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Genetic Relationship between Francisella Tularensis Strains from China and from Other Countries

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Biomedical and Environmental Sciences 2011年第3期24卷 310-314页

作者： WANG YanHua hai rong zhang ZhiKai XIA LianXu CAI Hong LIANG Ying SHEN XiaoNa YU DongZheng State Key Laboratory for Infectious Disease Prevention and Control National Institute for Communicable DiseaseControl and Prevention Chinese Center for Disease Control and Prevention Beijing 102206 China

Objective To study the types of subspecies of Francisella tularensis from China and to investigate the genetic relationships between F. tularensis strains from China and from other countries. Methods Ten strains of F. tulorensis isolated from China were amplified by using typing primers Cl/C4 and RD1. On the basis of the lengths of the polymerase chain reaction （PCR） products, it was concluded that these strains of F. tularensis belonged to the same subspecies. At the same time, thefopA, tul4, and 16S rRNA genes of the I0 strains were amplified, and a three-gene based phylogenetic analysis was performed using the Molecular Evolutionary Genetics Analysis software version 4.0. Results The 10 strains of F. tularensis from China were all identified as belonging to subspecies holarctica （type B）. We found no direct relationship between the genotypes of F. tulurensis subsp. holarctica and the geographical area from where they were isolated. Conclusion The F. tularensis strains isolated from North China mainly belong to subspecies holorctica （type B）. The strains of F. tularensis subsp, holarctico from China may have evolved earlier than those from Europe and North America.

关键词： Francisella tularensis Tularemia Phylogenetic analysis Genotyping, PCR

电子支气管镜下介入冷冻治疗联合全身化疗对晚期肺癌患者生存时间及血清学指标的影响

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中国现代医学杂志 2015年第31期25卷 62-65页

作者：张海容浙江省宁波市北仑区人民医院呼吸内科浙江宁波315800

目的分析电子支气管镜下介入冷冻治疗联合全身化疗对晚期肺癌患者生存时间以及血清学指标的影响。方法选择2011年7月-2012年7月在该院接受住院治疗的晚期肺癌患者86例作为研究对象,按照随机数表法将所有入组患者分为观察组(43例)接受电... 详细信息

目的分析电子支气管镜下介入冷冻治疗联合全身化疗对晚期肺癌患者生存时间以及血清学指标的影响。方法选择2011年7月-2012年7月在该院接受住院治疗的晚期肺癌患者86例作为研究对象,按照随机数表法将所有入组患者分为观察组(43例)接受电子支气管镜下介入冷冻治疗联合全身化疗,对照组(43例)接受单纯全身化疗,比较两组患者的血清肿瘤标记物水平、基质金属蛋白酶(MMP)含量、T细胞亚群水平及生存时间等差异。结果 1观察组患者接受治疗后血清CEA、NSE、CYFRA21-1及CA199等肿瘤标志物水平均明显低于对照组患者(P<0.05);2观察组患者接受治疗后血清MMP-2、MMP-9及CD8+水平低于对照组,CD4+和CD4+/CD8+水平高于对照组(P<0.05);3观察组患者接受治疗后1年生存率高于对照组,平均生存期及中位生存时间明显长于对照组(P<0.05)。结论电子支气管镜下介入冷冻治疗联合全身化疗可以有效降低晚期肺癌患者血清肿瘤指标及血管生成因子水平,提升全身免疫功能及生存时间。

关键词：晚期肺癌电子支气管镜介入冷冻治疗生存时间

Recent Advances in Artificial Sensory Neurons:Biological Fundamentals,Devices,Applications,and Challenges

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Nano-Micro Letters 2025年第3期17卷 168-216页

作者： Shuai Zhong Lirou Su Mingkun Xu Desmond Loke Bin Yu Yishu zhang rong Zhao Guangdong Institute of Intelligence Science and Technology HengqinZhuhai 519031People’s Republic of China College of Integrated Circuits Zhejiang UniversityHangzhou 3112000People’s Republic of China ZJU-Hangzhou Global Scientific and Technological Innovation Center Hangzhou 310027People’s Republic of China Department of Science Mathematics and TechnologySingapore University of Technology and DesignSingapore 487372Singapore Department of Precision Instruments Tsinghua UniversityBeijing 100084People’s Republic of China Center for Brain‑Inspired Computing Research Tsinghua UniversityBeijing 100084People’s Republic of China IDG/McGovern Institute for Brain Research Tsinghua UniversityBeijing 100084People’s Republic of China

