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Flexible and multifunctional triboelectric nanogenerator based on liquid metal/polyvinyl alcohol hydrogel for energy harvesting and self-powered wearable human-machine interaction

2012中国器官移植大会

作者： hai bi,xiaofei hou,lulin ma,lei zhao,guoliang wang department of urology,third hospital of peking university

【Background】For limited exposure with management of the native distal ureter ipsilateral to the transplanted kidney,we usually choose open nephroureterectomy(NU) or laparoscopic NU combined with an open approach in renal transplant(RTx) *** herein describe our preliminary experience with and evaluate the feasibility of total endoscopic NU with bladder cuff(BC) excision for RTx recipients.

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Rare Metals 2024年第3期43卷 1186-1196页

作者： hou-wang Zhou Cong zhao Ze-Yu zhao Jun-Chen Jiang Hui-Le Jin Shun wang Shuang Pan Min-Yi Xu Yi-Huang Chen hai-Ming Jin department of Orthopaedics The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou325027China College of Chemistry and materials Engineering Wenzhou UniversityWenzhou325035China Dalian Key Laboratory of marine Micro/Nano Energy and Self-Powered Systems Marine Engineering CollegeDalian Maritime UniversityDalian116026China

Hydrogel-based triboelectric nanoge nerator(TENG)has a promising applied prospect in wearable electronic ***,its low performance,poor stability,insufficient recyclability and inferior self-healing seriously hinder its ***,we report a robust route to a liquid metal(LM)/polyvinyl alcohol(PVA)hydrogel-based TENG(LP-TENG).Owing to the intrinsically liquid feature of conductive LM within the flexible PVA hydrogel,the as-prepared LP-TENG exhibited comprehensiye advantages of adaptability,biocompatibility,outstanding electrical performance,superior stability,recyclability and diverse applications,which were unattainable by traditional ***,the LP-TENG delivered appealing open circuit voltage of 250 V,short circuit current of 4μA and transferred charge of 120 nC with high stability,outperforming most advanced TENG *** LP-TENG was successfully employed for versatile applications with multifunctionality,including human motion detection,handwriting recognition,energy collection,message transmission and human-machine *** work presents significant prospects for crafting advanced materials and devices in the fields of wearable electronics,flexible skin and smart robots.

关键词： Liquid metal Hydrogel Wearable TENG Multifunctionality Human-machine interaction

Polycytosine RNA-binding protein 1 regulates osteoblast function via a ferroptosis pathway in type 2 diabetic osteoporosis

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World Journal of Diabetes 2024年第5期15卷 977-987页

作者： Hong-Dong ma lei Shi hai-Tian Li Xin-Dong wang mao-Wei Yang department of Orthopedics The Affiliated Hospital of Nantong UniversityNantong 226001Jiangsu ProvinceChina department of Orthopedics The First Hospital of China Medical UniversityShenyang 110001Liaoning ProvinceChina

BACKGROUND Recently,type 2 diabetic osteoporosis(T2DOP)has become a research hotspot for the complications of diabetes,but the specific mechanism of its occurrence and development remains *** caused by iron overload is con-sidered an important cause of *** RNA-binding protein 1(PCBP1),an iron ion chaperone,is considered a protector of *** To investigate the existence of ferroptosis and specific role of PCBP1 in the development of type 2 *** A cell counting kit-8 assay was used to detect changes in osteoblast viability under high glucose(HG)and/or ferroptosis inhibitors at different concentrations and *** electron microscopy was used to examine the morpho-logical changes in the mitochondria of osteoblasts under HG,and western blotting was used to detect the expression levels of PCBP1,ferritin,and the ferroptosis-related protein glutathione peroxidase 4(GPX4).A lentivirus silenced and overex-pressed *** blotting was used to detect the expression levels of the osteoblast functional proteins osteoprotegerin(OPG)and osteocalcin(OCN),whereas flow cytometry was used to detect changes in reactive oxygen species(ROS)levels in each *** Under HG,the viability of osteoblasts was considerably decreased,the number of mitochondria undergoing atrophy was considerably increased,PCBP1 and ferritin expression levels were increased,and GPX4 expression was *** blotting results demonstrated that infection with lentivirus overexpressing PCBP1,increased the expression levels of ferritin,GPX4,OPG,and OCN,compared with the HG *** cytometry results showed a reduction in ROS,and an opposite result was obtained after silencing *** PCBP1 may protect osteoblasts and reduce the harm caused by ferroptosis by promoting ferritin expression under a HG ***,PCBP1 may be a potential therapeutic target for T2DOP.

