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Clinical heterogeneity and five phenotypes identified in pediatric Behçet’s syndrome: a cohort study from Shanghai Behçet’s syndrome database

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World Journal of Pediatrics 2024年第8期20卷 801-808页

作者： Dan Hu Chun-Hui She Hua-Fang Bao Jun Zou Jian-Fei Cai Jing‑fen Ye Yan Shen hai‑fen ma Dan Luo Jian-Long Guan Department of Rheumatology and Immunology Huadong Hospital Affiliated to Fudan University221 Yan’an West Road200040ShanghaiChina

Objectives Behçet’s syndrome(BS)is a rare disease of unknown etiology,with limited reports especially in pediatric *** clinical characteristics and phenotypes of pediatric BS as a highly heterogeneous variable vessel vasculitis were investigated in this *** A cross-sectional study was conducted to compare clinical variables and descriptive characteristics of BS by age of onset and *** analysis was then performed to identify the phenotypes of pediatric *** A total of 2082 BS patients were included in this study,1834 adults and 248 *** with adult-onset BS,pediatric BS had a higher incidence of folliculitis[relative risks(RR)and 95%confidence interval(CI)1.3(1.0–1.5)],uveitis of the left eye[RR and 95%CI 2.3(1.0–5.0)],intestinal ulcer complications[RR and 95%CI 2.1(1.1–4.2)],pericarditis[RR and 95%CI 2.5(1.0–6.2)],and psychiatric disorders[RR and 95%CI 2.8(1.0–7.9)],while the incidence of thrombocytopenia was lower[RR 0.2(0.1–1.0)].Among pediatric BS,females had more genital ulcers,while males were more likely to have skin lesions,panuveitis,vascular involvement,venous lesions,cardiac involvement,and aortic *** analysis classified pediatric BS into five clusters(C1–C5):C1(n=61,24.6%)showed gastrointestinal(GI)involvement;C2(n=44,17.7%)was the central nervous system(CNS)type where 23 cases overlapped joint involvement;in C3(n=35,14.1%),all patients presented with arthritis or arthralgia;all patients in C4(n=29,11.7%)manifested ocular involvement,with a few patients overlapping with GI involvement or joint damage;C5(n=79,31.9%)was the mucocutaneous type,presenting both oral ulcers,genital ulcers,and skin *** The clinical features of pediatric and adult BS differ *** and female pediatric BS also have a distinct *** phenotypes including GI,CNS,joint,ocular,and mucocutaneous types were identified for pediatric BS.

关键词： Behget's syndrome Clinical manifestation Cluster analysis-Pediatric Phenotype

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A Review on Vibration Control of Multiple Cylinders Subjected to FlowInduced Vibrations

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China Ocean Engineering 2024年第2期38卷 183-197页

作者： XU Wan-hai ma Ye-xuan State Key Laboratory of Hydraulic Engineering Intelligent Construction and Operation Tianjin UniversityTianjin 300350China Institute of Mechanics Chinese Academy of SciencesBeijing 100190China

The fatigue damage caused by flow-induced vibration(FIV)is one of the major concerns for multiple cylindrical structures in many engineering *** FIV suppression is of great importance for the security of many cylindrical *** active and passive control methods have been employed for the vibration suppression of an isolated cylinder undergoing vortex-induced vibrations(VIV).The FIV suppression methods are mainly extended to the multiple cylinders from the vibration control of the isolated *** to the mutual interference between the multiple cylinders,the FIV mechanism is more complex than the VIV mechanism,which makes a great challenge for the FIV *** efforts have been devoted to vibration suppression of multiple cylinder systems undergoing FIV over the past two *** control methods,such as helical strakes,splitter plates,control rods and flexible sheets,are not always effective,depending on many influence factors,such as the spacing ratio,the arrangement geometrical shape,the flow velocity and the parameters of the vibration control *** FIV response,hydrodynamic features and wake patterns of the multiple cylinders equipped with vibration control devices are reviewed and *** FIV suppression efficiency of the vibration control methods are analyzed and compared considering different influence *** research on the FIV suppression of multiple cylinders is suggested to provide insight for the development of FIV control methods and promote engineering applications of FIV control methods.

