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Analysis of Crack Tip Stress of Transversal Crack on Slab Corner During Vertical-Horizontal Rolling Process by FEM

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Journal of Iron and Steel Research International 2008年第3期15卷 19-26页

作者： YU hai-liang liu Xiang-hua WANG Guo-dong The State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

Behavior of transversal crack notched on slab corner during vertical-horizontal rolling process was simulated by FEM. The crack tip stress in the whole rolling process was obtained. Influences of the friction coefficient, the initial crack size, the edger roll profile, and the groove fillet radii of grooved edger roll on crack tip stress were analyzed. For vertical rolling, the tension stress appears at crack tip near the slab top surface and the compression stress appears at crack tip near the slab side surface for the flat edger roll; however, the compression stress appears at crack tip near the slab top surface and the tension stress appears at crack tip near the slab side surface in the exit stage for the grooved edger roll. For horizontal rolling, the tension stress appears at crack tip just at the exit stage for the flat edger roll, and the tension stress appears in whole rolling stage; the tension stress value near the slab side surface is much larger than that near the slab top surface for the grooved edger roll.

关键词： transversal crack vertical-horizontal rolling process crack tip stress FEM

Influence of Dog-Bone Apex on Shape During Slab Horizontal Rolling Process

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Journal of Iron and Steel Research International 2007年第3期14卷 37-41页

作者： YU hai-liang liu Xiang-hua LI Chang-sheng WANG Guo-dong State Key Laboratory of Rolling and Automation Northeastern University Shenyang 110004 Liaoning China

The deformation of slab with dog-bone shape during the horizontal rolling process was simulated using FEM, and the influences of apical dislocation of dog-bone on the slab spread as well as the minimum crop end loss and the lost width at slab head and tail were analyzed. The results show that with the increase in the apical dislocation of dog-bone （LA）, the slab spread and the minimum crop end loss at slab head and tail decrease, while the lost width at slab head and tail increases. Meanwhile, the relationships of S/LA-LA, LH/LA-LA, WH/LA-LA, L T/LA- LA, and W T/LA-LA were obtained.

关键词： dog-bone apical dislocation horizontal rolling FEM

Influence of Edge Rolling Reduction on Plate-Edge Stress Distribution During Finish Rolling

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Journal of Iron and Steel Research International 2009年第1期16卷 22-26页

作者： YU hai-liang liu Xiang-hua CHEN Li-qing LI Chang-sheng ZHI Ying LI Xin-wen The State Key Laboratory of Roiling and Automation Northeastern University Shenyang 110004 Liaoning China

Dimensions of one kind of stainless steel plate before finish rolling were obtained through analysis of the rough rolling processes by finite element method and updated geometrical method. The FE models of finish rolling process with a front edge roll were built, and influences of the edge rolling reduction on the stress change in the plate edge during finish rolling were analyzed. The results show that when the edge rolling reduction is increased from 0 mm to 2 mm, the compressive stress in plate corner clearly increases in edge rolling process, and the zone of tensile stress during whole rolling decreases; when the edge rolling reduction is increased from 2 mm to 5 ram, the compressive stress in the plate corner seldom changes, and the compressive stress decreases after the horizontal rolling.

关键词： edge rolling reduction stress FEM finish rolling

Effect of Bcl-2 and Bax on survival of side population cells from hepatocellular carcinoma cells

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World Journal of Gastroenterology 2007年第45期13卷 6053-6059页

作者： Jing Fan Ren Li Rui Zhang hai-liang liu Ning Zhang Fu-Qing Zhang Ke-Feng Dou Department of Hepatobiliary Surgery Xijing Hospital the Fourth Military Medical University Xi'an 710032 Shaanxi Province China Department of Biochemistry and Molecular Biology the Fourth Military Medical University Xi'an 710032 Shaanxi Province China

