检索结果-南通市图书馆

有氧运动调节转化生长因子β/Smad通路缓解db/db糖尿病小鼠的肝脏纤维化

在线全文

学校读者我要写书评

暂无评论

中国组织工程研究 2025年第14期29卷 2951-2957页

作者：黄朝露黄毅吴昌燕李芳菲李海燕黔东南民族职业技术学院临床医学系贵州省凯里市556000 贵州医科大学基础医学院贵州省贵阳市550000 贵州中医药大学基础医学院贵州省贵阳市550000 温州医科大学附属第一医院康复科浙江省温州市325000

背景:有氧运动可抑制糖尿病小鼠肝纤维化,但具体作用机制尚未阐明。目的:基于转化生长因子β/Smad信号通路探讨有氧运动改善db/db小鼠肝纤维化的作用机制。方法:将8周龄雄性db/db小鼠和年龄匹配的m/m小鼠随机分为m/m对照组、m/m+运动组... 详细信息

背景:有氧运动可抑制糖尿病小鼠肝纤维化,但具体作用机制尚未阐明。目的:基于转化生长因子β/Smad信号通路探讨有氧运动改善db/db小鼠肝纤维化的作用机制。方法:将8周龄雄性db/db小鼠和年龄匹配的m/m小鼠随机分为m/m对照组、m/m+运动组、db/db对照组、db/db+运动组,每组10只,运动组小鼠接受12周有氧运动。运动结束后检测各组小鼠空腹血糖,进行葡萄糖耐量测试和胰岛素耐量测试;摘取肝脏计算肝脏指数,摘眼球取血检测生化指标;苏木精-伊红染色、油红O染色和Masson染色观察小鼠肝组织的病理变化,免疫组化检测肝组织中转化生长因子β1、p-Smad3的表达;Western blot检测肝组织中转化生长因子β1、Smad3、p-Smad3、α-平滑肌肌动蛋白、Ⅰ型胶原蛋白和Ⅲ型胶原蛋白表达水平。结果与结论:①与m/m组和m/m+运动组小鼠相比,db/db组小鼠体质量、肝质量、肝脏指数、空腹血糖、三酰甘油、总胆固醇、低密度脂蛋白和肌酶水平均显著升高(P<0.01);高密度脂蛋白水平显著降低(P<0.01);转化生长因子β1、p-Smad3、α-平滑肌肌动蛋白、Ⅰ型胶原蛋白和Ⅲ型胶原蛋白表达水平显著升高(P<0.01);葡萄糖、胰岛素耐量测试的曲线下面积显著增加(P<0.01);肝组织病理染色显示大量炎症细胞浸润,脂滴增多,明显纤维化;②与db/db组相比,db/db+运动组小鼠体质量、肝质量、肝脏指数、空腹血糖、三酰甘油、总胆固醇、低密度脂蛋白和肌酶水平显著降低(P<0.05或P<0.01);高密度脂蛋白水平显著升高(P<0.05);转化生长因子β1、p-Smad3、α-平滑肌肌动蛋白、Ⅰ型胶原蛋白和Ⅲ型胶原蛋白表达显著降低(P<0.05或P<0.01);此外,糖耐量、胰岛素耐量测试的曲线下面积明显减少(P<0.01,P<0.05),肝脏病理损伤得到明显改善;③结果表明,有氧运动有效减轻了糖尿病小鼠肝纤维化,其机制可能与调控转化生长因子β/Smad信号通路有关。

关键词：有氧运动转化生长因子β Smad 信号通路 db/db 肝纤维化

Insight into the adsorption of tetracycline onto amino and amino–Fe^(3+) gunctionalized mesoporous silica: Effect of functionalized groups

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2018年第3期30卷 171-178页

作者： Ziyang Zhang haiyan li Huijuan liu Beijing Engineering Research Center of Sustainable Urban Sewage System Construction and Risk Control Beijing University of Civil Engineering and Architecture Key Laboratory of Drinking Water Science and Technology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences

