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World Journal of Clinical Cases 2022年第23期10卷 8384-8391页

作者： hai-yun yu yu-Lan Jin Department of Pathology Beijing Obstetrics and Gynecology HospitalCapital Medical University.Beijing Maternal and Child Health Care HospitalBeijing 100003China

BACKGROUND Low-grade endometrial stromal sarcoma(LGESS)classically exhibits a proliferative ***,morphological variation of extrauterine tumors presents a diagnostic *** SUMMARY We report the case of a 76-year-old female patient with extensive extrauterine and abdominal neoplastic *** tomography showed massive pleural and ascitic fluid,and there was an increase in serum cancer antigen *** underwent bilateral adnexectomy and tumor *** right ovary had been replaced by a multinodular mass that was 8.5 cm×4.5 cm×3.5 cm in *** addition,there was a 24 cm×15 cm×13 cm mesenteric mass,which was also multinodular,with local invasion of the intestinal serosa and underlying *** the microscope,the tumors in different places exhibited two different patterns,thus presenting great challenges to diagnosis and *** pathological assessment eliminated all differential diagnoses in favor of metastatic LGESS derived from a 20-year-old primary tumor initially misdiagnosed as *** LGESS morphology varies according to tumor *** diagnosis is critical for appropriate treatment and improved prognosis and patient care.

关键词： Gastrointestinal stromal tumor Low-grade endometrial stromal sarcoma Mesentery Ovary Tumor Case report

Visible-light-responsive homologous heterostructure of oxynitrides constructed to boost charge separation and water splitting

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Science China Chemistry 2025年第1期68卷 186-191页

作者： hai Zou yunfeng Bao Xueshang Xin yu Qi Tengfeng Xie Fuxiang Zhang State Key Laboratory of Catalysis Dalian National Laboratory for Clean Energy Dalian Institute of Chemical Physics Chinese Academy of Sciences School of Chemistry and Chemical Engineering Liaoning Normal University College of Chemistry Jilin University

Constructing type II heterostructures represents a widely recognized strategy for enhancing charge separation and photocatalytic efficiency,but it remains challenging to fabricate homologous heterostructures based on visible-light-responsive semiconductors,especially for popularly investigated （oxy）nitrides with low thermal ***,we synthesized a homologous heterostructure （denoted as YTON＿H） based on the oxynitrides of YTaO4-xNyand YTa *** heterostructure exhibits type II band structure alignment and intimate interface achieved through a magnesium （Mg） powder-assisted nitridation *** with widely reported heterologous heterostructures,the as-obtained YTON＿H homologous heterostructure could similarly exhibit enhanced charge separation as well as photocatalytic water splitting performance with respect to its counterparts(YTaO4-xNyand YTaON2).Meanwhile,detailed structural characterizations and spectroscopy analysis have been made to confirm the formation of heterostructure and promotion of spatial charge separation.

关键词： charge separation heterostructure oxynitride photocatalysis visible light

Structural engineering of high-entropy alloys for advanced electrocatalytic reactions

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Tungsten 2025年第1期7卷 1-31页

作者： Qiao Xie Ying-Jie yu hai-Jun Zhang Ya-Ping Deng Wen Lei The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and Technology Department of Chemical Engineering Waterloo Institute for Sustainable Energy Waterloo Institute for Nanotechnology University of Waterloo

High-entropy alloys(HEAs) have emerged as promising candidates to replace traditional precious metal catalysts,owing to their unique chemical and physical *** review commences by revisiting the fundamental concepts of HEAs,including their synthesis methods and structural control strategies in *** underscores the critical role of meticulously manipulating both macroscopic and microscopic structures of the HEAs to optimize their catalytic performance.A deep understanding of the structure-activity relationship in HEAs across various configurations is pivotal in developing more effective *** review methodically encapsulates the research progress of structural control strategies for HEAs in achieving efficient energy conversion,with the aim of gaining a better understanding of the relationship between structure and *** review concludes by summarizing the current achievements and challenges,and suggestions for potential future directions of HEAs in the fields of energy conversion and environmental purification.

