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Carrier Recombination of Organic-Inorganic 3D Halide Perovskite Single Crystals

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Chinese Journal of Chemical Physics 2020年第2期33卷 252-257,I0003,I0004页

作者： Chao He Xia Li Yu-hao Wu hai-lung dai Dong-feng Zhao Yang Chen Hefei National Laboratory For Physical Sciences at the Microscale and Department of Chemical Physics University of Science and Technology of ChinaHefei 230026China Department of Chemistry Temple UniversityPhiladelphia 19122PennsylvaniaUnited States of America

Organic-inorganic 3D halide perovskite materials recently have become one of the major players of hybrid semiconductors for photovoltaic and optoelectronic *** diffusion length of charge carriers is one of the critical parameters for justifying photovoltaic applications of *** this work,we propose a realistic kinetic model in order to fully understand carrier relaxation rate of photoexcited organic perovskites with a negligible exciton formation in photoluminescence lifetime *** find that the extraction of carrier relaxation rate has to be made from multiple fluence-dependent photoluminescence lifetime measurements with global fittings,instead of a traditional single fluence lifetime *** demonstrate the validity of the model,two kinds of p-doped CH3NH3PbI3 single crystals were grown up by intentionally increasing *** fittings of the kinetic model to the two kinds of single crystals yield doping density,trap density,and recombination *** methodology provides a self-contained approach to determine diffusion lengths of organic 3D halide perovskite materials.

关键词： Perovskite CH3NH3PbI3 single crystal Photoluminescence lifetime Diffusion length

Study on the optimal incident proton energy of ^(7)Li(p,n)^(7)Be neutron source for boron neutron capture therapy

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Nuclear Science and Techniques 2024年第3期35卷 170-180页

作者： Yi-Nan Zhu Zuo-Kang Lin hai-Yan Yu Ye dai Zhi-Min dai Xiao-Han Yu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Science Beijing 100049China

Boron neutron capture therapy(BNCT)is recognized as a precise binary targeted radiotherapy technique that effectively eliminates tumors through the^(10)B(n,α)^(7)Li nuclear *** various neutron sources,accelerator-based sources have emerged as particularly promising for BNCT ***^(7)Li(p,n)^(7)Be reaction is highly regarded as a potential neutron source for BNCT,owing to its low threshold energy for the reaction,significant neutron yield,appropriate average neutron energy,and additional *** study utilized Monte Carlo simulations to model the physical interactions within a lithium target subjected to proton bombardment,including neutron moderation by an MgF_(2)moderator and subsequent BNCT dose analysis using a Snyder head *** study focused on calculating the yields of epithermal neutrons for various incident proton energies,finding an optimal energy at 2.7 ***,the Snyder head phantom was employed in dose simulations to validate the effectiveness of this specific incident energy when utilizing a^(7)Li(p,n)^(7)Be neutron source for BNCT purposes.

关键词： Boron neutron capture therapy ^(7)Li(p,n)7Be neutron source Incident proton energy Monte Carlo simulation

Defect detection and repair algorithm for structures generated by topology optimization based on 3D hierarchical fully convolutional network

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Biomimetic Intelligence & Robotics 2024年第2期4卷 24-31页

作者： Zhiyu Wan hai Lan Sichao Lin Houde dai School of Advanced Manufacturing Fuzhou UniversityJinjiang 362251China Quanzhou Institute of Equipment Manufacturing Haixi InstitutesChinese Academy of SciencesJinjiang 362216China Fujian Key Laboratory of Special Intelligent Equipment Safety Measurement and Control Fujian Special Equipment Inspection and Research InstituteFuzhou 350008China

Customized 3D-printed structural parts are widely used in surgical *** satisfy the mechanical properties and kinematic functions of these structural parts,a topology optimization technique is adopted to obtain the optimal structural layout while meeting the constraints and ***,topology optimization currently faces some practical challenges that must be addressed,such as ensuring that structures do not have significant defects when converted to additive manufacturing *** address this problem,we designed a 3D hierarchical fully convolutional network(FCN)to predict the precise position of the defective *** on the prediction results,an effective repair strategy is adopted to repair the defective structure.A series of experiments is conducted to demonstrate the effectiveness of our *** to the 2D fully convolutional network and the rule-based detection method,our approach can accurately capture most defect structures and achieve 89.88%precision and 95.59%***,we investigate the impact of different ways to increase the receptive field of our model,as well as the trade-off between different defect-repairing *** results of the experiment demonstrate that the hierarchical structure,which increases the receptive field,can substantially improve the defect detection *** the best of our knowledge,this paper is the first to investigate 3D defect prediction and repair for topology optimization in conjunction with deep learning algorithms,providing practical tools and new perspectives for the subsequent development of topology optimization techniques.

