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Arecoline causes cognitive impairment and potential addiction via disturbing Kenyon cells in bumblebee brain

Food Science and Human Wellness 2024年

作者： Huiling liu Xiaohuan Mu Rongrong fan Jieteng Chen Jie Ma Liang Meng Xiaosong Hu Hao Zheng Shanshan liu Xiaofei wang College of Food Science and Nutritional Engineering， National Engineering Research Center for Fruit and Vegetable Processing， Key Laboratory of Fruits and Vegetables Processing， Ministry of Agriculture， Engineering Research Centre for Fruits and Vegetables Processing， Ministry of Education， China Agricultural University BGI-Qingdao

Areca nut is the basic ingredient of betel quid， which is chewed by hundreds of millions of people in south-eastern Asia. Chewing of areca nut has been associated with oral cancers potentially due to its specific alkaloids， among which arecoline constitutes about 90% of total fraction. Being the world’s fourth most commonly used psychoactive substance， arecoline evokes stimulation， addiction， and other direct neurological effects， while its misuse correlates to neurotoxic effects. However， what might underlie its neurotoxic mechanisms has been poorly documented. The brain is encoded by a complex network of neuronal and glial cell types， and neurotoxicity of hazardous compounds present transcriptional heterogeneity. Recently， the eusocial bumblebee has been used as a model for studying brain effects， with sophisticated cognitive capability and precisely measured brain architecture. Here， we decipher cell-type-specific mental risks to arecoline using bumblebees. Arecoline induced locomotor hyperactivity and cognitive impairment. Single nucleus RNA sequencing (snRNA-seq) unearthed arecoline-induced cell-specific responses， primarily targeted on Kenyon cells (KC). Moreover， high-dose arecoline induced distinctive cell responses among KC subtypes， particularly class I large Kenyon cell (lKC)， leading to DNA damage， excitatory/inhibitory (E/I) imbalance， and calcium dyshomeostasis， which potentially resulted in cognitive impairment. Given arecoline’s popularity and growing exposure risks to humans， neurological health risks of areca nut warrant serious consideration.

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Multi-lump Kinetic Parameter Estimation and Simulation of Trickle-bed Reactor for Ultra-deep Hydrodesulfurization of Diesel

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China Petroleum Processing & Petrochemical Technology 2024年第3期26卷 147-157页

作者： Huang Zhen Zhang Xun Qiao Aijun Xue Nan liu Kaixiang Xu Song wang He SINOPEC Engineering Incorporation Co. Ltd.Beijing 100101China

A three-lumping Langmuir-Hinshelwood kinetic model was established based on the structures and reactivities of sulfur *** model described the ultra-deep hydrodesulfurization(UDHDS)performance of diesel,reducing sulfur content from 10000μg/g to less than 10μg/g,with experimental and predicted data showing a discrepancy of less than 10%.The diesel UDHDS reaction was simulated by combining the mass transfer,reaction kinetics model,and physical properties of *** results showed how the concentrations of H2S,hydrogen,and sulfur in the gas,liquid,and solid phases varied along the reactor ***,the study discussed the effects of each process parameter and impurity concentrations(H2S,basic nitrogen and,non-basic nitrogen)on diesel UDHDS.

关键词： diesel TBR ultra-deep HDS kinetic model simulation

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Investigation of reflection anisotropy induced by micropipe defects on the surface of a 4H-SiC single crystal using scanning anisotropy microscopy

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Chinese Physics B 2024年第3期33卷 630-637页

作者：黄威俞金玲刘雨彭燕王利军梁平陈堂胜徐现刚刘峰奇陈涌海 Key Laboratory of Semiconductor Materials Science Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China College of Materials Science and Opto-Electronic Technology University of Chinese Academy of SciencesBeijing 100049China National Key Laboratory of Solid-state Microwave Devices and Circuits Nanjing Electronic Devices InstituteNanjing 210016China Institute of Micro/Nano Devices and Solar Cells School of Physics and Information EngineeringFuzhou UniversityFuzhou 350108China State Key Laboratory of Crystal Materials Shandong UniversityJinan 250100China

Optical reflection anisotropy microscopy mappings of micropipe defects on the surface of a 4H-SiC single crystal are studied by the scanning anisotropy microscopy(SAM)*** reflection anisotropy(RA)image with a'butterfly pattern'is obtained around the micropipes by *** RA image of the edge dislocations is theoretically simulated based on dislocation theory and the photoelastic *** comparing with the Raman spectrum,it is verified that the micropipes consist of edge *** different patterns of the RA images are due to the different orientations of the Burgers ***,the strain distribution of the micropipes is also *** can identify the dislocation type,the direction of the Burgers vector and the optical anisotropy from the RA image by using ***,SAM is an ideal tool to measure the optical anisotropy induced by the strain field around a defect.