In order to study the influences of functionalized groups onto the adsorption of tetracycline,we prepared a series of amino and amino–Fe^（3＋）complex mesoporous silica adsorbents with diverse content of amino and Fe^（3＋）groups（named N,N-SBA15 and Fe-N,N-SBA15）.The resulting mesoporous silica adsorbents were fully characterized by X-ray powder diffraction（XRD）,Fourier transform infrared spectrometer（FTIR）and N2adsorption/desorption ***,the effects of functionalized groups on the removal of TC were *** results showed that the periodic ordered structure of SBA-15 was maintained after modification of amino/Fe^（3＋）*** functionalized amino groups decreased the adsorption capacity while the coordinated Fe^（3＋）increased the adsorption *** adsorption kinetics of TC fitted pseudo-second-order model well and the equilibrium was achieved *** adsorption isotherms fitted the Langmuir model well and with the Fe^（3＋）content increased from 3.93%to 8.26%,the Q（max）of the adsorbents increased from 102 to 188 mmol/*** solution p H affected the adsorption of TC onto amino complex adsorbents slightly while influenced the adsorption onto Fe-amine complex adsorbents *** adsorption of TC on SBA15 and N,N-SBA15 may be related to the formation of outer-sphere surface complexes,while the adsorption of TC onto Fe-N,N-SBA15 was mainly attributed to the inner-sphere surface *** study could offer potential materials that have excellent adsorption behavior for environmental remediation and suggested useful information for the preparing other adsorbents in environmental applications.

关键词： Adsorption Mesoporous silica Amino groups Fe3+ Tetracycline

Particle size distribution and characteristics of heavy metals in road-deposited sediments from Beijing Olympic Park

在线全文

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2015年第6期27卷 228-237页

作者： haiyan li Anbang Shi Xiaoran Zhang Key Lab of Urban Storm-Water System and Water Environment Beijing University of Civil Engineering and Architecture

Due to rapid urbanization and industrialization, heavy metals in road-deposited sediments（RDSs） of parks are emitted into the terrestrial, atmospheric, and water environment, and have a severe impact on residents＇ and tourists＇ health. To identify the distribution and characteristic of heavy metals in RDS and to assess the road environmental quality in Chinese parks, samples were collected from Beijing Olympic Park in the present study. The results indicated that particles with small grain size（〈150 μm） were the dominant fraction. The length of dry period was one of the main factors affecting the particle size distribution, as indicated by the variation of size fraction with the increase of dry days. The amount of heavy metal（i.e., Cu, Zn, Pb and Cd） content was the largest in particles with small size（〈150 μm） among all samples. Specifically, the percentage of Cu, Zn, Pb and Cd in these particles was 74.7%, 55.5%, 56.6% and 71.3%, *** metals adsorbed in sediments may mainly be contributed by road traffic emissions. The contamination levels of Pb and Cd were higher than Cu and Zn on the basis of the mean heavy metal contents. Specifically, the geoaccumulation index（I geo） decreased in the order：Cd〉Pb〉Cu〉Zn. This study analyzed the mobility of heavy metals in sediments using partial sequential extraction with the Tessier procedure. The results revealed that the apparent mobility and potential metal bioavailability of heavy metals in the sediments, based on the exchangeable and carbonate fractions, decreased in the order： Cd〉Zn≈Pb〉Cu.

关键词： Size distribution Characteristics Heavy metals Road-deposited sediments Contamination assessment Beijing Olympic Park

在线全文

学校读者我要写书评

暂无评论

微冻对蚕豆籽粒保鲜效果及成熟衰老的影响

食品科学 2025年第1期46卷 149-157页

作者：李蝶李海燕钟士宏付院生李梅青张海伟安徽农业大学茶与食品科技学院农业农村部江淮农产品精深加工与资源利用重点实验室安徽省特色农产品高值化利用工程研究中心安徽合肥230036 安徽迈涛食品有限公司安徽芜湖241000

探究微冻技术对新鲜蚕豆籽粒的保鲜效果。通过测定蚕豆籽粒的冰点,确定3个微冻温度,以冷藏(4℃)为对照组,分析不同微冻温度(-2、-3、-4℃)贮藏对蚕豆籽粒感官品质、叶绿素含量、色差值等品质指标的影响,再通过多酚氧化酶(polyphenol oxi... 详细信息

