检索结果-南通市图书馆

Prognostic significance of erythropoietin and erythropoietin receptor in gastric adenocarcinoma

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第34期17卷 3933-3940页

作者： lin Wang hai-gang li Zhong-Sheng Xia Jian-Ming Wen Jun Lv Department of Pathology Sun Yat- Sen Memorial Hospital Sun Yat-Sen University Guangzhou 510120 Guangdong Province China Department of Gastroenterology Sun Yat- Sen Memorial Hospital Sun Yat-Sen University Guangzhou 510120 Guangdong Province China Department of Pathology the First Affiliated Hospital Sun Yat-Sen University Guangzhou 510080 Guangdong Province China Department of Nephrology Sun Yat-Sen Memorial Hospital Sun Yat-Sen University Guangzhou 510120 Guangdong Province China

AIM: To investigate the expression of Erythropoietin (Epo) and its receptor (EpoR) in gastric adenocarcinoma (GAC) and the correlation with angiogenesis and clinicopathological features. METHODS: The expressions of Epo, EpoR and vascular endothelial growth factor (VEGF), as well as mi-crovessel density were evaluated in 172 GAC biopsies by immunohistochemical staining. The correlations between these parameters and patient’s clinicopathological features were analyzed statistically. RESULTS: The proportion of Epo and EpoR alterations in GAC was higher than that in adjacent normal mucosa (P = 0.035 and 0.030). Epo high-expression was associ-ated with EpoR high-expression, Lauren type, extensivelymph node metastasis and advanced stage of GAC (P = 0.018, 0.018, 0.004 and 0), while EpoR expression was linked with older age, World Health Organization type, extensive lymph node metastasis and advanced stage (P = 0.001, 0.013, 0.008 and 0.001). VEGF high expression was significantly correlated with EpoR low-expression, Lauren type, extensive lymph node metastasis and advanced stage (P = 0.001, 0.001, 0.001 and 0.007). The expression of Epo or EpoR was associated with microvessel density (P = 0.004 and 0.046). On multivariate analysis, only lymph node metastasis, abnormal Epo expression and tumor nodes metastases stage were independently associated with survival. In addition, a strong association with the immunohistochemical expression of EpoR and the angiogenic protein, VEGF, was noted. CONCLUSION: Increased expression of Epo and EpoR may play a signif icant role in the carcinogenesis, angiogenesis and progression of GAC. Epo may be an inde-pendent prognostic factor.

关键词： Erythropoietin Erythropoietin receptor Gas- tric adenocarcinoma Immunohistochemistry Prognosis

Primary clear cell carcinoma in the liver: CT and MRI findings

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第7期17卷 946-952页

作者： Qing-Yu liu hai-gang li Ming Gao Xiao-Feng lin Yong li Jian-Yu Chen Department of Radiology The Second Affiliated Hospitalof Sun Yat-sen University Guangzhou 510120 Guangdong Prov-ince China Department of Pathology The Second Affiliated Hospital of Sun Yat-sen University Guangzhou 510120Guangdong Province China

AIM: To retrospectively analyze the computed tomography (CT) and magnetic resonance imaging (MRI) appearances of primary clear cell carcinoma of the liver (PCCCL) and compare the imaging appearances of PCCCL and common type hepatocellular carcinoma (CHCC) to determine whether any differences exist between the two groups. METHODS: Twenty cases with pathologically proven PCCCL and 127 cases with CHCC in the Second Affiliated Hospital of Sun Yat-sen University were included in this study. CT or MRI images from these patients were retrospectively analyzed. The following imaging findings were reviewed: the presence of liver cirrhosis, tumor size, the enhancement pattern on dynamic contrast scanning, the presence of pseudo capsules, tumor rupture, portal vein thrombosis and lymph node metastasis. RESULTS: Both PCCCL and CHCC were prone to occur in patients with liver cirrhosis, the association rate of liver cirrhosis was 80.0% and 78.7%, respectively (P > 0.05). The mean sizes of PCCCL and CHCC tumors were (7.28 ± 4.25) cm and (6.96 ± 3.98) cm, respectively. Small HCCs were found in 25.0% (5/20) of PCCCL and 19.7% (25/127) of CHCC cases. No significant differences in mean size and ratio of small HCCs were found between the two groups (P = 0.658 and 0.803, respectively). Compared with CHCC patients, PCCCL patients were more prone to form pseudo capsules (49.6% vs 75.0%, P = 0.034). Tumor rupture, typical HCC enhancement patterns and portal vein tumor thrombosis were detected in 15.0% (3/20), 72.2% (13/18) and 20.0% (4/20) of patients with PCCCL and 3.1% (4/127), 83.6% (97/116) and 17.3% (22/127) of patients with CHCC, respectively. There were no significant differences between the two groups (all P > 0.05). No patients with PCCCL and 2.4% (3/127) of patients with CHCC showed signs of lymph node metastasis (P > 0.05). CONCLUSION: The imaging characteristics of PCCCL are similar to those of CHCC and could be useful for differentiating these from other liver tumors (such as h

