检索结果-南通市图书馆

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 821-835页

作者： jing Wang Bing Zhang Lanfang li Xiaomei tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang liu Youming Lu Xinyan li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

Water modeling of molten steel flow in a multi-strand tundish with gas blowing

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2010年第2期17卷 143-148页

作者： jing Jiang jing-she li Hua-jie Wu Shu-feng yang Tao li hai-yan tang School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China Engineering Research Institute University of Science and Technology Beijing Beijing 100083 China

Fluid flow characteristics in a four-strand tundish with gas blowing were studied by water modeling *** is found that gas blowing can greatly improve the flow characteristics in the tundish with a turbulence *** dramatically increases the peak concentration time,and greatly decreases the dead volume,and reduces the minimum residence *** gas blowing location,gas flow rate,and porous plug area greatly influence the flow characteristics in the tundish; the gas blowing location near the baffle,smaller gas flow rate,and smaller porous plug area are better for improving the fluid flow *** gas blowing can reduce the difference of flows at the middle outlets and side outlets for the multi-strand *** produced by gas blowing can absorb small inclusions and provide the condition for inclusion collision and ***,introducing gas blowing into a tundish and combining the turbulence inhibitor can improve inclusion floating and removal,and the cleanness of molten steel can be advanced.

关键词： continuous casting tundish water modeling gas blowing porous plug

AAV mediated carboxyl terminus of Hsp70 interacting protein overexpression mitigates the cognitive and pathological phenotypes of APP/PS1 mice

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 253-264页

作者： Zhengwei Hu jing yang Shuo Zhang Mengjie li Chunyan Zuo Chengyuan Mao Zhongxian Zhang Mibo tang Changhe Shi Yuming Xu Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Academy of Medical Sciences of Zhengzhou University ZhengzhouHenan ProvinceChina NHC Key Laboratory of Prevention and treatment of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Henan Key Laboratory of Cerebrovascular Diseases The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina Institute of Neuroscience Zhengzhou UniversityZhengzhouHenan ProvinceChina Sino-British Research Centre for Molecular Oncology National Centre for International Research in Cell and Gene TherapySchool of Basic Medical SciencesAcademy of Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou UniversityZhengzhouHenan ProvinceChina

The E3 ubiquitin ligase,carboxyl terminus of heat shock protein 70(Hsp70)interacting protein(CHIP),also functions as a co-chaperone and plays a crucial role in the protein quality control *** this study,we aimed to investigate the neuroprotective effect of overexpressed CHIP on Alzheimer’s *** used an adeno-associated virus vector that can cross the blood-brain barrier to mediate CHIP overexpression in APP/PS1 mouse *** overexpression significantly ameliorated the performance of APP/PS1 mice in the Morris water maze and nest building tests,reduced amyloid-βplaques,and decreased the expression of both amyloid-βand phosphorylated *** also alleviated the concentration of microglia and astrocytes around *** APP/PS1 mice of a younger age,CHIP overexpression promoted an increase in ADAM10 expression and inhibitedβ-site APP cleaving enzyme 1,insulin degrading enzyme,and neprilysin *** of HSP70 and HSP40,which have functional relevance to CHIP,were also *** nuclei transcriptome sequencing in the hippocampus of CHIP overexpressed mice showed that the lysosomal pathway and oligodendrocyte-related biological processes were up-regulated,which may also reflect a potential mechanism for the neuroprotective effect of *** research shows that CHIP effectively reduces the behavior and pathological manifestations of APP/PS1 ***,overexpression of CHIP could be a beneficial approach for the treatment of Alzheimer’s disease.

关键词： adeno-associated virus Alzheimer’s disease APP/PS1 mice carboxyl terminus of Hsp70 interacting protein gene therapy

Hot Working Characteristics of Corrosion-Resistant Alloys G3 and 825

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2011年第4期18卷 68-72页

作者： YU Man li jing she tang hai-yan BAO Yao-zong School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China Xinxing Ductile Pipe Co Ltd Wu'an 056300 Hebei China China Iron and Steel Research Institute Group Beijing 100081 China

The G3 and 825 alloys,with excellent combination of mechanical properties and corrosion resistance,can be used in hot,and acid *** simulation tests were conducted on the alloys G3 and 825 in the THERMECMASTOR-Z simulator,at temperature between 1030 and 1300 ℃,with strain rate from 1 to 50 s-1 and strain ε=*** variations of flow stress with deformation temperature and strain rate were *** of alloy structure with hot deformation and effect of strain rate on alloy dynamic recrystallization have been studied through microstructure observation by OM,SEM and ***,hot plasticity characteristics of alloy were analyzed by temperature-reduction of area *** results showed that available hot working temperature for G3,G3-Z and 825 was 1100 to 1240 ℃,1130 to 1220 ℃ and 1050 to 1240 ℃,*** reliable information on hot working in the alloy pilot production in steelwork is given.