关键词： scanning anisotropy microscopy SiC reflection anisotropy edge dislocation

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A novel dual-channel thermo-optic locking method for the whispering gallery mode microresonator

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Chinese Physics B 2024年第5期33卷 438-444页

作者：范文杰刘文耀潘梓文王蓉刘来邢恩博周彦汝唐军刘俊 State Key Laboratory of Dynamic Measurement Technology North University of ChinaTaiyuan 030051China Shanxi Province Key Laboratory of Quantum Sensing and Precision Measurement North University of ChinaTaiyuan 030051China

Mode locking can be effectively achieved by using the thermo-optic effects in the whispering gallery mode(WGM)optical microcavity,without the help of external ***,it has the advantages of small size,low integration costs,and self-locking,which shows great potential for ***,the conventional single-channel microcavity thermal-locking method that relies solely on internal thermal balance will inevitably be disturbed by the external *** limitation affects the locking time and ***,in this paper,we propose a new method for closed-loop thermal locking of a dual-channel *** thermal locking of the signal laser and the thermal regulation of the control laser are carried out respectively by synchronously drawing a dual-path tapered *** theoretical model of the thermal dynamics of the dual-channel microcavity system is established,and the influence of the control-laser power on the thermal locking of the signal laser is *** deviation between the locking voltage of the signal laser and the set point value is used as a closed-loop feedback parameter to achieve long-term and highly stable mode locking of the signal *** results show that in the 2.63 h thermal-locking test,the locking stability is an order of magnitude higher than that of the single tapered *** solution addresses the issue of thermal locking being disrupted by the external environment,and offers new possibilities for important applications such as spectroscopy and micro-optical sensor devices.

关键词： optical microcavity thermo-optic locking thermal nonlinearity effect

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Mechanism underlying the uprooting of taproot-type shrub species in the loess area of northeastern Qinghai-Xizang Plateau, China

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Journal of Arid Land 2024年第10期16卷 1426-1443页

作者： LIANG Shen wang Shu liu Yabin PANG jinghao ZHU haili LI Guorong HU Xiasong School of Geological Engineering Qinghai UniversityXining 810016China Key Laboratory of Genozoic Resource&Environment in North Margin of the Tibet Plateau Xining 810016China

Characteristics of root pullout resistance determine the capacity to withstand uprooting and the slope protection ability of ***,mechanism underlying the uprooting of taproot-type shrub species in the loess area of northeastern Qinghai-Xizang Plateau,China remains *** this study,a common taproot-type shrub,Caragana korshinskii Kom.,in northeastern Qinghai-Xizang Plateau was selected as the research *** of root-soil interaction of vertical root of *** was investigated via a combination of a single-root pullout test and numerical simulation *** results indicated that,when pulling vertically,axial force of the roots decreased with an increase in buried depth,whereas shear stress at root-soil interface initially increased and then decreased as burial depths *** the same buried depth,both axial force and shear stress of the roots increased with the increase in pullout *** stress and plastic zone of the soil surrounding the root were symmetrically distributed along the root *** zone was located close to the surface and was caused primarily by tensile *** nonvertical pulling,symmetry of shear stress and plastic zone of the soil surrounding the root was *** observed larger shear stress and plastic zones on the side facing the direction of root *** zone included both shear and tensile *** force of the root system near the surface decreased as deflection angle of the pullout force *** different rainfall infiltration depths had the same vertical pulling force,root axial force decreased with the increase of rainfall infiltration depth and total root displacement *** rainfall infiltration,shear stress and plastic zone of the soil surrounding the root were prone to propagating deeper into the *** findings provide a foundation for further investigation of soil reinforcement and slope protection mechanisms of taproot-type shrub spec

关键词： Qinghai-Xizang Plateau shrub roots pullout test numerical simulation mechanism root-soil interaction

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Multitap RF Canceller with Single LMS Loop for Adaptive Co-Site Broadband Interference Cancellation

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China Communications 2024年第9期21卷 179-197页