Spike-based neural networks,which use spikes or action potentialsto represent information,have gained a lot of attention because of their high energyefficiency and low power *** fully leverage its advantages,convertingthe external analog signals to spikes is an essential *** including analog-to-digital converters or ring oscillators,and sensorssuffer from high power and area *** efforts are devoted to constructingartificial sensory neurons based on emerging devices inspired by the biologicalsensory *** can simultaneously perform sensing and spike conversion,overcoming the deficiencies of traditional sensory *** review summarizesand benchmarks the recent progress of artificial sensory *** starts with thepresentation of various mechanisms of biological signal transduction,followed bythe systematic introduction of the emerging devices employed for artificial ***,the implementations with different perceptual capabilitiesare briefly outlined and the key metrics and potential applications are also ***,we highlight the challenges and perspectives for the future development of artificial sensory neurons.

关键词： Artificial intelligence Emerging devices Artificial sensory neurons Spiking neural networks Neuromorphic sensing

Inhibiting ceramide synthase 5 expression in microglia decreases neuroinflammation after spinal cord injury

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Neural Regeneration Research 2025年第10期20卷 2955-2968页

作者： Wei zhang Yubao Lu Ruoqi Shen Yingjie Wu Chenrui Liu Xingxing Fang Liangming zhang Bin Liu Limin rong Department of Spine Surgery The Third Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina National Medical Products Administration(NMPA)Key Laboratory for Quality Research and Evaluation of Cell Products GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery GuangzhouGuangdong ProvinceChina

Microglia,the resident monocyte of the central nervous system,play a crucial role in the response to spinal cord ***,the precise mechanism remains *** investigate the molecular mechanisms by which microglia regulate the neuroinflammatory response to spinal cord injury,we performed single-cell RNA sequencing dataset analysis,focusing on changes in microglial *** found that the MG1 subpopulation emerged in the acute/subacute phase of spinal cord injury and expressed genes related to cell pyroptosis,sphingomyelin metabolism,and neuroinflammation at high ***,we established a mouse model of contusive injury and performed intrathecal injection of siRNA and molecular inhibitors to validate the role of ceramide synthase 5 in the neuroinflammatory responses and pyroptosis after spinal cord ***,we established a PC12-BV2 cell co-culture system and found that ceramide synthase 5 and pyroptosis-associated proteins were highly expressed to induce the apoptosis of neuron *** ceramide synthase 5 expression in a mouse model of spinal cord injury effectively reduced ***,ceramide synthase 5-induced pyroptosis was dependent on activation of the NLRP3 signaling *** ceramide synthase 5 expression in microglia in vivo reduced neuronal apoptosis and promoted recovery of neurological ***2g7 formed a“bridge”between sphingolipid metabolism and ceramide synthase 5-mediated cell death by inhibiting the NLRP3 signaling ***,these findings suggest that inhibiting ceramide synthase 5 expression in microglia after spinal cord injury effectively suppressed microglial pyroptosis mediated by NLRP3,thereby exerting neuroprotective effects.

关键词： ceramide synthase 5 gasdermin D microglia neuroinflammation NLRP3 nuclear factor kappa B Pla2g7 pyroptosis sphingomyelin metabolism spinal cord injury

SAPT:a synchrotron-based proton therapy facility in Shanghai

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Nuclear Science and Techniques 2023年第10期34卷 36-46页

作者： Man-Zhou zhang De-Ming Li Li-Ren Shen hai-rong zhang Zhi-Ling Chen Han-Wen Du Ming Gu Rui Li De-Kang Liu Yue-Hu Pu Jun-Feng Yu Jian-Feng Chen Chu Chen Chun-Long Guo Hao Guo Ge-Yang Jiang Zhi-Qiang Jiang Lin Jin Wen-Jing Li Xiu-Fang Li Ye Lin Ming Liu Yong-Hao Liu Ya-Juan Liu Ming Lv Qing-Ru Mi Lian-Hua Ouyang Wei-Guo Shi Hang Shu Qi-Sheng Tang Kun Wang Zhi-Shan Wang Jun Wu Xiao-Bing Wu Jia-Qiang Xu Wen-Zhen Xu Chong-Xian Yin Cheng Yu Ren-Xian Yuan Qi-Bing Yuan hai-Qun zhang Miao zhang Wen-Zhi zhang Li-Ying Zhao Wei-Min Zhou Shou-Xian Fang Xi-Dong Sun Zhen-Tang Zhao Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China APACTRON Particle Equipment Co. Ltd.Shanghai 201815China The Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China

