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Long noncoding RNA NALT1-induced gastric cancer invasion and metastasis via NOTCH signaling pathway

World Journal of Gastroenterology 2019年第44期25卷 6508-6526页

作者： hai-yan piao Shuai Guo Yue Wang Jun Zhang Medical Oncology Department of Gastrointestinal Cancer Liaoning Province Cancer Hospital&Institute(Cancer Hospital of China Medical University)Shenyang 110042Liaoning ProvinceChina Gastric Cancer Department Liaoning Province Cancer Hospital&Institute(Cancer Hospital of China Medical University)Shenyang 110042Liaoning ProvinceChina

BACKGROUNDLong noncoding RNAs (lncRNAs) are aberrant and play critical roles in gastriccancer (GC) progression and metastasis. Searching for coexpressed lncRNAclusters or representative biomarkers related to malignant phenotypes of GC mayhelp to elucidate the mechanism of tumor development and predict the prognosisof *** investigate the prognostic value of NOTCH1 associated with lncRNA in T cellacute lymphoblastic leukemia 1 (NALT1) in GC and the mechanism of itsinvolvement in GC invasion and *** sequencing and corresponding clinical data were downloaded from TheCancer Genome Atlas database. The significance module was studied byweighted gene coexpression network analysis. A total of 336 clinical sampleswere included in the study. Gene silencing, reverse transcription polymerasechain reaction, western blotting, scrape motility assay, and Transwell migrationassay were used to assess the function of *** the transcriptome level, 3339 differentially expressed lncRNAs were *** gene coexpression network analysis was used to obtain 15 lncRNAclusters and observe their coexpression. Pearson’s correlation showed that blue module was correlated with tumor grade and survival. NALT1 was the hublncRNAof blue module and was an independent risk factor for GC ***1 was overexpressed in GC and its expression was closely related toinvasion and metastasis. The mechanism may involve NALT1 regulation ofNOTCH1, which is associated with lncRNA in T cell acute lymphoblasticleukemia, through cis regulation, thereby affecting the expression of the NOTCHsignaling ***1 is overexpressed and promotes invasion and metastasis of GC. Themechanism may be related to regulation of NOTCH1 by NALT1 and its effect onNOTCH signaling pathway expression.

关键词： Gastric cancer Weighted gene coexpression network analysis NALT1 NOTCH1 Cancer survival

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Development and validation of a three-long noncoding RNA signature for predicting prognosis of patients with gastric cancer

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World Journal of Gastroenterology 2020年第44期26卷 6929-6944页

作者： Jun Zhang hai-yan piao Yue Wang Mei-Yue Lou Shuai Guo yan Zhao Department of Gastric Cancer Liaoning Province Cancer Hospital and Institute(Cancer Hospital of China Medical University)Shenyang 110042Liaoning ProvinceChina Medical Oncology Department of Gastrointestinal Cancer Liaoning Province Cancer Hospital and Institute(Cancer Hospital of China Medical University)Shenyang 110042Liaoning ProvinceChina Department of Gastroenterological Surgery Kumamoto UniversityGraduate School of Medical SciencesKumamoto 860-8556KumamotoJapan

BACKGROUND Gastric cancer(GC)is one of the most frequently diagnosed gastrointestinal cancers throughout the *** prognostic biomarkers are required to predict the prognosis of *** To identify a multi-long noncoding RNA(lncRNA)prognostic model for *** Transcriptome data and clinical data were downloaded from The Cancer Genome *** and least absolute shrinkage and selection operator regression analyses were performed to screen for prognosis associated *** operating characteristic curve and Kaplan-Meier survival analyses were applied to evaluate the effectiveness of the *** The prediction model was established based on the expression of AC007991.4,AC079385.3,and AL109615.2 Based on the model,GC patients were divided into“high risk”and“low risk”groups to compare the differences in *** model was re-evaluated with the clinical data of our *** The 3-lncRNA combination model is an independent prognostic factor for GC.