作者： Jiang Yunhao liu Zhipeng Yuan Lei Xu Anfei wang Hang Zhao Nan Wu Minghu Hubei Key Laboratory for High-Efficiency Utilization of Solar Energy and Operation Control of Energy Storage System Hubei University of TechnologyWuhan 430068China Hubei Collaborative Innovation Center for High-Efficiency Utilization of Solar Energy Hubei University of TechnologyWuhan 430068China

With the development of wireless communication technology,an urgent problem to be solved is co-site broadband interference on independent communication platforms such as satellites,space stations,aircrafts and ***,the problem of strong selfinterference rejection should be solved in the co-time co-frequency full duplex mode which realizes spectrum multiplication in 5G communication *** the research of such interference rejection,interference cancellation technology has been *** order to reject multipath interference,multitap double LMS(Least Mean Square)loop interference cancellation system is often used for cancelling RF(Radio Frequency)domain interference ***,more taps will lead to a more complex structure of the cancellation system.A novel tap single LMS loop adaptive interference cancellation system was proposed to improve the system compactness and reduce the *** addition,a mathematical model was built for the proposed cancellation system,the correlation function of CP2FSK(Continuous Phase binary Frequency Shift Keying)signal was derived,and the quantitative relationship was established between the correlation function and the interference signal bandwidth and tap delay *** steadystate weights and the expression of the average interference cancellation ratio(ICR)were deduced in the scenes of LOS(Line of Sight)interference with antenna swaying on an independent communication platform and indoor multipath *** quantitative relationship was deeply analyzed between the interference cancellation performance and the parameters such as antenna swing,LMS loop gain,and interference signal bandwidth,which was verified by simulation *** the performance of the proposed interference cancellation system was compared with that of the traditional double LMS loop cancellation *** results showed that the compact single LMS loop cancellation system can achieve an average interference rejection ca

关键词： co-site broadband interference delay matching RF interference cancellation single LMS loop

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Discovery of first-in-class DOT1L inhibitors against the R231Q gain-of-function mutation in the catalytic domain with therapeutic potential of lung cancer

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Acta Pharmaceutica Sinica B 2024年第8期14卷 3605-3623页

作者： Zehui Tan Ning Guo Zhi Cao Shuyu liu Jiayu Zhang Deyi Ma Jiahao Zhang Wencai Lv Nan Jiang Linghe Zang Lihui wang Xin Zhai Key Laboratory of Structure-Based Drug Design and Discovery Ministry of EducationShenyang Pharmaceutical UniversityShenyang 110016China Department of Pharmacology Shenyang Pharmaceutical UniversityShenyang 110016China

Recent research certified that DOT1L and its mutations represented by R231Q were potential targets for the treatment of lung ***,a series of adenosine-containing derivatives were identified with DOT1LR231Q inhibition through antiproliferation assay and Western blot analysis in the H460R231Q *** most promising compound 37 significantly reduced DOT1LR231Q mediated H3K79 methylation and effectively inhibited the proliferation,self-renewal,migration,and invasion of lung cancer cell lines at low micromolar *** cell permeability and cellular target engagement of 37 were verified by both CETSA and DARTS *** the H460R231Q OE cell-derived xenograft(CDX)model,37 displayed pronounced tumor growth inhibition after intraperitoneal administration at 20 mg/kg dose for 3 weeks(TGI=54.38%),without obvious toxicities.A pharmacokinetic study revealed that 37 possessed tolerable properties(t_(1/2)=1.93±0.91 h,F=97.2%)after intraperitoneal administration in *** study confirmed that 37 suppressed malignant phenotypes of lung cancer carrying R231Q gain-of-function mutation via the MAPK/ERK signaling ***,analysis of the binding modes between molecules and DOT1LWT/R231Q proteins put forward the“Induced-fit”allosteric model in favor to the discovery of potent DOT1L candidates.

关键词： DOT1L R231Q mutation Lung cancer Adenosine-containing inhibitors Epigenetics

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考虑源荷不确定性及用户响应行为的电力系统低碳经济调度

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中国电机工程学报 2024年第3期44卷 905-917,I0005页

作者：廖望刘东巫宇锋翁嘉明电力传输与功率变换控制教育部重点实验室(上海交通大学) 上海市杨浦区200240

电力系统是未来实现碳中和目标的重要领域,随着源-荷不确定性的加剧,基于确定性模型的低碳经济调度方法无法准确描述不确定因素对碳排放的影响。针对上述问题,该文首先从系统层面构建考虑不确定性的低碳鲁棒优化模型,利用概率模型对源... 详细信息