Because of its excellent dose distribution,proton therapy is becoming increasingly popular in the medical application of cancer treatment.A synchrotron-based proton therapy facility was designed and constructed in *** synchrotron,beam delivery system,and other technical systems were commissioned and reached their expected *** a clinical trial of 47 patients was finished,the proton therapy facility obtained a registration certificate from the National Medical Products *** characteristics of the accelerator and treatment systems are described in this article.

关键词： Proton therapy Synchrotron Slow extraction Gantry Beam delivery system

膳食干预对肥胖合并非酒精性脂肪性肝病儿童糖脂代谢的影响

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世界华人消化杂志 2017年第24期25卷 2224-2229页

作者：盛俊霞章海华黄荣水杭州市余杭区第二人民医院浙江省杭州市311121

目的观察肥胖合并非酒精性脂肪性肝病(nonalc-oholic fatty liver disease,NAFLD)儿童糖脂代谢的变化及膳食干预对其的影响.方法选择2015-03/2016-12肥胖合并NAFLD儿童97例及健康体检儿童49例,比较2组儿童糖代谢指标[空腹、餐后30 min、... 详细信息

目的观察肥胖合并非酒精性脂肪性肝病(nonalc-oholic fatty liver disease,NAFLD)儿童糖脂代谢的变化及膳食干预对其的影响.方法选择2015-03/2016-12肥胖合并NAFLD儿童97例及健康体检儿童49例,比较2组儿童糖代谢指标[空腹、餐后30 min、1、2 h血糖及胰岛素水平、胰岛素抵抗指数(homeostatic model assessment-insulin resistance,HOMA-IR)、脂代谢指标水平血清胆固醇(cholesterol,TC)、甘油三酯(triglyeride,TG)、低密度脂蛋白胆固醇(low-density lipoprotein,LDL-C)、高密度脂蛋白胆固醇(high-density lipoprotein,HDL-C)、体质量指标(body mass index,BMI)、腰臀比(waist-to-hip ratio,WHR)].患儿组进行膳食干预6 mo,比较干预前后患儿糖、脂代谢指标、体质量指标及肝酶指标(谷丙转氨酶(alanine transaminase,ALT)、谷草转氨酶(aspartate transaminase,AST)水平的变化.结果最终有85例患儿完成了本研究.患儿组脂代谢指标(血清TC、TG、LDL-C水平)、各时间点胰岛素水平及HOMA-IR均明显高于健康对照组(P0.05).结论肥胖合并NAFLD患儿存在明显的糖脂代谢紊乱,膳食干预对其体质量指数、糖脂代谢及肝酶指标均有一定的改善作用.

关键词：膳食干预儿童肥胖非酒精性脂肪性肝病血脂胰岛素抵抗

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空间3-RPC柔顺并联机构拓扑优化设计

组合机床与自动化加工技术 2017年第9期 31-34,39页

作者：杜海堂张荣兴江西理工大学机电工程学院江西赣州341000

为了获得空间柔顺并联机构构型,基于传统并联机构的设计原型,采用拓扑优化理论对空间并联机构进行拓扑优化设计。首先,以空间3-RPC并联机构为研究对象,建立机构的微运动学矢量连续映射Jacobian矩阵。然后,建立空间3-RPC柔顺并联机构的... 详细信息

为了获得空间柔顺并联机构构型,基于传统并联机构的设计原型,采用拓扑优化理论对空间并联机构进行拓扑优化设计。首先,以空间3-RPC并联机构为研究对象,建立机构的微运动学矢量连续映射Jacobian矩阵。然后,建立空间3-RPC柔顺并联机构的拓扑优化SIMP模型,运用优化准则算法(Optimization Criterion)对所建立的SIMP模型求解。最后,运用曲线拟合方法对拓扑后的构型轮廓进行拟合修正,采用Solid Works软件建立其拟合修正后的模型,进而通过Hyper Works有限元软件对机构进行静力学分析。仿真结果表明:与同构型的传统并联机构相比,拓扑优化后的空间柔顺并联机构具有相同的微动特性,因而验证了空间并联机构的拓扑优化设计方法的有效性。

