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Chronic hepatitis-C infection in COVID-19 patients is associated with in-hospital mortality

World Journal of Clinical Cases 2021年第29期9卷 8749-8762页

作者： Diana Ronderos Alaa Mabrouk Salem Omar hafsa abbas Jasbir Makker Ahmed Baiomi Haozhe Sun Nikhitha Mantri Yongsun Choi Ked Fortuzi Dongmin Shin Harish Patel Sridhar Chilimuri Department of Internal Medicine BronxCare Hospital CenterBronxNY 10457United States Department of Cardiology Mount Sinai Morning SideNew YorkNY 10023United States Division of Gastroenterology Department of MedicineBronxCare Health SystemBronxNY 10457United States

BACKGROUND There is little evidence about the association of pre-existing hepatitis C infection(HCV)with outcomes in patients with coronavirus disease 2019(COVID-19).AIM To assess the prevalence of history of HCV among patients with COVID-19 and to study the relationship of in-hospital mortality in relation with other predictors of poor outcomes in the presence or absence of COVID-19 induced acute liver *** In a retrospective single-center study design,1193 patients with COVID-19 infection were *** were then classified into those with and without a history of HCV,50(4.1%)and 1157(95.9%)*** Multivariate cox-regression models showed that age,HCV,D-Dimer,and ferritin were the only predictors of in-hospital *** liver injury and fibrosis score(Fib-4 score)were not different between both *** coxregression model for liver profile revealed that aspartate aminotransferase/alanine aminotransferase ratio,Fib-4 score,and HCV were predictors of inhospital *** propensity score matching HCV was the only predictor of mortality in the multivariate cox-regression model.A model including HCV was found to add predictive value to clinical and laboratory *** In patients with COVID-19,history of HCV infection leads to an accentuated severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)virulence,irrespective of baseline comorbidities,admission laboratory variables,or COVID-19-induced liver injury,which may be related to extrahepatic effects of HCV leading to enhanced ACE-2/TMPRSS mechanisms of SARS-CoV-2 viral entry,baseline cytokine-mediated pro-inflammation,and endothelial dysfunction.

关键词： Hepatitis C Acute liver injury Seropositive COVID-19 Mortality

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Chemical colitis caused by hydrogen peroxide vaginal douche: A case report

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World Journal of Gastrointestinal Endoscopy 2019年第9期11卷 486-490页

作者： Ahmed Baiomi Harish Patel hafsa abbas Vamshidhar Vootla Jasbir Makker Department of Medicine Division of GastroenterologyBronx Care Health System1650 Selwyn AveBronxNY 10457United States Western Maryland Health System 12500 Willowbrook RdCumberlandMD 21502United States

BACKGROUND Hydrogen peroxide is one of the most common household disinfectants *** peroxide has been documented as a rare cause of chemical *** SUMMARY We present a case of 31 years old lady who presented to our hospital with rectal bleeding and abdominal pain after using hydrogen peroxide vaginal douche as an *** underwent colonoscopy which showed findings suggestive of chemical colitis and was managed *** peroxide can induce chemical injury in the *** presentation and endoscopic findings of chemical colitis are *** taking is an important tool in identifying the underlying *** of literature showed few case reports,mostly were managed with oral antibiotics and conservative *** Chemical colitis is usually managed *** including perforation,stricture and peritonitis may happen and need aggressive treatment accordingly.

关键词： Chemical colitis Hydrogen peroxide Colitis Vaginal douche Colonoscopy Case report

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Expanding role of antibodies in kidney transplantation

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World Journal of Transplantation 2025年第1期15卷 57-71页

作者： Khawar abbas Muhammed Mubarak Department of Transplant Immunology Sindh Institute of Urology&TransplantationKarachi 74200SindhPakistan Javed I.Kazi Department of Histopathology Sindh Institute of Urology&TransplantationKarachi 74200SindhPakistan

The role of antibodies in kidney transplant(KT)has evolved significantly over the past few *** role of antibodies in KT is multifaceted,encompassing both the challenges they pose in terms of antibody-mediated rejection(AMR)and the opportunities for improving transplant outcomes through better detection,prevention,and treatment *** our understanding of the immunological mechanisms continues to evolve,so too will the approaches to managing and harnessing the power of antibodies in KT,ultimately leading to improved patient and graft *** narrative review explores the multifaceted roles of antibodies in KT,including their involvement in rejection mechanisms,advancements in desensitization protocols,AMR treatments,and their potential role in monitoring and improving graft survival.

