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Cardiac patches made of brown adipose-derived stem cell sheets and conductive electrospun nanofibers restore infarcted heart for ischemic myocardial infarction

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Bioactive Materials 2023年第9期27卷 271-287页

作者： Xinbo Wei Li Wang Cuimi Duan Kai Chen Xia Li Ximin Guo Peng Chen haifeng liu Yubo Fan Key Laboratory for Biomechanics and Mechanobiology(Beihang University)of Ministry of Education Beijing Advanced Innovation Center for Biomedical EngineeringSchool of Biological Science and Medical EngineeringBeihang UniversityBeijing100083PR China Department of Advanced Interdisciplinary Studies Institute of Basic Medical SciencesBeijing100850PR China Beijing Citident Stomatology Hospital Beijing100032PR China Department of Ultrasound The Third Medical CenterChinese PLA General HospitalBeijingPR China

Cell sheet engineering has been proven to be a promising strategy for cardiac remodeling post-myocardial infarction. However, insufficient mechanical strength and low cell retention lead to limited therapeutic efficiency. The thickness and area of artificial cardiac patches also affect their therapeutic efficiency. Cardiac patches prepared by combining cell sheets with electrospun nanofibers, which can be transplanted and sutured to the surface of the infarcted heart, promise to solve this problem. Here, we fabricated a novel cardiac patch by stacking brown adipose-derived stem cells (BADSCs) sheet layer by layer, and then they were combined with multi-walled carbon nanotubes (CNTs)-containing electrospun polycaprolactone/silk fibroin nanofibers (CPSN). The results demonstrated that BADSCs tended to generate myocardium-like structures seeded on CPSN. Compared with BADSCs suspension-containing electrospun nanofibers, the transplantation of the CPSN-BADSCs sheets (CNBS) cardiac patches exhibited accelerated angiogenesis and decreased inflammation in a rat myocardial infarction model. In addition, the CNBS cardiac patches could regulate macrophage polarization and promote gap junction remodeling, thus restoring cardiac functions. Overall, the hybrid cardiac patches made of electrospun nanofibers and cell sheets provide a novel solution to cardiac remodeling after ischemic myocardial infarction.

关键词： Myocardial infarction brown adipose-derived stem cells Cell sheet engineering Electrospun nanofibers Polycaprolactone/silk fibroin Carbon nanotubes

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Chatter suppression techniques in milling processes:A state of the art review

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Chinese Journal of Aeronautics 2024年第7期37卷 1-23页

作者： Zhenmin LI Qinghua SONG Peijian JIN Zhanqiang liu Bing WANG haifeng MA Key Laboratory of High Efficiency and Clean Mechanical Manufacture Ministry of EducationSchool of Mechanical EngineeringShandong UniversityJinan 250061China National Demonstration Center for Experimental Mechanical Engineering Education Shandong UniversityJinan 250061China

Chatter in the machining system can result in a decrease in tool life,poor surface finish,conservative cutting parameters,*** many review papers promoting the understanding and research of this area,chatter suppression techniques are generally discussed within limited pages in the framework of comprehensive chatter-related *** recent years,the developments of smart materials,advanced sensing techniques,and more effective control strategies have led to some new progress in chatter ***,the widely used thin-walled parts present more and more severe machining challenges in their milling *** the above deficiencies,this paper summarizes the current state of the art in milling chatter *** classifications of chatter suppression techniques are proposed according to the working principle and control *** on the new classified framework,the mechanism and comparisons of different chatter suppression strategies are ***,the current challenges and potential tendencies of milling chatter suppression techniques are ***,integration,compactness,adaptability to workpiece geometry,and the collaboration of multiple control methods are predicted to be important trends in the future.

关键词： Active control Chatter suppression Damping Milling Regenerative effect

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Characterization of the flowability dynamics of granular material flowing down a narrow channel

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Particuology 2020年第6期18卷 72-82页

作者： Ningsheng Wang haifeng Lu Jianliang Xu Xiaolei Guo haifeng liu Key Laboratory of Coal Gasification and Energy Chemical Engineering of Ministry of Education East China University of Science and TechnologyP.O.Box 272Shanghai 200237China Shanghai Engineering Research Center of Coal Gasification East China University of Science and TechnologyP.O.Box 272Shanghai 200237China Ningbo Ruiling Institute for Energy and Environment Solutions Ningbo 315500China

The flowability of granular material is commonly determined from shear cell tests,but in the real world,the granular flow is quite different in many *** this paper,the flowabilities in a narrow channel of five different granular materials were *** flow parameters of the granular flows were determined to classify the flowabil让*** flow surface velocities and flow heights and thicknesses were measured,and it was found that the mean shear rates in the linear portions of the velocity profiles in crease with both flow rates and incli nation.A universal parameter,the ratio of the sine of the inclin ation to the shear rate in the linear part of the velocity profile,is proposed as a *** constant is independent of particle *** addition,a flowability parameter,the ratio of the mean shear rate to the cosine of the inclination,is proposed to characterize the friction between the particles in the flowing granular material.

