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On the stability of the three classes of Newtonian three-body planar periodic orbits

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Science China(Physics,Mechanics & Astronomy) 2014年第11期57卷 2121-2126页

作者： li XiaoMing liao ShiJun School of Naval Architecture Ocean and Civil EngineeringShanghai Jiao Tong University Ministry-of-Education Key Laboratory in Scientific Computing Nonlinear Analysis and Applied Mathematics Research Group (NAAM) King Abdulaziz University (KAU)JeddahSaudi Arabia

Currently,the fifteen new periodic orbits of Newtonian three-body problem with equal mass were found by Suvakov and Dmitra sinovi[Phys Rev Lett,2013,110:114301]using the gradient descent method with double *** this paper,these reported orbits are checked stringently by means of a reliable numerical approach(namely the"Clean Numerical Simulation",CNS),which is based on the arbitrary-order Taylor series method and data in arbitrary-digit precision with a procedure of solution *** is found that seven among these fifteen orbits greatly depart from the periodic ones within a long enough interval of time,and are thus most possibly unstable at *** is suggested to carefully check whether or not these seven unstable orbits are the so-called"computational periodicity"mentioned by Lorenz in *** work also illustrates the validity and great potential of the CNS for chaotic dynamic systems.

关键词： unstable Newtonian verification chaotic digit carefully periodicity Clean enough arbitrary

The role of circadian clocks in cancer:Mechanisms and clinical implications

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Genes & Diseases 2023年第4期10卷 1279-1290页

作者： Huiwen liu Ying liu Rihan hai Weihua liao Xiangjian Luo Key Laboratory of Carcinogenesis and Invasion Chinese Ministry of EducationDepartment of RadiologyXiangya HospitalCentral South UniversityChangshaHunan 410078China Cancer Research Institute School of Basic MedicineCentral South UniversityChangshaHunan 410078China Department of Medicine Hunan Traditional Chinese Medical CollegeZhuzhouHunan 412000China Molecular Imaging Research Center of Central South University ChangshaHunan 410078China Hunan Key Laboratory of Oncotarget Gene Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangshaHunan 410078China National Clinical Research Center for Geriatric Disorders Xiangya HospitalCentral South UniversityChangshaHunan 410078China

Circadian rhythm refers to the inherent 24-h cycle oscillation of biochemical,phys-iological and behavioral functions,which is almost universal in *** least 14 core clock genes have been reported to form multiple chain feedback loops that confer intrinsic circadian rhythmicity onto the molecular *** evidence has shown that the circadian gene dysfunction resulted from single nucleotide polymorphisms(SNPs),deletions,epigenetic modification,and deregulation is strongly associated with cancer *** the pre-sent review,we describe the composition of circadian rhythm *** highlight the func-tion and mechanism of clock genes in cancer pathogenesis and ***,their potential clinical implications as prognostic biomarkers and therapeutic targets have been ad-dressed.

关键词： Cancer Cancer metabolism Circadian clock Circadian rhythm Chronotherapy Tumor microenvironment

采用端口阻抗测试的车载充电机传导电磁干扰建模方法研究

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西安交通大学学报 2025年第1期59卷 172-182页

作者：李季风耿宇宇贾晋廖兴林路青洋重庆理工大学电气与电子工程学院重庆400054 重庆理工大学汽车零部件先进制造技术教育部重点实验室重庆400054

针对电动汽车车载充电机的设计过程中普遍存在的电磁干扰频率范围广、干扰源复杂的问题,提出了一种基于端口阻抗测试的等效电路建模和系统级协同仿真方法。首先,通过对车载充电机系统各部件进行阻抗测试和三维电磁仿真,建立了无源器件... 详细信息

针对电动汽车车载充电机的设计过程中普遍存在的电磁干扰频率范围广、干扰源复杂的问题,提出了一种基于端口阻抗测试的等效电路建模和系统级协同仿真方法。首先,通过对车载充电机系统各部件进行阻抗测试和三维电磁仿真,建立了无源器件、端口滤波器和高压屏蔽线缆模型,提取了系统印制电路板关键回路的高频寄生参数。其次,建立了有源器件的仿真电路模拟器等效模型,并通过双脉冲实验验证模型的精度;针对功率因数校正电路控制环节的仿真与建模难以同步实现的问题,采用协同建模的方法构建整个系统的等效电路模型。最后,将各部件模型组合在一起,建立了完整的车载充电机系统传导电磁干扰预测模型,并依据相关测试标准进行了系统传导电磁干扰仿真和实验。结果表明:在150 kHz~30 MHz频率范围内,预测结果与实际结果的误差小于9 dB,具有良好的一致性,表明该模型能够精确预测车载充电机系统高压交流端的传导干扰水平,可以有效指导充电机系统的电磁兼容正向设计。

关键词：车载充电机电磁干扰端口阻抗测试协同仿真

Crosstalk between glioblastoma and tumor microenvironment drives proneural–mesenchymal transition through ligand-receptor interactions

