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Small extracellular vesicles secreted by induced pluripotent stem cell-derived mesenchymal stem cells improve postoperative cognitive dysfunction in mice with diabetes

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Neural Regeneration Research 2023年第3期18卷 609-617页

作者： hai-li lang Yan-Zhi Zhao Ren-Jie Xiao Jing Sun Yong Chen Guo-Wen Hu Guo-hai Xu Department of Anesthesiology The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina The First Clinical Medical College of Nanchang University NanchangJiangxi ProvinceChina Department of Neurosurgery The Second Affiliated Hospital of Nanchang UniversityNanchangJiangxi ProvinceChina

Postoperative cognitive dysfunction(POCD)is a common surgical *** mellitus(DM)increases risk of developing POCD after *** patients with POCD seriously threaten the quality of patients’life,however,the intrinsic mechanism is unclear,and the effective treatment is *** studies have demonstrated neuronal loss and reduced neurogenesis in the hippocampus in mouse models of *** this study,we constructed a mouse model of DM by intraperitoneal injection of streptozotocin,and then induced postoperative cognitive dysfunction by transient bilateral common carotid artery *** found that mouse models of DM-POCD exhibited the most serious cognitive impairment,as well as the most hippocampal neural stem cells(H-NSCs)loss and neurogenesis ***,we hypothesized that small extracellular vesicles secreted by induced pluripotent stem cell-derived mesenchymal stem cells(iMSC-sEVs)might promote neurogenesis and restore cognitive function in patients with ***-sEVs were administered via the tail vein beginning on day 2 after surgery,and then once every 3 days for 1 month *** results showed that iMSC-sEVs treatment significantly recovered compromised proliferation and neuronal-differentiation capacity in H-NSCs,and reversed cognitive impairment in mouse models of ***,miRNA sequencing and qPCR showed miR-21-5p and miR-486-5p were the highest expression in *** found iMSC-sEVs mainly transferred miR-21-5p and miR-486-5p to promote H-NSCs proliferation and *** miR-21-5p was demonstrated to directly targete Epha4 and CDKN2C,while miR-486-5p can inhibit FoxO1 in *** then demonstrated iMSC-sEVs can transfer miR-21-5p and miR-486-5p to inhibit EphA4,CDKN2C,and FoxO1 expression in ***,these results indicate significant H-NSC loss and neurogenesis reduction lead to DM-POCD,the application of iMSC-sEVs may represent a novel cell-free therapeutic tool for diabe

关键词： diabetes mellitus hippocampus induced pluripotent stem cell mesenchymal stem cell miRNA neural stem cell neurogenesis postoperative cognitive dysfunction signaling pathway small extracellular vesicle

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认证认可促进产业高质量发展机理分析

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江苏商论 2024年第2期 117-119,132页

作者：李海浪王铁旦曾洪鑫昆明理工大学管理与经济学院云南昆明650500 东莞理工学院经济与管理学院广东东莞523808

产业发展是国民经济发展的重要基石,认证认可检验检测行业的发展可促进产业高质量发展,对经济的持续增长起到保障作用。本文在剖析认证认可以及产业高质量发展的内涵的基础上,提出建议,以期为今后的研究提供参考。

关键词：认证认可产业高质量发展机理分析

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Side-Channel Leakage Analysis of Inner Product Masking

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Computers, Materials & Continua 2024年第4期79卷 1245-1262页

作者： Yuyuan li lang li Yu Ou College of Computer Science and Technology Hengyang Normal UniversityHengyang421002China Hunan Provincial Key Laboratory of Intelligent Information Processing and Application Hengyang Normal UniversityHengyang421002China

The Inner Product Masking(IPM)scheme has been shown to provide higher theoretical security guarantees than the BooleanMasking(BM).This scheme aims to increase the algebraic complexity of the coding to achieve a higher level of *** previous work unfolds when certain(adversarial and implementation)conditions are met,and we seek to complement these investigations by understanding what happens when these conditions deviate from their expected *** this paper,we investigate the security characteristics of IPM under different *** adversarial condition,the security properties of first-order IPMs obtained through parametric characterization are preserved in the face of univariate and bivariate *** implementation condition,we construct two new polynomial leakage functions to observe the nonlinear leakage of the IPM and connect the security order amplification to the nonlinear *** observe that the security of IPMis affected by the degree and the linear component in the leakage *** addition,the comparison experiments from the coefficients,signal-to-noise ratio(SNR)and the public parameter show that the security properties of the IPM are highly implementation-dependent.