关键词： Dynamic characterization Granular flow Velocity profile Flowability Channel

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Surface vitrification of carbon by laser treatment: Insights of glass formation from molecular dynamics

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Journal of Advanced Ceramics 2024年第6期13卷 729-735页

作者： Yanhui Zhang haifeng Yu Yongying Jia Zhisheng Zhao Li-Min Wang Riping liu Center for Advanced Structural Materials State Key Laboratory of Metastable Materials Science and TechnologyYanshan UniversityQinhuangdao 066004China

Microstructural modification of carbon materials,such as carbon fibers(Cf)and pyrolytically deposited carbon,is important for engineering ***,the regulation of these materials is not an effortless *** understand the impacts of thermal spikes from pulsed laser processing on the structural adaptation of amorphous carbon(a-C),we performed melt quenching by molecular dynamics(MD)*** results confirm that the vitrification behavior of carbon can be tuned by adjusting the cooling rate(R),which is controlled by the thermal spikes of laser ***,we set up a two-step way to locate the critical cooling rate(R_(c))of monoatomic carbon,which is refined by the sharp change in the environmental similarity *** this novel technique,we demonstrate that the ordering degree and the local atomic motif can be largely modified by going across a bar of 100 K/ps,which is extracted as the critical cooling rate to ensure the complete amorphization of *** approach provides a criterion for both experimentally processing and theoretically simulating a-C ***,this work provides guidelines on how to tune the amorphous carbon structures of engineering materials and provides an outlook for the wonderland of amorphous carbon materials.

关键词： molecular dynamics(MD) structural order carbon fibers(Cf) vitrification critical cooling rate(R_(c))

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Vector field path following for a micro flapping-wing robot

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Science China(Information Sciences) 2024年第6期67卷 442-444页

作者： haifeng HUANG Yingte liu Tao NIU Chang WANG Yao ZOU Wei HE School of Intelligence Science and Technology University of Science and Technology Beijing Institute of Artificial Intelligence University of Science and Technology Beijing Key Laboratory of Intelligent Bionic Unmanned Systems Ministry of EducationUniversity of Science and Technology Beijing

Flapping-wing robots mimic the flight patterns of natural flying creatures,granting them natural *** hold promising applications in the military reconnaissance,urban surveillance,and various other fields[1–3].However,the current limitations in size often restrict the suitability of existing bird-like flapping-wing robots,

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Experimental Study on the Dynamic Mechanical Properties of Reinforced Concrete under Shock Loading

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Acta Mechanica Solida Sinica 2016年第1期29卷 22-30页

作者： haifeng liu Jie Fu Jianguo Ning Department of Civil and Hydraulic Engineering Ningxia University State Key Laboratory of Explosion Science and Technology Beijing Institute of Technology

A simple experimental method was introduced to study the mechanical properties of reinforced concrete under shock loading. The one-stage light gas gun was used to test the me- chanical properties of reinforced concrete with different reinforcement ratios under various impact velocities. Three Mn-Cu piezoresistive pressure gauges embedded in the target were used to record the voltage-time signals, from which the stress-strain curves of reinforced concrete were obtained using Lagrangian analysis. Experimental results indicated that the load-bearing capacities of re- inforced concrete increased greatly with the impact velocity and the reinforcement ratio. The peak stress of the shock wave decreased exponentially with the propagation distance.

关键词： reinforced concrete shock loading Lagrangian analysis dynamic mechanical properties

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武威市凉州区成年居民慢性病流行现状及相关因素分析

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中国初级卫生保健 2024年第5期38卷 28-32页

作者：李玉霞李晓春蔡辉民刘海峰裴泓波武威市疾病预防控制中心甘肃武威733000 武威市凉州区疾病预防控制中心甘肃武威733000 兰州大学公共卫生学院甘肃兰州730000

目的:了解甘肃省武威市凉州区成年居民慢性病流行现状及相关因素。方法:2023年4月,采用多阶段分层整群抽样方法,通过问卷调查、体格测量及血样检测,调查分析凉州区4个社区、8个乡镇9004名成年居民慢性病相关危险因素与流行水平。结果:... 详细信息

目的:了解甘肃省武威市凉州区成年居民慢性病流行现状及相关因素。方法:2023年4月,采用多阶段分层整群抽样方法,通过问卷调查、体格测量及血样检测,调查分析凉州区4个社区、8个乡镇9004名成年居民慢性病相关危险因素与流行水平。结果:凉州区居民当前患有的前3位慢性病分别为高血压、糖尿病、高脂血症,患病率分别为25.10%、7.94%、3.47%。农村居民高血压患病率高于城市居民,差异有统计学意义(P<0.05);城市男性居民高血压、糖尿病患病率高于城市女性,差异有统计学意义(P<0.05);60岁及以上人群中男性和女性高血压、糖尿病患病率远高于18~34岁、35~59岁人群。城市居民高血脂症患病率高于农村居民,差异有统计学意义(P<0.05)。除60岁以上人群女性高脂血症患病率略高于男性,其他年龄段男性高脂血症患病率均高于女性。凉州区成年居民中约有47.87%体重超过正常值(超重和肥胖),其中超重和肥胖者分别占37.14%、10.73%。农村居民超重、肥胖率高于城市居民;各年龄段男性超重、肥胖率均高于女性。结论:凉州区居民中心性肥胖问题突出,尤其是农村中青年男性居民的中心性肥胖问题值得关注。