关键词： Clear cell carcinoma Hepatocellular carcinoma Pathology Magnetic resonance imaging Computed Tomography X-ray

A special recurrent pattern in small hepatocellular carcinoma after treatment:Bile duct tumor thrombus formation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2011年第43期17卷 4817-4824页

作者： Qing-Yu liu Dong-Ming Lai Chao liu Lei Zhang Wei-Dong Zhang hai-gang li Ming Gao Department of Radiology Sun Yatsen Memorial Hospital Sun Yat-sen University Guangzhou 510120 Guangdong Province China

AIM:To investigate the clinicopathologic features of bile duct tumor thrombus(BDTT) occurrence after treatment of primary small hepatocellular carcinoma(sHCC) .METHODS:A total of 423 patients with primary sHCC admitted to our hospital underwent surgical resection or local *** follow-up,only six patients were hospitalized due to obstructive jaundice,which occurred 5-76 mo after initial *** clinicopathologic features of these six patients were ***:Six patients underwent hepatic resection(n=5) or radio-frequency ablation(n=1) due to primary *** cases had an R1 resection margin,and one case had an ablative margin less than 5.0 *** vascular infiltration,microsatellites or bile duct/canaliculus affection was noted in the initial resected *** the follow-up,imaging studies revealed a macroscopic BDTT extending to the common bile duct in all six *** patients had a concomitant intrahepatic recurrent *** re-resection of intrahepatic recurrent tumors and removal of BDTTs(n=4) ,BDTT removal through choledochotomy(n= 1) ,and conservative treatment(n=1) was *** portal vein invasion was noted in three of the four resected *** six patients died,with a mean survival of 11 mo after BDTT removal or conservative ***:BDTT occurrence is a rare,special recurrent pattern of primary *** with BDTTs extending to the common bile duct usually have an unfavorable prognosis even following aggressive *** resection or ablative margins against primary sHCC may be a risk factor for BDTT development.

关键词： Small hepatocellular carcinoma Recurrence Bile ducts Jaundice Diagnosis

Dual energy computed tomography for detection of metastatic lymph nodes in patients with hepatocellular carcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2019年第16期25卷 1986-1996页

作者： Yu-Rong Zeng Qi-Hua Yang Qing-Yu liu Jun Min hai-gang li Zhi-Feng liu Ji-Xin li Department of Radiology Sun Yat-sen Memorial Hospital Sun Yat-sen University Department of Hepatobiliary Surgery Sun Yat-sen Memorial Hospital Sun Yat-sen University Department of Pathology Sun Yat-sen Memorial Hospital Sun Yat-sen University Department of Radiology Zengcheng District People’s Hospital of Guangzhou

BACKGROUND Regional lymph node metastasis in patients with hepatocellular carcinoma(HCC)is not uncommon, and is often under-or misdiagnosed. Regional lymph node metastasis is associated with a negative prognosis in patients with HCC, and surgical resection of lymph node metastasis is considered feasible and efficacious in improving the survival and prognosis. It is critical to characterize lymph node preoperatively. There is currently no consensus regarding the optimal method for the assessment of regional lymph nodes in patients with *** To evaluate the diagnostic value of single source dual energy computed tomography(CT) in regional lymph node assessment for HCC *** Forty-three patients with pathologically confirmed HCC who underwent partial hepatectomy with lymphadenectomy were retrospectively enrolled. All patients underwent dual-energy CT preoperatively. Regional lymph nodes(n = 156) were divided into either a metastatic(group P, n = 52) or a non-metastasis group(group N, n = 104), and further, according to pathology, divided into an active hepatitis(group P1, n = 34; group N1, n = 73) and a non-active hepatitis group(group P2, n = 18; group N2, n = 31). The maximal short axis diameter(MSAD),iodine concentration(IC), normalized IC(NIC), and the slope of the spectralcurve(λ_(HU)) of each group in the arterial phase(AP), portal phase(PP), and delayed phase(DP) were *** Analysis of the MSAD, IC, NIC, and λ_(HU) showed statistical differences between groups P and N(P < 0.05) during all three phases. To distinguish benign from metastatic lymph nodes, the diagnostic efficacy of IC, NIC, and λ_(HU) in the PP was the best among the three phases(AP, PP, and DP), with a sensitivity up to 81.9%,83.9%, and 81.8%, and a specificity up to 82.4%, 84.1% and 84.1%, *** diagnostic value of combined analyses of MSAD with IC, NIC, or λ_(HU) in the PP was superior to the dual energy CT parameters alone, with a sensitivity up to84.5%, 86.9%

