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Link between mutations in ACVRL1 and PLA2G4A genes and chronic intestinal ulcers:A case report and review of literature

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 932-943页

作者： Yong-Jing Tang jian Zhang Jie Wang Ren-Dong Tian Wei-Wei zhong Ben-Sheng Yao Bing-Yu Hou Ying-Hua Chen Wei He Yi-Huai He Department of Infectious Diseases The Affiliated Hospital of Zunyi Medical UniversityZunyi 563000Guizhou ProvinceChina Department of Gastroenterology Dafang County People's HospitalBijie 551600Guizhou ProvinceChina Department of Internal Medicine Puchang BranchMedical CommunitySuiyang County People's HospitalZunyi 563300Guizhou ProvinceChina Department of Infectious Diseases Jingmen Central HospitalJingmen 448000Hubei ProvinceChina Department of Infectious Diseases Dafang County People's HospitalBijie 551600Guizhou ProvinceChina

BACKGROUND Genetic factors of chronic intestinal ulcers are increasingly garnering *** present a case of chronic intestinal ulcers and bleeding associated with mu-tations of the activin A receptor type II-like 1(ACVRL1)and phospholipase A2 group IVA(PLA2G4A)genes and review the available relevant *** SUMMARY A 20-year-old man was admitted to our center with a 6-year history of recurrent abdominal pain,diarrhea,and dark *** the onset 6 years ago,the patient had received treatment at a local hospital for abdominal pain persisting for 7 d,under the diagnosis of diffuse peritonitis,acute gangrenous appendicitis with perforation,adhesive intestinal obstruction,and pelvic *** surgical treat-ment included exploratory laparotomy,appendectomy,intestinal adhesiolysis,and pelvic abscess *** patient’s condition improved and he was ***,the recurrent episodes of abdominal pain and passage of black stools started again one year after *** the basis of these features and results of subsequent colonoscopy,the clinical diagnosis was established as in-flammatory bowel disease(IBD).Accordingly,aminosalicylic acid,immunotherapy,and related symptomatic treatment were administered,but the symptoms of the patient did not improve *** investigations revealed mutations in the ACVRL1 and PLA2G4A ***1 and PLA2G4A are involved in angiogenesis and coagulation,*** suggests that the chronic intestinal ulcers and bleeding in this case may be linked to mutations in the ACVRL1 and PLA2G4A *** Kangfuxin liquid was administered to promote healing of the intestinal mucosa and effectively manage clinical *** Mutations in the ACVRL1 and PLA2G4A genes may be one of the causes of chronic intestinal ulcers and bleeding in *** administered Kangfuxin liquid may have therapeutic potential.

关键词： Intestinal ulcers Crohn’s disease Ulcerative colitis Activin A receptor type II-like 1 Phospholipase A2 group 4A Case report

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Initial COVID-19 severity influenced by SARS-CoV-2-specific T cells imprints T-cell memory and inversely affects reinfection

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2791-2803页

作者： Gang Yang Jinpeng Cao jian Qin Xinyue Mei Shidong Deng Yingjiao Xia Jun Zhao Junxiang Wang Tao Luan Daxiang Chen Peiyu Huang Cheng Chen Xi Sun Qi Luo Jie Su Yunhui Zhang Nanshan zhong zhongfang Wang The Affiliated Hospital of Kunming University of Science and Technology.Department of Respiratory and Critical Care Medicine The First People’s Hospital of Yunnan provinceKunmingYunnanChina Guangzhou National Laboratory BiolandGuangzhouGuangdongChina State Key Laboratory of Respiratory Disease&National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory Healththe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou Medical UniversityGuangzhouChina

