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Preliminary experience with transperitoneal laparoendoscopic single-site radical nephrectomy using a home-made single-port device in China

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Chinese Medical Journal 2014年第2期127卷 279-283页

作者： bi hai ma lulin hou xiaofei zhang Shudong Wang Guoliang Zhao lei department of urology Peking University Third Hospital Beijing 100191 China

Background Laparoendoscopic single-site （LESS） surgery represents a technique to further reduce morbidity and scarring associated with *** present our preliminary experience with transperitoneal LESS radical nephrectomy （RN） using a home-made single-port device in *** From July 2010 to November 2011,eleven patients with renal tumor not greater than T2 underwent LESS-RN by an experienced laparoscopic surgeon.A home-made single-port device was used through a 5-cm umbilical incision.A combination of standard and articulating laparoscopic instruments was *** sequence of steps of LESS-RN was similar to transperitoneal laparoscopic *** characteristics,perioperative variables and postoperative outcomes were recorded and *** Except for two transperitoneal laparoscopic conversions and one hand-assisted laparoscopic conversion,the other procedures were completed successfully without conversion to open *** mean operative time was 224.5 （155-297） minutes,estimated blood loss was 270.9 （50-900） ml,and hospital stay was 10.4 （5-15） *** mean visual analog pain scale （VAPS） on the first postoperative day was 4.0/*** pathological analysis revealed renal cell carcinoma in all cases with a stage distribution of three T1a,five T1b,and three T2a *** the mean followup period of 21.4 （12-28） months,all patients were alive without evidence of tumor recurrence or metastasis,and were satisfied with the appearance of the *** Transperitoneal LESS-RN using a home-made single-port device is technically feasible and safe in a selected group of patients （low body mass index and stage tumor） and has excellent cosmetic *** preliminary oncologic outcome is not compromised,the long-term evaluation of these patients is awaited.

关键词： renal cell carcinoma laparoendoscopic single-site surgery nephrectomy

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HCCDB v2.0:Decompose Expression Variations by Single-cell RNA-seq and Spatial Transcriptomics in HCC

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Genomics, Proteomics & bioinformatics 2024年第1期22卷 131-142页

作者： Ziming Jiang Yanhong Wu Yuxin Miao Kaige Deng Fan Yang Shuhuan Xu Yupeng Wang Renke You lei zhang Yuhan Fan Wenbo Guo Qiuyu Lian lei Chen Xuegong zhang Yongchang Zheng Jin Gu Eight-Year Program of Clinical Medicine Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100006China MOE Key Laboratory of bioinformatics BNRIST Bioinformatics DivisionInstitute for Precision Medicine&Department of AutomationTsinghua UniversityBeijing 100084China department of Liver Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China Fuzhou Institute for Data Technology Fuzhou 350207China university of Michigan-Shanghai Jiao Tong university Joint Institute Shanghai Jiao Tong UniversityShanghai 200240China department of Automation Shanghai Jiao Tong UniversityShanghai 200240China International Cooperation Laboratory on Signal Transduction Eastern Hepatobiliary Surgery InstituteSecond Military Medical UniversityShanghai 200438China National Center for Liver Cancer Shanghai 201805China

Large-scale transcriptomic data are crucial for understanding the molecular features of hepatocellular carcinoma(HCC).Integrated 15 transcriptomic datasets of HCC clinical samples,the first version of HCC database(HCCDB v1.0)was released in *** the meta-analysis of differentially expressed genes and prognosis-related genes across multiple datasets,it provides a systematic view of the altered biological processes and the inter-patient heterogeneities of HCC with high reproducibility and *** four years having passed,the database now needs integration of recently published ***,the latest single-cell and spatial transcriptomics have provided a great opportunity to decipher complex gene expression variations at the cellular level with spatial ***,we present HCCDB v2.0,an updated version that combines bulk,single-cell,and spatial transcriptomic data of HCC clinical *** dramatically expands the bulk sample size by adding 1656 new samples from 11 datasets to the existing 3917 samples,thereby enhancing the reliability of transcriptomic meta-analysis.A total of 182,832 cells and 69,352 spatial spots are added to the single-cell and spatial transcriptomics sections,respectively.A novel single-cell level and 2-dimension(sc-2D)metric is proposed as well to summarize cell type-specific and dysregulated gene expression *** are all graphically visualized in our online portal,allowing users to easily retrieve data through a user-friendly interface and navigate between different *** extensive clinical phenotypes and transcriptomic data in the database,we show two applications for identifying prognosis-associated cells and tumor *** v2.0 is available at http://***/database/hccdb2.

