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A privacy-preserving method for publishing data with multiple sensitive attributes

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 222-238页

作者： Tong Yi Minyong Shi Wenqian Shang haibin zhu School of Computer Science and Engineering Guangxi Normal UniversityGuilinChina School of Computer Science Communication University of ChinaBeijingChina Department of Computer Science and Mathematics Nipissing UniversityNorth BayOntarioCanada

The overgeneralisation may happen because most studies on data publishing for multiple sensitive attributes(SAs)have not considered the personalised privacy requirement.Furthermore,sensitive information disclosure may also be caused by these personalised requirements.To address the matter,this article develops a personalised data publishing method for multiple SAs.According to the requirements of individuals,the new method partitions SAs values into two categories:private values and public values,and breaks the association between them for privacy guarantees.For the private values,this paper takes the process of anonymisation,while the public values are released without this process.An algorithm is designed to achieve the privacy mode,where the selectivity is determined by the sensitive value frequency and undesirable objects.The experimental results show that the proposed method can provide more information utility when compared with previous methods.The theoretic analyses and experiments also indicate that the privacy can be guaranteed even though the public values are known to an adversary.The overgeneralisation and privacy breach caused by the personalised requirement can be avoided by the new method.

关键词： data privacy data publishing

Sulfated Cyclocarya paliurus polysaccharides exert immunomodulatory potential on macrophages via Toll-like receptor 4 mediated MAPK/NF-κB signaling pathways

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Food Science and Human Wellness 2024年第1期13卷 115-123页

作者： Yue Yu haibin zhu Mingyue Shen Qiang Yu Yi Chen Shiru Mo Jianhua Xie State Key Laboratory of Food Science and Technology Nanchang UniversityNanchang 330047China International Institute of Food Innovation Nanchang UniversityNanchang 330200China

The biological activity of plant polysaccharides can be enhanced by sulfated modification.In this study,the immunomodulatory effect of sulfated Cyclocarya paliurus polysaccharides(SCP3)on macrophages RAW264.7 and its potential molecular mechanism were investigated.Results showed that SCP3 at 25-100μg/m L increased viability and improved phagocytosis of RAW264.7 cells.Meanwhile,SCP3 could activate mitogen-activated protein kinase(MAPK)and nuclear factor kappa B(NF-κB)signaling pathways,which increased the phosphorylation of Erk1/2,JNK,p38 and NF-κB p65,promoting secretion of cytokines tumor necrosis factorα(TNF-α),interleukin 6(IL-6)and nitric oxide(NO)as well as the production of reactive oxygen species(ROS).In addition,Toll-like receptor 4(TLR4)receptor inhibitors were able to block the production of NO and TNF-αby SCP3-stimulated macrophages.Based on Western blot analysis and validation using specific inhibitors against MAPK and NF-κB signaling pathways,the results demonstrated that SCP3 induced macrophages activation and enhanced TNF-αand NO production via TLR4-mediated MAPK and NF-κB pathways.In summary,SCP3 has significant immunomodulatory potential.The underlying molecular mechanism was that SCP3 activates macrophages via TLR4 receptors to promote ROS production,which in turn activates the downstream MAPK/NF-κB signaling pathway and then increases the secretion levels of cytokines and NO.

关键词： Cyclocarya paliurus Sulfated polysaccharides Macrophages Immunomodulatory Mechanism

Medical data publishing based on average distribution and clustering

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CAAI Transactions on Intelligence Technology 2022年第3期7卷 381-394页

作者： Tong Yi Minyong Shi haibin zhu School of Computer Science and Engineering Guangxi Normal UniversityGuilinChina School of Computer Science Communication University of ChinaBeijingChina Department of Computer Science and Mathematics Nipissing UniversityNorth BayOntarioCanada

Most of the data publishing methods have not considered sensitivity protection,and hence the adversary can disclose privacy by sensitivity attack.Faced with this problem,this paper presents a medical data publishing method based on sensitivity determination.To protect the sensitivity,the sensitivity of disease information is determined by semantics.To seek the trade-off between information utility and privacy security,the new method focusses on the protection of sensitive values with high sensitivity and assigns the highly sensitive disease information to groups as evenly as possible.The experiments are conducted on two real-world datasets,of which the records include various attributes of patients.To measure sensitivity protection,the authors define a metric,which can evaluate the degree of sensitivity disclosure.Besides,additional information loss and discernability metrics are used to measure the availability of released tables.The experimental results indicate that the new method can provide better privacy than the traditional one while the information utility is guaranteed.Besides value protection,the proposed method can provide sensitivity protection and available releasing for medical data.