关键词： Computed tomography Hepatocellular carcinoma Lymph node Metastasis Hepatitis Dual energy

High-performance magnesium/sodium hybrid ion battery based on sodium vanadate oxide for reversible storage of Na^(+)and Mg^(2+)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第9期96卷 79-88页

作者： Xiaoke Wang Titi li Xixi Zhang Yaxin Wang Hongfei li hai-Feng li gang Zhao Cuiping Han Institute of Applied Physics and Materials Engineering University of MacaoAvenida da UniversidadeTaipaMacao 999078China School of Physics and Technology University of JinanJinan 250022ShandongChina Songshan Lake Materials Laboratory Dongguan 523808GuangdongChina Faculty of Materials Science and Energy Engineering Shenzhen University of Advanced TechnologyShenzhen 518055GuangdongChina Institute of Technology for Carbon Neutrality Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongChina

Magnesium ion batteries(MIBs)are a potential field for the energy storage of the future but are restricted by insufficient rate capability and rapid capacity ***-sodium hybrid ion batteries(MSHBs)are an effective way to address these ***,we report a new type of MSHBs that use layered sodium vanadate((Na,Mn)V_(8)O_(20)·5H_(2)O,Mn-NVO)cathodes coupled with an organic 3,4,9,10-perylenetetracarboxylic diimide(PTCDI)anode in Mg^(2+)/Na^(+)hybrid *** electrochemical cycling,Mg^(2+)and Na^(+)co-participate in the cathode reactions,and the introduction of Na^(+)promotes the structural stability of the Mn-NVO cathode,as cleared by several ex-situ ***,the Mn-NVO cathode presents great specific capacity(249.9 mA h g^(−1)at 300 mA g^(−1))and cycling(1500 cycles at 1500 mA g^(−1))in the Mg^(2+)/Na^(+)hybrid ***,full battery displays long lifespan with 10,000 cycles at 1000 mA g^(−1).The rate performance and cycling stability of MSHBs have been improved by an economical and scalable method,and the mechanism for these improvements is discussed.

关键词： Aqueous battery Hybrid ion battery Mg^(2+)/Na^(+)co-intercalation High-rate performance Organic-water hybrid electrolyte

Hot versus cold subduction initiation

在线全文

学校读者我要写书评

暂无评论

National Science Review 2024年第2期11卷 101-102页

作者： Zhong-hai li Key Laboratory of Computational Geodynamics College of Earth and Planetary SciencesUniversity of Chinese Academy of Sciences

In the framework of plate tectonics, subduction initiation(SI) indicates the birth of a plate convergent boundary, which is a key point of plate tectonics and Wilson's cycle; however, its dynamic process is not well c... 详细信息

关键词： DRIVEN CRUST

Comparative transcriptomic evidence of physiological changes and potential relationships in vertebrates under different dormancy states

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Zoological Research 2024年第2期45卷 341-354页

作者： Yu-Han Niu li-Hong Guan Cheng Wang hai-Feng Jiang Guo-gang li lian-Dong Yang Shun-Ping He State Key Laboratory of Freshwater Ecology and Biotechnology Institute of HydrobiologyChinese Academy of SciencesWuhanHubei 430072China College of life Sciences Qinghai Normal UniversityXiningQinghai 810008China Academy of Plateau Science and Sustainability Qinghai Normal UniversityXiningQinghai 810016China Key Laboratory of Biodiversity Formation Mechanism and Comprehensive Utilization of the Qinghai-Tibet Plateau in Qinghai Province Qinghai Normal UniversityXiningQinghai 810008China College of life Sciences and Technology Xinxiang Medical UniversityXinxiangHenan 453003China College of Animal Science and Technology Northwest A&F UniversityYanglingShaanxi 712100China