The immunoprotective components control COVID-19 disease severity,as well as long-term adaptive immunity maintenance and subsequent reinfection risk discrepancies across initial COVID-19 severity,remain ***,we longitudinally analyzed SARS-CoV-2-specific immune effectors during the acute infection and convalescent phases of 165 patients with COVID-19 categorized by *** found that early and robust SARS-CoV-2-specific CD4^(+)and CD8^(+)T cell responses ameliorate disease progression and shortened hospital stay,while delayed and attenuated virus-specific CD8^(+)T cell responses are prominent severe COVID-19 *** antiviral antibody generation rather than titer level associates with severe ***,initial COVID-19 severity imprints the long-term maintenance of SARS-CoV-2-specific adaptive immunity,demonstrating that severe convalescents exhibited more sustained virus-specific antibodies and memory T cell responses compared to mild/moderate ***,initial COVID-19 severity inversely correlates with SARS-CoV-2 reinfection ***,our study unravels the complicated interaction between temporal characteristics of virus-specific T cell responses and COVID-19 severity to guide future SARS-CoV-2 wave management.

关键词： severity immunity infection

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中国北方青杨派杨树遗传多样性研究

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西北林学院学报 2024年第2期39卷 79-84,114页

作者：姚建忠山西省桑干河杨树丰产林实验局山西大同037006

青杨派杨树是我国广泛分布的一类生态、经济型树种。目前尚未对青杨派杨树资源开展有效评价、利用及保护工作。以中国北方地区青杨派杨树19个种群的112个样本为材料,利用15对微卫星标记进行遗传多样性和遗传结构分析。结果表明,青杨派杨... 详细信息

青杨派杨树是我国广泛分布的一类生态、经济型树种。目前尚未对青杨派杨树资源开展有效评价、利用及保护工作。以中国北方地区青杨派杨树19个种群的112个样本为材料,利用15对微卫星标记进行遗传多样性和遗传结构分析。结果表明,青杨派杨树19个种群总等位基因数(N a)为118,有效等位基因数(N e)为3.439,观测杂合度(H o)为0.392,期望杂合度(H e)为0.347,信息指数(I)为0.582,表明青杨派杨树具有较高的遗传多样性水平;遗传分化系数(F st)为0.39,表明青杨派不同杨树种群间存在显著的遗传分化。通过遗传结构分析和聚类分析,将青杨派杨树19个种群分为2个大类群,大青杨与香杨、二白杨与小叶杨种群间具有相近的亲缘关系;其中的9个青杨种群可分为3个大类群,且遗传距离与地理距离、气候因子距离呈显著相关性(r=0.758,P=0.010;r=0.330,P=0.04),表明青杨种群遗传分化受到地理隔离以及气候条件差异影响。研究结果为杨树遗传改良、种质资源保存和利用提供理论依据,同时对青杨派系统发育和进化机制也提供重要参考价值。

关键词：青杨派青杨遗传多样性遗传结构

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Mental health and insomnia problems in healthcare workers after the COVID-19 pandemic:A multicenter cross-sectional study

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World Journal of Psychiatry 2024年第5期14卷 704-714页

作者： Wei Ding Min-zhong Wang Xian-Wei Zeng Zhen-Hua Liu Yao Meng Hui-Ting Hu Yuan Zhang Yu-Guang Guan Fan-Gang Meng jian-Guo Zhang Shu Wang Department of Public Health Liaocheng People’s HospitalLiaocheng 252000Shandong ProvinceChina Department of Neurology Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Neurosurgery Qilu Hospital of Shandong UniversityJinan 250012Shandong ProvinceChina Sleep Medicine Center Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021Shandong ProvinceChina Department of Neurology The First Affiliated Hospital of Shandong First Medical UniversityJinan 250014Shandong ProvinceChina Department of Neurology Heze Mudan People’s HospitalHeze 274000Shandong ProvinceChina Neonatal Center Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Neurosurgery SanBo Brain HospitalCapital Medical UniversityBeijing 100093China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China