关键词： Polycytosine RNA-binding protein 1 Ferroptosis Reactive oxygen species Ferritin Osteoblast Type 2 diabetic osteoporosis

Prognostic value of PEA3 subfamily gene expression in cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 4014-4027页

作者： Li wang Zhe Zhang hai-Zhang ma department of Emergency The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina department of Emergency Medicine The First People’s Hospital of Linping District HangzhouHangzhou 311100Zhejiang ProvinceChina department of General Surgery Qilu Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina

BACKGROUND Cholangiocarcinoma(CCA)is a lethal malignancy with limited treatment options and poor *** PEA3 subfamily of E26 transformation specific genes:ETV1,ETV4,and ETV5 are known to play significant roles in various cancers by influencing cell proliferation,invasion,and *** To analyze PEA3 subfamily gene expression levels in CCA and their correlation with clinical parameters to determine their prognostic value for *** The expression levels of PEA3 subfamily genes in pan-cancer and CCA data in the cancer genome atlas and genotype-tissue expression project databases were analyzed with R language *** curve and receiver operating characteristic analyses were performed using the SurvMiner,Survival,and Procr language *** gene expression profiling interactive analysis 2.0 database was used to analyze the expression levels of PEA3 subfamily genes in different subtypes and stages of *** Gestalt was used to perform the gene ontology/Kyoto encyclopedia of genes and genomes(GO/KEGG)analysis,and STRING database analysis was used to determine the genes and proteins related to PEA3 subfamily *** ETV1,ETV4,and ETV5 expression levels were significantly increased in *** were significant differences in ETV1,ETV4,and ETV5 expression levels among the different subtypes of CCA,and predictive analysis revealed that only high ETV1 and ETV4 expression levels were significantly associated with shorter overall survival in patients with ***/KEGG analysis revealed that PEA3 subfamily genes were closely related to transcriptional misregulation in *** vitro and in vivo experiments revealed that PEA3 silencing inhibited the invasion and metastasis of CCA *** The expression level of ETV4 may be a predictive biomarker of survival in patients with CCA.

关键词： PEA3 subfamily Cholangiocarcinoma The cancer genome atlas ETV4 The prognosis Prognostic biomarker

Inducing mitochondriopathy-like damages by transformable nucleopeptide nanoparticles for targeted therapy of bladder cancer

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National Science Review 2024年第4期11卷 216-227页

作者： Da-Yong hou Ni-Yuan Zhang Lu wang Mei-Yu Lv Xiang-Peng Li Peng Zhang Yue-Ze wang lei Shen Xiu-hai Wu Bo Fu Peng-Yu Guo Zi-Qi wang Dong-bing Cheng Hao wang Wanhai Xu NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics Heilongjiang Key Laboratory of Scientific Research in Urology Harbin Medical University department of urology Harbin Medical University Cancer Hospital CAS Key Laboratory for biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST) School of Chemistry Chemical Engineering & Life Science Hubei Key Laboratory of Nanomedicine for Neurodegenerative Diseases Wuhan University of Technology