关键词： flow-induced vibration vibration control multiple cylinders tandem side-by-side staggered

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Study on trifluoromethanesulfonic acid-promoted synthesis of daidzein: Process optimization and reaction mechanism

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Chinese Journal of Chemical Engineering 2024年第7期71卷 132-139页

作者： hai Cao haibin Yang Yanxiong Fang Yuandi Zeng Xiaolan Cai Jingjing ma School of Chemical Engineering and Light Industry Guangdong University of TechnologyGuangzhou 510006China Jieyang Branch of Chemistry and Chemical Engineering Guangdong Laboratory(Rongjiang Laboratory) Jieyang 515200China

Daidzein has been widely used in pharmaceuticals,nutraceuticals,cosmetics,feed additives,*** preparation process and related reaction mechanism need to be further investigated.A cost-effective process for synthesizing daidzein was developed in this *** this article,a two-step synthesis of daidzein(Friedel–Crafts acylation and[5+1]cyclization)was developed via the employment of trifluoromethanesulfonic acid(TfOH)as an effective promoting *** effect of reaction conditions such as solvent,the amount of TfOH,reaction temperature,and reactant ratio on the conversion rate and the yield of the reaction,respectively,was systematically investigated,and daidzein was obtained in 74.0%isolated yield under optimal *** to the facilitating effect of TfOH,the Friedel–Crafts acylation was completed within 10 min at 90℃ and the[5+1]cyclization was completed within 180 min at 25℃.In addition,a possible reaction mechanism for this process was *** results of the study may provide useful guidance for industrial production of daidzein on a large scale.

关键词： Synthesis Optimal design Chemical processes Reaction mechanism

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Human influence on the duration of extreme temperature events in Asia's hotspot regions

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Advances in Climate Change Research 2024年第2期15卷 312-326页

作者： Zi-Meng WANG Hong-Yun ma Wei LI hai-Shan CHEN Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)/Key Laboratory of Meteorological Disaster Ministry of Education(KLME)Nanjing University of Information Science and TechnologyNanjing 210044China

Observations and models indicate that human activities exert a considerable impact on the frequency and intensity of extreme temperature events,which are associated with global ***,changes in the duration of extreme temperature events and their association with human influence have not been considered in most ***,the possible relationship between the observed changes in the warm and cold spell duration(WSDI and CSDI)in hotspot regions during 1960-2014 and human influence was investigated based on the NCEP/NCAR reanalysis version 1 and Coupled Model Inter-comparison Project Phase 6(CMIP6)*** projection based on these attribution results was also *** optimal fingerprinting technique was used to compare observed changes in WSDI and CSDI to simulated changes averaged across eight CMIP6 *** show that anthropogenic(ANT)forcing contributed to the observed increase in WSDI in the three hotspot regions(West Asia,South Asia and Southeast Asia),with the majority of the changes being attributed to greenhouse gas ***,a generally weak ANT signal can be observed in the decreasing trend of CSDI and can be detected in South and Southeast *** influence of aerosol forcing remains undetected in either WSDI or CSDI,which differs from the results for frequency and intensity of extreme *** attribution results revealed that the constrained projection of WSDI is lower than the raw projection for 2015-2100 in West Asia and Southeast ***,no differences in future CSDI changes are found in Southeast Asia between the constrained and raw projections.