探究微冻技术对新鲜蚕豆籽粒的保鲜效果。通过测定蚕豆籽粒的冰点,确定3个微冻温度,以冷藏(4℃)为对照组,分析不同微冻温度(-2、-3、-4℃)贮藏对蚕豆籽粒感官品质、叶绿素含量、色差值等品质指标的影响,再通过多酚氧化酶(polyphenol oxidase,PPO)、过氧化物酶(peroxidase,POD)、苯丙氨酸解氨酶(phenylalamine ammonia lyase,PAL)活性、总酚含量、可溶性蛋白含量及细胞组织结构等研究微冻贮藏对蚕豆籽粒成熟衰老的影响。结果表明,4℃冷藏条件下蚕豆籽粒保鲜期为7 d,3个微冻温度贮藏均能显著提高样品的感官品质,其中-3℃使蚕豆籽粒保鲜期达35 d,能显著减缓叶绿素含量的降低和质量损失率、色差值的升高,能较好地维持蚕豆籽粒的硬度,采用主成分分析也得出-3℃为最佳微冻温度。-3℃微冻贮藏能减缓PPO、PAL活性升高,维持较高的POD活性,延缓蚕豆籽粒中淀粉和可溶性蛋白的生成、总酚的积累及变化速率,还能维持细胞组织结构、形态的相对稳定,减缓蚕豆籽粒的成熟衰老。

关键词：蚕豆籽粒微冻保鲜贮藏期品质变化成熟衰老

Transcriptome analysis of sugar beet root maggot （Tetanops myopaeformis） genes modulated by the Beta vulgaris host

在线全文

学校读者我要写书评

暂无评论

Insect Science 2018年第2期25卷 222-234页

作者： haiyan li Ann C. Smigocki USDA-ARS Molecular Plant Pathology Laboratory Beltsville Maryland US

Sugar beet root maggot （SBRM, Tetanops myopaeformis von R6der） is a major but poorly understood insect pest of sugar beet （Beta vulgaris L.）. The molecular mecha- nisms underlying plant defense responses are well documented, however, little information is available about complementary mechanisms for insect adaptive responses to overcome host resistance. To date, no studies have been published on SBRM gene expression pro- filing. Suppressive subtractive hybridization （SSH） generated more than 300 SBRM ESTs differentially expressed in the interaction of the pest with a moderately resistant （F1016） and a susceptible （F1010） sugar beet line. Blast2GO v. 3.2 search indicated that over 40% of the differentially expressed genes had known functions, primarily driven by fruit fly D. melanogaster genes. Expression patterns of 18 selected EST clones were confirmed by RT-PCR analysis. Gene Ontology （GO） analysis predicted a dominance of metabolic and catalytic genes involved in the interaction of SBRM with its host. SBRM genes function- ing during development, regulation, cellular process, signaling and under stress conditions were annotated. SBRM genes that were common or unique in response to resistant or susceptible interactions with the host were identified and their possible roles in insect responses to the host are discussed.

关键词： Beta vulgaris resistant sugar beet root maggot suppressive subtractivehybridization susceptible transcriptome

Effect of densification distribution on the Young's modulus of porous coatings after nano-indentation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Metallurgica Sinica(English Letters) 2012年第5期25卷 383-390页

作者： Xiaojuan L U Ping XIAO haiyan li School of Environment Science and Engineering North China Electric Power University Yonghua North Street Baoding 071000 China School of Materials The University of Manchester Manchester M1 7HS UK School of Mechanical Aerospace and Civil Engineering The University of Manchester P.O. Box 88Sackville Street Manchester M60 1QD UK

Nano-indentation of a porous ceramic coating leads to crushing and densification of the coating under the indenter. In this work, finite element simulations of indentation on the porous coating have been carried out to study the effect of the size and dis- tribution of densification on Youngts modulus measured by nano-indentation. Two totally different distribution patterns have been simulated in this work. In the case of gradient densification, the Youngts modulus increased by 8.6% when the densifi- cation has occurred in the maximum influenced area. While the Young^s modulus increased by 2% with a uniformed densification. Examinations of the cross-section of the coatings have suggested that the densification after the indentation is close to the second model. The measured Young＇s modulus could have differed by 2%. The effect of densification on the Young＇s modulus measured by using nano-indentation is strongly dependent on the densification patterns of the porous coating.