Mitochondriopathy inspired adenosine triphosphate(ATP) depletions have been recognized as a powerful way for controlling tumor growth. Nevertheless, selective sequestration or exhaustion of ATP under complex biological environments remains a prodigious challenge. Harnessing the advantages of in vivo self-assembled nanomaterials, we designed an Intracellular ATP Sequestration(IAS) system to specifically construct nanofibrous nanostructures on the surface of tumor nuclei with exposed ATP binding sites,leading to highly efficient suppression of bladder cancer by induction of mitochondriopathy-like ***, the reported transformable nucleopeptide(NLS-FF-T) self-assembled into nuclear-targeted nanoparticles with ATP binding sites encapsulated inside under aqueous conditions. By interaction with KPNA2, the NLS-FF-T transformed into a nanofibrous-based ATP trapper on the surface of tumor nuclei,which prevented the production of intracellular energy. As a result, multiple bladder tumor cell lines(T24,EJ and RT-112) revealed that the half-maximal inhibitory concentration(IC50) of NLS-FF-T was reduced by approximately 4-fold when compared to NLS-T. Following intravenous administration, NLS-FF-T was found to be dose-dependently accumulated at the tumor site of T24 xenograft mice. More significantly, this IAS system exhibited an extremely antitumor efficacy according to the deterioration of T24 tumors and simultaneously prolonged the overall survival of T24 orthotopic xenograft mice. Together, our findings clearly demonstrated the therapeutic advantages of intracellular ATP sequestration-induced mitochondriopathy-like damages, which provides a potential treatment strategy for malignancies.

关键词： self-assembly nucleopeptide nanomaterial bladder cancer mitochondriopathy

Prevalence of Reproductive Tract Infections and Association with Human Papillomavirus Infection Among Reproductive-Age Women—Six Tertiary hospitals,China,June 2021-December 2022

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China CDC weekly 2024年第10期6卷 189-194,I0002页

作者： Di Gao Jiayue Li Gengli zhao zhaohui Liu Hui bi Dai Zhang Fengxia Xue Chen Liu Hongtao ma Bei Lin Xu wang Xiaosong Zhang Linhong wang department of Obstetrics and Gynecology Peking University First HospitalBeijingChina School of Medicine University College DublinIreland Beijing Obstetrics and Gynecology hospital BeijingChina Tianjin Medical university General hospital TianjinChina Northwest Women’s and Children’s hospital Xi’an CityShaanxi ProvinceChina third Affiliated hospital of Zhengzhou university Zhengzhou CityHenan ProvinceChina Shengjing hospital of China Medical university Shenyang CityLiaoning ProvinceChina National Center for Chronic and Non-Communicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina

Summary What is already known about this topic?Previous studies have indicated a possible association between reproductive tract infections(RTIs)and highrisk human papillomavirus(HPV)infection,but the evidence is still *** is added by this report?This multicenter study found significantly higher positive rates of HPV,including general HPV,highrisk HPV.

关键词： Tertiary infection Reproductive

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伴静脉癌栓的肾上腺皮质癌的临床治疗及预后

北京大学学报（医学版） 2024年第4期56卷 624-630页

作者：刘帅刘磊刘茁张帆马潞林田晓军侯小飞王国良赵磊张树栋北京大学第三医院泌尿外科北京100191

目的:分析肾上腺皮质癌伴静脉癌栓患者的临床病理特征、预后,并总结手术治疗经验。方法:回顾性分析北京大学第三医院泌尿外科2018—2023年接受手术治疗的肾上腺皮质癌患者的相关数据,将其分为伴静脉癌栓组和不伴静脉癌栓组。采用Wilcoxo... 详细信息