关键词： Extreme temperature events Duration Detection attribution Constraint projection Hotspot regions

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Prognostic value of PEA3 subfamily gene expression in cholangiocarcinoma

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World Journal of Gastrointestinal Oncology 2024年第9期16卷 4014-4027页

作者： Li Wang Zhe Zhang hai-Zhang ma Department of Emergency The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Emergency Medicine The First People’s Hospital of Linping District HangzhouHangzhou 311100Zhejiang ProvinceChina Department of General Surgery Qilu Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina

BACKGROUND Cholangiocarcinoma(CCA)is a lethal malignancy with limited treatment options and poor *** PEA3 subfamily of E26 transformation specific genes:ETV1,ETV4,and ETV5 are known to play significant roles in various cancers by influencing cell proliferation,invasion,and *** To analyze PEA3 subfamily gene expression levels in CCA and their correlation with clinical parameters to determine their prognostic value for *** The expression levels of PEA3 subfamily genes in pan-cancer and CCA data in the cancer genome atlas and genotype-tissue expression project databases were analyzed with R language *** curve and receiver operating characteristic analyses were performed using the SurvMiner,Survival,and Procr language *** gene expression profiling interactive analysis 2.0 database was used to analyze the expression levels of PEA3 subfamily genes in different subtypes and stages of *** Gestalt was used to perform the gene ontology/Kyoto encyclopedia of genes and genomes(GO/KEGG)analysis,and STRING database analysis was used to determine the genes and proteins related to PEA3 subfamily *** ETV1,ETV4,and ETV5 expression levels were significantly increased in *** were significant differences in ETV1,ETV4,and ETV5 expression levels among the different subtypes of CCA,and predictive analysis revealed that only high ETV1 and ETV4 expression levels were significantly associated with shorter overall survival in patients with ***/KEGG analysis revealed that PEA3 subfamily genes were closely related to transcriptional misregulation in *** vitro and in vivo experiments revealed that PEA3 silencing inhibited the invasion and metastasis of CCA *** The expression level of ETV4 may be a predictive biomarker of survival in patients with CCA.

关键词： PEA3 subfamily Cholangiocarcinoma The cancer genome atlas ETV4 The prognosis Prognostic biomarker

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Prediction of surface settlement caused by synchronous grouting during shield tunneling in coarse-grained soils:A combined FEM and machine learning approach

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Underground Space 2024年第3期16卷 206-223页

作者： Chao Liu Zepan Wang hai Liu Jie Cui Xiangyun Huang Lixing ma Shuang Zheng School of Civil Engineering Guangzhou UniversityGuangzhou 510006China Guangdong Engineering Research Center for Underground Infrastructural Protection in Coastal Clay Areas Guangzhou UniversityGuangzhou 510006China Earthquake Engineering Research&Test Center Guangzhou UniversityGuangzhou 510006China CSCEC4 Civil Engineering Co. Ltd.Shenzhen 518052China

This paper presents a surrogate modeling approach for predicting ground surface settlement caused by synchronous grouting during shield tunneling *** proposed method combines finite element simulations with machine learning algorithms and introduces an intelligent optimization algorithm to invert geological parameters and synchronous grouting variables,thereby predicting ground surface settlement without conducting numerous finite element *** surrogate models based on the random forest algorithm are *** first is a parameter inversion surrogate model that combines an artificial fish swarm algorithm with random forest,taking into account the actual number and distribution of complex soil *** second model predicts surface settlement during synchronous grouting by employing actual cover-diameter ratio,inverted soil parameters,and grouting *** avoid changes to input parameters caused by the number of overlying soil layers,the dataset of this model is generated by the finite element model of the homogeneous soil *** surrogate modeling approach is validated by the case history of a large-diameter shield tunnel in Beijing,providing an alternative to numerical computation that can efficiently predict surface settlement with acceptable accuracy.

