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Gas-propelled nanomotors alleviate colitis through the regulation of intestinal immunoenvironment-hematopexis-microbiota circuits

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2732-2747页

作者： Bo Xiao Yuqi Liang Ga Liu Lingshuang Wang Zhan Zhang Libin Qiu haiting xu Sean Carr Xiaoxiao Shi Rui LReis Subhas CKundu Zhenghua Zhu Department of Gastroenterology the First Affiliated Hospital of Nanchang UniversityNanchang 330006China College of Sericulture Textileand Biomass SciencesSouthwest UniversityChongqing 400715China Department of Neurology School of MedicineEmory UniversityAtlantaGA 30322USA Atlanta Veterans Affairs Medical Center DecaturGA 30033USA Department of Surgery School of MedicineEmory UniversityAtlantaGA 30322USA Bs Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarcoGuimaraes 4805-017Portugal

The progression of ulcerative colitis(UC)is associated with immunologic derangement,intestinal hemorrhage,and microbiota *** traditional medications mainly focus on mitigating inflammation,it remains challenging to address multiple ***,a versatile gas-propelled nanomotor was constructed by mild fusion of post-ultrasonic CaO_(2) nanospheres with Cu_(2)O *** resulting CaO_(2)–Cu_(2)O possessed a desirable diameter(291.3 nm)and a uniform size *** could be efficiently internalized by colonic epithelial cells and macrophages,scavenge intracellular reactive oxygen/nitrogen species,and alleviate immune reactions by pro-polarizing macrophages to the anti-inflammatory M2 *** nanomotor was found to penetrate through the mucus barrier and accumulate in the colitis mucosa due to the driving force of the generated oxygen *** administration of CaO_(2)–Cu_(2)O could stanch the bleeding,repair the disrupted colonic epithelial layer,and reduce the inflammatory responses through its interaction with the genes relevant to blood coagulation,anti-oxidation,wound healing,and ***,it restored intestinal microbiota balance by elevating the proportions of beneficial bacteria(e.g.,Odoribacter and Bifidobacterium)and decreasing the abundances of harmful bacteria(e.g.,Prevotellaceae and Helicobacter).Our gas-driven CaO_(2)–Cu_(2)O offers a promising therapeutic platform for robust treatment of UC via the rectal route.

关键词： Nanomotor Anti-inflammation Blood coagulation Immune regulation Hematopexis Microbiota rebalance Ulcerative colitis Rectal administration

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Mulberry Biomass-Derived Nanomedicines Mitigate Colitis through Improved Inflamed Mucosa Accumulation and Intestinal Microenvironment Modulation

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Research 2024年第1期2023卷 791-807页

作者： Wenjing Yang Ya Ma haiting xu Zhenhua Zhu Jiaxue Wu Cheng xu Wei Sun Erhu Zhao Min Wang Rui L.Reis Subhas C.Kundu Xiaoxiao Shi Bo Xiao State Key Laboratory of Silkworm Genome Biology College of SericultureTextileand Biomass SciencesSouthwest UniversityChongqing 400715China Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing Faculty of Materials and EnergySouthwest UniversityChongqing 400715China Department of Gastroenterology The First Affiliated Hospital of Nanchang UniversityNanchang 330006China Bs Research Group I3Bs—Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarco 4805-017GuimaraesPortugal ICVS/3B’s-PT Government Associate Laboratory BragaGuimarãesPortugal

The therapeutic outcomes of conventional oral medications against ulcerative colitis(UC)are restricted by inefficient drug delivery to the colitis mucosa and weak capacity to modulate the inflammatory ***,a fluorinated pluronic(FP127)was synthesized and employed to functionalize the surface of mulberry leaf-derived nanoparticles(MLNs)loading with resveratrol nanocrystals(RNs).The obtained FP127@RN-MLNs possessed exosome-like morphologies,desirable particle sizes(around 171.4 nm),and negatively charged surfaces(−14.8 mV).The introduction of FP127 to RN-MLNs greatly improved their stability in the colon and promoted their mucus infiltration and mucosal penetration capacities due to the unique fluorine effect.

关键词： fluorine sizes Biomass

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Author correction to“Gas-propelled nanomotors alleviate colitis through the regulation of intestinal immunoenvironmenthematopexis-microbiota circuits”[Acta Pharm Sin B 14(2024)2732e2747]

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4193-4193页

作者： Bo Xiao Yuqi Liang Ga Liu Lingshuang Wang Zhan Zhang Libin Qiu haiting xu Sean Carr Xiaoxiao Shi Rui LReis Subhas CKundu Zhenhua Zhu Department of Gastroenterology the First Affiliated Hospital of Nanchang UniversityNanchang 330006China College of Sericulture Textileand Biomass SciencesSouthwest UniversityChongqing 400715China Department of Neurology School of MedicineEmory UniversityAtlantaGA 30322USA Atlanta Veterans Affairs Medical Center DecaturGA 30033USA Department of Surgery School of MedicineEmory UniversityAtlantaGA 30322USA 3Bs Research Group I3Bs d Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkBarcoGuimaraes 4805-017Portugal

