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Distributional characteristics and sources of elements in soil from typical area of Pearl River Delta economic zone, Guangdong Province, China

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Chinese Journal Of Geochemistry 2015年第3期34卷 299-310页

作者： Lei Dou Shu-Zhen Shen hai-yan du Geological Survey of Guangdong Province Beijing Normal University Zhuhai Campus

Dongguan City, located in the Pearl River Delta economic zone of China, is famous for its rapid developing township-enterprises in the past 30 years. A total of 759 composite soil samples, including 606 surface soil samples and 153 deep soil samples, have been collected in the city. These samples have been analyzed for 13elements(Al, As, Cu, Cd, Co, Cr, Fe, Hg, Mn, Ni, Pb, Si,and Zn) and other parameters(p H values and organic matter) to evaluate the influence of anthropic activities on the soil environmental quality and to identify the spatial distribution of heavy metals and their possible sources. The results indicate that the average concentrations of heavy metals in soil were significantly lower than the threshold of the second grade of the Soil Environment Quality Standard in China(GB15618-1995) and the soil environmental quality in this area is comparatively good. But in comparison with local soil geochemical baseline values, As,Cd, Cu, Hg, Pb, and Zn have accumulated ***, the average concentrations of As, Cd, Cu, and Hg in the small part samples of the west plain and central areas are higher than the national second-grade quality standard, indicating some level of contamination. Multivariate and geostatistical methods have been applied to differentiate the influences of natural processes and human activities on the concentration of heavy metals in surface soils in the study area. Cluster and factor analyses result in the grouping of Al, As, Cr, Cu, Fe, Ni, and Si into factor F1; Co, Mn, Pb, and Zn into F2; and Cd and Hg into *** spatial pattern of the three factors may be well demonstrated by geostatistical analysis. It is shown that the first factor could be considered as a natural source controlled by parent material. The second factor could be referred to as ‘‘industrial and traffic pollution sources' '. The source of the third factor is mainly controlled by long-term anthropic activities, including agricultural activities, fossil f

关键词：珠江三角洲经济区元素分布特征土壤样品土壤重金属含量典型区广东省土壤环境质量交通污染源

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Screener3D:a gaseous time projection chamber for ultra-low radioactive material screening

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Nuclear Science and Techniques 2021年第12期32卷 103-115页

作者： hai-yan du Cheng-Bo du Karl Giboni Ke Han Sheng-Ming He Li-Qiang Liu Yue Meng Shao-Bo Wang Tao Zhang Li Zhao Ji-Fang Zhou INPAC Shanghai Laboratory for Particle Physics and CosmologyKey Laboratory for Particle Astrophysics and Cosmology(MOE)School of Physics and AstronomyShanghai Jiao Tong UniversityShanghai 200240China Yalong River Hydropower Development Company Ltd.288 Shuanglin RoadChengdu 610051China SJTU-ParisTech Elite Institute of Technology(SPEIT) Shanghai Jiao Tong UniversityShanghai 200240China

In experiments searching for rare signals,background events from the detector itself are some of the major factors limiting search *** for ultra-low radioactive detector materials is becoming ever more *** propose to develop a gaseous time projection chamber(TPC)with a Micromegas readout for radio *** TPC records three-dimensional trajectories of charged particles emitted from a flat sample placed in the active volume of the *** detector can distinguish the origin of an event and identify the particle types with information from trajectories,which significantly increases the screening *** a particles from the sample surface,we observe that our proposed detector can reach a sensitivity higher than 100 l Bq m-2 within two days.

关键词： Charged-particle detector Surface a measurement Ultra-low radioactivity Material screening

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Structure and contribution to the anti-thrombotic mechanism of dermatan sulfate derivatives

Structure and contribution to the anti-thrombotic mechanism ...

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山东省药学会第一届学术年会

作者： hai-yan du, Sheng-Li Ji (Institute of Biochemical and Biotech Drugs, School of Pharmacy, Shandong University, Jinan 250012, China)

