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Toward Artificial Peptide Nanocapsules

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Nano-Micro Letters 2024年第10期16卷 240-243页

作者： yuan Wang Bing chen Laboratory for Biomaterials and Drug Delivery Department of AnesthesiologyDivision of Critical Care MedicineBoston Children's HospitalHarvard Medical SchoolBostonMA 02115USA College of Electronic and Optical Engineering and College of Flexible Electronics(Future Technology) Nanjing University of Posts and TelecommunicationsNanjing 210023People's Republic of China

HIGHLIGHTS The formation of peptide nanocapsules is facilitated by a gradient interface,where the differential solvent concentration drives the peptides to preferentially localize and *** peptide nanocapsules,characterized by their hollow structures,demonstrated potential as carriers for targeted drug delivery.1 Introduction Peptide nanocapsules are a type of nanoscale delivery system that encapsulates active substances within a shell composed of peptides,leveraging the unique properties of peptides such as biocompatibility and biodegradability[1].Historically,the development of peptide nanocapsules was inspired primordially by the natural biological processes.

关键词： Peptide nanocapsules Self-assembly Drug delivery Nanomedicine

Correlation of An Ultrasonic Scoring System and Intraoperative Blood Loss in Placenta Accreta Spectrum Disorders: A Retrospective Cohort Study

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Biomedical and Environmental Sciences 2021年第2期34卷 163-169页

作者： chen Lian SHI Hui Feng JIANG hai SHI Xiao Ming WANG yuan yuan ZHANG Ai Qing CHONG Yi Wen ZHAO Yang Yu Department of Obstetrics and Gynecology Peking University Third HospitalBeijing 100191China

Objective This study aims to investigate the correlation of an ultrasonic scoring system with intraoperative blood loss(IBL) in placenta accreta spectrum(PAS) *** A retrospective cohort study was conducted between January 2015 and November *** data for patients with PAS have been obtained from medical records. Generalized additive models were used to explore the nonlinear relationships between ultrasonic scores and IBL. Logistic regressions were used to determine the differences in the risk of IBL ≥ 1,500 m L among groups with different ultrasonic *** A total of 332 patients participated in the analysis. Generalized additive models showed a significant positive correlation between score and blood loss. The amount of IBL was increased due to the rise in the ultrasonic score. All cases were divided into three groups according to the scores(low score group: ≤ 6 points, n = 147;median score group: 7-9 points, n = 126;and high score group: ≥ 10 points, n = 59). Compared with the low score group, the high score group showed a higher risk of IBL≥ 1,500 m L [odds ratio, 15.09;95% confidence interval(3.85, 59.19);P ≤ 0.001] after a multivariable *** The risk of blood loss equal to or greater than 1,500 m L increases further when ultrasonic score greater than or equal to 10 points, the preparation for transfusion and referral mechanism should be considered.

关键词： Ultrasonic scoring system Intraoperative blood loss Placenta accreta spectrum disorders

Exact solutions of the Schrodinger equation for a class of hyperbolic potential well

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Chinese Physics B 2022年第4期31卷 109-115页

作者： Xiao-Hua Wang Chang-yuan chen yuan You Fa-Lin Lu Dong-Sheng Sun Shi-hai Dong School of Physics and Electronic Engineering Yancheng Teachers UniversityYancheng 224007China Research Center for Quantum Physics Huzhou UniversityHuzhou 313000China Laboratorio de Informaci´on Cu´antica CIDETECInstituto Polit´ecnico NacionalUPALMC.P 07700CDMXMexico

We propose a new scheme to study the exact solutions of a class of hyperbolic potential *** first apply different forms of function transformation and variable substitution to transform the Schrodinger equation into a confluent Heun differential equation and then construct a Wronskian determinant by finding two linearly dependent solutions for the same *** then in terms of the energy spectrum equation which is obtained from the Wronskian determinant,we are able to graphically decide the quantum number with respect to each eigenstate and the total number of bound states for a given potential *** a procedure allows us to calculate the eigenvalues for different quantum states via Maple and then substitute them into the wave function to obtain the expected analytical eigenfunction expressed by the confluent Heun *** linearly dependent relation between two eigenfunctions is also studied.