关键词： Electrocatalytic Energy conversion High-entropy alloys Structural modulation

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu yu Leng Lei Ma yu Zheng Ruizhi Li Yin Wang Peifeng Li hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Oxygen vacancies enriched Ir/WOx catalysts for the directly chem-catalytic conversion of cellulose to ethanol

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Tungsten 2025年第1期7卷 88-99页

作者： yu-Jing Weng Zhao-Ying Ding Ying-Chao Li yuan-Feng Wu yuan-Yang Xu Rui Chen Xiao-Lei Zhao hai-Yong Wang Da-Lei Zhang yu-Long Zhang Henan Key Laboratory of Coal Green Conversion and International Joint Laboratory of Coal Clean Utilization College of Chemistry and Chemical Engineering Henan Polytechnic University Key Laboratory of Renewable Energy Guangzhou Institute of Energy Conversion Chinese Academy of Sciences Liaoning Institute of Energy Technology

Tungsten and its oxides are highly versatile catalysts with unique properties that hold great promise for a wide array of applications,including biological pathways and chemical *** chemo-catalysis of cellulose to ethanol presents a promising avenue for ethanol synthesis with the potential for enhanced efficiency compared to conventional methods,offering a sustainable and carbon-neutral alternative to existing petrochemical and biological ***,Ir/WOxcatalysts enriched with oxygen vacancies were meticulously prepared and demonstrated remarkable catalytic performance in converting cellulose to ethanol directly in the presence of tungstic *** catalyst achieved a high ethanol yield of 66.5%under optimal reaction conditions,approaching the theoretical yield limit of traditional ethanol *** results revealed the presence of oxygen defects,Bronsted/Lewis acidity,and Ir nanoclusters on the catalyst surface,working synergistically to facilitate the cascade catalysis of cellulose hydrolysis,sugar retro-aldol condensation reaction,and C2 intermediate hydrodeoxygenation to *** situ Fourier transform infrared spectrometer analysis confirmed the catalyst's ability to enhance the adsorption and activation of ethylene glycol for ethanol *** manipulating subtle structural features,this study offers a fresh perspective on tungsten group catalyst design and underscores the importance of synergistic effects among catalytic sites for the efficient production of ethanol from cellulose.

关键词： Cellulosic ethanol Chem-catalysis Hydrogenolysis Retro-aldol condensation Tungsten

NADPH oxidase-derived superoxide mediates cardiovascular effects of UrotensinⅡin spontaneously hypertensive rats

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NADPH oxidase-derived superoxide mediates cardiovascular eff...

中国生理学会第23届全国会员代表大会暨生理学学术大会

作者： Ning LU,hai-yun yu,Rui WANG,Yi-Chun ZHU Department of Physiology and Pathophysiology,Shanghai Medical College,Fudan University,Shanghai 200032,China

Central UrotensinⅡ(U-Ⅱ) may participate in the regulation of cardiovascular functions by stimulating sympathy ***,their central mechanism remained *** studies have shown that brain reactive oxygen species(ROS) mediate the sympatho-excitaory *** present study,we tested the hypothesis that ROS mediate central cardiovascular effects of *** were completed in Wistar-Kyoto(WKY) rats and spontaneously hypertensive rats(SHR).The following observations were made:(1) Expressions of U-Ⅱreceptors of rostral ventrl medulla(RVLM) and Nucleus tractus solitarii(NTS) were increased in SHR rats compared with WKY rats.(2) Doubling Immunoflurescence analysis showed that U-Ⅱreceptor and NADPH oxidase subunit gp91 were co-localized in the RVLM and NTS.(3) Intracerebroventricular U-Ⅱor microinjection of U-Ⅱin RVLM significantly increased mean arterial pressure(MAP) and heart rate(HR).Tempol(a superoxide dismutase mimetic) or Apocinin(NADPH oxidase inhibitor) pretreatment eliminated these effects of U-Ⅱ.(4) Brain superoxide levels were enhanced in U-Ⅱ-treated rats compared with CSF-treated rats.(5) Intracerebroventricular UⅡsignificantly increased gp91 or p47 mRNAlevel in the *** importantly,a significant elevation in phosporylated P47 was detected 5 min after microinjection of UⅡinto the *** results indicate that superoxide mediates central cardiovascular effects of U-Ⅱand provide evidence for a novel relationship between U-Ⅱand ROS.

