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Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu hai-feng zhou Wei Yang Di Zhu Bi-Fei Wu hai-Bin Shi Sheng Liu Wei-Zhong zhou Department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis

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Predicting the prognosis of hepatic arterial infusion chemotherapy in hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2380-2393页

作者： Qi-feng Wang Zong-Wei Li hai-feng zhou Kun-Zhong Zhu Ya-Jing Wang Ya-Qin Wang Yue-Wei Zhang Department of Hepatobiliary Pancreatic Center Beijing Tsinghua Changgung Hospital Affiliated to Tsinghua UniversityBeijing 102218China Department of Hepatobiliary and Pancreatic Surgery Qinghai University Affiliated HospitalXining 810000Qinghai ProvinceChina

Hepatic artery infusion chemotherapy(haiC)has good clinical efficacy in the treatment of advanced hepatocellular carcinoma(HCC);however,its efficacy *** review summarized the ability of various markers to predict the efficacy of haiC and provided a reference for clinical *** of October 25,2023,51 articles have been retrieved based on keyword predictions and *** eligible articles were selected for inclusion in this *** literature analysis found that methods used to predict the efficacy of haiC include serological testing,gene testing,and imaging *** above indicators and their combined forms showed excellent predictive effects in retrospective *** review summarized the strategies currently used to predict the efficacy of haiC in middle and advanced HCC,analyzed each marker's ability to predict haiC efficacy,and provided a reference for the clinical application of the prediction system.

关键词： Hepatocellular carcinoma Hepatic artery infusion chemotherapy Prediction Prognosis Imaging Biomarkers Genomics

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Outcome of in vitro fertilization in endometriosis-associated infertility： a 5-year database cohort study

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Chinese Medical Journal 2012年第15期125卷 2688-2693页

作者： LIN Xiao-na WEI Min-ling TONG Xiao-mei XU Wei-hai zhou feng HUANG Qiong-xiao WEN Guo-feng ZHANG Song-ying Assisted Reproduction Unit Department of Obstetrics andGynecology Sir Run Run Shaw Hospital Zhejiang UniversitySchool of Medicine Hangzhou Zhejiang 310016 China

Background Endometriosis affects natural fertility through various approaches, and in vitro fertilization （IVF） is a good treatment. But the IVF result of endometriosis patients is still under debate. We investigated the effect of endometriosis on IVF by analyzing the data from a single reproductive center. Methods A retrospective, database-searched cohort study was performed. Relevant information was collected from the electronic records of women who underwent IVF/intracytoplasmic sperm injection between January 2006 and December 2010 in the Assisted Reproductive Unit of Sir Run Run Shaw Hospital. Patients with endometriosis were enrolled the study group. The rest of the women formed the control group. The main outcome was the clinical pregnancy rate. Secondary outcomes were oocytes retrieved number, fertilization rate, high-quality embryo rate, number of high-quality embryo for embryo transplantation, and implantation embryo/high-quality embryo ratio （IE/HQE ratio）. Comparisons were performed by the z2-test and independent t-test. Results The endometriosis group （n=177） had a markedly lower oocytes retrieved number, fertilization rate, implantation rate, and clinical pregnancy rate （7.6_＋5.1, 63.6%, 27.7%, and 45.2%, respectively） compared with the non-endometriosis group （n=4267; 11.8＋7.3, 68.4%, 36.2%, and 55.2%, respectively）. Stratified analysis showed that this difference was found in the subgroup younger than 35-years old, while only fertilization rate and implantation rate were different in the elder subgroup. The ratio of high-quality embryos transferred is lower in endometriosis group （53.7% vs. 71.8%, P 〈0.05）, but there is no difference in IE/HQE ratio between two groups. There is no significant difference in fertilization rate, implantation rate, and clinical pregnancy rate between mild and severe endometriosis patients. Conclusions Endometriosis patients suffer a decreasing IVF pregnancy rates mainly caused by reducing oocytes number and fertilization

关键词： fertilization in vitro, endometriosis pregnancy rate cohort study

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Microalbuminuria associated with systolic blood pressure and arterial compliance in Chinese metabolic syndrome patients

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Chinese Medical Journal 2007年第16期120卷 1395-1399页

作者： LI Xin-li XU Qiong LU Xin-zheng ZHANG hai-feng zhou Yan-li CAO Ke-jiang HUANG Jun Department of Cardiology First Aftiliated Hospital of Nanjing Medical University Nanjing 210029 China