关键词： corrosion-resistant alloy G3 825 stress-strain curve hot plasticity

Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： Na li Yue-Yue Ren Ying tang Qi yang Tian-Tian Meng Song li jing Zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUMMARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture Multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

Rational argon stirring for a 150-t ladle furnace

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2009年第4期16卷 383-386页

作者： hai-yan tang jing-she li Cui-hong Xie Shu-feng yang Kai-ming Sun De-song Wen School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China Steelmaking Plant of Tianjin Pipe Corporation Ltd. Tianjin 300301 China

Based on the principle of similarity, water modeling experiments were carried out for a 150-t ladle furnace. The rational parameters of argon stirring were determined as the optimized positions of nozzles, top area of the porous brick, and gas flow rate. The following results are obtained： 1） the optimized positions of two nozzles are at 0.333R （R refers to the radius of the ladle at bottom） with an angle of 135°; 2） the top diameter of the porous brick should be 130 mm; 3） the flow rate of gas should be 25.0-30.6 m^3/h. The plant trial shows that the improved process is effective in enhancing the cleanliness of round billets. The total oxygen content, microinclusions, and macroinclusions in round billets are reduced by 12.5%, 8.2%, and 20%, respectively.

关键词： ladle furnace argon stirring refining inclusions

The impacts of market reform on the market penetration of natural gas-fired electricity and renewable energy in China

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2017年第4期14卷 831-841页

作者： li-jing Zhu yan li yan-yan tang Yao-Ming li Qi Zhang Academy of Chinese Energy Strategy China University of Petroleum-BeijingBeijing 102249China

Natural gas-fired electricity(NGFE) is expected to play a more important role in the future due to its characteristics of low pollution, high efficiency and flexibility. However, its development in China is impeded by its high regulation price compared with coal power. Market reform is therefore of vital importance to promote the penetration of NGFE. The objective of this study is to analyze the impacts of market reform and the renewable electricity(RE) subsidy policy on the promotion of NGFE and RE. A dynamic game-theoretic model is developed to analyze the interaction among the NG supplier, the power sector and the power grid. Three scenarios are proposed with different policies, including a fixed regulation price of NG and electricity, real-time pricing(RTP) of NG and electricity, and subsidy targeted at RE. The results show that:(1) market reform can sharply decrease the NG price and consequently promote the development of NGFE and RE;(2) subsidy targeted at RE not only promotes the penetration of NGFE and RE, but also increases the utilization ratio of renewables significantly;(3) market reform and the subsidy also enhance consumers’ welfare by reducing their power consumption expenditure.

关键词： Natural gas-fired electricity Renewable electricity Real-time pricing Market reform Game-theoretic model

Influence of Non-uniform Parameter of Bolt Joint on Complexity of Frequency Characteristics of Cylindrical shell

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Mechanical Engineering 2023年第2期36卷 206-219页

作者： Qiansheng tang Houxin she Chaofeng li Bangchun Wen School of Engineering Anhui Agricultural UniversityHefei 230036China School of Mechanical Engineering and Automation Northeastern UniversityShenyang 110819China Key Laboratory of Vibration and Control of Aero‑Propulsion System Ministry of EducationNortheastern UniversityShenyang 110819China

Bolt connection is one of the main fixing methods of cylindrical shell structures.A typical bolted connection model is considered as a tuned ***,in the actual working conditions,due to the manufacturing error,installation error and uneven materials of bolts,there are always random errors between different *** investigate the influence of non-uniform parameters of bolt joint,including the stiffness and the distribution position,on frequency complexity characteristics of cylindrical shell through a statistical method is the main aim of this *** bolted joints considered here were simplified as a series of springs with random *** vibration equation of the bolted joined cylindrical shell was derived based on Sanders’thin shell *** Monte Carlo simulation and statistical theory were applied to the statistical analysis of mode characteristics of the ***,the frequency and mode shape of the tuned system were investigated and compared with ***,the effect of the random distribution and the random constraint stiffness of the bolts on the frequency and mode shape were *** the statistical analysis on the natural frequencies was evaluated for different mistuned *** some special cases were presented to help understand the effect of random *** research introduces random theory into the modeling of bolted joints and proposes a reference result to interpret the complexity of the modal characteristics of cylindrical shells with non-uniform parameters of bolt joints.

关键词： Bolted joint Random mistuning shell vibration Mode shape Statistical analysis

Solid solubility extension and microstructure evolution of cast zirconium yttrium alloy

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2016年第4期35卷 325-330页

作者： Jia-Qing Peng yang Chen Guo-Qing yan Ming Wu li-Jun Wang jing-she li Division of Rare Metals Metallurgy and Materials General Research Institute for Nonferrous Metals School of Metallurgical and Ecological Engineering University of Science and Technology Beijing

Yttrium addition can improve the oxidation resistance, mitigate hydrogen embrittlement and thus enhance the mechanical properties of the zirconium alloy. To study solid solubility extension of yttrium in zirconium alloy, the lattice parameters of ：t-Zr phase in Zr-Y alloy were accurately determined by X-ray diffraction （XRD）. Yttrium exhibits solid solubility extension in the cast zirconium alloy which forms a metastable supersaturated solid solution with solubility limit of around 3 wt%. The effect of yttrium and thermal treatment on the microstructure of the alloys was investigated by optical microscopy （OM） and scanning electron microscope （SEM）. The cast Zr-Y alloy shows a normal polycrys- talline structure with dispersed α-Y particles when Y content is lower than 4 wt%, while the alloy shows a eutectic structure with dendrites formation when the Y content is higher. Yttrium exhibits a strong grain refining effect on zirconium alloy and precipitates from the metastable supersaturated Zr matrix after annealing at 700 and 900 ℃.

关键词： Zirconium alloy Yttrium addition Solidsolubility extension Microstructure