关键词： Antibodies Humoral theory Kidney transplantation Rejection

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Experiments on image data augmentation techniques for geological rock type classification with convolutional neural networks

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Journal of Rock Mechanics and Geotechnical Engineering 2025年第1期17卷 106-125页

作者： Afshin Tatar Manouchehr Haghighi abbas Zeinijahromi School of Chemical Engineering Discipline of Mining and Petroleum EngineeringThe University of AdelaideAdelaideSA 5005Australia

The integration of image analysis through deep learning(DL)into rock classification represents a significant leap forward in geological *** traditional methods remain invaluable for their expertise and historical context,DL offers a powerful complement by enhancing the speed,objectivity,and precision of the classification *** research explores the significance of image data augmentation techniques in optimizing the performance of convolutional neural networks(CNNs)for geological image analysis,particularly in the classification of igneous,metamorphic,and sedimentary rock types from rock thin section(RTS)*** study primarily focuses on classic image augmentation techniques and evaluates their impact on model accuracy and *** demonstrate that augmentation techniques like Equalize significantly enhance the model's classification capabilities,achieving an F1-Score of 0.9869 for igneous rocks,0.9884 for metamorphic rocks,and 0.9929 for sedimentary rocks,representing improvements compared to the baseline original ***,the weighted average F1-Score across all classes and techniques is 0.9886,indicating an ***,methods like Distort lead to decreased accuracy and F1-Score,with an F1-Score of 0.949 for igneous rocks,0.954 for metamorphic rocks,and 0.9416 for sedimentary rocks,exacerbating the performance compared to the *** study underscores the practicality of image data augmentation in geological image classification and advocates for the adoption of DL methods in this domain for automation and improved *** findings of this study can benefit various fields,including remote sensing,mineral exploration,and environmental monitoring,by enhancing the accuracy of geological image analysis both for scientific research and industrial applications.

关键词： Deep learning(DL) Image analysis Image data augmentation Convolutional neural networks(CNNs) Geological image analysis Rock classification Rock thin section(RTS)images

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Transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN T.ASGHAR Z.abbas Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

This paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. The influence of magnetic fields is also inspected in terms of their physical characteristics. To depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).The effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词： analytical solution Cattaneo-Christov heat and mass flux chemical reaction gyrotactic microorganism hybrid nanofluid O368 oscillating curved stretchable sheet

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“Superimposed”spectral characteristics of fluorophores arising from cross-conjugation hybridization

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Chinese Chemical Letters 2025年第1期36卷 442-446页

作者： Kai An Qinglong Qiao Lovelesh Syed Ali abbas Abedi Xiaogang Liu Zhaochao Xu CAS Key Laboratory of Separation Science for Analytical Chemistry Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China University of Chinese Academy of Sciences Beijing 100049China Fluorescence Research Group Singapore University of Technology and DesignSingapore 487372Singapore

The demand for enhanced optical properties in advanced fluorescence technologies has driven research into the structure-property relationship of *** this paper,we use naphthalene fluorophores Na DC-Aze and PhDO-Aze as a case study to emphasize the pivotal role of cross conjugation in tuning the optical structure-property *** DC-Aze and PhDO-Aze,formed by hybridizing two distinct conjugated systems in a single naphthalene molecule,exhibit spectral characteristics from both conjugated *** data and theoretical calculations demonstrate the coexistence of two electron-delocalization systems in a cross-conjugation manner in both Na DC-Aze and *** cross-conjugation fluorophores exhibit high brightness,large Stokes shift,and a broad absorption wavelength range by combining distinct spectral properties from its parent *** spectral properties will be advantageous for certain applications(i.e.,panchromatic absorption in organic solar cells,and fluorophores compatible with a wide range of excitation wavelengths).

