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Food Science and Human Wellness 2024年

作者： xia Li Shanshan Wei Ruixue Zhao Yue Zhang Zixin Gao Zhanpeng Wang Yu Wang bo Nan Yuhua Wang College of Food Science and Engineering and Jilin Province Innovation Center for Food Biological Manufacture， Jilin Agricultural University

Lactiplantibacillusplantarum 104， which was previously screened in the laboratory， has been confirmed to have the effect of lowering lipids and regulating intestinal microbial homeostasis. However， the mechanism of action of its fermentation supernatant in alleviating metabolic disorders is ***104 cell-freesupernatant (LP104s) was fed to high-fat C57BL/6N mice for 8 weeks. The intervention of LP104s increased the concentration of conjugated bile acids in the ileum， especially taur-α/β-muricholic acid sodium salt (T-α-MCA or T-β-MCA)， inhibited intestinal farnesoid X receptor (FXR)-related signaling pathways. LP104s reduced cholesterol levels by increasing the synthesis of hepatic cholic acid (CA)， chenodeoxycholic acid (CDCA)， and the excretion of bile acids in feces. Moreover， western blotting results showed that TLR2/NF-?B signaling pathway expression was inhibited. In addition， 16S rDNA sequencing results showed that LP104s regulated the relative abundance of bacteria associated with inflammatory response and obesity (Prevotella， Ruminococcus， and Clostridium). Therefore， this paper further elaborates the role of gut microbiology and bile acids in improving metabolism from the perspective of secondary bile acids and intestinal chronic inflammation and also lays a theoretical foundation for the next step in the development of fermentation products of this strain.

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Mechanism of Pediococcuspentosaceus PP04 in Alleviating High-fat Diet Caused Hyperlipidemiavia Modulation of Intestinal Flora and It′s Metabolites

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Food Science and Human Wellness 2024年

作者： Yu Wang Xinyue Xing Yamei He Yue Zhang Yuxuan Ma bo Nan xia Li Yuhua Wang Jingsheng Liu College of Food Science and Engineering， Jilin Agricultural University Jilin Province Innovation Center for Food Biological Manufacture， Jilin Agricultural University National Processing Laboratory for Soybean Industry and Technology National Engineering Research Center for Wheat and Corn Deep Processing

The gut microbiota and it′s metabolism are vital targets of probiotics regulating high fat-diet (HFD) induced hyperlipidemia， which can relieve the pressure caused by the striking growth of sub-health people. Pediococcus pentosaceus PP04 (PP04) could colonize in intestine to regulate gut microbiota and it′s metabolites directly， the rebalanced intestinal flora mediated by PP04 could facilitate the secretion of short chain fatty acids to control body weight gain， PP04 intervention also changed bile acids (BAs) profiles and enhanced the ileal concentrations of antagonists including tauro-α/β-muricholic acid sodium salt and ursodeoxycholic acid to inhibit intestinal farnesoid X receptor/fibroblast growth factor 15 (FXR/FGF15) signaling coupled with the activation of hepatic FXR/small heterodimer partners signaling (SHP)， which accelerated the hepatic BAs de novo synthesis and excretion with feces to eliminate HFD caused hyperlipemia effectively. This study provided important evidence regarding PP04 as dietary supplement to relieve hyperlipidemia by influencing BAs enterohepatic circulation.

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一种用于肼氧化-复合海水电解制氢的富吡啶氮碳纸

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Science China Materials 2024年第3期67卷 752-761页

作者：马闪闪喻博夏宝玉游波 Key Laboratory of Material Chemistry for Energy Conversion and Storage(Ministry of Education) Hubei Key Laboratory of Material Chemistry and Service FailureSchool of Chemistry and Chemical EngineeringHuazhong University of Science and TechnologyWuhan 430074China