关键词： Gastric cancer Prognosis Least absolute shrinkage and selection operator Survival analysis Long noncoding RNA

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Trajectory Time Series Compression Algorithm Based on Unsupervised Segmentation

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Journal of Systems Science and Information 2024年第3期12卷 360-378页

作者： Shuang SUN yan CHEN Zaiji piao School of Maritime Economics and Management Dalian Maritime University School of Software Dalian University of Foreign Languages

Aiming at the problem of ignoring the importance of starting point features of trajecory segmentation in existing trajectory compression algorithms, a study was conducted on the preprocessing process of trajectory time series. Firstly, an algorithm improvement was proposed based on the segmentation algorithm GRASP-UTS(Greedy Randomized Adaptive Search Procedure for Unsupervised Trajectory Segmentation). On the basis of considering trajectory coverage, this algorithm designs an adaptive parameter adjustment to segment long-term trajectory data reasonably and the identification of an optimal starting point for segmentation. Then the compression efficiency of typical offline and online algorithms, such as the Douglas-Peucker algorithm, the Sliding Window algorithm and its enhancements, was compared before and after segmentation. The experimental findings highlight that the Adaptive Parameters GRASP-UTS segmentation approach leads to higher fitting precision in trajectory time series compression and improved algorithm efficiency post-segmentation. Additionally, the compression performance of the Improved Sliding Window algorithm post-segmentation showcases its suitability for trajectories of varying scales, providing reasonable compression accuracy.

关键词： trajectory time series unsupervised segmentation trajectory compression greedy randomized adaptive search

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Clinical characteristics and treatment of splenic infarction in children with systemic lupus erythematosus

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World Journal of Pediatrics 2024年第5期20卷 525-531页

作者： yan Li Yu-Rong piao Tong-Xin Han Hua-Wei Mao Department of Immunology Ministry of Education Key Laboratory of Major Diseases in ChildrenBeijing Key Laboratory for Genetics of Birth DefectsNational Center for Children’s HealthBeijing Children’s HospitalCapital Medical UniversityNo.56 Nan Li Shi LuBeijing100045China

Splenic infarction(SI)is a rare clinical phenomenon that occurs when the blood supply to the spleen is interrupted,resulting in tissue ischemia and necrosis[1].There are many causes of SI;in adult patients,cardioembolism,hematological malignancy,and infectious disease are the most common[2].Rheumatic diseases,especially systemic lupus erythematosus(SLE)and granulomatosis with polyangitis,can also lead to SI[3];however,only a few cases have been *** are currently no statistically meaningful data on the etiology of SI in *** most patients with SI can recover after conservative treatment,a small number of patients develop complications,such as splenic abscess,splenic rupture,splenic hemorrhage,and hemoperitoneum,and may even undergo splenectomy in severe cases.

关键词： erythematosus lupus treatment

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Supermassive Primordial Black Holes for Nano-Hertz Gravitational Waves and High-redshift JWST Galaxies

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Research in Astronomy and Astrophysics 2024年第9期24卷 3-8页

作者： hai-Long Huang Yong Cai Jun-Qian Jiang Jun Zhang Yun-Song piao School of Physical Sciences University of Chinese Academy of Sciences Institute for Astrophysics School of Physics Zhengzhou University International Centre for Theoretical Physics Asia-Pacific University of Chinese Academy of Sciences Taiji Laboratory for Gravitational Wave Universe (Beijing/Hangzhou) University of Chinese Academy of Sciences School of Fundamental Physics and Mathematical Sciences Hangzhou Institute for Advanced Study UCAS Institute of Theoretical Physics Chinese Academy of Sciences

Recently, observational hints for supermassive black holes have been accumulating, prompting the question: Can primordial black holes（PBHs） be supermassive, particularly with masses M?10～9M⊙? A supercritical bubble,containing an inflating baby universe, that nucleated during inflation can evolve into a PBH in our observable universe. We find that when the inflaton slowly transitions past a neighboring vacuum, the nucleation rate of supercritical bubbles inevitably peaks, leading to a mass distribution of multiverse PBHs with a peak mass up to M?1011M⊙. Thus, our mechanism naturally provides a primordial origin for supermassive black holes.