关键词： Topology optimization Additive manufacturing Deep learning 3D semantic segmentation Defect detection

Consensus on glycemic management for patients with coronary heart disease and type 2 diabetes

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Journal of Geriatric Cardiology 2024年第7期21卷 689-702页

作者： Li-Nong JI Yun-dai CHEN Jing LIU Xiang-hai ZHOU Cardiovascular Subcommittee of Chinese International Exchange and Promotion Association for Medical and Healthcare Peking University People's Hospital Chinese PLA General Hospital

The prevalence of patients with coronary heart disease(CHD)and diabetes mellitus is notably high,posing sig-nificant residual cardiovascular risks even after routine interventions such as antihypertensive,lipid-lowering,and antithrombot-ic *** studies have demonstrated that certain glucose-lowering medications confer cardiovascular benefits for pa-tients with type 2 ***,a survey indicates that cardiologists may not be fully acquainted with the optimal screen-ing timing,indicators,and diagnostic criteria for type 2 diabetes,and there is insufficient awareness and a low rate of prescrip-tion of novel glucose-lowering medications with proven cardiovascular efficacy,such as glucagon-like peptide-1 receptor agon-ists(GLP-1 RAs)and sodium-glucose co-transporter-2 inhibitors(SGLT-2i).In this context,based on domestic and international guidelines or consensus and the latest evidence-based evidence,this consensus aims to standardize the glycemic management for patients with acute coronary syndrome,chronic coronary syndrome,and perioperative management for percutaneous coronary *** highlights the key points of screening and diagnosis of type 2 diabetes,and the comprehensive management of cardiovascular risk in patients with *** consensus elaborates on the principles and algorithms of glycemic management for CHD patients,without involving acute complications of diabetes,clarifies the clinical practice of glucose-lowering medications with cardiovascular benefits,and promotes the standardized use of these medications in cardiovascular and other related spe-cialty ***,it addresses the glucose-lowering treatment to comprehensively reduce cardiovascular risks.

关键词： coronary patients routine

Species profile and reactivity of volatile organic compounds emission in solvent uses,industry activities and from vehicular tunnels

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Journal of Environmental Sciences 2024年第1期135卷 546-559页

作者： haimei Huang Zhangwei Wang Chunhao dai hai Wu Jia Guo Chunjie Wang Xiaoshan Zhang State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China Hunan Agricultural University Changsha 430106China National Institute of Metrology Beijing 100029China

A survey was conducted of the volatile organic compounds(VOCs)released from sources of solvent use,industry activities and vehicle emissions in Guiyang,a capital city of *** were collected by canisters and analyzed by *** species profiles of VOCs emitted from sources were *** showed that xylenes,ethylbenzene,acetone and dichloromethane were the characteristics species for painting,2-propanol and ethyl acetate for printing,α-pinene for solid wood furniture manufacturing,and 2-butanone for biscuit *** characteristics species could be as tracers for the sources *** most of samples from the solvent use,the benzene/toluene(B/T)ratio was less than 0.3,indicating that the ratio could be as the indicator for tracing the solvent use related *** results also suggested that the toluene/xylene(T/X)ratio be as the indicator to distinguish the VOCs sources of painting(2).Aromatics contributed the most to ozone formation potential(OFP)of most painting and non-paper printing sources,and oxygen-containing VOCs(OVOCs)were major species contributing to OFP of the sources from food production and paper *** OFP of the VOCs emissions from vehicle in tunnels and from other manufactures were dominated by both aromatics and ***α-pinene could explain 56.94%and 32.54%of total OFP of the VOCs sources from filing cabinet and solid wood furniture manufacturing,which was rarely been involved in previous studies of VOCs source profiles,indicating that the species of concern for VOCs sources are still insufficient at present.