BACKGROUND Healthcare workers(HCWs)are at increased risk of contracting coronavirus disease 2019(COVID-19)as well as worsening mental health problems and *** problems can persist for a long period,even after the ***,less is known about this *** To analyze mental health,insomnia problems,and their influencing factors in HCWs after the COVID-19 *** This multicenter cross-sectional,hospital-based study was conducted from June 1,2023 to June 30,2023,which was a half-year after the end of the COVID-19 ***-stratified population-based cluster sampling was applied at the provincial level for Chinese *** such as anxiety,depression,and insomnia were evaluated by the Generalized Anxiety Disorder-7,Patient Health Questionnaire-9,and Insomnia Severity *** influencing the symptoms were identified by multivariable logistic *** A total of 2000 participants were invited,for a response rate of 70.6%.A total of 1412 HCWs[618(43.8%)doctors,583(41.3%)nurses and 211(14.9%)nonfrontline],254(18.0%),231(16.4%),and 289(20.5%)had symptoms of anxiety,depression,and insomnia,respectively;severe symptoms were found in 58(4.1%),49(3.5%),and 111(7.9%)of the ***,female sex,and hospitalization for COVID-19 were risk factors for anxiety,depression,and insomnia symptoms;moreover,death from family or friends was a risk factor for insomnia *** the COVID-19 outbreak,most[1086(76.9%)]of the participating HCWs received psychological interventions,while nearly all[994(70.4%)]of them had received public psychological *** 102(7.2%)of the HCWs received individual counseling from *** Although the mental health and sleep problems of HCWs were relieved after the COVID-19 pandemic,they still faced challenges and greater risks than did the general *** risk factors would help in providing targeted *** addition,although a major proportion of

关键词： COVID-19 Mental health Psychological symptoms Insomnia Sleep disorders Cross-sectional study Epidemiological study

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基于改进Bouc-Wen模型的RC柱数值模拟方法

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吉林大学学报（工学版） 2024年第4期54卷 1028-1037页

作者：郭玉荣潘建中湖南大学土木工程学院长沙410082 湖南大学建筑安全与节能教育部重点实验室长沙410082

为模拟钢筋混凝土(RC)柱进入非线性状态后的力学性能,首先,提出了一种改进Bouc-Wen模型,从刚度退化、捏拢效应与非对称特性等方面对Bouc-Wen-Baber-Noori(BWBN)模型进行修正,并结合参数规一化处理与混沌粒子群算法建立模型参数识别方法... 详细信息

为模拟钢筋混凝土(RC)柱进入非线性状态后的力学性能,首先,提出了一种改进Bouc-Wen模型,从刚度退化、捏拢效应与非对称特性等方面对Bouc-Wen-Baber-Noori(BWBN)模型进行修正,并结合参数规一化处理与混沌粒子群算法建立模型参数识别方法。然后,实现了改进Bouc-Wen材料在OpenSees平台中的二次开发,并应用该材料定义RC柱塑性铰的弯矩-转角关系,完成基于集中塑性铰模型的RC柱数值建模。最后,根据钢筋混凝土柱的低周往复加载试验数据,分别通过直接识别水平恢复力-侧移曲线与集中塑性铰数值建模的方法描述RC柱的滞回特性。与试验结果对比表明:改进Bouc-Wen模型模拟精度较BWBN模型有明显提高;纤维模型的计算精度依赖设计信息的准确性,未能较好地模拟经历性能变化后RC柱的非线性响应;基于改进Bouc-Wen模型的数值建模方法能够更为准确地模拟经历震损后RC柱的刚度退化、捏拢效应与非对称特性。

关键词： RC柱集中塑性铰模型 Bouc-Wen模型参数识别

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SARS-CoV-2 envelope protein impairs airway epithelial barrier function and exacerbates airway inflammation via increased intracellular Cl^(-)concentration

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Signal Transduction and Targeted Therapy 2024年第4期9卷 1745-1759页