关键词： (cosmology:) early universe (cosmology:) inflation (galaxies:) quasars: supermassive black holes

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Mobile mini-fluorimeter for antibiotic aptasensing based on surface-plasmonic effect of burlike nanogolds enhanced by digitized imaging diagnosis

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Chinese Chemical Letters 2024年第5期35卷 418-422页

作者： Tiantian Man Fulin Zhu Yaqi Huang Yuhao piao yan Su Shengyuan Deng Ying Wan School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing 210094China Key Laboratory of Metabolic Engineering and Biosynthesis Technology Ministry of Industry and Information TechnologySchool of Environmental and Biological EngineeringNanjing University of Science and TechnologyNanjing 210094China

Antibiotic abuse now poses a grave threat to global ecology and bestirs public concerns about the residue issue in daily *** traceability measurements along supply chain or logistic circulation have become increasingly essential given the labile nature of diverse synthetic residuals on *** an attempt to answer this urgency,here a miniaturized fluorometric aptasensor prototype was contrived that catered to the point-of-care screening norm for two typical additives:chloramphenicol and *** key target-indicating module worked in vitro based on the competitive binding-induced fluorescence recovery of fluorescein-labeled aptamers,which were photobleached beforehand in the format of double helix on burlike nanogold ***“prickly”geometry of the latter not just enriched the capture probes at preferentially substrate-accessible spires;but also contributed to a tip-enhanced surface plasmon effect,sensitizing the signal-on during the duplex dissociation even at nanomolar threshold of the *** the other hand,to encompass a full portable,a set of optical devices were mounted within a 3D-printed cartridge(adaptor)to converge the light beam and route it towards the detector,for which the smartphone camera came up in handy with a home-developed App for calibrating the emissive *** by the high-dynamic-range compression,an imaging diagnostic algorithm was built in to grid and digitize each slide in the album for augmented detection ***,a novel bio-to-silico integration was invented that capable of in situ rapid reporting on the antibiotic presence with high sensitivity and *** field practices in spiked milk on sales proved the precision and rudimentary feasibility of the well-assembled model of appliance,thus holding nice prospects in nonexpert(e.g.,family and local community)utilities for foodborne antibiotic identification.

关键词： Chloramphenicol and enrofloxacin Aptasensor Gold nanoburs Smartphone fluorimetric suite Digitized image postprocessing

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Ancient mitochondrial genome depicts sheep maternal dispersal and migration in Eastern Asia

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Journal of Genetics and Genomics 2024年第1期51卷 87-95页

作者： Liu yang Xing Zhang yaning Hu piao Zhu Hua Li Zhenyu Peng hai Xiang Xinying Zhou Xingbo Zhao National Engineering Laboratory for Animal Breeding Key Laboratory of AnimalGeneticsBreeding and ReproductionMinistry of Agriculture and Rural AffairsCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding School of Life Science and EngineeringFoshan UniversityFoshanGuangdong 528225China State Key Laboratory of Agricultural Genomics BGI-ShenzhenShenzhenGuangdong 518083China Key Laboratory of Vertebrate Evolution and Human Origins Institute of Vertebrate Paleontology and PaleoanthropologyChinese Academy of SciencesBeijing 100044China

Sheep have been one of the most important groups of animals since ancient ***,the knowledge of their migration routes and genetic relationships is still poorly *** investigate sheep maternal migration histories alongside Eurasian communications routes,in this study,we obtain mitochondrial genomes(mitogenomes)from 17 sheep remains in 6 Chinese sites and 1 Uzbekistan site dated 4429–3100 years before present(BP).By obtaining the mitogenomes from the sheep(4429–3556 BP)found in the Tongtian Cave site in Xinjiang,Altai region of northwest China,our results support the emergence of haplogroup C sheep in Xinjiang as early as 4429–3556 *** combined phylogenetic analyses with extant ancient and modern sheep mitogenomes suggest that the Uzbekistan-Altai region may have been a migration hub for early sheep in eastern *** least two migration events have taken place for sheep crossing Eurasia to China,one passing by Uzbekistan and Northwest China to the middle and lower reaches of the Yellow River at approximately 4000 BP and another following the Altai region to middle Inner Mongolia from 4429 BP to 2500 ***,this study provides further evidence for early sheep utilization and migration patterns in Eastern Asia.