丰富的中性海水有望替代高纯淡水用于绿氢制备,然而基于过渡金属材料催化的直接海水电解会因析氯反应(ClER)引发严重的腐蚀问题并造成二次重金属污染,且析氧反应(OER)的动力学缓慢.本工作中,我们报道了一种稳定的富吡啶氮的碳纸(N-CP-80... 详细信息

丰富的中性海水有望替代高纯淡水用于绿氢制备,然而基于过渡金属材料催化的直接海水电解会因析氯反应(ClER)引发严重的腐蚀问题并造成二次重金属污染,且析氧反应(OER)的动力学缓慢.本工作中,我们报道了一种稳定的富吡啶氮的碳纸(N-CP-800),可以有效地催化肼氧化反应(HzOR),以取代中性海水中的OER用于节能制氢.结合电化学实验、原位衰减全反射-表面增强傅里叶变换红外光谱表征和密度泛函理论计算,我们发现:相较于吡咯氮和石墨氮,zig和arm构型的吡啶氮更有利于决速步(^(*)H+N_(2)H_(1))的质子脱附,以促进肼氧化反应.因此,N-CP-800在中性介质中进行HzOR时,仅需0.78 V(相对于可逆氢电势)便可达到10 mA cm^(-2),低于其OER/ClER竞争反应.当N-CP-800与非贵金属析氢催化剂CoP耦合进行HzOR-复合海水电解时,仅需1.56 V的电压即可达到10 mA cm^(-2),并能稳定运行200 h,优于Pt/C和RuO_(2)标准电极对催化的海水电解.

关键词： seawater electrolysis hydrazine oxidation hydrogen evolution nitrogen doping metal-free carbon

Enhanced potency of an IgM-like nanobody targeting conserved epitope in SARS-CoV-2 spike N-terminal domain

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2726-2737页

作者： bo Liu Honghui Liu Pu Han xiaoyun Wang Chunmei Wang Xinxin Yan Wenwen Lei Ke Xu Jianjie Zhou Jianxun Qi Ruiwen Fan Guizhen Wu Wen-xia Tian George F.Gao Qihui Wang College of Veterinary Medicine Shanxi Agricultural University030801 JinzhongChina CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of Sciences(CAS)100101 BeijingChina School of Life Sciences Yunnan University650504 KunmingYunnan ProvinceChina NHC Key Laboratory of Biosafety National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and Prevention(China CDC)102206 BeijingChina Savaid Medical School University of Chinese Academy of Sciences101408 BeijingChina

Almost all the neutralizing antibodies targeting the receptor-binding domain(RBD)of spike(S)protein show weakened or lost efficacy against severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)emerged or emerging variants,such as Omicron and its *** suggests that highly conserved epitopes are crucial for the development of neutralizing ***,we present one nanobody,N235,displaying broad neutralization against the SARS-CoV-2 prototype and multiple variants,including the newly emerged Omicron and its ***-electron microscopy demonstrates N235 binds a novel,conserved,cryptic epitope in the N-terminal domain(NTD)of the S protein,which interferes with the RBD in the neighboring S *** neutralization mechanism interpreted via flow cytometry and Western blot shows that N235 appears to induce the S1 subunit shedding from the trimeric S ***,a nano-IgM construct(MN235),engineered by fusing N235 with the human IgM Fc region,displays prevention via inducing S1 shedding and cross-linking virus *** to N235,MN235 exhibits varied enhancement in neutralization against pseudotyped and authentic viruses in *** intranasal administration of MN235 in low doses can effectively prevent the infection of Omicron sub-variant BA.1 and XBB in vivo,suggesting that it can be developed as a promising prophylactic antibody to cope with the ongoing and future infection.