目的:分析肾上腺皮质癌伴静脉癌栓患者的临床病理特征、预后,并总结手术治疗经验。方法:回顾性分析北京大学第三医院泌尿外科2018—2023年接受手术治疗的肾上腺皮质癌患者的相关数据,将其分为伴静脉癌栓组和不伴静脉癌栓组。采用Wilcoxon秩和检验比较定量变量,卡方检验/Fisher精确检验比较分类变量,采用Kaplan-Meier法计算生存率。结果:共纳入27例肾上腺皮质癌患者,其中11例(40.7%)伴静脉癌栓,包括8例女性,3例男性,中位年龄49(36,58)岁,中位体重指数26.0(24.1,30.4)kg/m^(2);7例初诊时有症状,6例有高血压病史,2例皮质醇水平增高;中位肿瘤直径9.4(6.5,12.5)cm。3例肿瘤侧别为左侧,其中1例局限在左肾上腺中央静脉未侵入左肾静脉,2例癌栓生长达肝下下腔静脉;8例肿瘤侧别为右侧,其中1例在右肾上腺中央静脉未侵入下腔静脉,4例侵入肝下下腔静脉,3例生长达肝后下腔静脉。10例患者为欧洲肾上腺肿瘤研究协作网(European Network for the Study of Adrenal Tumors,ENSAT)临床分期Ⅲ期,1例为Ⅳ期。手术方式为开放手术6例,单纯腹腔镜手术者4例,机器人辅助腹腔镜手术1例;2例切除同侧肾脏;中位手术时间332(261,440)min,术中中位出血量900(700,2200)mL,术后中位住院时间9(5,10)d;中位生存时间24.0个月,中位复发时间7.0个月,16例不伴静脉癌栓患者均未达到中位生存时间和中位复发时间。与不伴静脉癌栓组相比,静脉癌栓组有更差的3年总体生存(overall survival,OS)率(71.4%vs.40.9%;Log-rank,P=0.038)和2年无复发生存(recurrence-free survival,RFS)率(53.7%vs.9.1%;Log-rank,P=0.015)。结论:肾上腺皮质癌伴静脉癌栓患者预后较差,肾上腺肿瘤切除术和静脉癌栓取出术治疗该疾病安全有效。

关键词：肾上腺皮质癌癌栓临床病理特征预后

How variable progenitor clones construct a largely invariant neocortex

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National Science Review 2024年第1期11卷 129-144页

作者： Zhongfu Shen Jiajun Yang Qiangqiang Zhang Kuiyu wang Xiaohui Lv Xiaolin Hu Jian ma Song-hai Shi New Cornerstone Science Laboratory IDG/McG overn Institute for Brain Research Tsinghua-Peking Center for Life Sciences Beijing Frontier Research Center for Biological Structure School of Life Sciences Tsinghua University department of Computer Sciences Tsinghua University College of Life Sciences Nankai University Chinese Institute for Brain Research

The neocortex contains a vast collection of diverse neurons organized into distinct layers. While nearly all neocortical neurons are generated by radial glial progenitors(RGPs), it remains largely unclear how a complex yet organized neocortex is constructed reliably and robustly. Here, we show that the division behavior and neuronal output of RGPs are highly constrained with patterned variabilities to support the reliable and robust construction of the mouse neocortex. The neurogenic process of RGPs can be well-approximated by a consistent Poisson-like process unfolding over time, producing deep to superficial layer neurons progressively. The exact neuronal outputs regarding layer occupation are variable; yet, this variability is constrained systematically to support all layer formation, largely reflecting the variable intermediate progenitor generation and RGP neurogenic entry and exit timing differences. Together, these results define the fundamental features of neocortical neurogenesis with a balanced reliability and variability for the construction of the complex neocortex.