关键词： Side-channel analysis inner product masking mutual information nonlinear leakage

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Ultrathin organic solvent nanofiltration membrane with polydopamine-HKUST-1 interlayer for organic solvent separation

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Journal of Environmental Sciences 2024年第7期141卷 182-193页

作者： haike li Xindong li Guozai Ouyang lijinhong Huang lang li Wenhao li Wanfu Huang Duokun li Ganzhou Key Laboratory of Basin Pollution Simulation and Control Jiangxi University of Science and TechnologyGanzhou 341000China Innovation Center for Water Quality Security Technology at Ganjiang River Basin Jiangxi University of Science and TechnologyGanzhou 341000China School of Architecture and Design Jiangxi University of Science and TechnologyGanzhou 341000China WA School of Mines:Minerals Energy and Chemical EngineeringCurtin UniversityWA 6845Australia School of Materials Science and Engineering Tiangong UniversityTianjin 300387China

Polydopamine(PDA)and metal-organic skeleton HKUST-1 were co-deposited on the base membrane of hexamethylenediamine(HDA)-crosslinked polyetherimide(PEI)ultrafiltration membrane as the interlayer,and high-throughput organic solvent nanofiltration membrane(OSN)was prepared by interfacial polymerization and solvent activation *** polyamide(PA)layer surface roughness from 28.4 nm in PA/PEI to 78.3 nm in PA/PDA-HKUST-10.6/PEI membrane,reduced the thickness of the separation layer from 79 to 14 nm,and significantly improved the hydrophilic,thermal and mechanical *** flux of the PA/PDA-HKUST-10.6/PEI membrane in a 0.1 g/L Congo Red(CR)ethanol solution at 0.6 MPa test pressure reached 21.8 L/(m^(2)·hr)and the rejection of CR was 92.8%.Solvent adsorption test,N,N-dimethylformamide(DMF)immersion experiment,and long-term operation test in ethanol showed that the membranes had high solvent *** solvent flux test demonstrated that,under the test pressure of 0.6 MPa,the flux of different solvents ranked as follows:methanol(56.9 L/(m^(2)·hr))>DMF(39.6 L/(m^(2)·hr))>ethanol(31.2 L/(m^(2)·hr))>IPA(4.5 L/(m^(2)·hr))>N-hexane(1.9 L/(m^(2)·hr)).The ability of the membranes to retain dyes in IPA/water dyes solution was also *** flux of the membrane was 30.4 L/(m^(2)·hr)and the rejection of CR was 91.6%when the IPA concentration reached 50%.This OSN membrane-making strategy is economical,environment-friendly and efficient,and has a great application prospect in organic solvent separation systems.

关键词： Interfacial polymerization Organic solvent nanofiltration Interlayer Metal-organic frameworks Polydopamine

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Efficient and selective recovery of Gd(Ⅲ)via polyethyleneimine modification of lanthanum-based metal-organic frameworks

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Journal of Rare Earths 2024年第1期42卷 210-219,I0007页

作者： Wenhao li lijinhong Huang Bin Xiao Xiaoguang Duan haike li lang li Wanfu Huang Ganzhou Key Laboratory of Basin Pollution Simulation and Control Jiangxi University of Science and TechnologyGanzhou341000China Innovation Center for Water Quality Security Technology at Ganjiang River Basin Jiangxi University of Science and TechnologyGanzhou341000China Faculty of Science and Engineering WA School of Mines:MineralsEnergy and Chemical EngineeringCurtin UniversityWAAustralia School of Architecture and Design Jiangxi University of Science and TechnologyGanzhou341000China School of Resources and Architectural Engineering Gannan University of Science and TechnologyGanzhou341000China School of Chemical Engineering and Advanced Materials The University of AdelaideAdelaideSA5005Australia School of Resource and Environmental Engineering Jiangxi University of Science and TechnologyGanzhou341000China

With the development of the economy and the increasing demand for environmental protection,the efficient and selective recovery of Gd(Ⅲ)from actual wastewater is of critical *** this work,lanthanum-based metal-organic framework(LaBDC)materials were prepared by a hydrothermal method,and then polyethyleneimine(PEI)and LaBDC were combined by an impregnation method to form a novel LaBDC@xPEI *** prepared materials were characterized using Fourier transfo rm infrared spectroscopy(FTIR),X-ray diffraction(XRD),scanning electron microscopy(SEM),energy dispersive X-ray spectroscopy(EDX),B runauer-Emmett-Teller(BET),thermogravimetric analysis(TGA)and X-ray photoelectron spectroscopy(XPS).Experiments show that LaBDC@50%PEI has the highest adsorption capacity(181.77 mg/g)among lanthanum-based MOFs with different PEI loadings at pH=5.5,which is about 5.1 times that of bare *** adsorption isotherm analysis shows that LaBDC@50%PEI follows the langmuir *** addition,the adsorption kinetics of LaBDC@50%PEI follows a pseudo-second-order kinetic model,indicating that the adsorption process is chemical *** is worth noting that LaBDC@50%PEI maintains good adsorption performance and stability after three recycling tests,and exhibits excellent selectivity in cation interference ***,the LaBDC@50%PEI composites possess good stability and hold great promises in rapid recovery of Gd(Ⅲ)from practical aqueous environments.