关键词： data publishing information utility security semantics sensitive values sensitivity

Human HAND1 inhibits the conversion of cholesterol to steroids in trophoblasts

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Journal of Genetics and Genomics 2022年第4期49卷 350-363页

作者： haibin zhu Qianlei Ren Ziyi Yan Shouying Xu Jiahao Luo Ximei Wu Chao Tang National Clinical Research Center for Child Health of the Children’s Hospital Zhejiang University School of MedicineHangzhouZhejiang 310052China Department of Obstetrics and Gynaecology The First Affiliated Hospital of Zhejiang University School of MedicineHangzhouZhejiang 310003China Department of Pharmacology School of MedicineZhejiang UniversityHangzhouZhejiang 310058China

Steroidogenesis from cholesterol in placental trophoblasts is fundamentally involved in the establishment and maintenance of pregnancy.The transcription factor gene heart and neural crest derivatives expressed1(Hand1)promotes differentiation of mouse trophoblast giant cells.However,the role of HAND1 in human trophoblasts remains unknown.Here,we report that HAND1 inhibits human trophoblastic progesterone(P4)and estradiol(E2)from cholesterol through downregulation of the expression of steroidogenic enzymes,including aromatase,P450 cholesterol side-chain cleavage enzyme(P450 scc),and 3β-hydroxysteroid dehydrogenase type 1(3β-HSD1).Mechanically,although HAND1 inhibits transcription of aromatase by directly binding to aromatase gene promoter,it restrains transcription of P450 scc by upregulation of the methylation status of P450 scc gene promoter through its binding to ALKBH1,a demethylase.Unlike aromatase and P450 scc,HAND1 decreases 3β-HSD1 m RNA levels by the reduction of its RNA stability through binding to and subsequent destabilizing protein Hu R.Finally,HAND1 suppresses circulating P4 and E2 levels derived from JEG-3 xenograft and attenuates uterine response to P4 and E2.Thus,our results uncover a hitherto uncharacterized role of HAND1 in the regulation of cholesterol metabolism in human trophoblasts,which may help pinpoint the underlying mechanisms involved in supporting the development and physiological function of the human placenta.

关键词： HAND1 Trophoblast Cholesterol Steroids

A multiple sensitive attributes data publishing method with guaranteed information utility

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CAAI Transactions on Intelligence Technology 2023年第2期8卷 288-296页

作者： haibin zhu Tong Yi Songtao Shang Minyong Shi zhucheng Li Wenqian Shang Department of Computer Science and Mathematics Nipissing UniversityNorth BayOntarioCanada Key Lab of Education Blockchain and Intelligent Technology Ministry of EducationGuangxi Normal UniversityGuilinChina Guangxi Key Lab of Multi‐Source Information Mining and Security Guangxi Normal UniversityGuilinChina School of Computer and Communication Engineering Zhengzhou University of Light IndustryZhengzhouChina School of Computer Science Communication University of ChinaBeijingChina Business College Beijing Union UniversityBeijingChina

Data publishing methods can provide available information for analysis while preserving privacy.The multiple sensitive attributes data publishing,which preserves the relationship between sensitive attributes,may keep many records from being grouped and bring in a high record suppression ratio.Another category of multiple sensitive attributes data publishing,which reduces the possibility of record suppression by breaking the relationship between sensitive attributes,cannot provide the sensitive attributes association for analysis.Hence,the existing multiple sensitive attributes data publishing fails to fully account for the comprehensive information utility.To acquire a guaranteed information utility,this article defines comprehensive information loss that considers both the suppression of records and the relationship between sensitive attributes.A heuristic method is leveraged to discover the optimal anonymity scheme that has the lowest comprehensive information loss.The experimental results verify the practice of the proposed data publishing method with multiple sensitive attributes.The proposed method can guarantee information utility when compared with previous ones.