关键词：成年居民慢性病流行现状相关因素

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堆外核测量系统裂变电离室线性响应研究

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核电子学与探测技术 2024年第3期44卷 454-463页

作者：邱顺利董进诚葛孟团肖伟孙光智周宇琳曾乐刘海峰翟春荣汤仲鸣石先武刘文臻武汉第二船舶设计研究所武汉430205 国核自仪系统工程有限公司上海200233

为满足先进反应堆堆外核测量系统中间量程测量通道灵敏度高、探测器灵敏区长、反应堆线性响应好的需求,采用多支灵敏区长度具有一定比例关系、同时机械结构完全相同的裂变电离室,进行热中子灵敏度标定和反应堆线性响应研究,以为核电厂... 详细信息

为满足先进反应堆堆外核测量系统中间量程测量通道灵敏度高、探测器灵敏区长、反应堆线性响应好的需求,采用多支灵敏区长度具有一定比例关系、同时机械结构完全相同的裂变电离室,进行热中子灵敏度标定和反应堆线性响应研究,以为核电厂实际所需长灵敏区裂变电离室提供一种在现有试验堆条件下进行其核性能试验的方法。通过测量不同灵敏区长度的裂变电离室热中子灵敏度和反应堆高中字注量率下的线性响应,对其热中子灵敏度随灵敏区长度的线性变化和反应堆线性响应进行试验验证。测量结果表明,裂变电离室热中子灵敏度随灵敏区长度呈线性关系,且在反应堆热中子注量率1.23×10^(2)~3.10×10^(10)nv(1nv=1n·cm^(-2)·s^(-1))范围内进行计数率模式和MSV模式线性拟合,裂变电离室最大线性度为-1.23%。

关键词：堆外核测量系统裂变电离室反应堆线性响应热中子灵敏度线性度

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基于LSSVM的直流电源系统蓄电池剩余容量在线检测

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河北电力技术 2024年第1期43卷 28-33页

作者：刘海峰万宁坤苏琨单保涛王浩彬国网河北省电力有限公司雄安新区供电公司河北雄安071800 河北五一八智能科技有限公司河北邯郸056107

为了解决现有蓄电池剩余容量检测方法存在检测精度较低、检测耗时较长的问题,提出基于LSSVM的直流电源系统蓄电池剩余容量在线检测方法。分析直流电源系统蓄电池剩余容量影响因素,获取蓄电池电压、内阻、温度等运行数据,由采样录波单元... 详细信息

为了解决现有蓄电池剩余容量检测方法存在检测精度较低、检测耗时较长的问题,提出基于LSSVM的直流电源系统蓄电池剩余容量在线检测方法。分析直流电源系统蓄电池剩余容量影响因素,获取蓄电池电压、内阻、温度等运行数据,由采样录波单元实现数据采集和信号的完全隔离,通过智能检测单元在分析蓄电池容量影响因素后,构建了基于LSSVM的蓄电池剩余容量检测模型,选取开路电压、内阻、温度参数作为基于LSSVM的蓄电池剩余容量检测模型的输入,利用灰狼优化算法求解惩罚系数、误差以及核系数的最优解,输出蓄电池剩余容量检测结果,实现蓄电池剩余容量在线检测。实验结果表明:本方法的检测误差控制在±0.01之内,检测时间保持在2 s以下,具有较高的检测精度和检测效率,具有较好的实际应用性能。

关键词： LSSVM 直流电源系统蓄电池剩余容量灰狼优化算法信息交互

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BIM技术在西宁——成都铁路(甘青段)建设中的应用

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铁路技术创新 2024年第2期 113-118页

作者：刘海峰邢培刚阎震李源和英圣魏亚瑞兰新铁路甘青有限公司甘肃兰州730000 中国铁道科学研究院集团有限公司电子计算技术研究所北京100081

随着BIM等数字化技术的普及和应用,在铁路工程中的作用日益凸显。依托西成铁路(甘青段)建设项目,开展全线、全专业的BIM、GIS模型创建、整合及深化应用,为建设管理决策提供全过程、多层次、全方位的支撑。详细阐述西成铁路(甘青段)工程... 详细信息

随着BIM等数字化技术的普及和应用,在铁路工程中的作用日益凸显。依托西成铁路(甘青段)建设项目,开展全线、全专业的BIM、GIS模型创建、整合及深化应用,为建设管理决策提供全过程、多层次、全方位的支撑。详细阐述西成铁路(甘青段)工程BIM应用标准及其BIM应用管理平台,从电子沙盘、进度管理、征拆管理、质量管理和交付协同等方面介绍BIM应用实践情况。研究表明,与传统方法相比,BIM技术在提升铁路建设项目的精细化管理水平方面发挥了积极作用,有助于促进铁路智能建造有序发展。

关键词：铁路工程西成铁路 BIM GIS 智能建造建设管理

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