关键词： Fluorophore Cross conjugation Absorption Emission Naphthalene

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Rainfall-induced wind erosion in soils stabilized with alkali-activated waste materials

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Journal of Rock Mechanics and Geotechnical Engineering 2025年第1期17卷 465-480页

作者： Alireza Komaei abbas Soroush Seyed Mohammad Fattahi Hesam Ghanbari Department of Civil and Environmental Engineering Amirkabir University of TechnologyTehran159163431Iran

This study evaluates the efficacy of sustainable erosion control using slag-based alkali-activated cement crusts under varying rainfall and wind conditions. The rainfall intensities ranged from 30 mm/h to 120 mm/h, with durations ranging from 15 min to 90 min, and crust slopes of ∼2° (gentle) and 30° (steep). Wind tunnel experiments were conducted at wind velocities of 14 m/s, 21 m/s, and 28 m/s to investigate post-rainfall wind erodibility, along with changes in crust strength and microstructure analysis. The findings show the development of hydrated cementitious phases in alkali-activated material, which form around and between the particles during the alkaline activation process. Alkali-activated cement crusts significantly reduced erosion caused by rainfall and subsequent wind by several orders of magnitude. At the highest rainfall intensity of 120 mm/h, rainfall erosion was measured to be 1654.81 kg/m2 for untreated samples and 0.89 kg/m2 for treated samples, demonstrating a substantial 99.95% reduction in erosion due to the treatment. Similarly, at the highest wind speed tested, wind erosion was 122.75 kg/m2 for untreated samples and 0.095 kg/m2 for treated samples, indicating a significant 99.92% reduction in erosion due to the formation of an alkali-activated cement crust on the soil surface. However, exposure of the samples to 120 mm/h rainfall for 90 min resulted in a 5.2-fold increase in wind erosion compared to pre-rainfall conditions. Similarly, penetrometer results indicated a 37%–54% reduction in post-rainfall surface strength.

关键词： Rainfall erosion Alkali-activated material Wind erosion Crust formation

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Spectrum of venous thromboembolism in adult patients with ulcerative colitis in Pakistan:A single center retrospective study

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World Journal of Clinical Cases 2025年第6期13卷 9-13页

作者： Masood Muhammad Karim hafsa Shaikh Faisal Wasim Ismail Department of Medicine The Aga Khan University HospitalKarachi 74800Pakistan Department of General Surgery The Aga Khan University HospitalKarachi 74800Pakistan

BACKGROUND Patients with inflammatory bowel disease are at a 2-8-fold higher risk of deve-loping venous thromboembolism(VTE)as compared to the general *** the exact pathogenesis is unclear,the literature suggests that increased risk of thromboembolic events in such patients occurs as a result of increased coagulation factors,inflammatory cytokines,and reduction in anticoagulants leading to a prothrombotic *** To assess the prevalence,risk factors,management,and outcome of ulcerative colitis(UC)patients who develop *** This was a retrospective chart review done in The Gastroenterology Department of The Aga Khan University *** was collected from medical records for all patients admitted with a diagnosis of UC from January 2012 to December *** Seventy-four patients fulfilled the inclusion *** mean±SD of age at presentation of all UC patients was 45 years±10 years whereas for those who developed VTE,it was 47.6 years±14.7 *** and diabetes were the most common co-morbid seen among UC patients with a frequency of 17(22.9%)and 12(16.2%),respectively.A total of 5(6.7%)patients developed *** venous thrombosis was the most common thromboembolic phenomenon seen in 3(60%)*** the patients with UC and concomitant VTE were discharged home(5;100%).CONCLUSION The prevalence of VTE with UC in Pakistani patients corresponds with the international ***,multi-centric studies are required to further explore these results.

关键词： Deep venous thrombosis Inflammatory bowel disease Low-middle-income country Anticoagulation Protein C deficiency

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Fibrotic liver extracellular matrix induces cancerous phenotype in biomimetic micro-tissues of hepatocellular carcinoma model

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Hepatobiliary & Pancreatic Diseases International 2025年第1期24卷 92-103页

作者： Kosar Nouri abbas Piryaei Homeyra Seydi Ibrahim Zarkesh Ibrahim Ghoytasi Bahare Shokouhian Mustapha Najimi Massoud Vosough Department of Developmental Biology University of Science and Culture Department of Regenerative Medicine Cell Science Research Center Royan Institute for Stem Cell Biology and Technology Department of Stem Cells and Developmental Biology Cell Science Research Center Royan Institute for Stem Cell Biology and Technology Department of Biology and Anatomical Sciences School of Medicine Shahid Beheshti University of Medical Sciences Department of Tissue Engineering and Applied Cell Sciences School of Advanced Technologies in Medicine Shahid Beheshti University of Medical Sciences Department of Cell Engineering Cell Science Research Center Royan Institute for Stem Cell Biology and Technology Department of Medical Biotechnology School of Advanced Technologies in Medicine Tehran University of Medical Sciences Laboratory of Pediatric Hepatology and Cell Therapy Institute of Experimental and Clinical Research(IREC) Experimental Cancer Medicine Institution for Laboratory Medicine Karolinska Institute