To study the relationship between the structure of Dermatan sulfate (DS) derivatives and their anti-thrombotic mechanism, on the basis of the DS derivatives’ anti-thrombotic activity research, the effects of DS-derived oligosaccharides with different structure and molecular weight on the activities of heparin cofactor II (HCII), activated protein C (APC), blood platelet and vascular endothelial cells were also studied. The major disaccharides of DS and polysulfated Dermatan sulfate (PSDS) were IdoA-1→3-GalNAc-4-SO3and IdoA-2SO3-l→3-GalNAc4, 6-diSO:t, respectively. The results showed that: The consequence of the thrombotic inhibition effects of DS and its derivatives were as follows: PSDS> LPSDS>DS. DS and PSDS all inhibited platelet aggregation in a concentration-dependent manner with IC50 values of 15.15±3.30, 29.10±3.07, respectively. DS oligosaccharides (DSOSs) and PSDS oligosaccharides (PSDSOSs) all significantly inhibit P-selectin expression on platelet surface (Pduce the plasminogen activator inhibitor (PAI) activity from cultured human umbilical vein endothelial cells, causing the ratio of t-PA/PAI going up. The most active PSDSOS was PSDSOS, with Mr of 4959. PSDSOSs were more active than DSOSs on the basis of comparable Mr in above activity assay, except for platelet aggregation.

关键词： Dermatan sulfate polysulfated Dermatan sulfate DS oligosaccharides PSDS oligosaccharides anti-thrombotic mechanism, heparin cofactor II activated protein C tissue plasminogen activator plasminogen activator inhibitor P-selectin, platelet aggregation.

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Enantio-divergent C–H borylation with two different ligands from a single chiral source

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Science China Chemistry 2025年第1期68卷 226-232页

作者： Rongrong du Senmiao Xu State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics Chinese Academy of Sciences College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of Education Hangzhou Normal University University of Chinese Academy of Sciences

Reported here is an iridium-catalyzed enantio-divergent C（sp3）–H borylation of α-gem-dimethyl groups of trifluoromethyl ketone-derived hydrazones to construct a series of acyclic all-carbon quaternary stereocenters with a high level of chiral induction. Two different chiral bidentate boryl ligands from a common chiral source not only can switch the enantioselectivity but also are complementary in terms of the substrate scope.

关键词： asymmetric catalysis C–H borylation all-carbon quaternary stereocenters synthetic methods

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两层模式下内波K-dv方程的频散关系

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水动力学研究与进展（A辑） 2005年第5期20卷 673-679页

作者：李海艳杜涛中国海洋大学海洋环境学院物理所青岛266003

为了更好地了解内孤立波的特性,分别利用椭圆余弦波方法和摄动展开方法,对两层模型下内孤立波K-dv方程的频散关系进行了推导。结果显示:利用后一种方法得到的两层模式下内孤立波K-dv方程的频散关系是一种方便、实用的解析式。据此解析... 详细信息

为了更好地了解内孤立波的特性,分别利用椭圆余弦波方法和摄动展开方法,对两层模型下内孤立波K-dv方程的频散关系进行了推导。结果显示:利用后一种方法得到的两层模式下内孤立波K-dv方程的频散关系是一种方便、实用的解析式。据此解析式可进一步得到内孤立波半波宽度与内波波数间的关系,从而可将内孤立波理论与内波合成孔径雷达(SAR)图像联系起来。用此解析式计算得到的内孤立波频率和相速度与实测结果具有很好的一致性,因而为进一步进行分析和利用数据估计内孤立波的部分参数提供了理论依据。对解析式中频散项和非线性项量级的进一步分析认为,非线性项的作用在从SAR图像中提取内波振幅等参数时最好不予忽略。

关键词：内孤立波频散关系合成孔径雷达

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Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： Lin-yan Huang Yi-De Zhang Jie Chen hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng Li hai-Wei Pu Xin-Yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

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From text to image:challenges in integrating vision into ChatGPT for medical image interpretation

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Neural Regeneration Research 2025年第2期20卷 487-488页

作者： Shunsuke Koga Wei du Department of Pathology and Laboratory Medicine Hospital of the University of PennsylvaniaPhiladelphiaPAUSA

Large language models(LLMs),such as ChatGPT developed by OpenAI,represent a significant advancement in artificial intelligence(AI),designed to understand,generate,and interpret human language by analyzing extensive text *** potential integration into clinical settings offers a promising avenue that could transform clinical diagnosis and decision-making processes in the future(Thirunavukarasu et al.,2023).This article aims to provide an in-depth analysis of LLMs’current and potential impact on clinical *** ability to generate differential diagnosis lists underscores their potential as invaluable tools in medical practice and education(Hirosawa et al.,2023;Koga et al.,2023).