Dormancy represents a fascinating adaptive strategy for organisms to survive in unforgiving *** a period of dormancy,organisms often exhibit exceptional *** period is typically divided into hibernation and aestivation based on seasonal ***,the mechanisms by which organisms adapt to their environments during dormancy,as well as the potential relationships between different states of dormancy,deserve further ***,we selected Perccottus glenii and Protopterus annectens as the primary subjects to study hibernation and aestivation,*** on histological and transcriptomic analysis of multiple organs,we discovered that dormancy involved a coordinated functional response across *** analyses revealed noteworthy disparities between the two dormant species in their responses to extreme ***,similarities in gene expression patterns pertaining to energy metabolism,neural activity,and biosynthesis were noted during hibernation,suggesting a potential correlation between hibernation and *** further explore the relationship between these two phenomena,we analyzed other dormancy-capable species using data from publicly available *** comparative analysis revealed that most orthologous genes involved in metabolism,cell proliferation,and neural function exhibited consistent expression patterns during dormancy,indicating that the observed similarity between hibernation and aestivation may be attributable to convergent *** conclusion,this study enhances our comprehension of the dormancy phenomenon and offers new insights into the molecular mechanisms underpinning vertebrate dormancy.

关键词： Hibernation Aestivation Multi-organs Convergent evolution

Interaction mechanism between BaZrO_(3)/Y_(2)O_(3) refractory and Ti_(2)Ni alloy melts

在线全文

学校读者我要写书评

暂无评论

Journal of Iron and Steel Research International 2024年第6期31卷 1376-1388页

作者： Xiao Hou Guang-yao Chen Jian liu Ming-rui Lv Fei-hai Yu Qi-sheng Feng Rong-bin li Xiong-gang Lu Chong-he li State Key Laboratory of Advanced Special Steel and Shanghai Key Laboratory of Advanced Ferromeallurgy and School of Materials Science and Engineering Shanghai UniversityShanghai 200072China Shanghai Special Casting Engineering Technology Research Center Shanghai 201605China Zhejiang Institute of Advanced Materials Shanghai UniversityJiashan 314100ZhejiangChina School of Materials Science and Engineering Shanghai DianJi UniversityShanghai 201306China

The titanium alloys with highly chemical activity require stable crucible refractories that can withstand the erosion of alloy *** phase composition and microstructure are crucial factors that affect the stability of the refractory *** effect of Y_(2)O_(3) on the composition and microstructure of BaZrO_(3) crucible was systematically investigated,and the improved mechanism of the stability of BaZrO_(3)/Y_(2)O_(3) crucible was clarified in comparison with the BaZrO_(3) *** results showed that the erosion layer thickness of the BaZrO_(3)/Y_(2)O_(3) crucible was only 63μm,which was far less than that in the BaZrO_(3) crucible(485μm),and the erosion layer in the BaZrO_(3)/Y_(2)O_(3) crucible also exhibited a higher density than that in the BaZrO_(3) *** the sintering,Y_(2)O_(3) could improve the densification of the BaZrO_(3) crucible due to the solid solution effect between Y_(2)O_(3) and ZrO_(2),which also caused the evaporation of BaO,resulting in the generation of a Y_(2)O_(3)(ZrO_(2))film on the surface of the ***,the Y_(2)O_(3)(ZrO_(2))had higher thermodynamic stability than Y_(2)O_(3),confirming that the BaZrO_(3)/Y_(2)O_(3) crucible with high density exhibited a superior erosion resistance to titanium *** dual-phase structure provides a strategy to design a long-life and stable refractory for melting titanium alloys.

关键词： Barium zirconate Yttrium oxide Dual-phase refractory Titanium alloy Interaction

Design optimization of a hexapod vibration isolation system for electro-optical payload

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Aeronautics 2024年第2期37卷 330-342页

作者： Jing li Weipeng li Xiaoyan ZHANG hai HUANG School of Astronautics Beihang UniversityBeijing 100191China

The electro-optical payloads on mobile platforms generally suffer undesirable vibrations generated by maneuvers and *** vibrations are in six degrees of freedom and cause line-of-sight jitters,resulting in image blurring and loss of tracking *** this paper,a Hexapod Vibration Isolation System(HVIS)is proposed and optimized to solve this *** optimization aims to centralize and minimize the natural frequencies of HVIS,for expanding the vibration isolation bandwidth and improving the vibration isolation in the higher frequency *** that the design space for HVIS is limited and interfered with the frames of the mobile platform,a non-collision algorithm is proposed and applied in the optimization to obtain the feasible optimal *** optimization result shows that the natural frequency bandwidth has been reduced by 42.9%,and the maximum natural frequency is reduced by 30.2%.The prototypes of initial and optimal designs are manufactured and *** simulated and experimental results demonstrate the validity of the optimization,and the optimal design provides a maximum of 15 dB more isolation in rotation direction than the initial design.

关键词： Electro-optical payload Vibrations Isolation system Hexapod Optimization Non-collision design