Background There is significant evidence showing that microalbuminuria and arterial compliance are sensitive markers for early cardiovascular diseases. However, whether microalbuminuria is associated with reduced arterial compliance in Chinese metabolic syndrome （MS） patients remains unknown. Methods According to the definition of MS proposed by ATPⅢ in 2001, USA, subjects （n=362） were divided into three groups according to the number of risk factors： group 1 （control）, group 2 （medium, 〈 3 risk factors） and group 3 （MS, ≥ 3 risk factors）. Both large artery compliance （C1） and small artery compliance （C2） were measured with the CVProfilor DO-2020 Cardiovascular Profiling System, and microalbuminuria was evaluated with the ratio of albumin to urine creatinine. Results （1） As C1 and C2 levels elasticity decreased, albumin creatinine ratio （ACR） and the prevalence of microalbuminuria increased within those groups with MS risk factors. C1 and C2 were negatively correlated with the ranking of MS risk factors, ACR was positively correlated with the ranking of MS risk factors （all P〈0.05）. （2） Subjects were also categorized into a microalbuminuria group and a normal group, C1 and C2 in the microalbuminuria group were lower than in the normal group. （3） Multivariate regression analysis showed that increased systolic blood pressure （SBP） and reduced arterial compliance were the main risk factors for microalbuminuria in the MS group. Conclusions The risk of developing microalbuminuria was higher in the subjects with multiple metabolic abnormalities. Increased systolic blood pressure and reduced arterial compliance may be the main predictors for microalbuminuria in MS.

关键词： metabolic syndrome microalbuminuria arterial elasticity

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A hybrid technique： intra-arterial catheter-directed thrombolysis following the recanalization of superior mesenteric artery in acute mesenteric ischemia

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Chinese Medical Journal 2013年第7期126卷 1381-1383页

作者： ZHU Jie-chang DAI Xiang-chen FAN hai-lun feng zhou ZHANG Yi-wei LUO Yu-dong Department of General Surgery General Hospital of Tianjin Medical University Tianjin 300052 China

Acute mesenteric ischemia is a deadly process withoverall mortality rate of 40%. Acute thrombosis of an atherosclerotic lesion with previous partial occlusion isone of the common causes. Peri-operative mortality ofsu... 详细信息

关键词： superior mesenteric artery mesenteric ischemia thrombosis embolectomy angioplasty intra-arterial catheter-directed thrombolysis

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碳/酚醛燃气舵热化学烧蚀过程数值研究

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推进技术 2016年第10期37卷 1900-1908页

作者：薛海峰陈雄周长省南京理工大学机械工程学院江苏南京210094

为了研究碳/酚醛燃气舵热化学烧蚀问题,在Fluent平台上采用UDF二次开发方法,对碳/酚醛燃气舵二维非定常流固热耦合过程进行了数值仿真研究。对几何建模、边界条件、热解气体逸出过程以及热化学烧蚀导致的边界退移等问题进行了详尽的描述... 详细信息

为了研究碳/酚醛燃气舵热化学烧蚀问题,在Fluent平台上采用UDF二次开发方法,对碳/酚醛燃气舵二维非定常流固热耦合过程进行了数值仿真研究。对几何建模、边界条件、热解气体逸出过程以及热化学烧蚀导致的边界退移等问题进行了详尽的描述,并选取了合适的计算模型。对不同舵偏角下燃气舵温度分布、热解气体逸出通量以及热化学烧蚀等问题进行了分析研究。结果表明:燃气舵表面化学反应以及热解气体的逸出过程能够有效降低燃气舵壁面以及内部温度,下降温度最高值约为325K;燃气舵前缘一直是热化学烧蚀最严重区域,达到0.5mm,迎风面烧蚀量次之,而背风面几乎不存在热化学烧蚀现象;迎风面热化学烧蚀会随着舵偏角的增大而变得更为严重。

关键词：碳/酚醛燃气舵流固热耦合热化学烧蚀

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Improvement on the wave absorbing property of a lossy frequency selective surface absorber using a magnetic substrate

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Chinese Physics B 2012年第5期21卷 378-382页

作者：孙良奎程海峰周永江王军 Key Laboratory of Advanced Ceramic Fibers and Composites College of Aerospace and Materials EngineeringNational University of Defence Technology

An equivalent-circuit model is used to analyse the improvement of the wave absorbing performance of the lossy frequency selective surface（FSS） absorber by using a magnetic substrate,showing that it is possible to widen the wave absorbing *** pieces of magnetic substrates are *** to the complex permittivity and permeability,the reflectivity of the corresponding absorber is calculated by the finite difference time-domain（FDTD） method,and the bandwidth of the reflectivity below 10 dB is optimized by genetic *** calculated results indicate that the wave absorbing performance is significantly improved by increasing the complex permeability of the substrate;the reflectivity bandwidth below 10 dB of the single layer FSS absorber can reach 3.6-18 GHz with a thickness of 5 mm,which is wider than that with a dielectric *** density of the FSS absorber is only 0.92 g/cm ***,the absorption band can be further widened by inserting a second lossy ***,a double layer lossy FSS absorber with a magnetic substrate is fabricated based on the design *** experimental result is consistent with the design one.