关键词： image diagnosis text

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia yang Qian-Ru He Fei Ding hai-yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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pH响应性阳离子微凝胶-纳米Pd催化剂的制备及性能

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高分子学报 2014年第6期24卷 815-821页

作者：叶丹锋申迎华杨振芳杜海燕刘旭光太原理工大学化学化工学院太原030024

以聚乙二醇甲基丙烯酸酯(PEGMA)为大分子稳定剂,通过乳液聚合制备稳定性良好的具有pH响应性聚甲基丙烯酸二乙基氨基乙酯(PDEA)微凝胶,以其为模板将一定量的四氯钯酸钠(Na2PdCl4)溶液通过静电作用充分络合到高分子微凝胶的网络结构中,并... 详细信息

以聚乙二醇甲基丙烯酸酯(PEGMA)为大分子稳定剂,通过乳液聚合制备稳定性良好的具有pH响应性聚甲基丙烯酸二乙基氨基乙酯(PDEA)微凝胶,以其为模板将一定量的四氯钯酸钠(Na2PdCl4)溶液通过静电作用充分络合到高分子微凝胶的网络结构中,并以NaBH4为还原剂,原位合成法制备pH响应性阳离子微凝胶-纳米Pd催化剂.利用透射电镜(TEM)、动态光散射(DLS)、紫外-可见分光光度计(UV-Vis)、热重分析(TGA)和X射线衍射仪(XRD)分别对阳离子微凝胶-纳米Pd催化剂的形貌、pH响应性、静电力、Pd负载量和Pd晶型进行了表征及分析.结果表明,制备得到的纳米Pd的平均粒径约为3.5 nm;紫外吸收光谱图中,PDEA-Na2PdCl4复合体系在波长280 nm出现吸收峰,证明PdCl42-与微凝胶之间存在相互作用力;pH响应性阳离子微凝胶-纳米Pd催化剂还原4-硝基苯酚具有很好的催化活性,其催化活性与微凝胶网络的pH响应性有一定关系.此外对阳离子微凝胶-纳米Pd催化剂循环使用的状况进行了初步研究.

关键词：阳离子微凝胶 pH响应性纳米Pd 催化活性

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Structure-efficacy relationships of immunostimulatory activity of CpG-containing oligodeoxynucleotides on mouse spleen cells

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Acta Pharmacologica Sinica 2007年第10期28卷 1637-1644页

作者： hai-yan du~3,Shao-you XIA~4,hai-feng SONG~(2,5),Na LI~2,Ming-mei SHANG~2,Jia ZOU~2,Qing-qing WANG~2,Lun OU~2,XiaoSUN~2,Ai-guo JI~3,Zhong-ming TANG~2~2 Department of Pharmacology and Toxicology,Beijing Institute of Radiation Medicine,Beijing 100850,China ~3 Institute of Biochemical andBiotech Drugs,School of Pharmacy,Shandong University,Ji-nan 250012,China ~4 Department of General Surgery,General Hospital of PLA,Beijing100853,China Department of Pharmacology and Toxicology Beijing Institute of Radiation Medicine Beijing 100850 China. songhf@***.

Aim:To study the relationship between primary structures of oligodeoxynucleo-tides （ODN） containing unmethylated deoxycytidyl-deoxyguanosine （CpG）dinucleotide motifs and their immunostimulatory activities in mouse spleen ***:A series of CpG ODN with different primary structures were *** capabilities to stimulate mouse spleen cell proliferation were determined by[3H]thymidine incorporation *** （interleukin [IL]-6,IL-12,and IFN-α）secretion spectra induced by CpG ODN were assessed by *** ability ofCpG ODN to activate natural killer cells was evaluated by standard 4 *** cytometry was utilized to examine the expressions of various lympho-cyte surface molecules on diverse *** effective CpG ODN for murine,ODN1826,was set as the template of modification and the positive ***:The immunostimulatory activities of CpG ODN with different sequencesand compositions varied markedly,both in character and in *** was uselessfor improving the immunostimulatory activity of ODN1826 by simply increasingthe functional hexameric CpG motif number,modifying the site of CpG motifs,orchanging the distance between multi-CpG ***,an addition of a self-complementary palindrome structure at the 3'-end,but not the 5'-end of CpG ODN,aroused marked improvement in its *** designed ODN had superiorcomprehensive immunostimulatory properties compared to ODN ***:The immunostimulatory activity of a CpG ODN was relevant to its primary *** was useless for promoting immunostimulatory activity to simply change CpGmotif number,space,or *** 3'-end palindrome structure of CpG ODN isassociated with enhanced immunostimulatory activity.

关键词： CpG oligodeoxynucleotides immunostimulation structure-activity relationship

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