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Genes & Diseases 2024年第2期11卷 874-889页

作者： Yancheng Lai Xiaole Lu Yankai liao Pei Ouyang hai Wang Xian Zhang Guanglong Huang Songtao Qi Yaomin li Department of Neurosurgery Institute of Brain DiseaseNanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China Laboratory for Precision Neurosurgery Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong 510515China

Glioblastoma(GBM)is the most common intrinsic and aggressive primary brain tumor in adults,with a median survival of approximately 15 *** heterogeneity is considered responsible for the treatment resistance and unfavorable ***-mesenchymal transition(PMT)represents GBM malignant progression and recurrence,which might be a breakthrough to understand GBM heterogeneity and overcome treatment *** is a complicated process influenced by crosstalk between GBM and tumor microenvironment,depending on intricate ligand-receptor *** this review,we summarize the autocrine and paracrine pathways in the GBM microenvironment and related ligand-receptor interactions inducing *** also discuss the current therapies targeting the PMT-related autocrine and paracrine ***,this review offers a comprehensive understanding of the failure of GBM-targeted therapy and ideas for future tendencies of GBM treatment.

关键词： Autocrine Glioblastoma ligand-receptor interaction Microenvironment Paracrine Proneural-mesenchymal transition

Programmed DNA walkers for biosensors

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Chinese Chemical Letters 2024年第9期35卷 119-129页

作者： Chang liu Tao Wu lijiao Deng Xuzi li Xin Fu Shuzhen liao Wenjie Ma Guoqiang Zou hai Yang School of Chemistry and Chemical Engineering Hunan Institute of EngineeringXiangtan 411104China College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China

Nowadays,due to excellent biological and polymeric characteristics,DNA has been widely noted as an emerging building block to construct diverse materials for biosensing,in vivo imaging,drug delivery,and disease ***,relying on programmability,predictability,and stability of DNA,DNA walkers have opened new and exciting opportunities in modern life sciences for target detection and biological analysis,which are constructed by self-assembly of DNA or combining DNA with other nanomaterials(e.g.,quantum dots,gold nanoparticles,magnetic nanoparticles,polymers).Compared with conventional nanomaterials(lanthanide-doped upconversion nanoparticles,magnetic nanomaterials,carbon dots,silicon dots,and so on),DNA walkers showed convenient modification,lower biotoxicity,excellent biocompatibility and high biostability,improving the biological ***,with high-speed operating efficiency and sustainable operation,DNA walkers powered by strand displacement reaction or protein enzyme/DNAzyme reaction,have highly sensitive detection and signal amplification abilities,which are applied in biosensing,material assembly and synthesis,and early cancer ***,DNA walkers could be regarded as signal amplifiers,which enhanced the signal transduction and amplified biosensor sensing ***,we systematically and comprehensively summarized the operating principles of various DNA walkers,categorized rational design of the DNA walker,and outlined the application of DNA walker in ***,the challenges and future trends of DNA walkers were discussed.

关键词： DNA walker Biosensors Signal amplification strategies Operating principles Design strategies

Spatial-temporal variability of throughfall in a subtropical deciduous forest from the hilly regions of eastern China

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Journal of Mountain Science 2019年第8期16卷 1788-1801页

作者： ZHANG hai-xia WU Hua-wu li Jing HE Bin liU Jiu-fu WANG Niu DUAN Wei-li liao Ai-min Key Laboratory of Watershed Geographic Sciences Nanjing Institute of Geography and LimnologyChinese Academy of SciencesNanjing 210008China University of Chinese Academy of Sciences Beijing 100049China Chuzhou Hydrology Laboratory Nanjing Hydraulic Research InstitutesNanjing 210029China Tourism School Jiujiang CollegeJiujiang 332005China State Key Laboratory of Desert and Oasis Ecology Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China

Throughfall variability plays a crucial role in regulating hydrological and biogeochemical processes in forest ecosystems. However, throughfall variability and its potential influencing factors remain unclear in the subtropical deciduous forest because of its complex canopy and meteorological conditions. Here, the spatial variability and temporal stability of throughfall were investigated from October 2016 to December 2017 within a deciduous forest in the subtropical hilly regions of eastern China, and the effects of meteorological variables and distance from nearest tree trunk on throughfall variability were systematically evaluated. Throughfall variability during the leafed period was slightly higher than that during the leafless period inferred from the coefficient of variation of throughfall amounts(CVTF), with 13.2%-40.9% and 18.7%-31.9%, respectively. The multiple regression model analysis suggested that the controlling factors of throughfall variability were different in studied periods: Maximum 10-min rainfall intensity, wind speed and air temperature were the dominant influencing factors on throughfall variability during the leafed period, with the relative contribution ratio(RCR) of 25.9%, 18.7% and 8.9%, respectively. By contrast, throughfall variability was affected mainly by the mean rainfall intensity(RCR=40.8%) during the leafless period. The temporal stability plots and geostatistical analysis indicated that spatial patterns of throughfall were stable and similar among rainfall events. Our findings highlight the important role of various meteorological factors in throughfall variability and are expected to contribute to the accurate assessment of throughfall, soil water and runoff within the subtropical forests.