关键词： wave absorbing performance lossy frequency selective surface(FSS) bandwidth

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铁路轨道高低不平顺的预测方法

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同济大学学报（自然科学版） 2003年第3期31卷 291-295页

作者：许玉德李海峰周宇同济大学沪西校区铁道建筑工程系上海200331

轨道变形是有碴轨道结构无法避免的 .通过轨道不平顺的描述 ,预测轨道不平顺的变化规律是近代轨道力学的基本课题 ,也是制定养护维修计划的关键 .据此在介绍轨道不平顺的分类和分析国外有关轨道高低不平顺预测模型的基础上 ,提出一个利... 详细信息

轨道变形是有碴轨道结构无法避免的 .通过轨道不平顺的描述 ,预测轨道不平顺的变化规律是近代轨道力学的基本课题 ,也是制定养护维修计划的关键 .据此在介绍轨道不平顺的分类和分析国外有关轨道高低不平顺预测模型的基础上 ,提出一个利用特性矩阵描述轨道变形并进行预测的方法 .这一方法利用动态实测数据 ,全面反映不平顺的影响因素。

关键词：轨道不平顺高低预测方法特性矩阵

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Clinical effects of phospholipase D2 in attenuating acute pancreatitis

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World Journal of Gastroenterology 2025年第2期31卷 52-60页

作者： Jin-Wei Niu Guo-Chao Zhang Wu Ning hai-Bin Liu Hua Yang Chao-feng Li Department of General Surgery China-Japan Friendship HospitalBeijing 100029China

BACKGROUND The objective of the current study was to elucidate the clinical mechanism through which phospholipase D2(PLD2)exerted a regulatory effect on neutrophil migra-tion,thereby alleviating the progression of acute *** To elucidate the clinical mechanism through which PLD2 exerted a regulatory effect on neutrophil migration,thereby alleviating the progression of acute *** The study involved 90 patients diagnosed with acute pancreatitis,admitted to our hospital between March 2020 and November 2022.A retrospective analysis was conducted,categorizing patients based on Ranson score severity into mild(n=25),moderate(n=30),and severe(n=35)*** data was collected for each *** blot analysis assessed PLD2 protein expression in patient ***-time reverse transcription polymerase chain reaction was used to evaluate the mRNA expression of chemokine receptors associated with neutrophil *** levels of inflammatory factors in patients were detected using enzyme-linked immunosorbent *** migration tests were conducted to compare migration of neutrophils across groups and analyze the influence of PLD2 on neutrophil *** Overall data analysis did not find significant differences between patient groups(P>0.05).The expression of PLD2 protein in the severe group was lower than that in the moderate and mild groups(P<0.05).The expression level of PLD2 in the moderate group was also lower than that in the mild group(P<0.05).The severity of acute pancreatitis is negatively correlated with PLD2 expression(r=-0.75,P=0.002).The mRNA levels of C-X-C chemokine receptor type 1,C-X-C chemokine receptor type 2,C-C chemokine receptor type 2,and C-C chemokine receptor type 5 in the severe group are significantly higher than those in the moderate and mild groups(P<0.05),and the expression levels in the moderate group are also higher than those in the mild group(P<0.05).The levels of C-reactive protein,tumo

关键词： Phospholipase D2 Neutrophil migration Acute pancreatitis Retrospective analysis Inflammatory response

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Bioinspired Passive Tactile Sensors Enabled by Reversible Polarization of Conjugated Polymers

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Nano-Micro Letters 2025年第1期17卷 361-377页

作者： feng He Sitong Chen Ruili zhou Hanyu Diao Yangyang Han Xiaodong Wu School of Mechanical Engineering Sichuan UniversityChengdu 610065People’s Republic of China School of Software Engineering Chongqing University of Posts and TelecommunicationsChongqing 400065People’s Republic of China State Key Laboratory of Polymer Materials Engineering Sichuan UniversityChengdu 610065People’s Republic of China

Tactile perception plays a vital role for the human body and is also highly desired for smart prosthesis and advanced *** to active sensing devices,passive piezoelectric and triboelectric tactile sensors consume less power,but lack the capability to resolve static ***,we address this issue by utilizing the unique polarization chemistry of conjugated polymers for the first time and propose a new type of bioinspired,passive,and bio-friendly tactile sensors for resolving both static and dynamic ***,to emulate the polarization process of natural sensory cells,conjugated polymers(including poly(3,4-ethylenedioxythiophen e):poly(styrenesulfonate),polyaniline,or polypyrrole)are controllably polarized into two opposite states to create artificial potential *** controllable and reversible polarization process of the conjugated polymers is fully in situ ***,a micro-structured ionic electrolyte is employed to imitate the natural ion channels and to encode external touch stimulations into the variation in potential difference *** with the currently existing tactile sensing devices,the developed tactile sensors feature distinct characteristics including fully organic composition,high sensitivity(up to 773 mV N^(−1)),ultralow power consumption(nW),as well as superior *** demonstrations,both single point tactile perception(surface texture perception and material property perception)and two-dimensional tactile recognitions(shape or profile perception)with high accuracy are successfully realized using self-defined machine learning *** tactile sensing concept innovation based on the polarization chemistry of conjugated polymers opens up a new path to create robotic tactile sensors and prosthetic electronic skins.

关键词： Passive tactile sensors Reversible polarization of conjugated polymers Tactile perception Machine learning algorithm Object recognition

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