关键词： data analysis data privacy security of data

Group Multi-Role Assignment With Conflicting Roles and Agents

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IEEE/CAA Journal of Automatica Sinica 2020年第6期7卷 1498-1510页

作者： haibin zhu IEEE Department of Computer Science and Mathematics Nipissing UniversityNorth BayOntarioP1B 8L7Canada

Group role assignment(GRA)is originally a complex problem in role-based collaboration(RBC).The solution to GRA provides modelling techniques for more complex problems.GRA with constraints(GRA+)is categorized as a class of complex assignment problems.At present,there are few generally efficient solutions to this category of problems.Each special problem case requires a specific solution.Group multi-role assignment(GMRA)and GRA with conflicting agents on roles(GRACAR)are two problem cases in GRA+.The contributions of this paper include:1)The formalization of a new problem of GRA+,called group multi-role assignment with conflicting roles and agents(GMAC),which is an extension to the combination of GMRA and GRACAR;2)A practical solution based on an optimization platform;3)A sufficient condition,used in planning,for solving GMAC problems;and 4)A clear presentation of the benefits in avoiding conflicts when dealing with GMAC.The proposed methods are verified by experiments,simulations,proofs and analysis.

关键词： Group Multi-Role Assignment With Conflicting Roles and Agents

Progress in the Study of the Correlation between Apolipoproteins and Endometrial Cancer

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Journal of Biosciences and Medicines 2022年第12期10卷 110-121页

作者： Luqing Lou haibin zhu Department of Obstetrics and Gynecology College of Medicine Zhejiang University Hangzhou China Department of Gynecology The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou China

In recent years, Lipid metabolism disorder has been closely related to malignant tumors. Apolipoprotein (Apo), as an important protein in lipoprotein transport and metabolism, plays an important role in the process of tumor proliferation. Endometrial carcinoma (EC) is a common gynecological malignant tumor, and its incidence is increasing year by year;in which obesity is an independent risk factor for the occurrence and prognosis of EC. This paper discusses the correlation and possible mechanism between different types of Apo and the occurrence, development and prognosis of EC, and briefly reviews the clinical application of some drugs in EC.

关键词： Endometrial Carcinoma Apolipoprotein Carcinogenesis

SVM-DT-Based Adaptive and Collaborative Intrusion Detection

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IEEE/CAA Journal of Automatica Sinica 2018年第1期5卷 108-118页

作者： Shaohua Teng Naiqi Wu haibin zhu Luyao Teng Wei Zhang School of Computer Science and Technology Guangdong University of Technology Guangzhou 510006 China Institute of Systems Engineering Macao University of Science and Technology Macao 999078 China school of Electro-Mechanical Engineering Guangdong University of Technology Guangzhou 510006 China Collaborative Systems Laboratory Nipissing University North Bay Ontario PICILZ Canada College of Engineering and Science Victoria University Ballarat Rd Footscray VIC 3011 Australia IEEE

As a primary defense technique, intrusion detection becomes more and more significant since the security of the networks is one of the most critical issues in the world. We present an adaptive collaboration intrusion detection method to improve the safety of a network. A self-adaptive and collaborative intrusion detection model is built by applying the Environmentsclasses, agents, roles, groups, and objects(E-CARGO) model. The objects, roles, agents, and groups are designed by using decision trees(DTs) and support vector machines(SVMs), and adaptive scheduling mechanisms are set up. The KDD CUP 1999 data set is used to verify the effectiveness of the method. The experimental results demonstrate the feasibility and efficiency of the proposed collaborative and adaptive intrusion detection method. Also, the proposed method is shown to be more predominant than the methods that use a set of single type support vector machine(SVM) in terms of detection precision rate and recall rate.

关键词： Adaptive and collaborative intrusion detection decision tree(DT) support vector machines(SVM)

An elastic-plastic contact model for line contact structures

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Science China(Physics,Mechanics & Astronomy) 2018年第5期61卷 36-45页

作者： haibin zhu Yingtao Zhao Zhifeng He Ruinan Zhang Shaopeng Ma School of Aerospace Engineering Beijing Institute of Technology Beijing 100081 China State Key Laboratory of Explosion Seience and technology Beijing Institute of Technology Beijing 100081 China National Engineering Research Centre of Surveying and Mapping Beijing 100039 China

Although numerical simulation tools are now very powerful,the development of analytical models is very important for the prediction of the mechanical behaviour of line contact structures for deeply understanding contact problems and engineering applications.For the line contact structures widely used in the engineering field,few analytical models are available for predicting the mechanical behaviour when the structures deform plastically,as the classic Hertz’s theory would be invalid.Thus,the present study proposed an elastic-plastic model for line contact structures based on the understanding of the yield mechanism.A mathematical expression describing the global relationship between load history and contact width evolution of line contact structures was obtained.The proposed model was verified through an actual line contact test and a corresponding numerical simulation.The results confirmed that this model can be used to accurately predict the elastic-plastic mechanical behaviour of a line contact structure.

关键词：接触结构接触模型弹性塑料模拟工具接触问题设计预言行为