Background: Despite considerable advancements in identifying factors contributing to the development of hepatocellular carcinoma(HCC), the pathogenesis of HCC remains unclear. In many cases, HCC is a consequence of prolonged liver fibrosis, resulting in the formation of an intricate premalignant microenvironment. The accumulation of extracellular matrix(ECM) is a hallmark of premalignant microenvironment. Given the critical role of different matrix components in regulating cell phenotype and function, this study aimed to elucidate the interplay between the fibrotic matrix and malignant features in HCC. Methods: Liver tissues from both control(normal) and carbon tetrachloride(CCl4)-induced fibrotic rats were decellularized using sodium dodecyl sulfate(SDS) and Triton X-100. The resulting hydrogel from decellularized ECM was processed into micro-particles via the water-in-oil emulsion method. Microparticles were subsequently incorporated into three-dimensional liver biomimetic micro-tissues(MTs) comprising Huh-7 cells, human umbilical vein endothelial cells(HUVECs), and LX-2 cells. The MTs were evaluated using the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium(MTS) assay at day 11, immunofluorescence staining, immunoblotting, and spheroid migration assay at day 14 after co-culture. Results: Fibrotic matrix from CCl4-treated rat livers significantly enhanced the growth rate of the MTs and their expression of CCND1 as compared to the normal one. Fibrotic matrix, also induced the expression of epithelial-to-mesenchymal transition(EMT)-associated genes such as TWIST1, ACTA2, MMP9, CDH2, and VIMENTIN in the MTs as compared to the normal matrix. Conversely, the expression of CDH1 and hepatic maturation genes HNF4A, ALB, CYP3A4 was decreased in the MTs when the fibrotic matrix was used. Furthermore, the fibrotic matrix increased the migration of the MTs and their secretion of alpha-fetoprotein. Conclusions: Our findings suggest a reg

关键词： Liver fibrosis Decellularized extracellular matrix Spheroid Epithelial-to-mesenchymal transition Cell differentiation Hepatocellular carcinoma

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Deep Learning and Artificial Intelligence-Driven Advanced Methods for Acute Lymphoblastic Leukemia Identification and Classification: A Systematic Review

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Computer Modeling in Engineering & Sciences 2025年第2期142卷 1199-1231页

作者： Syed Ijaz Ur Rahman Naveed abbas Sikandar Ali Muhammad Salman Ahmed Alkhayat Jawad Khan Dildar Hussain Yeong Hyeon Gu Department of Computer Science Islamia CollegePeshawar25120Pakistan Department of Information Technology The University of HaripurHaripur22620Pakistan College of Technical Engineering The Islamic UniversityNajaf100986Iraq School of Computing Gachon UniversitySeongnam13120Republic of Korea Department of AI and Data Science Sejong UniversitySeoul05006Republic of Korea

Automatic detection of Leukemia or blood cancer is one of the most challenging tasks that need to be addressed in the healthcare *** of white blood cells(WBCs)in the blood or bone marrow microscopic slide images play a crucial part in early identification to facilitate medical *** Acute Lymphocytic Leukemia(ALL),the most preferred part of the blood or marrow is to be analyzed by the experts before it spreads in the whole body and the condition becomes *** researchers have done a lot of work in this field,to demonstrate a comprehensive analysis few literature reviews have been published focusing on various artificial intelligence-based techniques like machine and deep learning detection of *** systematic review has been done in this article under the PRISMA guidelines which presents the most recent advancements in this *** image segmentation techniques were broadly studied and categorized from various online databases like Google Scholar,Science Direct,and PubMed as image processing-based,traditional machine and deep learning-based,and advanced deep learning-based models were *** Neural Networks(CNN)based on traditional models and then the recent advancements in CNN used for the classification of ALL into its subtypes.A critical analysis of the existing methods is provided to offer clarity on the current state of the ***,the paper concludes with insights and suggestions for future research,aiming to guide new researchers in the development of advanced automated systems for detecting life-threatening diseases.

关键词： Acute lymphoblastic bone marrow segmentation classification machine learning deep learning convolutional neural network

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