关键词： Hepatocellular carcinoma Database Integrative analysis Single-cell RNA sequencing Spatial transcriptomics

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Unveiling quality of clinical trial in China:from concern to confirmation

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Cancer Communications 2024年第5期44卷 576-579页

作者： Huiyao Huang Yiru hou Hong Fang Ling Xu Yue Yu Huifang zhang Jing zhang Yu Tang Gongtao Lan Wenbao zhang Ning Li Clinical Trials Center National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingP.R.China School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjingJiangsuP.R.China department of Quality Medicine Boehringer Ingelheim(China)Investment Co LtdShanghaiP.R.China department of Clinical Development Quality Pfizer Research and Development(China)BeijingP.R.China department of Drug Registration National Medical Products AdministrationBeijingP.R.China Bureau of Medical Administration National Health CommissionBeijingP.R.China

The cornerstone of scientifically valid and ethically sound clinical trials is in compliance with established global quality *** China has made significant progress over the past 20 years in terms of the clinical trial quantity[1],quality and participation in multiregional trials[2],there still remain concerns regarding the trial quality,which could be associated with the self-inspection initiative in 2015[3].

关键词： clinical corners confirmation

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International Journal of Oral Science 2024年第3期16卷 398-412页

作者： Yunfan zhang Jiale Yan Yuning zhang Hao liu bing Han Weiran Li department of Orthodontics Peking University School and Hospital of Stomatology&National Center for Stomatology&National Clinical Research Center for Oral Diseases&National Engineering Laboratory for Digital and Material Technology of Stomatology&Beijing Key Laboratory of Digital Stomatology&Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health&NMPA Key Laboratory for Dental MaterialsBeijingChina

Compared with teenage patients,adult patients generally show a slower rate of tooth movement and more pronounced alveolar bone loss during orthodontic treatment,indicating the maladaptation of alveolar bone homeostasis under orthodontic ***,this phenomenon is not well-elucidated to date,leading to increased treatment difficulties and unsatisfactory treatment outcomes in adult *** to provide a comprehensive knowledge and further inspire insightful understanding towards this issue,this review summarizes the current evidence and underlying *** age-related abatements in mechanosensing and mechanotransduction in adult cells and periodontal tissue may contribute to retarded and unbalanced bone metabolism,thus hindering alveolar bone reconstruction during orthodontic *** this end,periodontal surgery,physical and chemical cues are being developed to reactivate or rejuvenate the aging periodontium and restore the dynamic equilibrium of orthodontic-mediated alveolar bone *** anticipate that this review will present a general overview of the role that aging plays in orthodontic alveolar bone metabolism and shed new light on the prospective ways out of the impasse.

关键词： alveolar metabolism homeostasis

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Anti-inflammatory and DNA Repair Effects of Astragaloside IV on PC12 Cells Damaged by Lipopolysaccharide

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Current Medical Science 2024年第4期44卷 854-863页

作者： hai-long LI Li-hua SHAO Xi CHEN Meng WANG Qi-jie QIN Ya-li YANG Guang-run zhang Yang hai Yi-hong TIAN department of Geriatrics The Affiliated Hospital of Gansu University of Chinese MedicineLanzhou730000China Key Laboratory for Mining Innovation and Transformation of Traditional Chinese Medicine in Gansu Province and the New Product Creation Engineering Laboratory of Traditional Chinese Medicine in Gansu ProvinceLanzhou730000China department of Neurology the First People’s Hospital of LanzhouLanzhouGansu730000China School of Public Health Gansu University of Chinese MedicineLanzhou730000China People’s hospital of Gansu Province Lanzhou730000China Scientific Research and Experimental Center Gansu University of Chinese MedicineLanzhou730000China