关键词： Sheep Ancient DNA Eastern Asia Mitochondrial genome Migration Altai

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Does the continuous wetting of the Tibetan Plateau contribute to the accelerated degradation of permafrost?

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Science China Earth Sciences 2024年第5期67卷 1714-1718页

作者： Yuyang WANG Jinzhi DING Shilong piao Sino-French Institute for Earth System Science College of Urban and Environmental SciencesPeking UniversityBeijing 100871China State Key Laboratory of Tibetan Plateau Earth System Environment and ResourcesInstitute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China

Global warming is causing the Tibetan permafrost to degrade, as evidenced by rising ground temperatures, thicker active layer thickness, thinner permafrost layer, and melting underground ice, etc.(Ran et al., 2018;Wang et al., 2020).The degradation of permafrost not only profoundly alters the carbon cycling processes in high-altitude ecosystems,thereby influencing the regional climate system, but also affects landscape hydrological connectivity。

关键词： Tibetan landscape altitude

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A Case of Brucellosis Concomitant with Severe Fever with Thrombocytopenia Syndrome—Weifang City,Shandong Province,China,2023

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China CDC weekly 2024年第27期6卷 677-680页

作者： Qingqing Xu Cuiping Wu Hui Liu Chao Geng Jinhui Zhang Dongri piao Hongyan Zhao Yu Fan Guozhong Tian hai Jiang National Key Laboratory of Intelligent Tracing and Forecasting for Infectious Diseases National Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Department of Infectious Diseases Yidu Central Hospital of WeifangWeifang CityShandong ProvinceChina Institute of Bacterial Disease Jinan Center for Disease Control and PreventionJinan CityShandong ProvinceChina Tongliao Center for Disease Control and Prevention Tongliao CityInner Mongolia Autonomous RegionChina

Summary What is already known about this topic?Brucellosis and severe fever with thrombocytopenia syndrome(SFTS)are neglected zoonoses,attributable respectively to Brucella and the SFTS virus(SFTSV).While the incidence of these diseases has been rising,instances of co-infection remain *** is added by this report?This represents the first documented case of a rare coinfection involving Brucella and SFTSV.

关键词： neglected instance Shandong

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A Unified Motion Generation Approach for Quadruped L-S Walk and Trot Gaits Based on Linear Model Predictive Control

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Journal of Bionic Engineering 2024年第4期21卷 1707-1719页

作者： Yapeng Shi Zhicheng He Xiaokun Leng Songhao piao Lining Sun Harbin Institute of Technology No.92 West Dazhi StreetHarbin150001HeilongjiangChina yanshan University No.438 West Hebei AvenueQinhuangdao066004HebeiChina

The goal of this paper is to develop a unified online motion generation scheme for quadruped lateral-sequence walk and trot gaits based on a linear model predictive control ***,the dynamics of the linear pendulum model is formulated over a predictive horizon by dimensional *** gait pattern conversion,the lateral-sequence walk and trot gaits of the quadruped can be regarded as unified biped gaits,allowing the dynamics of the linear inverted pendulum model to serve quadruped motion *** addition,a simple linearization of the center of pressure constraints for these quadruped gaits is developed for linear model predictive control ***,the motion generation problem can be solved online by quadratic programming with foothold *** is demonstrated that the proposed unified scheme can generate stable locomotion online for quadruped lateral-sequence walk and trot gaits,both in simulation and on *** results show significant performance improvements compared to previous ***,the results also suggest the linearly simplified scheme has the ability to robustness against unexpected disturbances.

关键词： Motion generation Gait pattern conversion Model predictive control Quadruped locomotion

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