关键词： Film Mechanical property Finite element simulation Porosity Electron Microscopy

Qualitative analysis of a parabolic-elliptic attraction-repulsion chemotaxis model with logistic source

在线全文

学校读者我要写书评

暂无评论

International Journal of Biomathematics 2016年第4期9卷 41-57页

作者： haiyan li Jianguo Cao Department of Mathematics Beifang University of Nationalities Ningxia 750021 P. R. China

In this paper, we focus on the qualitative analysis of a parabolic^lliptic attraction- repulsion chemotaxis model with logistic source. Applying a fixed point argument, LP- estimate technique and Moser＇s iteration, we derive that the model admits a unique 1 global solution provided the initial cell mass satisfying ｜｜u0｜｜L1≤ X4/xaCGN-2＋1/σ＋1σ（σ ＋ 1）-1/σ-1｜Ω｜ for σ = 1. While for σ〉 1, there are no restrictions on the initial cell mass and the result still holds.

关键词： Chemotaxis global existence logistic source attraction-repulsion.

OPERATOR SPliTTING SCHEMES FOR THE NON-STATIONARY THERMAL CONVECTION PROBLEMS

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Computational Mathematics 2011年第4期29卷 474-490页

作者： Hongen Jia Kaitai li haiyan Sun College of Science Xi'an Jiaotong University Xi'an 710049 China

In this work, a new numerical scheme is proposed for thermal/isothermal incompressible viscous flows based on operator splitting. Unique solvability and stability analysis are presented. Some numerical result are give... 详细信息

关键词： θ scheme Stability Isothermal incompressible viscous flows.

β-diversity Patterns of Plant Community in Fragmented Habitat in a Degenerated Meadow in Songnen Plain,China

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Geographical Science 2009年第4期19卷 375-381页

作者： HAN Dayong li haiyan YANG Yunfei Key Laboratory for Vegetation Ecology of Ministry of Education Institute of Grassland Science Northeast Normal University Changchun 130024 China

A number of isolated islands of Leymus chinensis ＋ herbosa community were investigated in fragmented habitat islands, by Braun-Blanquet field survey approach, in a degenerated meadow in the Songnen Plain, China in 2007. These islands were classified as large, medium, and small scales on the basis of the island area （100-1000m2, large island; 50-100m2, middle island; 10-50m2, small island）. Each scale of the investigation involved eight islands. The responses ofβ-diversity patterns of plant taxon to the habitat fragmentation at local community and metacommunity levels were analyzed on different scales of 24 isolated islands. The results indicated that at the local community level, there were 57 species belonging to 20 families and 49 genera in large islands, 49 species belonging to 16 families and 40 genera in middle islands, and 27 species belonging to eight families and 23 genera in small islands, β-diversity indexes for species, genus and family in large, middle, and small islands varied greatly, and the highest value of the indexes was not noted in the largest island. However, the average of the data obtained at the three scales showed that across large islands, Whittaker indexes were low and Bray-Curtis similarity indexes were high, while across small islands, Whittaker indexes were high and Bray-Curtis similarity indexes were low. At the metacommunity level, Whittaker indexes for species and genus showed a great significantly negative double logarithmic correlation （p〈0.01） with the island area, whereas the Bray-Curtis indexes for species, genus and family showed a great significantly positive double logarithmic correlation （p〈0.01） with the island area. At both local community and metacommunity levels, tumovers of species and genus could respond more sensitively to spatial changes of plant diversity patterns than that of family. Hence, the species and the genus could be used for the analysis offl-diversity patterns of plant community.

关键词： habitat fragmentation local community metacommunity plant taxon β-diversity