关键词： neocortex radial glial progenitor intermediate progenitor neurogenesis clonal variability layer formation

A positive feedback inhibition of isocitrate dehydrogenase 3β on paired-box gene 6 promotes Alzheimer-like pathology

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2324-2340页

作者： Xin wang Qian Liu hai-tao Yu Jia-zhao Xie Jun-ning zhao Zhi-ting Fang Min Qu Yao Zhang Ying Yang Jian-Zhi wang department of Pathophysiology School of Basic MedicineKey Laboratory of Education Ministry of China/Hubei Province for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina department of Fundamental Medicine Wuxi School of MedicineJiangnan UniversityWuxiJiangsu 214122China Hubei Provincial Key Laboratory for Applied Toxicology Hubei Provincial Center for Disease Control and PreventionHubei Provincial Academy of Preventive MedicineWuhan 430000China Endocrine department of Liyuan hospital Key Laboratory of Ministry of Education of China for Neurological DisordersTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430077China Co-innovation Center of Neuroregeneration Nantong UniversityNantong 226000China

Impaired brain glucose metabolism is an early indicator of Alzheimer’s disease(AD);however,the fundamental mechanism is *** this study,we found a substantial decline in isocitrate dehydrogenase 3β(IDH3β)levels,a critical tricarboxylic acid cycle enzyme,in AD patients and AD-transgenic mice’s *** investigations demonstrated that the knockdown of IDH3βinduced oxidation-phosphorylation uncoupling,leading to reduced energy metabolism and lactate *** resulting increased lactate,a source of lactyl,was found to promote histone lactylation,thereby enhancing the expression of paired-box gene 6(PAX6).As an inhibitory transcription factor of IDH3β,the elevated PAX6 in turn inhibited the expression of IDH3β,leading to tau hyperphosphorylation,synapse impairment,and learning and memory deficits resembling those seen in *** AD-transgenic mice,upregulating IDH3βand downregulating PAX6 were found to improve cognitive functioning and reverse AD-like ***,our data suggest that impaired oxidative phosphorylation accelerates AD progression via a positive feedback inhibition loop of IDH3β-lactate-PAX6-IDH3β.Breaking this loop by upregulating IDH3βor downregulating PAX6 attenuates AD neurodegeneration and cognitive impairments.

关键词： metabolism Alzheimer impaired

Clinical manifestations and spermatogenesis outcomes in Chinese patients with congenital hypogonadotropic hypogonadism caused by inherited or de novo FGFR1 mutations

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Asian Journal of Andrology 2024年第4期26卷 426-432页

作者： Yu-Fan Yang hai-Lu ma Xi wang Min Nie Jiang-Feng mao Xue-Yan Wu department of Endocrinology Peking Union Medical College HospitalChinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China.

Fibroblast growth factor receptor 1(FGFR1)mutations are associated with congenital hypogonadotropic hypogonadism(CHH)through inheritance or spontaneous *** detected FGFR1 mutations in a Chinese cohort of 210 CHH patients at peking Union Medical College hospital(Beijing,China)using next-generation and Sanger *** assessed missense variant pathogenicity using six bioinformatics tools and compared clinical features and treatment outcomes between inherited and de novo mutation *** 19 patients with FGFR1 mutations,three were recurrent,and 16 were novel *** of the novel mutations were likely pathogenic according to the American College of Medical Genetics and Genomics(ACMG)guidelines,with the prevalent P366L *** majority of FGFR1 mutations was inherited(57.9%),with frameshift mutations exclusive to the de novo mutation *** inherited mutation group had a lower incidence of cryptorchidism,short stature,and skeletal *** the inherited mutation group,luteinizing hormone(LH)levels were 0.5 IU l−1,follicle-stimulating hormone(FSH)levels were 1.0 IU l−1,and testosterone levels were 1.3 nmol l−*** contrast,the de novo group had LH levels of 0.2 IU l−1,FSH levels of 0.5 IU l−1,and testosterone levels of 0.9 nmol l−1,indicating milder hypothalamus–pituitary–gonadal axis(HPGA)functional deficiency in the inherited *** inherited mutation group showed a tendency toward higher spermatogenesis *** conclusion,this study underscores the predominance of inherited FGFR1 mutations and their association with milder HPGA dysfunction compared to de novo mutations,contributing to our understanding of the genetic and clinical aspects of FGFR1 mutations.

关键词： congenital hypogonadotropic hypogonadism de novo FGFR1 inherited