关键词： doses prevention conserved

基于均衡性和能力利用的高速铁路标杆车运行图编制方法研究

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铁道科学与工程学报 2024年第6期21卷 2162-2171页

作者：夏铭泽李博张博张新中国铁道科学研究院研究生部北京100081 中国铁道科学研究院集团有限公司中国铁路列车运行图技术中心北京100081 中国铁道科学研究院集团有限公司运输及经济研究所北京100081 中国国家铁路集团有限公司运输部北京100844

高速铁路标杆车的服务品质对于提高铁路客运产品的竞争力具有重要意义,在现场实际编图过程中,高速铁路标杆车须优先铺画,因此标杆车运行图的编制结果决定了整个列车运行图的框架。为了提高高速铁路标杆车的服务品质,考虑标杆车区间运行... 详细信息

高速铁路标杆车的服务品质对于提高铁路客运产品的竞争力具有重要意义,在现场实际编图过程中,高速铁路标杆车须优先铺画,因此标杆车运行图的编制结果决定了整个列车运行图的框架。为了提高高速铁路标杆车的服务品质,考虑标杆车区间运行时分约束、交路接续时间约束等编图基本约束,结合标杆车始发时间约束、成组约束等特殊约束,基于事件活动网络构建以OD服务均衡性和能力利用为目标的整数线性规划模型。设计分阶段迭代求解算法框架,嵌套商业求解器进行求解,第1阶段为不考虑安全间隔时间约束的标杆车分组问题,以OD服务均衡性为目标进行求解;第2阶段以求解得到的标杆车分组为输入,增加安全间隔时间约束,以能力利用为目标进行求解。最后以京广高速铁路为案例,使用实际编图参数,运用优化求解器ILOG CPLEX进行求解,验证模型的有效性和可行性。实验结果表明:优化模型可以在较短时间内高效求解,与实际图对比,上下行OD服务均衡性分别提升38.2%和51.7%,能力损失降低50%,针对不同规模的算例,在200 s内均能得到最优解。针对不同交路接续时间,得出限制标杆车在北京西站的交路接续时间在45 min以内,不会对OD服务均衡性和能力利用造成较大影响。研究结果可为高速铁路标杆车运行图编制及优化提供参考。

关键词：铁路运输列车运行图整数规划模型标杆车多目标优化

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教科书评价的时代境遇与优化策略

课程．教材．教法 2024年第6期44卷 45-51页

作者：叶波李霞湖南师范大学教育科学学院长沙410081

网络空间教科书评议是教科书评价的新议题,对全面落实教材建设国家事权、推进教材高质量发展、建设好人民满意的教材具有积极意义。网络空间教科书评议由公共关切与技术赋权、集体记忆与知识普及、信息虚拟与制度现实多维互动建构而成,... 详细信息

网络空间教科书评议是教科书评价的新议题,对全面落实教材建设国家事权、推进教材高质量发展、建设好人民满意的教材具有积极意义。网络空间教科书评议由公共关切与技术赋权、集体记忆与知识普及、信息虚拟与制度现实多维互动建构而成,是教科书的公共产品属性和评价的情感价值属性共同作用的结果,存在价值主体与评价主体相脱节、理性要求与非理性行为相冲突、网络空间与制度空间相隔离等现实问题,容易形成教科书负面舆情,影响教科书功能的正常发挥。未来,网络空间教科书评议,需要在规制性要素、规范性要素和文化—认知要素三个维度,通过加强制度设计、注重价值引导、实施主体培育,全面提升网络空间教科书评议的公共品质。

关键词：教科书评价网络空间网络空间教科书评议教材建设

Prognostic value of ultrasound in early arterial complications post liver transplant

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World Journal of Gastrointestinal Surgery 2024年第1期16卷 13-20页

作者： Ning-bo Zhao Yi Chen Rui xia Jian-bo Tang Dong Zhao Department of Ultrasound National Clinical Research Centre for Infectious DiseaseShenzhen Third People's HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518112Guangdong ProvinceChina Department of Thyroid and Hernia Surgery The Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen 51800Guangdong ProvinceChina Department of Liver Surgery and Organ Transplantation Center Shenzhen Third People's HospitalThe Second Affiliated Hospital of Southern University of Science and TechnologyNational Clinical Research Center for Infectious DiseaseShenzhen 518112Guangdong ProvinceChina