关键词： Volatile organic compounds(VOCs) Species profile BTEX ratio Source reactivity

Fangji Fuling Decoction Alleviates Sepsis by Blocking MAPK14/FOXO3A Signaling Pathway

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Chinese Journal of Integrative Medicine 2024年第3期30卷 230-242页

作者： WANG Yi CHEN Ming-qi dai Lin-feng ZHANG hai-dong WANG Xing Department of Critical Care Medicine Changzhou Hospital of Traditional of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineChangzhouJiangsu Province213000China Department of Critical Care Medicine Jiangsu Province Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese MedicineNanjing210029China

Objective:To examine the therapeutic effect of Fangji Fuling Decoction(FFD) on sepsis through network pharmacological analysis combined with in vitro and in vivo ***:A sepsis mouse model was constructed through intraperitoneal injection of 20 mg/kg lipopolysaccharide(LPS).RAW264.7 cells were stimulated by 250 ng/m L LPS to establish an in vitro cell *** pharmacology analysis identified the key molecular pathway associated with FFD in *** ectopic expression and depletion experiments,the effect of FFD on multiple organ damage in septic mice,as well as on cell proliferation and apoptosis in relation to the mitogen-activated protein kinase 14/Forkhead Box O 3A(MAPK14/FOXO3A) signaling pathway,was ***:FFD reduced organ damage and inflammation in LPS-induced septic mice and suppressed LPS-induced macrophage apoptosis and inflammation in vitro(Plung tissue of septic mice(P<0.05).Conclusion:FFD could ameliorate the LPS-induced inflammatory response in septic mice by inhibiting the MAPK14/FOXO3A signaling pathway.

关键词： sepsis Fangji Fuling Decoction mitogen-activated protein kinase 14/Forkhead Box O 3A signaling pathway inflammatory response apoptosis lung injury Chinese medicine

Redox responsive polymeric nanoparticles enhance the efficacy of cyclin dependent kinase 7 inhibitor for enhanced treatment of prostate cancer

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Chinese Chemical Letters 2024年第8期35卷 443-448页

作者： Yiran Tao Chunlei dai Zhaoxiang Xie Xinru You Kaiwen Li Jun Wu hai Huang Department of Urology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China Department of Urology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510120China Biomedical Innovation Center The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510120China School of Biomedical Engineering Sun Yat-sen UniversityShenzhen 518107China Center for Nanomedicine and Department of Anesthesiology Brigham and Women’s HospitalHarvard Medical SchoolBostonMA 02115United States Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat-sen Memorial HospitalSun Yat-Sen UniversityGuangzhou 510120China Department of Urology The Sixth Affiliated Hospital of Guangzhou Medical UniversityQingyuan People’s HospitalQingyuan 511518China Bioscience and Biomedical Engineering Thrust The Hong Kong University of Science and Technology(Guangzhou)Guangzhou 511400China Division of Life Science The Hong Kong University of Science and TechnologyHong KongChina Guangdong Provincial Clinical Research Center for Urological Diseases Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhou 510120China

Traditional therapies such as surgery and endocrine therapy no longer meet the clinical needs in prostate cancer treatment,and more effective treatments are urgently *** studies have reported that targeted inhibition of the transcription factor cyclin dependent kinase 7(CDK7)could effectively suppress prostate cancer ***,the toxicity of CDK7 inhibitors such as THZ1 is the main limitation of the clinical *** this work,we synthesized Cys8E(C8E)nanoparticles(NPs)loaded with THZ1(C8E@THZ1),a novel GSH-targeting and stimuli-responsive nano-delivery platform,and investigated its anti-tumor potential and biosafety *** vitro,C8E@THZ1 potently inhibited the proliferation and promoted the apoptosis of prostate cancer *** tumor-bearing mice,C8E@THZ1 inhibited tumors by up to 85%,while the damage of THZ1 to liver function was effectively *** results confirmed that inhibition of CDK7 can effectively block the progression of prostate cancer,and that Cys8E NPs is a highly prospective delivery platform to promote the clinical application of CDK7 inhibitors.