The authors regret that there are errors in the author information and author *** name of the corresponding author,Zhenghua Zhu,should be corrected to Zhenhua *** modification does not affect the results of the *** au... 详细信息

关键词： journal correction contributions

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研学旅行背景下广西文创产品营销策略研究——以广西壮锦为例

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市场周刊 2024年第19期37卷 100-103页

作者：赖洁云徐海婷向思敏广西农业职业技术大学广西南宁530000

广西壮锦,与云锦、蜀锦、宋锦并称为中国四大明锦,在20世纪90年代初,广西壮锦发展总体呈现上升趋势,广西经济得以快速发展。然而这些年,广西壮锦在现代化传承与发展中遭遇瓶颈。文章在以研学旅行为契机,深入研究广西壮锦文创产品营销策... 详细信息

广西壮锦,与云锦、蜀锦、宋锦并称为中国四大明锦,在20世纪90年代初,广西壮锦发展总体呈现上升趋势,广西经济得以快速发展。然而这些年,广西壮锦在现代化传承与发展中遭遇瓶颈。文章在以研学旅行为契机,深入研究广西壮锦文创产品营销策略的优化,为壮锦传承发展提供有效对策,提升壮锦文创产品市场竞争力的同时还能以丰富研学旅行教学活动的内容和形式,实现研学旅行与壮锦文创产品发展的双赢。

关键词：广西研学旅行文创营销壮锦

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某中心医院“战创伤救治中心”运行成效

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医学研究与战创伤救治 2024年第6期37卷 636-639页

作者：刘海霞虞大为王忠祥徐海婷张烨范振宇王诗波解放军联勤保障部队第九〇四医院普外科无锡214044 解放军联勤保障部队第九〇四医院急诊医学科无锡214044

战创伤救治中心建设是军队医院围绕“平时应急保障、战时高效救治”要求,立足本职岗位练兵备战的有效举措。文章探索总结了某中心医院战创伤救治中心建设管理的做法和运行以来的成效。结果表明,战创伤救治中心不仅能明显提升平时严重创... 详细信息

战创伤救治中心建设是军队医院围绕“平时应急保障、战时高效救治”要求,立足本职岗位练兵备战的有效举措。文章探索总结了某中心医院战创伤救治中心建设管理的做法和运行以来的成效。结果表明,战创伤救治中心不仅能明显提升平时严重创伤救治效率和质量,而且强化了团队的紧密协作,立足创伤练战伤,能显著提升战创伤救治整体能力水平。

关键词：军队医院创伤中心建设战伤创伤

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Numerical quadrature for singular and near-singular integrals of boundary element method and its applications in large-scale acoustic problems

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Chinese Journal of Acoustics 2017年第3期36卷 289-301页

作者： GONG Jiayuan AN Junying MA Li xu haiting Qingdao Branch Institute of AcousticsChinese Academy of SciencesQingdao 266023 School of Electrical and Information Engineering Hubei University of Automotive Technology ShiyanHubei Province 442002 Key Laboratory of Underwater Acoustic Environment Institute of AcousticsChinese Academy of SciencesBeijing 100190

The numerical quadrature methods for dealing with the problems of singular and near-singular integrals caused by Burton-Miller method are proposed, by which the conventional and fast multipole BEMs （boundary element methods） for 3D acoustic problems based on constant elements are improved. To solve the problem of singular integrals, a Hadamard finite-part integral method is presented, which is a simplified combination of the methods proposed by Kirkup and Wolf. The problem of near-singular integrals is overcome by the simple method of polar transformation and the more complex method of PART （Projection and Angular ＆ Radial Transformation）. The effectiveness of these methods for solving the singular and near-singular problems is validated through comparing with the results computed by the analytical method and/or the commercial software LMS ***. In addition, the influence of the near-singular integral problem on the computational precisions is analyzed by computing the errors relative to the exact solution. The computational complexities of the conventional and fast multipole BEM are analyzed and compared through numerical computations. A large-scale acoustic scattering problem, whose degree of freedoms is about 340,000, is implemented successfully. The results show that, the near singularity is primarily introduced by the hyper-singular kernel, and has great influences on the precision of the solution. The precision of fast multipole BEM is the same as conventional BEM, but the computational complexities are much lower.