Liver transplantation is the primary therapeutic intervention for end-stage liver ***,vascular complications,particularly those involving the hepatic artery,pose significant risks to *** clinical manifestations associated with early arterial complications following liver transplantation are often *** timely intervention,these complications can result in graft fai-lure or patient ***,early diagnosis and the formulation of an op-timal treatment plan are *** examination remains the pre-dominant imaging modality for detecting complications post liver *** article comprehensively reviews common causes and clinical present-ations of early hepatic artery complications in the post-transplantation period and delineates abnormal sonographic findings for accurate diagnosis of these ***,ultrasound offers the advantages of convenience,safety,effect-iveness,and *** enables real-time,dynamic,and precise evalua-tion,making it the preferred diagnostic method for post-liver transplantation *** Liver transplantation stands as the primary therapeutic approach for end-stage liver *** advancements in surgical techniques and the application of novel immunosuppressive agents contribute to ongoing improvements in the success rate and overall survival in patients undergoing liver transplantation *** these advan-cements,vascular complications,particularly those involving the hepatic artery,pose significant risks to *** the early stages following liver transplantation(within the first 30 d),proper hepatic artery function is crucial for hepatic arterial blood *** later stages,collateral circulation,including arteries such as the phrenic artery,right gastric artery,and gastroduodenal artery,becomes important for maintaining hepatic blood *** is now understood that the establishment of effective collat

关键词： Liver transplantation Vascular complication Arterial complication Ultrasound

Effect of aflibercept combined with triamcinolone acetonide on aqueous humor growth factor and inflammatory mediators in diabetic macular edema

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 297-303页

作者： De-Shuang Li Hong-xia Liao Jing-Lin Zhang bo Qin Shenzhen Aier Eye Hospital Aier Eye HospitalJinan UniversityShenzhen 518031Guangdong ProvinceChina Guangzhou Aier Eye Hospital Jinan UniversityGuangzhou 510040Guangdong ProvinceChina

AIM:To investigate the efficacy of aflibercept combined with sub-tenon injection of triamcinolone acetonide(TA)in treating diabetic macular edema(DME)and to examine changes in growth factors and inflammatory mediator levels in aqueous humor after ***:Totally 67 DME patients(67 eyes)and 30 cataract patients(32 eyes)were enrolled as the DME group and the control group,*** DME group was divided into the aflibercept group(34 cases)and the aflibercept combined with TA group(combined group,33 cases).The aqueous humor of both groups was collected during the study *** aqueous levels of vascular endothelial growth factor(VEGF),monocyte chemoattractant protein-1(MCP-1),interleukin-6(IL-6),interleukin-8(IL-8),and interleukin-1β(IL-1β)were detected using a microsphere suspension array technology(Luminex 200TM).Aqueous cytokines,best-corrected visual acuity(BCVA),central macular thickness(CMT),and complications before and after treatment were compared between the aflibercept group and combined ***:The concentrations of VEGF,MCP-1,IL-6,and IL-8 in the aqueous humor were significantly higher in the DME group than those of the control group(all P0.05).CONCLUSION:The cytokines VEGF,MCP-1,IL-6,and IL-8 in the aqueous humor of DME patients are significantly *** and aflibercept combined with TA have good efficacy in DME patients,can effectively reduce CMT,improve the patient’s vision,and have high *** combined with TA can quickly downregulate the aqueous humor cytokines and help to relieve macular edema ***,the long-term eff

关键词： diabetic macular edema aqueous humor cytokines aflibercept triamcinolone acetonide

Anodic Electrosynthesis of Amide from Alcohol and Ammonia

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CCS Chemistry 2024年第1期6卷 125-136页