AIM： To understand the role and significance of side population （SP） cells from hepatocellular carcinoma （HCC） in hepatocarcinogenesis, development, relapse and metastasis, we simulated the denutrition conditions that cancer cells experience in clinical therapy, observed the different anti-apoptosis ability of SP cells and non-SP cells under such conditions, and established the possible effects of P53, Bcl-2 and Bax on survival of SP cells. METHODS： We used flow cytometry to analyze and sort the SP and non-SP cells in established HCC lines MHCC97 and hHCC. We evaluated cell proliferation by methyl thiazolyl tetrazolium （MTT） assay and investigated the expression of p53, bcl-2 and bax genes during denutrition, by RT-PCR and immunofluorescence staining. RESULTS： The percentage of SP cells in the two established HCC lines was 0.25% and 0.5%, respectively. SP cells had greater anti-apoptosis and proliferation ability than non-SP cells. Expression of Bcl-2 and Bax in SP and non-SP cells differed during denutrition. The former was up-regulated in SP cells, and the latter was up-regulated in non-SP cells. CONCLUSION： It may be that different upstream molecules acted and led to different expression levels of Bcl-2 and Bax in these two cell lines. There was a direct relationship between up-regulation of Bcl-2 and down-regulation of Bax and higher anti-apoptosis ability in SP cells. It may be that the existence and activity of SP cells are partly responsible for some of the clinical phenomena which are seen in HCC, such as relapse or metastasis. Further research on SP cells may have potential applications in the field of anticancer therapy.

关键词： Side population Hepatocellular carcinoma Bax Bcl-2 Apoptosis

SND67, a novel sinomenine derivative, ameliorates collagen-induced arthritis in mice through suppressing inflammatory macrophage polarization and Th1-Th17 responses via blocking the interaction of TRAF6 and IRF-5

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SND67, a novel sinomenine derivative, ameliorates collagen-i...

第八届全国免疫学学术大会

作者： hai-liang liu Xu-Dong Wu Xue-Feng Wu Yang Sun Qiang Xu State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University

Aims:Macrophages can be phenotypically polarized to mount specific functional programs, which play an indispensable role in Rheumatoid *** objectives were to investigate whether a novel Sinomenine derivative, SND67, exerts anti-arthritis activity by regulating macrophage ***:Collagen-induced arthritis(CIA) was induced in DBA/1 mice, and SND67 was intraperitoneally injected at 10 and 30 mg/***:SND67 inhibited paw swelling, protected against cartilage and bone erosion, reduced cellular infiltration and cytokine production in CIA ***67 suppressed CD11 c expression, reduced the levels of TNF-α and increased IL-10 in M1 *** addition, SND67 decreased the proliferation of T lymphocytes and Th1-Th17 ***, SND67 disrupted LPS-induced interaction of IRF-5 with TRAF6 and suppressed the nuclear translocation of ***:SND67 exhibits anti-inflammatory properties through suppressing M1 macrophage polarization and Th1-Th17 responses via blocking the interaction of TRAF6 and *** macrophage polarization by SND67 may provide a potential therapeutic strategy for the treatment of Rheumatoid arthritis.

关键词： Rheumatoid arthritis macrophage polarization Sinomenine

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聚间苯二甲酰间苯二胺中空纤维膜研究

高分子学报 2016年第4期26卷 428-435页

作者：陈明星肖长发王纯刘海亮天津工业大学材料科学与工程学院省部共建分离膜与膜过程国家重点实验室天津300387

以聚间苯二甲酰间苯二胺(PMIA)为成膜聚合物,N,N-二甲基乙酰胺(DMAc)为溶剂,氯化钙(Ca Cl2)、氯化锂(Li Cl)和聚乙二醇(PEG)为添加剂,调制铸膜液,采用干—湿法纺丝技术制备了PMIA中空纤维膜.研究表明,PEG的加入可显著提高PMIA中空纤维... 详细信息

以聚间苯二甲酰间苯二胺(PMIA)为成膜聚合物,N,N-二甲基乙酰胺(DMAc)为溶剂,氯化钙(Ca Cl2)、氯化锂(Li Cl)和聚乙二醇(PEG)为添加剂,调制铸膜液,采用干—湿法纺丝技术制备了PMIA中空纤维膜.研究表明,PEG的加入可显著提高PMIA中空纤维膜的纯水通量,而随PEG添加量增加,膜的纯水通量呈现先增加后减小趋势;膜对牛血清蛋白(BSA)有较好的截留性能,截留率可达92%;膜具有良好的亲水性能,膜对纯水接触角可低至44°;膜的断裂强度达5.8 MPa,具有较好的力学性能,以及良好的耐热水和耐碱性能,可用于高温和碱性水处理等领域.