关键词： Shield tunnel machine learning Synchronous grouting Surrogate modeling Surface settlement

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Effect of Sonic hedgehog gene-modified bone marrow mesenchymal stem cells on graft-induced retinal gliosis and retinal ganglion cells survival in diabetic mice

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 34-41页

作者： Tong Wang hai-Chun Li Jin ma Xi-Ling Yu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangzhou 510060Guangdong ProvinceChina

AIM:To investigate the effects of Sonic hedgehog(Shh)gene-modified bone marrow mesenchymal stem cells(MSCs)on graft-induced retinal gliosis and retinal ganglion cells(RGCs)survival in diabetic ***:Bone marrow-derived MSCs were genetically modified with the Shh gene to generate a stably transfected cell line of Shh-modified MSCs(MSC-Shh).Intravitreal injections of MSC-Shh and green fluorescent protein-modified MSCs(MSC-Gfp;control)were administered in diabetic *** 4wk,the effects of MSC-Shh on retinal gliosis were evaluated using fundus photography,and markers of gliosis were examined by immunofluorescence and Western *** neurotrophic factors expression and RGCs survival in the host retina were evaluated using Western blotting and *** mechanisms underlying the effects of MSC-Shh was ***:A significant reduction of proliferative vitreoretinopathy(PVR)was observed after intravitreal injection of MSC-Shh compared to *** downregulation of glial fibrillary acidic protein(GFAP)was demonstrated in the host retina after MSC-Shh administration compared to *** extracellular signal-regulated kinase 1/2(ERK1/2),protein kinase B(AKT)and phosphatidylin-ositol-3-kinase(PI3K)pathways were significantly downregulated after MSC-Shh administration compared to ***-derived neurotrophic factor(BDNF)and ciliary neurotrophic factor(CNTF)levels were significantly increased in the host retina,and RGCs loss was significantly prevented after MSC-Shh ***:MSC-Shh administration reduces graft-induced reactive gliosis following intravitreal injection in diabetic *** ERK1/2,AKT and PI3K pathways are involved in this ***-Shh also increases the levels of neurotrophic factors in the host retina and promoted RGCs survival in diabetic mice.

关键词： mesenchymal stem cells Sonic hedgehog signaling reactive gliosis diabetic retinopathy retinal ganglion cells

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Research on casing deformation prevention technology based on cementing slurry system optimization

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Petroleum Science 2024年第2期21卷 1231-1240页

作者： Yan Yan Meng Cai Wen-hai ma Xiao-Chuan Zhang Li-Hong Han Yong-Hong Liu State Key Laboratory for Performance and Structure Safety of Petroleum Tubular Goods and Equipment materials CNPC Tubular Goods Research InstituteXi©an710077ShaanxiChina College of Mechanical and Electrical Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Shale Gas Evaluation and Exploitation Key Laboratory of Sichuan Province Chengdu610095SichuanChina CNPC Daqing Oilfield Company Daqing163453HeilongjiangChina

The casing deformation prevention technology based on the optimization of cement slurry is proposed to reduce the casing deformation of shale oil and gas wells during hydraulic fracturing. In this paper, the fracture mechanism of hollow particles in cement sheath was firstly analyzed by discrete element method, and the effect of hollow particles in cement on casing deformation was investigated by laboratory experiment method. Finally, field test was carried out to verify the improvement effect of the casing deformation based on cement slurry modification. The results show that the formation displacement can be absorbed effectively by hollow particles inside the cement transferring the excessive deformation away from casing. The particles in the uncemented state provide deformation space during formation slipping. The casing with diameter of 139.7 mm could be passed through by bridge plug with the diameter of 99 mm when the mass ratio of particle/cement reaches 1:4. According to the field test feedback, the method based on optimization of cement slurry can effectively reduce the risk of casing deformation, and the recommended range of hollow microbeads content in the cement slurry is between 15% and 25%.