关键词： BEM Numerical quadrature for singular and near-singular integrals of boundary element method and its applications in large-scale acoustic problems

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Sound scattering from underwater elastic spherical shell covered with multilayered medium approximated acoustic cloak

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Chinese Journal of Acoustics 2014年第2期33卷 97-108页

作者： SUN Yang AN Junying xu haiting Qingdao Acoustics Laboratory Institute of AcousticsChinese Academy of Sciences National Laboratory of Acoustics Institute of AcousticsChinese Academy of Sciences

The anechoic performance and mechanism of underwater elastic spherical shell covered with coating are studied at low *** acoustic cloak is anisotropic material,which can be designed with homogeneous isotropic materials on the basis of effective medium approximation *** analytic expression of scattering acoustic field from the shell covered with multilayered medium is formulated and the scattering form function,resonance mode,acoustic field distribution are computed,the scattering characteristics and mechanism of transmission are *** results show that the direction of sound transmission inside the multilayered medium is changed,the acoustic field is deflected gradually,and the acoustic energy flux is guided around the target,which reduces the scattering intensity at low frequencies,the acoustic intensity of target＇s surface is very *** the first resonance peak in spectrum produced by the zero order partial wave,the other resonance modes of elastic spherical shell are not excitated and the multilayered medium can suppress the resonance of the spherical shell effectively.

关键词： Sound scattering from underwater elastic spherical shell covered with multilayered medium approximated acoustic cloak

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Acoustic reflection of rib-stiffened double plates coated with a viscoelastic layer

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Chinese Journal of Acoustics 2014年第3期33卷 193-211页

作者： GONG Jiayuan AN Junying MA Li xu haiting Qingdao Branch Institute of AcousticsChinese Academy of Sciences Key Laboratory of Underwater Acoustic Environment Institute of AcousticsChinese Academy of Sciences University of Chinese Academy of Sciences

To predict sound-absorbing performance of anechoic materials,the acoustic reflection problem of a viscoelastic layer backed with periodically rib-stiffened infinite double plates is studied in this *** reason why structural theories of plates are not applicable to viscoelastic plates is explained through comparing dispersion and attenuation curves of flexural waves with those of Lamb *** a result,（visco-）elastic theory is adopted to deal with（visco-）elastic plates,and ribs are treated by structural theories of *** coupling between ribs and plates are solved by Hull＇s method,and solution of the reflected field is *** accuracy of present method is validated by comparing with the results by the structural theories of *** influence of a backing on the acoustic reflection of the viscoelatic layer is analyzed by computing reflection *** of different viscoelastic materials are evaluated by the average reflection *** computational results show that,influence of a backing on the acoustic reflection cannot be suppressed by the viscoelastic materials in low *** resonance is determined by the coupling of the fluid layer and the double *** ribs,which are coupled with the double plates,mainly reduce the acoustic reflection.

关键词： exp Acoustic reflection of rib-stiffened double plates coated with a viscoelastic layer

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Sound scattering from partially water-filled elastic spherical shell with an internal elastic plate

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Chinese Journal of Acoustics 2008年第2期27卷 111-118页

作者： SUN Yang xu haiting Qingdao Acoustics Laboratory Institute of Acoustics Chinese Academy of Sciences Qingdao 266023

According to the equation of motion in the elastic medium and integral equation of target scattering, the sound scattering from the partially water-filled elastic spherical shells with and without an inner plate is studied using the finite element and boundary element method, and the scattering normalized form functions of the shell filled with different volume of water are computed and the mechanism of resonance scattering is analyzed. The results show that the resonance of the shell with partially water-filled and without the plate is mainly related to the volume of water, and the resonance is produced by inner water and the spherical shell. The resonance characteristics of partially water-filled elastic shell with the plate are similar to that of empty structured elastic spherical shell, and the sound field in inner water is weaker which indicates the main resonance characteristics are decided by spherical shell and the plate. In addition, the scattering characteristics of spherical shell with plate and one side full water-filled are greatly different from the partially water-filled ones.

关键词： Sound scattering from partially water-filled elastic spherical shell with an internal elastic plate mode

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边界积分方程法求解目标的声散射T矩阵

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声学学报 2008年第5期33卷 396-401页

作者：高华徐海亭中国科学院声学所声场声信息国家重点实验室北京100190 中国科学院声学所北海研究站青岛266023

提出了计算任意表面形状刚性边界目标散射的基于边界积分方程的T矩阵方法(TMM-BIE)。利用Helmholtz积分方程法(HIEM)计算目标表面声场,替代扩展边界法(EBCM)计算中对目标表面声场的近似处理,解决了扩展边界法不能计算任意形状目标的散射... 详细信息

提出了计算任意表面形状刚性边界目标散射的基于边界积分方程的T矩阵方法(TMM-BIE)。利用Helmholtz积分方程法(HIEM)计算目标表面声场,替代扩展边界法(EBCM)计算中对目标表面声场的近似处理,解决了扩展边界法不能计算任意形状目标的散射T矩阵问题。文中计算了刚性边界的球目标、有限长圆柱目标以及非对称的三维散射体——猫眼(cat's-eye)模型的散射指向性和T矩阵。通过与解析解和HIEM结果比较,证明该方法的有效性。

关键词：边界积分方程法 T矩阵方法声散射求解表面声场三维散射体有限长圆柱目标散射

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