关键词： reactive oxygen species UrotensinⅡ central cardiovascular effects

NRSF regulates its target genes via epigenetic mechanisms in PD cell model

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NRSF regulates its target genes via epigenetic mechanisms in...

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： hai-yun SUO,Mei yu,Jie LIU,Fang HUANG~* National Key Laboratory of Medical Neurobiology,Shanghai Medical College,Fudan University,Shanghai 200032, China

Neuron-restrictive silencer factor/repressor element-1 silencing transcription factor(NRSF/REST) silences a large network of genes through histone deacetylation,methylation and other epigenetic *** previous study showed that the expression of NRSF target gene BDNF,TH,synapsin I and UCH-L1 were transiently decreased in PD cell *** we investigated the effect of epigenetic modulation on the expression of NRSF target genes in the SH-SY5Y cells intoxicated with MPP CHIP assays showed that the binding of NRSF to the target gene promoters was *** we found the MPP treatment promoted deacetylation of histones H3,demethylation of H3-K4 and dimethylation of H3-K9 over the promoters of these target genes,which are the signatures of epigenetic gene *** sequencing results showed that the methylation pattern over the promoters of BDNF and TH transient altered in this PD cell ***,an HDAC inhibitor,has frequently been used to study the effects of HDAC inhibition on NRSF-mediated *** confirm the epigenetic mechanisms regulating the expression of NRSF target genes in PD cell model,we investigated whether the transcriptional repression of NRSF target gene BDNF,TH,synapsin I and UCH-L1 could be relieved by TSA ***-SY5Y cells were pretreated with TSA (100 nM) for 24 h,and then intoxicated with MPP+ for 8 *** RT-PCR analyses showed that TSA treatment induced obviously activation of the BDNF,TH and synapsinl genes,However,the expression of NRSF and REST4 did not vary significantly under the treatment of *** assays showed that TSA treatment did not affect the levels of NRSF occupancy,but caused coordinated changes of histone modifications around the RE1 sites that consistent with a transition from transcriptional repression to *** results demonstrated that NRSF represseses the expression of target genes via an HDAC-dependent pathway,and the cross-talk between acetylation and methylation of histo

关键词： NRSF HDAC PD target genes

Effect of order–disorder transition on thermodynamic and electronic properties of σ and χ phases in W–Re alloy: the first-principles calculation

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Tungsten 2025年第1期7卷 195-213页

作者： Zhi-Peng Zhu Dian Jia William Yi Wang Jun-Lei Yin Xing-yu Gao Shu-Feng Yang hai-Feng Song Jin-Shan Li State Key Laboratory of Solidification Processing Northwestern Polytechnical University Laboratory of Computational Physics Institute of Applied Physics and Computational Mathematics School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

The Tungsten-Rhenium(W-Re) alloys,celebrated for their high melting point,strength at elevated temperatures,electrical resistivity,and radiation resistance,have been widely utilized in high-temperature components,aerospace,electronics,and nuclear *** constituents of the topologically close-packed(TCP) phases,the sigma phase(σ) and chi phase(χ) formed within W-Re alloys wield considerable influence on the mechanical properties and the stability of the *** calculations were utilized in the present work to explore the structural,thermodynamic,and electronic properties of both ordered and disordered configurations within the σ and χ phases,culminating in a systematic elucidation of the higher phase stability exhibited by the ordered *** is found that the bulk modulus of these two phases is directly proportional to the concentration of Re in the alloy,while the equilibrium volume is inversely *** thermodynamic parameters of the σ and χ phases are calculated via the mean-field potential *** similar trends observed in the isobaric heat capacity,enthalpy increment,and entropy change curves for these two phases suggest they possess comparable thermodynamic *** is noteworthy that the contribution of ionic vibrations predominantly affects the isobaric heat capacity,while the contribution of thermal electronic excitations increases linearly with *** the structure and thermodynamic properties of TCP phases in W-Re alloys at low temperatures has profound significance for optimizing material performance,microstructures features,establishing theoretical foundations,and predicting material behavior.