关键词： Cement slurry Hollow ceramsite Casing deformation Formation slip Field test

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Influence of initial check, information exchange, final accuracy check, reaction information nursing on the psychology of elderly with lung cancer

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World Journal of Clinical Cases 2024年第4期12卷 737-745页

作者： Cui Jiang Jing ma Wen He hai-Ying Zhang The Second Ward of Thoracic Radiotherapy Hubei Cancer Hospital Affiliated to Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430079Hubei ProvinceChina Nursing School Henan University of Science and TechnologyLuoyang 471000Henan ProvinceChina Department of Intensive Care Unit Wuhan First HospitalWuhan 430033Hubei ProvinceChina Department of Nursing Huangpi District People′s Hospital of WuhanWuhan 430300Hubei ProvinceChina

BACKGROUND As one of the fatal diseases with high incidence,lung cancer has seriously endangered public health and *** patients usually have poor self-care and are more likely to show a series of psychological *** To investigate the effectiveness of the initial check,information exchange,final accuracy check,reaction(IIFAR)information care model on the mental health status of elderly patients with lung *** This study is a single-centre *** randomly recruited 60 elderly patients with lung cancer who attended our hospital from January 2021 to January *** elderly patients with lung cancer were randomly divided into two groups,with the control group taking the conventional propaganda and education and the observation group taking the IIFAR information care model based on the conventional care *** differences in psychological distress,anxiety and depression,life quality,fatigue,and the locus of control in psychology were compared between these two groups,and the causes of psychological distress were *** After the intervention,Distress Thermometer,Hospital Anxiety and Depression Scale(HADS)for anxiety and the HADS for depression,Revised Piper’s Fatigue Scale,and Chance Health Locus of Control scores were lower in the observation group compared to the pre-intervention period in the same group and were significantly lower in the observation group compared to those of the control group(Pmation care model can help elderly patients with lung cancer by reducing their anxiety and depression,

关键词： Initial check,information exchange,final accuracy check,reaction information care model Lung cancer Mental health

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Enhanced hydrogen evolution performance by 3D ordered macroporous Ru-CoP@NC electrocatalysts

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Rare Metals 2024年第3期43卷 1095-1107页

作者： Chen-Chen Zhang Sheng Wei Li-Xian Sun Yi-Fang Ouyang fen Xu hai-Liang Chu Hong-GePan Li-Xin Chen Xue-Zhang Xiao School of material Science and Engineering Guilin University of Electronic TechnologyGuilin541004China School of Chemistry and Chemical Engineering Guangxi UniversityNanning530004China Shenzhen Institute of Advanced Technology Chinese Academy of SciencesShenzhen518055GuangdongChina Institute of Science and Technology for New Energy Xi'an Technological UniversityXi'an710021China School of materials Science and Engineering Zhejiang UniversityHangzhou310058China

Electrocatalytic water splitting coupled with sustainable energies is identified as an environmentally friendly and renewable strategy to generate high-quality hydrogen for the fuel ***,the main challenge is to develop high performance,low cost and chemically stable electrocatalysts to decline the energy barriers and enhance the sluggish kinetics of hydrogen evolution reaction(HER).Herein,a three-dimensional hierarchically ordered macroporous Ru-CoP@NC electrocatalyst(3DOM Ru-CoP@NC)derived from ordered macro-microporous metal-organic frameworks has been prepared using the precursor@template and double-solvent *** prepared 3DOM Ru-CoP@NC catalyst exhibits an overpotential of 15 mV(j=10 ma·cm^(-2))and a reaction Tafel slope of 38 mV·dec^(-1)in alkaline electrolyte,which are superior to commercial Pt@C ***,the overpotential and reaction Tafel slope of this catalyst in acidic media are 45 mV and 50 mV·dec^(-1),*** outstanding HER activities of 3DOM Ru-CoP@NC catalysts are ascribed to the 3D highly interconnectedreticular nanospaces that can increase effective reaction active *** N dope d carbon framework improves the electronic properties and ***,the strong interaction of Ru and CoP nanoparticles also boosts the HER *** results indicate that 3DOM Ru-CoP@NC catalysts with high catalytic activities have a broad application prospect in the future.

关键词： Hydrogen evolution reaction Template method 3D ordered macroporous Ru-CoP@NC

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