关键词： Wet-impregnation method Polyethylene imine Metaleorganic frameworks Lanthanum Recovery of Gd(Ⅲ) Rare earths

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Ginsenoside Rb1 induces hepatic stellate cell ferroptosis to alleviate liver fibrosis via the BECN1/SLC7A11 axis

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Journal of Pharmaceutical Analysis 2024年第5期14卷 744-757页

作者： lifan lin Xinmiao li Yifei li Zhichao lang Yeping li Jianjian Zheng Key Laboratory of Diagnosis and Treatment of Severe Hepato-Pancreatic Diseases of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325000China Department of Urology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325000China Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang325000China

liver fibrosis is primarily driven by the activation of hepatic stellate cells(HSCs),a process associated with *** Rb1(GRb1),a major active component extracted from Panax ginseng,inhibits HSC ***,the potential role of GRb1 in mediating HSC ferroptosis remains *** study examined the effect of GRb1 on liver fibrosis both in vivo and in vitro,using CCl4-induced liver fibrosis mouse model and primary HSCs,LX-2 *** findings revealed that GRb1 effectively inactivated HSCs in vitro,reducing alpha-smooth muscle actin(a-SMA)and type I collagen(Col1A1)***,GRb1 significantly alleviated CCl4-induced liver fibrosis in *** a mechanistic standpoint,the ferroptosis pathway appeared to be central to the antifibrotic effects of ***,GRb1 promoted HSC ferroptosis both in vivo and in vitro,characterized by increased glutathione depletion,malondialdehyde production,iron overload,and accumulation of reactive oxygen species(ROS).Intriguingly,GRb1 increased Beclin 1(BECN1)levels and decreased the System Xc-key subunit *** experiments showed that BECN1 silencing inhibited GRb1-induced effects on HSC ferroptosis and mitigated the reduction of SLC7A11 caused by ***,BECN1 could directly interact with SLC7A11,initiating HSC *** conclusion,the suppression of BECN1 counteracted the effects of GRb1 on HSC inactivation both in vivo and in ***,this study highlights the novel role of GRb1 in inducing HSC ferroptosis and promoting HSC inactivation,at least partly through its modulation of BECN1 and SLC7A11.

关键词： Ginsenoside Rb1 Ferroptosis liver fibrosis Hepatic stellate cells

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Robust-augmentation nonlinear dynamic inversion control of over-actuated coaxial high-speed helicopter in transition mode

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Chinese Journal of Aeronautics 2024年第8期37卷 404-420页

作者： Yuqing QIU Yan li Jinxi lang Yuxian liU Zhong WANG School of Automation Northwestern Polytechnical UniversityXi’an 710129China

As the elevator and rudder can be used actively for control,in addition to the rotors,Coaxial High-speed Helicopters(CHHs)have the problems of control redundancy and changing control authority in the transition *** paper presents a robust-augmentation transitioning flight control design for a CHH under the adverse conditions of parametric uncertainties and external ***,based on control characteristic analysis,an Adaptive Filtered Nonlinear Dynamic Inversion(AFNDI)controller is proposed for the angular rate to handle the effect of unknown unstructured uncertainties and external *** analysis proves that the presented angular rate controller can guarantee steady-state and transient ***,the attitude angle and velocity controllers are also ***,an Incremental-based Nonlinear Prioritizing Control Allocation(INPCA)method is designed to take into account control surface transition and changing control authority,which efficiently distributes the required moments between coaxial rotors and aero-surfaces,and avoids the control reversal problem of the yaw *** the proposed control architecture,the low-pass filter is introduced to alleviate the adverse influence of time delay and measurement ***,the effectiveness of the proposed controller is demonstrated through nonlinear numerical simulations,and is compared with existing *** results show that the proposed control law can improve both capabilities of disturbance rejection and fast response,and works satisfactorily for the CHH transitioning control characteristic.