Objective This study aimed to establish a neural cell injury model in vitro by stimulating PC12 cells with lipopolysaccharide(LPS)and to examine the effects of astragaloside IV on key targets using high-throughput sequence technology and bioinformatics *** PC12 cells in the logarithmic growth phase were treated with LPS at final concentrations of 0.25,0.5,0.75,1,and 1.25 mg/mL for 24 *** morphology was evaluated,and cell survival rates were calculated.A neurocyte inflammatory model was established with LPS treatment,which reached a 50%cell survival ***12 cells were treated with 0.01,0.1,1,10,or 100µmol/L astragaloside IV for 24 *** concentration of astragaloside IV that did not affect the cell survival rate was selected as the treatment group for subsequent *** activity was detected by colorimetry;the expression levels of ERCC2,XRCC4,XRCC2,TNF-α,IL-1β,TLR4,NOS and COX-2 mRNA and protein were detected by RT-qPCR and Western *** differentially expressed genes(DEGs)between the groups were screened using a second-generation sequence(fold change>2,Pbility of PC12 cells was not altered by treatment with 0.01,0.1,or 1µmol/L astragaloside IV for 24 h(P>0.05).However,after treatment with 0.5,0.75,1,or 1.25 mg/mL LPS for 24 h,the viability steadily decreased(P<0.01).The mRNA and protein expression levels of ERCC2,XRCC4,XRCC2,TNF-α,IL-1β,TLR4,NOS,and COX-2 were significantly increased after PC12 cells were treated with 1 mg/mL LPS for 24 h(P<0.01);however,these changes were reversed when PC12 cells were pretreated with 0.01,0.1,or 1µmol/L astragaloside IV in PC12 cells and then treated with 1 mg/mL LPS for 24 h(P<0.05).Second-generation sequencing revealed that 1026 genes were upregulated,while 1287 genes were downregulat

关键词： PC12 cells astragaloside IV inflammation DNA damage

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Establishment of a prognosis predictive model for liver cancer based on expression of genes involved in the ubiquitin-proteasome pathway

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World Journal of Clinical Oncology 2024年第3期15卷 434-446页

作者： Hua Li Yi-Po ma hai-Long Wang Cai-Juan Tian Yi-Xian Guo Hong-Bo zhang Xiao-Min liu Peng-Fei liu department of Endoscopy Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and Therapy of TianjinTianjin’s Clinical Research Center for CancerTianjin 300060China department of Critical Care Medicine Dingzhou City People’s HospitalDingzhou 073000Hebei ProvinceChina department of Oncology Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300120China Tianjin marvel Medical Laboratory Tianjin Marvelbio Technology Co.LtdTianjin 300180China department of Intelligent Technology Tianjin Yunquan Intelligent Technology Co.LtdTianjin 300381China department of Oncology Tianjin Huanhu HospitalTianjin 300350China

BACKGROUND The ubiquitin-proteasome pathway(UPP)has been proven to play important roles in *** To investigate the prognostic significance of genes involved in the UPP and develop a predictive model for liver cancer based on the expression of these *** In this study,UPP-related E1,E2,E3,deubiquitylating enzyme,and proteasome gene sets were obtained from the Kyoto Encyclopedia of Genes and Genomes(KEGG)database,aiming to screen the prognostic genes using univariate and multivariate regression analysis and develop a prognosis predictive model based RESULTS Five genes(including autophagy related 10,proteasome 20S subunit alpha 8,proteasome 20S subunit beta 2,ubiquitin specific peptidase 17 like family member 2,and ubiquitin specific peptidase 8)were proven significantly correlated with prognosis and used to develop a prognosis predictive model for liver *** training,validation,and Gene Expression Omnibus sets,the overall survival differed significantly between the high-risk and low-risk *** expression of the five genes was significantly associated with immunocyte infiltration,tumor stage,and postoperative recurrence.A total of 111 differentially expressed genes(DEGs)were identified between the high-risk and low-risk groups and they were enriched in 20 and 5 gene ontology and KEGG *** division cycle 20,Kelch repeat and BTB domain containing 11,and DDB1 and CUL4 associated factor 4 like 2 were the DEGs in the E3 gene set that correlated with *** We have constructed a prognosis predictive model in patients with liver cancer,which contains five genes that associate with immunocyte infiltration,tumor stage,and postoperative recurrence.