作者： Yuxuan Lu Yingying Li bo Zhou Jingcheng Wu Ling Zhou Yuping Pan Zhongcheng xia Ming Yang Yandong Wu Zhenran Yuan Rixin Peng Zhijie Kong Shuangyin Wang Yuqin Zou State Key Laboratory of Chemo/Biosensing and Chemometrics College of Chemistry and Chemical EngineeringAdvanced Catalytic Engineering Research Center of the Ministry of EducationHunan UniversityChangsha 410082 Shenzhen Institute of Hunan University Shenzhen 518057 School of Chemistry and Chemical Engineering Jishou UniversityJishouHunan 416000

Amide is essential in biologically active compounds,synthetic materials,and building ***,conventional amide production relies on energyintensive consumption and activating agents that modulate processes to construct the C–N ***,for the first time,we have successfully realized the formation of amides at industrial current density via the anodic coelectrolysis of alcohol and ammonia under ambient *** have proved thatmodulation of the interface microenvironment concentration of nucleophile by electrolyte engineering can regulate the reaction pathways of amides rather than acetic *** C-N coupling strategy can be further extended to the electrosynthesis of the long-chain and aryl-ring amide with high selectivity by replacing ammonia with *** work opens up a vast store of information on the utilization of biomass alcohol for high-value N-containing chemicals via an electrocatalytic C-N coupling reaction.

关键词： electrocatalysis electrocatalysts biomass upgrading elctrochemical oxidation coupling amide production

A unique role of the pyrimidine de novo synthesis enzyme ODCase in Lysobacter enzymogenes

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Journal of Integrative Agriculture 2024年第9期23卷 3066-3077页

作者： Mingming Yang Yunxiao Tan Jiabing Ma Yingjia Zhao xia Yan Nana Wang Pingping Wang Jiaqi Tan Suilong Ai xiaofei Liang Bangshuai Chang Obadah E.A.Yousif Chao Zhao bo Wang Guoliang Qian Lili Huang State Key Laboratory for Crop Stress Resistance and High-Efficiency Production Northwest A&F UniversityYangling 712100China College of Plant Protection Northwest A&F UniversityYangling 712100China College of Life Sciences Northwest A&F UniversityYangling 712100China College of Natural Resources and Environment Northwest A&F UniversityYangling 712100China Shaanxi Provincial Tobacco Corporation of China National Tobacco Corporation Xi’an 710061China Institute of Plant Protection Jiangsu Academy of Agricultural SciencesNanjing 210014China College of Plant Protection Laboratory of Plant ImmunityNanjing Agricultural UniversityNanjing 210095China

Bacterial species of the genus Lysobacter are environmentally ubiquitous with strong antifungal biocontrol ***-stable antifungal factor(HSAF)secreted by the biocontrol bacterium Lysobacter enzymogenes OH11 has broad-spectrum and highly efficient antifungal *** the biosynthetic regulations of HSAF would lay an important foundation for strain engineering toward improved HSAF *** this work,we demonstrate that Le0752,an orotidine-5´-phosphate decarboxylase enzyme(ODCase)catalyzing a pivotal step of the UMP de novo biosynthesis pathway,is vital for HSAF-mediated antimicrobial activities and growth of *** OH11,but not for twitching *** gene regulates the production of HSAF by affecting the expression of lafB,a key gene in the HSAF biosynthesis operon,through the transcription factor ***,bioinformatics analysis revealed that Le0752 belongs to the Group III ODCases,whereas its homologs in the closely related genera Xanthomonas and Stenotrophomonas belong to Group I,which contains most ODCases from Gram-positive bacteria,Gram-negative bacteria and ***,the Group I ODCase PXO_3614 from the Xanthomonas oryzae *** PXO99A strain complemented the Le0752 mutant in regulating HSAF-mediated antagonistic ***,these results highlight the important requirement of de novo pyrimidine biosynthetic enzymes for antibiotic HSAF production in ***,which lays an important foundation for improving HSAF production via metabolic flow design and for dissecting the regulatory functions of bacterial ODCases.

关键词： ODCase pyrimidine de novo synthesis secondary metabolite HSAF Lysobacter enzymogenes