关键词： hyperbolic potential well Schrodinger equation Wronskian determinant confluent Heun function

Topography Multiplicity of Titanyl Phthalocyanine on Ultrathin Insulating Films Observed by STM

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Chinese Physics Letters 2013年第10期30卷 139-142页

作者： yuan Bing-Kai chen Peng-cheng ZHANG Jun DENG Ke chenG Zhi-hai WANG chen National Center for Nanoscience and Technology Beijing 100190

Individual titanyl phthalocyanine(TiOPc)molecules on ultrathin sodium chloride striped films grown on Cu(110)exhibit two different topographies with 8-lobes and 6-lobes when imaged by scanning tunneling microscopy(STM).Direct images of the molecular orbitals of the molecules with 8-lobes are obtained,indicating that the electronic structure of the TiOPc molecule are decoupled from the metallic *** the TiOPc molecule with 6-lobes,the STM images at negative and positive bias polarities show the same structures as 2-fold symmetry except for the 90°rotation with respect to each *** phenomenon may be attributed to the splitting of the two former degenerate lowest unoccupied molecular orbitals due to the negative charging of the *** identification of the molecular orbital splitting on the ultrathin insulating layer could deepen the understanding of the intrinsic properties of semi-conducting molecules.

关键词： splitting cyanine attributed

The YSZ,Planck - YSZ,XMM scaling relation and its difference between cool-core and non-cool-core clusters

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Research in Astronomy and Astrophysics 2019年第7期19卷 151-162页

作者： Yue Zhu yuan-Hao Wang hai-Hui Zhao Shu-Mei Jia cheng-Kui Li Yong chen Key Laboratory for Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Department of Physics and Institute of Theoretical Physics Nanjing Normal UniversityNanjing 210023China

We construct a sample of 70 clusters using data from XMM-Newton and Planck to investigate the YSZ,Planck-YSZ,XMM scaling relation and the cool-core influences on this ***,XMM is calculated by accurately de-projected temperature and electron number density profiles derived from ***,Planckis the latest Planck data restricted to our precise X-ray cluster size θ*** study the cool-core influences on the YSZ,Planck-YSZ,XMM scaling relation,we apply two criteria,namely the limits of central cooling time and classic mass deposition rate,to distinguish cool-core clusters(CCCs) from non-cool-core clusters(NCCCs).We also use YSZ,Planckfrom other papers,which are derived from different methods,to confirm our *** intercept and slope of the YSZ,Planck-YSZ,XMM scaling relation are A =-0.86 ± 0.30 and B = 0.83 ± 0.06 *** intrinsic scatter is σins= 0.14 ± *** ratio of YSZ,Planck/YSZ,XMM is 1.03 ± 0.05,which is in excellent statistical agreement with *** in the YSZ,Planck-YSZ,XMM scaling relation between CCCs and NCCCs are found in the *** are independent of the cool-core classification criteria and YSZ,Planckcalculation methods,although the discrepancies are more significant under the classification criteria of classic mass deposition *** intrinsic scatter of CCCs(0.04) is quite small compared to that of NCCCs(0.27).The ratio of YSZ,Planck/YSZ,XMM for CCCs is 0.89 ± 0.05,suggesting that CCCs’ YSZ,XMM may overestimate the Sunyaev-Zel’dovich(SZ)*** contrast,the ratio of YSZ,Planck/YSZ,XMM for NCCCs is 1.14 ± 0.12,which indicates that NCCCs’ YSZ,XMM may underestimate the SZ signal.

关键词： galaxies:clusters:intracluster medium X-rays:galaxies:clusters cosmology:observations

An early neuroprotective effect of atorvastatin against subarachnoid hemorrhage

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Neural Regeneration Research 2020年第10期15卷 1947-1954页

作者： Jun-Hui chen Ting Wu Wen-yuan Xia Zhong-Hua Shi Chun-Lei Zhang Lei chen Qian-Xue chen Yu-hai Wang Department of Neurosurgery Renmin Hospital of Wuhan UniversityWuhanHubei ProvinceChina Department of Neurosurgery Wuxi Clinical College of Anhui Medical University904 Hospital of Joint Logistic Support Force of PLAWuxiJiangsu ProvinceChina Department of Cardiology Wuxi Clinical College of Anhui Medical University904 Hospital of Joint Logistic Support Force of PLAWuxiJiangsu ProvinceChina Department of Science and Education Wuxi Clinical College of Anhui Medical University904 Hospital of Joint Logistic Support Force of PLAWuxiJiangsu ProvinceChina