关键词： Liver cancer Ubiquitin-proteasome pathway Prognosis prediction Gene expression Immune infiltration

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Clinicopathological analysis of small intestinal metastasis from extra-abdominal/extra-pelvic malignancy

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World Journal of Gastrointestinal Oncology 2024年第10期16卷 4138-4145页

作者： Zhi zhang Jing liu Peng-Fei Yu hai-Rui Yang Jin-Yang Li Zhi-Wei Dong Wei Shi Guo-Li Gu department of General Surgery Anhui Medical University First Affiliated HospitalHefei 230002Anhui ProvinceChina department of General Surgery Air Force Clinical CollegeChina Medical UniversityBeijing 100142China department of General Surgery Air Force Medical CenterAir Force Clinical College of China Medical UniversityBeijing 100142China department of General Surgery Air Force Medical CenterChinese People’s Liberation ArmyFifth Clinical(Air Force Clinical College)of China Medical UniversityBeijing 100142China department of General Surgery Beijing Changping HospitalBeijing 102200China department of General Surgery Air Force Medical CenterBeijing 100142China

BACKGROUND The metastatic tumors in the small intestine secondary to extra-abdominal/extrapelvic malignancy are extremely ***,the small intestine metastases are extremely prone to misdiagnosis and missed diagnosis due to the lack of specific clinical manifestations and examination methods,thus delaying its ***,in order to improve clinical diagnosis and treatment capabilities,it is necessary to summarize its clinical pathological characteristics and *** To summarize the clinicopathological characteristics of patients with small intestinal metastases from extra-abdominal/extra-pelvic malignancy,and to improve the clinical capability of diagnosis and treatment for rare metastatic tumors in the small *** The clinical data of patients with small intestinal metastases from extra-abdominal/extra-pelvic malignancy were retrieved and summarized,who admitted to and treated in the Air Force Medical Center,Chinese People’s Liberation *** descriptive statistics were performed on the general conditions,primary tumors,secondary tumors in the small intestine,diagnosis and treatment processes,and *** Totally 11 patients(9 males and 2 females)were enrolled in this study,including 8 cases(72.3%)of primary lung cancer,1 case(9.1%)of malignant lymphoma of the thyroid,1 case(9.1%)of cutaneous malignant melanoma,and 1 case(9.1%)of testicular *** median age at the diagnosis of primary tumors was 57.9 years old,the median age at the diagnosis of metastatic tumors in the small intestine was 58.81 years old,and the average duration from initial diagnosis of primary tumors to definite diagnosis of small intestinal metastases was 9 months(0-36 months).Moreover,small intestinal metastases was identified at the diagnosis of primary tumors in 4 *** small intestinal metastases were distributed in the jejunum and ileum,with such clinical manifestations as hematochezia(5,45.4%)and abdominal pain,vomiting and other obstr

关键词： Small intestinal Metastases Clinicopathological features Prognostic analysis malignancy

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Algorithm of automatic identification of diabetic retinopathy foci based on ultra-widefield scanning laser ophthalmoscopy

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 610-615页

作者： Jie Wang Su-Zhen Wang Xiao-Lin Qin Meng Chen Heng-Ming zhang Xin liu Meng-Jun Xiang Jian-bin Hu hai-Yu Huang Chang-Jun Lan Aier Eye hospital(East of Chengdu) Chengdu 610051Sichuan ProvinceChina department of Ophthalmology Chengdu First People’s HospitalChengdu 610095Sichuan ProvinceChina School of Computer and Artificial Intelligence Southwest Jiaotong UniversityChengdu 610097Sichuan ProvinceChina Chengdu Aier Eye hospital Chengdu 610041Sichuan ProvinceChina

AIM:To propose an algorithm for automatic detection of diabetic retinopathy(DR)lesions based on ultra-widefield scanning laser ophthalmoscopy(SLO).METHODS:The algorithm utilized the FasterRCNN(Faster Regions with CNN features)+ResNet50(Residua Network 50)+FPN(Feature Pyramid Networks)method for detecting hemorrhagic spots,cotton wool spots,exudates,and microaneurysms in DR ultra-widefield *** segmentation combined with a deeper residual network FasterRCNN+ResNet50 was employed for feature extraction to enhance intelligent learning *** fusion was carried out by the feature pyramid network FPN,which significantly improved lesion detection rates in SLO fundus ***:By analyzing 1076 ultra-widefield SLO images provided by our hospital,with a resolution of 2600×2048 dpi,the accuracy rates for hemorrhagic spots,cotton wool spots,exudates,and microaneurysms were found to be 87.23%,83.57%,86.75%,and 54.94%,***:The proposed algorithm demonstrates intelligent detection of DR lesions in ultra-widefield SLO,providing significant advantages over traditional fundus color imaging intelligent diagnosis algorithms.