关键词： Coaxial high-speed helicopter Transition mode Attitude control Control allocation Robust adaptive control

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Tensile strength behavior of cement-stabilized dredged sediment reinforced by polypropylene fiber

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Frontiers of Structural and Civil Engineering 2024年第3期18卷 380-392页

作者： Lei lang Jiangshan li Xin CHEN lijun HAN Ping WANG State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicChinese Academy of SciencesWuhan 430071China Hubei Provincial Key Laboratory of Contaminated Sludge and Soil Science and Engineering Wuhan 430071China University of Chinese Academy of Sciences Beijing 100049China

This study evaluated the feasibility of using polypropylene fiber(PF)as reinforcement in improving tensile strength behavior of cement-stabilized dredged sediment(CDS).The effects of cement content,water content,PF content and length on the tensile strength and stress–strain behavioral evolutions were evaluated by conducting splitting tensile strength ***,the micro-mechanisms characterizing the tensile strength behavior inside PF-reinforced CDS(CPFDS)were clarified via analyzing macro failure and microstructure *** results indicate that the highest tensile strengths of 7,28,60,and 90 d CPFDS were reached at PF contents of 0.6%,1.0%,1.0%,and 1.0%,exhibiting values 5.96%,65.16%,34.10%,and 35.83%higher than those of CDS,***,3 mm,PF of showed the best reinforcement *** CPFDS exhibited obvious tensile strain-hardening characteristic,and also had better ductility than *** mix factor(C_(C)^(a)/C_(w)^(b))and time parameter(q_(t0)(t))of CDS,and the reinforcement index(k_(t-PF))of CPFDS were used to establish the tensile strength prediction models of CDS and CPFDS,considering multiple *** PF“bridge effect”and associated cementation-reinforcement coupling actions inside CPFDS were mainly responsible for tensile strength behavior *** key findings contribute to the use of CPFDS as recycled engineering soils.

关键词： dredged sediment chemical stabilization fiber reinforcement splitting tensile strength micro-mechanisms

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SFGA-CPA: A Novel Screening Correlation Power Analysis Framework Based on Genetic Algorithm

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Computers, Materials & Continua 2024年第6期79卷 4641-4657页

作者： Jiahui liu lang li Di li Yu Ou College of Computer Science and Technology Hengyang Normal UniversityHengyang421002China Hunan Provincial Key Laboratory of Intelligent Information Processing and Application Hengyang Normal UniversityHengyang421002China

Correlation power analysis(CPA)combined with genetic algorithms(GA)now achieves greater attack efficiency and can recover all subkeys ***,two issues in GA-based CPA still need to be addressed:key degeneration and slow evolution within *** challenges significantly hinder key recovery *** paper proposes a screening correlation power analysis framework combined with a genetic algorithm,named SFGA-CPA,to address these ***-CPA introduces three operations designed to exploit CPA characteris-tics:propagative operation,constrained crossover,and constrained ***,the propagative operation accelerates population evolution by maximizing the number of correct bytes in each ***,the constrained crossover and mutation operations effectively address key degeneration by preventing the compromise of correct ***,an intelligent search method is proposed to identify optimal parameters,further improving attack *** were conducted on both simulated environments and real power traces collected from the SAKURA-G *** the case of simulation,SFGA-CPA reduces the number of traces by 27.3%and 60%compared to CPA based on multiple screening methods(MS-CPA)and CPA based on simple GA method(SGA-CPA)when the success rate reaches 90%.Moreover,real experimental results on the SAKURA-G platform demonstrate that our approach outperforms other methods.

关键词： Side-channel analysis correlation power analysis genetic algorithm crossover mutation

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Vibration and noise mechanism of a 110 kV transformer under DC bias based on finite element method

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Global Energy Interconnection 2024年第4期7卷 503-512页

作者： Ziyang li Xujun lang Bo Yang Xiaolin liu Hao Wang Zhang li Shandong Electric Power Engineering Consulting Institute Co. Ltd.Jinan 250013P.R.China School of Electrical Engineering Shandong UniversityJinan 250061P.R.China

Global energy and environmental issues are becoming increasingly problematic,and the vibration and noise problem of 110 kV transformers,which are the most widely distributed,have attracted widespread attention from both inside and outside the *** bias is one of the main contributing factors to vibration noise during the normal operation of *** clarify the vibration and noise mechanism of a 110 kV transformer under a DC bias,a multi-field coupling model of a 110 kV transformer was established using the finite element *** electromagnetic,vibration,and noise characteristics during the DC bias process were compared and quantified through field circuit coupling in parallel with the power frequency of AC,harmonic,and DC power *** was found that a DC bias can cause significant distortions in the magnetic flux density,force,and displacement distributions of the core and *** contributions of the DC bias effect to the core and winding are different at Kdc=*** this point,the core approached saturation,and the increase in the core force and displacement ***,the saturation of the core increased the leakage flux,and the stress and displacement of the winding increased *** sound field distribution characteristics of the 110 kV transformer under a DC bias are related to the force *** the DC bias coefficient was 1.25,the noise sound pressure level reached 73.6 dB.

关键词： Transformer DC bias Vibration Noise

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