电力系统是未来实现碳中和目标的重要领域,随着源-荷不确定性的加剧,基于确定性模型的低碳经济调度方法无法准确描述不确定因素对碳排放的影响。针对上述问题,该文首先从系统层面构建考虑不确定性的低碳鲁棒优化模型,利用概率模型对源荷不确定因素进行建模,并采用机会约束对目标满足期望的显著性水平进行描述,通过最大化不确定因素的置信水平得出风险规避策略下的鲁棒调度方案。接着从用户层面构建基于事件驱动的用户低碳响应模型,根据系统层计算结果,通过设定事件触发的碳排放阈值定义碳排放超额事件,并以价格形式引导用户的低碳用能行为。最后通过算例分析,验证所提模型能有效量化评估系统的低碳经济调度不确定性水平,充分发挥用户侧降碳能力,实现源荷双侧低碳目标的协同。

关键词：鲁棒优化低碳经济调度事件驱动需求响应

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对象随型粗糙面近红外单目视觉测量与基准图像自愈

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红外与毫米波学报 2024年第1期43卷 134-142页

作者：侯旺屈也频刘坚强吕余海海军研究院上海200436

针对复杂应用环境中近红外单目视觉位姿测量系统偏离预置合作目标对象后,无法完成位姿测量的特殊情况,提出一种以合作目标周边随型粗糙面图像为测量对象的单目视觉测量方法,以及图像受损后的动态自愈方法。通过将实时获取的随型粗糙面... 详细信息

针对复杂应用环境中近红外单目视觉位姿测量系统偏离预置合作目标对象后,无法完成位姿测量的特殊情况,提出一种以合作目标周边随型粗糙面图像为测量对象的单目视觉测量方法,以及图像受损后的动态自愈方法。通过将实时获取的随型粗糙面图像特征与预存基准图像特征进行匹配计算,完成特殊情况下的应急测量。同时,为减少随型粗糙面图像污染或受损后对位姿测量精度的影响,实时计算污染或受损程度并动态自愈基准图像特征。实验结果表明,以随型粗糙面为对象的位姿测量精度稍低于合作目标对象,但能够满足特殊情况下的应急使用需求,提高了测量系统的鲁棒性;当随型粗糙面图像污染或受损达到70%时,采用自愈处理与未做自愈处理相比,方位角测量误差减少72%以上,验证了基准图像自愈方法的有效性。

关键词：对象随型粗糙面近红外单目视觉测量基准图像自愈基准图像特征特征匹配

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甘氨酸钾溶液吸收二氧化碳的结合能及动力学分析

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石油炼制与化工 2024年第3期55卷 75-81页

作者：刘均隆成怀刚刘倩王瑾潘子鹤山西大学资源与环境工程研究所 CO_(2)减排与资源化利用教育部工程研究中心太原030006 青海大学化工学院山西大地生态环境技术研究院

针对CO_(2)吸收过程因缺乏定量动力学研究而制约新型吸收剂开发的问题,模拟计算了甘氨酸钾(PG)与CO_(2)的结合能,并与乙醇胺(MEA)-CO_(2)体系进行比较,进而通过试验研究了不同条件下PG溶液吸收CO_(2)的动力学规律。结果表明:PG-CO_(2)... 详细信息

针对CO_(2)吸收过程因缺乏定量动力学研究而制约新型吸收剂开发的问题,模拟计算了甘氨酸钾(PG)与CO_(2)的结合能,并与乙醇胺(MEA)-CO_(2)体系进行比较,进而通过试验研究了不同条件下PG溶液吸收CO_(2)的动力学规律。结果表明:PG-CO_(2)双分子体系的结合能明显大于MEA-CO_(2),但二者在水溶液模型中结合能相差不大,吸附剂与水分子之间的相互作用可能影响其吸收CO_(2)能力;PG溶液浓度越高,其CO_(2)吸收负荷越低,1 mol L的PG溶液的CO_(2)吸收负荷为0.584 mol mol,与相同浓度的MEA溶液相近;与其他温度相比,40℃下PG溶液的CO_(2)吸收量最高;提高CO_(2)流速,反应速率增大,CO_(2)吸收率下降;PG与CO_(2)的反应活化能为28 kJ mol,比MEA吸收CO_(2)反应所需的活化能低;而PG与MEA具有相近的CO_(2)吸收能力,这为开发无腐蚀性新型吸收剂提供了动力学基础数据。

关键词：甘氨酸钾二氧化碳结合能动力学

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