作者： jian-Bang Xu Wei-Jie Guan Yi-Lin Zhang Zhuo-Er Qiu Lei Chen Xiao-Chun Hou Junqing Yue Yu-Yun Zhou Jie Sheng Lei Zhao Yun-Xin Zhu Jing Sun Jincun Zhao Wen-Liang Zhou Nan-Shan zhong State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory DiseaseNational Center for Respiratory MedicineDepartment of Respiratory and Critical Care MedicineGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Department of Thoracic Surgery Guangzhou Institute for Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhouP.R.China Guangzhou National Laboratory GuangzhouP.R.China School of Life Sciences Sun Yat-sen UniversityGuangzhouP.R.China Guangdong Provincial Key Laboratory of Pharmaceutical Functional Genes School of Life SciencesSun Yat-sen UniversityGuangzhouP.R.China Department of Physiology School of Basic Medical SciencesGuangzhou Medical UniversityGuangzhouP.R.China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection disrupts the epithelial barrier and triggers airway *** envelope(E)protein,a core virulence structural component of coronaviruses,may play a role in this *** could interfere with transepithelial Cl^(-)transport via impairment of the cystic fibrosis transmembrane conductance regulator(CFTR),which modulates nuclear factor kB(NF-kB)***,the pathological effects of SARS-CoV-2 E protein on airway epithelial barrier function,Cl^(-)transport and the robust inflammatory response remain to be ***,we have demonstrated that E protein down-regulated the expression of tight junctional proteins,leading to the disruption of the airway epithelial *** addition,E protein triggered the activation of Toll-like receptor(TLR)2/4 and downstream c-Jun N-terminal kinase(JNK)signaling,resulting in an increased intracellular Cl^(-)concentration([Cl^(-)]_(i))via up-regulating phosphodiesterase 4D(PDE4D)expression in airway epithelial *** elevated[Cl^(-)]_(i);contributed to the heightened airway inflammation through promoting the phosphorylation of serum/glucocorticoid regulated kinase 1(SGK1).Moreover,blockade of SGK1 or PDE4 alleviated the robust inflammatory response induced by E ***,these findings provide novel insights into the pathogenic role of SARS-CoV-2 E protein in airway epithelial damage and the ongoing airway inflammation during SARS-CoV-2 infection.

关键词： airway inflammation elevated

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Follow-up study of gallbladder stones in 44 children

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World Journal of Clinical Cases 2024年第18期12卷 3403-3409页

作者： jian-Xiong Yu Zhi-zhong jiang Yuan-Hao Cai Lin Zhou Bin Cai Department of Pediatric The Firs Affiliated Hospital of Naval Medical UniversityShanghai 20000China

BACKGROUND Cholesterol stones affect a certain subpopulation of *** have been raised on the impact of gallbladder surgery on the growth of children and *** To study the population characteristics,clinical features,treatment,and prognosis of gallstones in *** The clinical data of 44 children with gallstones admitted to The First Affiliated Hospital of Naval Medical University from August 2009 to August 2021 were collected,the children were followed up by telephone to monitor their *** follow-up ended in August *** shortest follow-up time was 2 years and 6 months,whereas the longest was 13 years and 11 *** population characteristics,general clinical characteristics,and treatments were retrospectively *** children were divided according to whether they underwent surgical gallbladder removal into an operation group(n=28)and a non-operation group(n=16),The effects of surgical gallbladder resection on the growth and development of children were *** The male–female ratio in the population was 6:5 and 84.09%of the children had onset in ***,29.55%of the children were overweight or *** study identified 26 cases with metabolic abnormalities,9 with hemolytic anemia,and 4 with choledochal *** the population,68.18%had recurrent symptomatic *** treatment accounted for 63.64%,with laparoscopic cholecystectomy accounting for 71.43%of surgical *** significant differences were observed in symptoms and complications between the surgery and non-surgery ***,no significant differences were found between the two groups in the attainment of genetic height target and the rightward shift of height curve during *** The sex characteristics of gallstones in children were not *** gallstones occurred in adolescents and rarely in young children.A considerable proportion of children have inborn causes,which are of

关键词： Gallstones in children Clinical characteristics Growth and development Operation Clinical features

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论习惯国际法的重构——基于南北国家利益平衡的视角

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开放时代 2024年第1期 144-160,M0007,M0008页

作者：钟燕慧吴坚华南师范大学东南亚研究中心华南师范大学东南亚中文教师教育学院、东南亚研究中心

对习惯国际法的政治目的研究是重构习惯国际法的核心要义。习惯国际法的普适性与发展中国家的崛起提升了习惯国际法重构的必要性。同时,习惯国际法在分配国际利益与塑造政治秩序中的功能被学理上的分类所掩盖。对习惯国际法的“形式渊... 详细信息