关键词： 3-RPC柔顺并联机构微运动矢量映射拓扑优化设计静力学仿真

复方托品酰胺对不同年龄段低度近视人员验光结果的影响

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国际眼科杂志 2014年第12期14卷 2295-2296页

作者：张海容刁红星陈翔中山大学中山眼科中心中国广东省广州市510060

目的：观察复方托品酰胺滴眼液对不同年龄近视患者的屈光检查、睫状肌麻痹效果的影响，探究睫状肌麻痹对低度近视验光结果的影响，为临床患者合理使用散瞳药物提出指导。方法：分别选取三个年龄段低度近视患者45例，在自然瞳孔状态下... 详细信息

目的：观察复方托品酰胺滴眼液对不同年龄近视患者的屈光检查、睫状肌麻痹效果的影响，探究睫状肌麻痹对低度近视验光结果的影响，为临床患者合理使用散瞳药物提出指导。方法：分别选取三个年龄段低度近视患者45例，在自然瞳孔状态下及散瞳后不同时间点使用“Shin-Nippon”开放式电脑验光仪测量双眼屈光度及调节幅度。结果：各年龄组在使用散瞳剂后在20～60 min区间均出现明显调节幅度下降趋势，但调节幅度的下降与散瞳前后的“Shin-Nippon”开放式电脑验光结果无统计学意义。结论：我们应根据调节幅度随着散瞳后不同时间的变化规律安排好患者的验光窗口，而针对低度近视人群，使用开放式电脑验光仪可以有效减少睫状肌麻痹剂的使用。

关键词：托品酰胺低度近视屈光检查睫状肌麻痹

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珍芪滴眼液熏蒸疗法对干眼的短期疗效

眼科 2016年第5期25卷 347-350页

作者：张海娟黄蓉张俊秀武宇影马科首都医科大学附属北京同仁医院北京同仁眼科中心北京市眼科研究所眼科学与视觉科学北京市重点实验室 100005

目的观察珍芪滴眼液熏蒸疗法对干眼的疗效。设计前瞻性、随机、开放、阳性滴眼液平行对照的临床试验。研究对象 2013-2015年北京同仁医院眼科门诊干眼患者96例,平均年龄(60.95±12.22)岁。方法 96例受试者随机分为试验组与对照组,各48... 详细信息

目的观察珍芪滴眼液熏蒸疗法对干眼的疗效。设计前瞻性、随机、开放、阳性滴眼液平行对照的临床试验。研究对象 2013-2015年北京同仁医院眼科门诊干眼患者96例,平均年龄(60.95±12.22)岁。方法 96例受试者随机分为试验组与对照组,各48例。两组均给予玻璃酸钠滴眼液,每日4次,每次1滴。在此基础上,试验组使用珍芪滴眼液熏蒸疗法,每天1次,每次20分钟。对照组给予珍芪滴眼液点眼,每日4次,每次1滴。观察用药4周受试者干眼症状及体征改善情况。主要指标总有效率(临床显效+有效)、症状总分、Schirmer I试验(schirmer I test,SIt)、泪膜破裂时间(break-up time,BUT)、角膜荧光素染色评分。结果治疗前试验组与对照组在症状总分、SIt、BUT、角膜荧光素染色计分上均无显著性差异。治疗4周试验组总有效率(81.25%)明显高于对照组(62.50%)(P=0.041)。治疗4周时试验组BUT为(7.53±3.78)s,对照组为(6.08±2.99)s,试验组明显高于对照组(P=0.041)。症状总分试验组为1.92±1.99,对照组为2.32±2.30,试验组明显低于对照组(P=0.031)。结论珍芪滴眼液熏蒸疗法能有效治疗干眼,在玻璃酸钠滴眼液的基础上,该疗法优于珍芪滴眼液点眼治疗。

关键词：干眼中药熏蒸按摩