关键词： First-principles calculations Phase stability TCP phases Thermodynamic properties W–Re alloy

Mechanisms of central cardiovascular effects of H2S in SHR rats:the role of reactive oxygen species

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Mechanisms of central cardiovascular effects of H2S in SHR r...

中国神经科学学会第九届全国学术会议暨第五次会员代表大会

作者： hai-yun yu,Hong MA,Yan yu,Yin-Xiang CAO,Rui WANG,Yi-Chun ZHU,Ning LU~* Department of Physiology and Pathophysiology,Shanghai Medical College,Fudan University,Shanghai 200032, China

Objective Hydrogen sulfide(HS)is considered to be a new gaseous molecular alongside with NO and *** of evidences indicate that HS performs a wide range of physiological and pathological ***, the central cardiovascular effects of HS are not fully *** present study,we tested the hypothesis that HS in CNS may inhibit NADPH oxidase and decrease the production of ROS,thus mediate central cardiovascular effects. Methods Experiments were completed in Wistar-Kyoto(WKY)rats and spontaneous hypertensive rats(SHR).We used morphological and molecular biological techniques to explore the mechanisms of central cardiovascular effects of *** The following observations were made:(1)Expressions of CBS of RVLM were increased in WKY rats compared with SHR rats.(2)Intracerebroventricular(ICV)SAM(1 nmol/10μL)significantly decreased mean arterial pressure(MAP);ICV NaHS by low concentration(4 nmol/10μL)significantly decreased mean arterial pressure(MAP), while high concentration(20 nmol/10μL)could increase mean arterial pressure(MAP).(3)Microinjection of NaHS (400 pmol/0.1μL)into the RVLM notably decreased MAP.(4)The level of ROS in RVLM of SHR rats was higher than WKY rats,and after ICV with NaHS(4 nmol/10μL),the level of ROS decreased compared with SHR rats. Moreover,we also certified that the decrease of ROS associated with the inhibition of the activity of NADPH oxidase. Conclusion The results of present study suggest that HS in CNS may lower blood pressure by inhibiting the activity of NADPH oxidase in the RVLM in SHR.

关键词： hydrogen sulfide ROS SHR NADPH oxidase RVLM

Central cardiovascular effects of Hydrogen sulfide in spontaneously hypertensive rat

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Central cardiovascular effects of Hydrogen sulfide in sponta...

中国神经科学学会第四次会员代表大会暨第八届全国学术会议

作者： hai-yun yu,Nan CHENG,Hua-Ding ZHOU,Rui WANG,Ning LU~* Department of Physiology and Pathophysiology,Shanghai medical college,Fudan university,Shanghai,China 200032

Increasing evidence has clarified that Hydrogen sulfide(HS) performs a wide range of physiological and pathological *** is formed from cysteine by cystathionineβ-synthase(CBS) and cystathionineγ-Iyase(CSE), and it is produced mainly by CBS in *** much less is known about its roles than about its two counterparts, NO and CO,it is currently considered to be the third gaseous *** present study,we test the distribution of CBS in the rostral ventrolateral medulla(RVLM) and the effects of HS on regulating central blood *** were completed in Wistar-Kyoto(WKY) rats and spontaneous hypertensive rats(SHR).The following observations were made: (1) Expressions of CBS of RVLM were increased in SHR rats compared with WKY rats.(2) Doubling immunoflurescence analysis showed that U-II receptor and CBS were co-localized in the RVLM.(3) Introcerbroventricular NaHS by low concentration(200-400 mol,10μl) significantly decreased mean arterial pressure(MAP),while high concentration(1-2 mmol,10μl) could increase mean arterial pressure(MAP).These results indicate that HS produced by CBS in brain may regulate blood pressure and have some relationship with Urotensin II(U-II),a peptide can regulate cardiovascular functions by stimulating sympathy pathway.

关键词： Hydrogen sulfide Urotensin II central cardiocvascular effects