Atorvastatin has been shown to reduce early brain edema and neuronal death after subarachnoid hemorrhage,but its mechanism is not *** this study,rat models of subarachnoid hemorrhage were established by autologous blood injection in the cisterna *** models were intragastrically administered 20 mg/kg atorvastatin 24 hours before subarachnoid hemorrhage,12 and 36 hours after subarachnoid *** with the controls,atorvastatin treatment demonstrated that at 72 hours after subarachnoid hemorrhage,neurological function had clearly improved;brain edema was remarkably relieved;cell apoptosis was markedly reduced in the cerebral cortex of rats;the number of autophagy-related protein Beclin-1-positive cells and the expression levels of Beclin-1 and LC3 were increased compared with subarachnoid hemorrhage *** ultrastructural damage of neurons in the temporal lobe was also noticeably *** similarities between the effects of atorvastatin and rapamycin were seen in all the measured outcomes of subarachnoid ***,these were contrary to the results of 3-methyladenine injection,which inhibits the signaling pathway of *** findings indicate that atorvastatin plays an early neuroprotective role in subarachnoid hemorrhage by activating *** experimental protocol was approved by the Animal Ethics Committee of Anhui Medical University,China(904 Hospital of Joint Logistic Support Force of PLA;approval ***-2017-09)on February 22,2017.

关键词： 3-methyladenine apoptosis atorvastatin autophagy early brain injury LC3 neuroprotection rapamycin subarachnoid hemorrhage

Bischler-Napieralski Cyclization:A Versatile Reaction towards Functional Aza-PAHs and Their Conjugated Polymers

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Chinese Journal of Chemistry 2021年第11期39卷 3101-3112,3113-3114,3115页

作者： Mengwei Li yuan yuan Yulan chen Institute of Molecular Plus Department of ChemistryTianjin UniversityTianjin300354 China

Nitrogen atom doped polycyclic aromatic hydrocarbons,the so-called aza-PAHs,and their conjugated polymers are applicable as functional chromophores and organic *** developments of PAHs and heterocyclic chemistry have been made possible by considerable improvements in synthetic methodologies,among which one-step reactions leading directly to an aza-conjugated ring are highly ***-Napieralski cyclization,an old yet efficient reaction,can accomplish this *** the last ten years,this reaction has been successfully used to synthesize a great variety of aza-PAHs *** combination with polymer chemistry is able to provide the corresponding *** feature article summarizes the up-to-data advances,mainly achieved by our groups,on the design and synthesis of new and well-tailored aza-PAHs and macromolecular architectures using Bischler-Napieralski cyclization as the key ***,the versatile applications of these functional materials in the fields of chemosensors,optoelectronic devices,and biomolecular probes are also covered in detail.

关键词： Bischler-Napieralski cyclization Aza-PAHs Conjugated polymers Fluorescence Nitrogen heterocycles Synthetic methods

Synthesis of novel calix[4]crown telomers and selective extraction of cesium ions

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Chinese Chemical Letters 2007年第3期18卷 263-265页

作者： hai Bing Li yuan Yin chen De Jun Xiong Jun Yan Zhan Cui Ping Han Key Laboratory of Pesticide ＆ Chemical Biology （CCNU） Ministry of Education College of Chemistry Central China Normal University Wuhan 430079 China Department of Chemistry Wuhan University Wuhan 430072 China

p-tert-Butylcalix[4]diazacrown-4 telomer, which contains hard and soft ion binding sites, was synthesized. It exhibited high selectivity toward cesium ions. The binding sites may complex alkali metal ions selectively.

关键词： Calixcrown Telomer Ion-binding Cesium ions

Visible Light-driven Self-healable Mechanochromic Polyurethanes

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Chemical Research in Chinese Universities 2023年第5期39卷 757-762页

作者： HAN Jinpeng yuan yuan chen Yulan Tianjin Key Laboratory of Molecular Optoelectronic Science Department of ChemistryTianjin UniversityTianjin 300354P.R.China State Key Laboratory of Supramolecular Structure and Materials College of ChemistryJilin UniversityChangchun 130012P.R.China

Polyurethanes incorporating spiropyran(SP)and diselenide(DiSe)in the main chain,which are confined in different hard segments are *** light-driven diselenide metathesis and mechanically induced ring opening of SP offer self-healing and mechanochromic properties of the polymers,*** selection of the polymer backbone is found essential to promote the dual *** particular for polyurethane with SP coupled into 4,4'-methylenebis(cyclohexyl isocyanate)and DiSe linked with isophorone diisocyanate,excellent mechanical,mechanochromic and self-healing properties are ***,combining self-healing and self-reporting moieties in one chain allows the discrimination of different healing mechanisms,including bond formation and chain entanglement,in a visualized way.

关键词： Self-healing Self-reporting Polyurethane Mechano-chromic Diselenide