关键词：聚间苯二甲酰间苯二胺中空纤维膜聚乙二醇耐高温性能耐碱性能

NiMo催化剂载体中纳米HY分子筛和氧化铝混合方式对柴油加氢脱硫性能的影响（英文）

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燃料化学学报 2018年第8期46卷 950-956页

作者：尹海亮刘新亮周同娜蔺爱国中国石油大学(华东)科学技术研究院山东东营257061 东营市环境保护局山东东营257300

以纳米HY分子筛-氧化铝混合物为载体,根据两者混合方式的不同(溶胶凝胶法和机械混合法)制备了两种NiMo加氢脱硫催化剂,并对其进行了XRD、BET、TPD、H2-TPR、HRTEM和FT-IR等表征。与溶胶凝胶法催化剂相比,机械混合法催化剂表现出了较好... 详细信息

以纳米HY分子筛-氧化铝混合物为载体,根据两者混合方式的不同(溶胶凝胶法和机械混合法)制备了两种NiMo加氢脱硫催化剂,并对其进行了XRD、BET、TPD、H2-TPR、HRTEM和FT-IR等表征。与溶胶凝胶法催化剂相比,机械混合法催化剂表现出了较好的纹理结构和更高酸量,其金属相更易还原,边角位Mo原子的分散度更高,表现出了更高的加氢脱硫性能。但溶胶凝胶法催化剂的type-Ⅱ Ni-Mo-S活性相前驱物比例更高,Mo S2晶片长度更大,堆垛程度更高,活性组分分散度较差。虽然溶胶凝胶法有利于提高type-Ⅱ Ni-Mo-S活性相前驱物比例,但是该方法导致的较差孔结构抑制了这种优势,并且降低了活性组分分散度,减弱了催化活性。

关键词：纳米分子筛加氢脱硫混合方式

Potential dependence in electrocatalysis: a theoretical perspective

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Science China Chemistry 2025年第1期 21-25页

作者： Leyu liu Zhaoming Xia Zeyu Wang Yinjuan Chen hai Xiao Department of Chemistry Tsinghua University Fundamental Science Center of Rare Earths Ganjiang Innovation Academy Chinese Academy of Sciences Key Laboratory of Advanced Catalytic Materials and Technology Advanced Catalysis and Green Manufacturing Collaborative Innovation Center Changzhou University

Electrocatalysis is a key technology for the new energy era and sustainable development, serving as the interface for interconversion of electrical and chemical energies, which spans a wide spectrum of applications in sustainable energy and environmental engineering. Electrocatalytic reactions including electrochemical CO2reduction reaction （eCO2RR）, hydrogen evolution reaction （HER）, and oxygen evolution/reduction reactions （OER/ORR）, hold essential promise for renewable energy technologies as well as complement the biogeochemical carbon and oxygen cycles.

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无机粒子杂化FEP微孔膜结构与性能研究

高分子学报 2015年第9期25卷 1078-1084页

作者：张海芬黄庆林肖长发刘海亮陈凯凯王纯天津工业大学纺织学院分离膜与膜过程省部共建国家重点实验室材料科学与工程学院天津300387

以聚全氟乙丙烯(FEP)为成膜聚合物,复合无机粒子(由微纳米级Si O2、Na Cl及界面处理剂等构成)为成孔剂,邻苯二甲酸二辛酯(DOP)为增塑剂,用热压法制得了具有界面孔结构特征的均质FEP/无机粒子杂化平板膜.研究了复合无机粒子含量对FEP平... 详细信息

以聚全氟乙丙烯(FEP)为成膜聚合物,复合无机粒子(由微纳米级Si O2、Na Cl及界面处理剂等构成)为成孔剂,邻苯二甲酸二辛酯(DOP)为增塑剂,用热压法制得了具有界面孔结构特征的均质FEP/无机粒子杂化平板膜.研究了复合无机粒子含量对FEP平板膜结构与性能的影响,并对其渗透性能,截留率,孔隙率及机械性能进行测试表征.结果表明,FEP杂化膜表层无机粒子分布较少,大部分都被基质相包裹.由于FEP的低表面能,FEP易与无机粒子发生界面相分离,水溶性无机粒子经溶解后形成微孔结构.随无机粒子含量增加,膜孔数量增加,孔隙率和渗透性能明显提高,而碳素墨水截留率有所降低,力学性能呈先增大后减小的趋势.

关键词：聚全氟乙丙烯无机粒子杂化平板膜微滤