin University Changchun 130021 P. R. China Affiliated Hospital of Changchun University of Chinese Medicine Changchun 130021 P. R. China

In this paper, we synthesized a series of proteolysis targeting chimeras（PROTACs） using VHL E3 ligase ligands for BRD4 protein degradation. One of the most promising compound 19g exhibited robust potency of BRD4 inhibition with IC50 value of （18.6±1.3） nmol/L, respectively. Furthermore, compound 19g potently inhibited cell proliferation in BRIM-sensitive cell lines RS4;11 with IC50 value of （34.2±4.3） nmol/L and capable of inducing de- gradation of BRD4 protein at 0.4-0.6 μmol/L in the RS4;11 leukemia cells. These data show that compound 19g is a highly potent and efficacious BRIM degrader.

关键词： Proteolysis targeting chimera(PROTAC) BRD4 degrader VHL ligand

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