对习惯国际法的政治目的研究是重构习惯国际法的核心要义。习惯国际法的普适性与发展中国家的崛起提升了习惯国际法重构的必要性。同时,习惯国际法在分配国际利益与塑造政治秩序中的功能被学理上的分类所掩盖。对习惯国际法的“形式渊源”与“实质渊源”的概念区分,可能淡化了后殖民时代习惯国际法形成中的政治意图,并忽视了思想、文化、价值观等“元概念”在习惯国际法中的表达。习惯国际法所体现的南北国家的利益冲突,不仅在于发展中国家难以在规则形成与话语权分配中占据主动,更在于无论是传统还是现代的习惯国际法的形成方式与程序,都很难关照发展中国家的法律诉求。对此,应建构一种以强调审慎理性,具备普遍司法公义,兼顾各国法律实践及以确信为基础的“后现代”习惯国际法,以消弭南北国家在习惯国际法形成规则与利益分配等方面的差距与矛盾。

关键词：习惯国际法国际法渊源政治意图话语权分配国际法律治理

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Identification of Xunxi Shujin Decoction by TLC

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Medicinal Plant 2024年第1期15卷 8-12页

作者： Fengxian ZHAO Yuanming zhong Deren LI Yong CHEN Chaolan WANG jian CUI Jingxi People s Hospital Jingxi 533800China Guangxi University of Chinese Medicine Nanning 530200China First Affiliated Hospital of Guangxi University of Chinese Medicine Nanning 530023China

[Objectives]To establish a TLC qualitative method for the determination of Radix Aconiti,Radix Aconiti Kusnezoffii,Caesalpinia sappan *** Radix zanthoxyli.[Methods]TLC was used to study the quality of Radix Aconiti,Radix Aconiti Kusnezoffii and *** *** Xunxi Shujin Decoction,and the influencing factors were investigated to optimize the TLC conditions.[Results]In the TLC identification test of Radix Aconiti,Radix Aconiti Kusnezoffii,*** *** *** in Xunxi Shujin Decoction,the spots were clear,the resolution was good,the specific value was moderate,the negative control was not disturbed,and the specificity was strong.[Conclusions]The established TLC method was simple,specific and reproducible,and could be used for the quality control of Xunxi Shujin Decoction.

关键词： Xunxi Shujin Decoction Radix Aconiti Radix Aconiti Kusnezoffii Caesalpinia sappan L. Radix zanthoxyli Thin layer chromatography

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中子衍射应力分析技术及其应用进展

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金属学报 2024年第8期60卷 1017-1030页

作者：林皓李建杨钊龙钟圣怡上海交通大学材料科学与工程学院上海200240 上海交通大学中子科学与技术全国重点实验室上海200240 中国工程物理研究院核物理与化学研究所绵阳621999 上海交通大学巴黎卓越工程师学院上海200240

中子衍射依托中子源大科学装置,能够非破坏性地获取材料内部微结构的统计信息,是建立物质微观、介观和宏观结构与性能内在联系的重要表征手段,同时也是航空发动机涡轮盘/叶片、反应堆压力容器等重大技术与装备关键部件内部残余应力定量... 详细信息

中子衍射依托中子源大科学装置,能够非破坏性地获取材料内部微结构的统计信息,是建立物质微观、介观和宏观结构与性能内在联系的重要表征手段,同时也是航空发动机涡轮盘/叶片、反应堆压力容器等重大技术与装备关键部件内部残余应力定量无损评价的重要方法。本文简要介绍了中子衍射技术测量原理和基本方法,阐述了该技术在材料基础与前沿探索的研究进展,评述了其在工程构件设计、制造、服役及安全评估中的地位与作用。基于新材料和新工艺开发的共性需求,展望了中子衍射技术跨尺度、多参量分析的开发潜力,及其未来在高通量表征中的发展方向。

关键词：中子衍射残余应力高通量表征服役安全

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