关键词： Prostate cancer Nanoparticles CDK7 THZ1 THZ1@Cys8E NPs

Air-Ground Collaborative Mobile Edge Computing:Architecture,Challenges,and Opportunities

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China Communications 2024年第5期21卷 1-16页

作者： Qin Zhen He Shoushuai Wang hai Qu Yuben dai haipeng Xiong Fei Wei Zhenhua Li hailong College of Communications Engineering Army Engineering University of PLANanjing 210000China Department of Information and Communication Noncommissioned Officer Academy of PAPHangzhou 310000China Key Laboratory of Dynamic Cognitive System of Electromagnetic Spectrum Space Ministry of Industry and Information TechnologyNanjing 211106China College of Electronic and Information Engineering Nanjing University of Aeronautics and AstronauticsNanjing 211106China State Key Laboratory for Novel Software Technology Nanjing UniversityNanjing 210023China CMC Political and Law Commission Beijing100120China Xi’an Research Institute of High Technology Xi’an 710025China

By pushing computation,cache,and network control to the edge,mobile edge computing(MEC)is expected to play a leading role in fifth generation(5G)and future sixth generation(6G).Nevertheless,facing ubiquitous fast-growing computational demands,it is impossible for a single MEC paradigm to effectively support high-quality intelligent services at end user equipments(UEs).To address this issue,we propose an air-ground collaborative MEC(AGCMEC)architecture in this *** proposed AGCMEC integrates all potentially available MEC servers within air and ground in the envisioned 6G,by a variety of collaborative ways to provide computation services at their best for ***,we introduce the AGC-MEC architecture and elaborate three typical use ***,we discuss four main challenges in the AGC-MEC as well as their potential ***,we conduct a case study of collaborative service placement for AGC-MEC to validate the effectiveness of the proposed collaborative service placement ***,we highlight several potential research directions of the AGC-MEC.

关键词： air-ground architecture collaborative mobile edge computing

Preoperatively predicting vessels encapsulating tumor clusters in hepatocellular carcinoma:Machine learning model based on contrast-enhanced computed tomography

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 857-874页

作者： Chao Zhang hai Zhong Fang Zhao Zhen-Yu Ma Zheng-Jun dai Guo-Dong Pang Department of Radiology The Second Hospital of Shandong UniversityJinan 250033Shandong ProvinceChina Department of Radiology Qilu Hospital of Shandong UniversityJinan 250014Shandong ProvinceChina Department of Radiology Linglong Yingcheng HospitalYantai 265499Shandong ProvinceChina Department of Scientific Research Huiying Medical Technology Co.LtdBeijing 100192China

BACKGROUND Recently,vessels encapsulating tumor clusters(VETC)was considered as a distinct pattern of tumor vascularization which can primarily facilitate the entry of the whole tumor cluster into the bloodstream in an invasion independent manner,and was regarded as an independent risk factor for poor prognosis in hepatocellular carcinoma(HCC).AIM To develop and validate a preoperative nomogram using contrast-enhanced computed tomography(CECT)to predict the presence of VETC+in *** We retrospectively evaluated 190 patients with pathologically confirmed HCC who underwent CECT scanning and immunochemical staining for cluster of differentiation 34 at two medical *** analysis was conducted on intratumoral and peritumoral regions in the portal vein *** features,essential for identifying VETC+HCC,were extracted and utilized to develop a radiomics model using machine learning algorithms in the training *** model’s performance was validated on two separate test *** operating characteristic(ROC)analysis was employed to compare the identified performance of three models in predicting the VETC status of HCC on both training and test *** most predictive model was then used to constructed a radiomics nomogram that integrated the independent clinical-radiological *** and decision curve analysis were used to assess the performance characteristics of the clinical-radiological features,the radiomics features and the radiomics *** The study included 190 individuals from two independent centers,with the majority being male(81%)and a median age of 57 years(interquartile range:51-66).The area under the curve(AUC)for the combined radiomics features selected from the intratumoral and peritumoral areas were 0.825,0.788,and 0.680 in the training set and the two test sets.A total of 13 features were selected to construct the *** nomogram,combining clinicalradiological and combined radiomics features could acc

关键词： Hepatocellular carcinoma Vessels encapsulating tumor clusters Intratumoral and peritumoral regions Radiomics features Nomog