关键词： Throughfall variability Spatial heterogeneity Temporal stability Meteorological variables Canopy structure Subtropical forest

Subtidal variability in the Taiwan Strait induced by combined forcing of winter monsoon and topography

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Science China Earth Sciences 2018年第4期61卷 483-493页

作者： li li Xiaogang GUO Enhui liao Yuwu JIANG Third Institute of Oceanography State Oceanic Administration State Key Laboratory of Marine Environmental Science Xiamen University College of Earth Ocean and EnvironmentUniversity of Delaware

As an important channel connecting the East and South China Seas, circulations in the Taiwan Strait are strongly influenced by the East Asian monsoon and the topography of the strait, especially the Taiwan Bank(TWB), which is a remarkable topographic feature located at the southern entrance to the strait. Based on a series of pressure gauges deployed roughly 40 km offshore along the western Strait, subtidal sea-level variability under the combined impact of winter monsoon and topography was studied. The analyses show significant along-strait coherences of subtidal sea levels and their coherences with the large-scale monsoon wind for periods from 2 to 14 days. It is suggested that these fluctuations are mainly forced waves driven by the large-scale winds. In addition to the normal cross-shore wind setup, a sea-level setup in the along-strait direction is confirmed, which is induced by the combined forcing of the fluctuating winter monsoon and the blocking of the TWB. A southward current surge driven by a northerly wind event will cause a rising sea level over the TWB inducing a southward alongshore slope anomaly to the north of the TWB and a reversed slope anomaly to the south The subtidal current through the channel to the west of the TWB is found to be influenced by the reversed slope anomalies generated via the along-shore setup.

关键词： Subtidal variabilities Along-strait sea level setup Taiwan Strait Taiwan Bank

Hollow TiO_2 spheres with improved visible light photocatalytic activity synergistically enhanced by multi-stimulative: Morphology advantage,carbonate-doping and the induced Ti^(3+)

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Journal of Environmental Sciences 2018年第10期30卷 153-165页

作者： Guoliang li Chunyang liao Guibin Jiang State Key Laboratory of Environmental Chemistry and Eco-toxicology Research Center for Eco-Environmental SciencesChinese Academy of Sciences

Great efforts have been devoted to improve the photocatalytic activity of TiO2 in the visible light region. Rational design of the external structure and adjustment of intrinsic electronic status by impurity doping are two main effective ways to achieve this purpose. A facile onepot synthetic approach was developed to prepare C-doped hollow TiO2 spheres, which simultaneously realized these advantages. The synthesized TiO2 exhibits a mesoporous hollow spherical structure composed of fine nanocrystals, leading to high specific surface area（~180 m^2/g） and versatile porous texture. Carbonate-doping was achieved by a postthermal treatment at a relatively low temperature（200°C）, which makes the absorption edge red-shifted to the visible region of the solar spectrum. Concomitantly, Ti^（3＋） induced by C-doping also functions in improving the visible-light photocatalytic activity by reducing the band gap. There exists a synergistic effect from multiple stimulatives to enhance the photocatalytic effect of the prepared TiO2 catalyst. It is not out of expectation that the asprepared C-doped hollow TiO2 spheres exhibits an improved photocatalytic activity under visible light irradiation in organic pollutant degradation.

关键词： Hollow TiO2 sphere Carbonate Ti^3+ Visible light Photo-degradation Synergistic enhancement

Indirect Radau pseudospectral method for the receding horizon control problem

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Chinese Journal of Aeronautics 2016年第1期29卷 215-227页

作者： liao Yuxin li Huifeng Bao Weimin School of Astronautics Beihang University Science and Technology Committee China Aerospace Science and Technology Corporation

To solve the receding horizon control （RHC） problem in an online manner, a novel numerical method called the indirect Radau pseudospectral method （IRPM） is proposed in this paper. Based on calculus of variations and the first-order necessary optimality condition, the RHC problem for linear time-varying （LTV） system is transformed into the two-point boundary value problem （TPBVP）. The Radau pseudospectral approximation is employed to discretize the TPBVP into well-posed linear algebraic equations. The resulting linear algebraic equations are solved via a matrix partitioning approach afterwards to obtain the optimal feedback control law. For the nonlinear system, the linearization method or the quasi linearization method is employed to approximate the RHC problem with successive linear approximations. Subsequently, each linear problem is solved via the similar method which is used to solve the RHC problem for LTV system. Simulation results of three examples show that the IRPM is of high accuracy and of high compu- tation efficiency to solve the RHC problem and the stability of closed-loop systems is guaranteed.

关键词： Indirect Radau pseudospec-tral method linear time-varying system Nonlinear system Receding horizon control Two-point boundary valueproblem