关键词： diabetic retinopathy ultra-widefield scanning laser ophthalmoscopy intelligent diagnosis system

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Effectiveness and mechanisms of sodium-dependent glucose transporter 2 inhibitors in type 2 diabetes and heart failure patients

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World Journal of Cardiology 2024年第10期16卷 611-615页

作者： Yan-Xi zhang hai-Sheng Hu Bao-Qing Sun department of Clinical Laboratory The First Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory DiseaseNational Center for Respiratory MedicineNational Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthGuangzhou 510120Guangdong ProvinceChina

We comment on an article by GrubićRotkvićet al published in the recent issue of the World Journal of *** specifically focused on possible factors affecting the therapeutic effectiveness of sodium-dependent glucose transporter inhibitors(SGLT2i)in patients with type 2 diabetes mellitus(T2DM)and their impact on ***2i inhibits SGLT2 in the proximal tubules of the kidneys,lowering blood glucose levels by inhibiting glucose reabsorption by the kidneys and causing excess glucose to be excreted in the *** studies have demonstrated a role of SGLT2i in cardiovascular function in patients with diabetes who take metformin but still have poor glycemic *** addition,SGLT2i has been shown to be effective in anti-apoptosis,weight loss,and cardiovascular ***,it is feasible to treat patients with T2DM with cardiovascular or renal diseases using SGLT2i.

关键词： Sodium-dependent glucose transporter inhibitors Type 2 diabetes mellitus Heart failure Treatment Cardiovascular disease

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Lipid-lowering effects of gefarnate in statin-treated patients with residual hypertriglyceridemia:a randomized controlled study

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Journal of Geriatric Cardiology 2024年第8期21卷 791-798页

作者： Jing SHI Ming-Lu XU Mei-Jiao HE Wan-Lan BO hai-Yu zhang Dang-Hui SUN Ding-Yu WANG Xiao-Yu WANG Qun SHAO Yu-Jiao PAN Yu zhang Chen-Guang DAI Jing-Ying WANG Lin-Wei zhang Guang-Zhong liu Yue LI for the GPROT Study Group department of Cardiology the First Affiliated HospitalHarbin Medical UniversityHarbinChina department of Gastroenterology the Fourth Affiliated HospitalHarbin Medical UniversityHarbinChina department of Cardiology Harbin Medical University Cancer HospitalHarbinChina department of Cardiology Shenzhen People’s HospitalShenzhenChina National Key Laboratory of Frigid Zone Cardiovascular Diseases Harbin Medical UniversityHarbinChina NHC Key Laboratory of Cell Transplantation Key Laboratory of Cardiovascular Disease Acousto-Optic Electromagnetic Diagnosis and Treatment in Heilongjiang ProvinceHeilongjiang Province Clinical Medical Research Center for Hypertensionthe First Affiliated HospitalHarbin Medical UniversityHarbinChina Institute of Metabolic Disease Heilongjiang Academy of Medical ScienceHarbinChina 不详

BACKGROUND The prevention of coronary artery disease(CAD)faces dual challenges:the aspirin-induced gastrointestinal injury,and the residual cardiovascular risk after statin *** acetate(Gefarnate)is an anti-ulcer *** was reported that geraniol might participate in lipid metabolism through a variety of *** aim of this study was to assess the lipid-lowering effects of gefarnate in statin-treated CAD patients with residual *** In this prospective,open-label,randomized,controlled trial,69 statin-treated CAD patients with residual hypertriglyceridemia were randomly assigned to gefarnate group and control group,received gefarnate(100 mg/3 times a day)combined with statin and statin alone,*** baseline and after one-month treatment,the levels of plasma triglyceride,high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)and total cholesterol were *** After one-month gefarnate treatment,triglyceride level was significantly lowered from 2.64 mmol/L to 2.12 mmol/L(P=0.0018),LDL-C level lowered from 2.7 mmol/L to 2.37 mmol/L(P=0.0004),HDL-C level increased from 0.97 mmol/L to 1.17mmol/L(P=0.0228).Based on statin therapy,gefarnate could significantly reduce the plasma triglyceride level(P=0.0148)and increase the plasma HDL-C level(P=0.0307).Although the LDL-C and total cholesterol levels tended to decrease,there was no statistically significant *** The addition of gefarnate to statin reduced triglyceride level and increased HDL-C level to a significant extent compared to statin alone in CAD patients with residual *** suggested that gefarnate might provide the dual benefits of preventing gastrointestinal injury and lipid lowering in CAD patients.

关键词： nat alone Lipid

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