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Helicobacter pylori eradication in West Asia:A review

World Journal of Gastroenterology 2014年第30期20卷 10355-10367页

作者： hafez fakheri Zohreh Bari Mohsen Aarabi Reza Malekzadeh Inflammatory Diseases of the Upper Gastrointestinal Tract Research Center Mazandaran University of Medical Sciences*** SariIran Mazandaran University of Medical Sciences *** SariIran Health Sciences Research Center *** SariIran Digestive Disease Research Institute Tehran University of Medical SciencesShariati HospitalKargar Shomali Avenue14117 TehranIran

The efficacy of first-and second-line Helicobacter pylori(***)eradication regimens varies considerably in West Asian countries,mainly due to the variable prevalence of resistant ***,no review article has yet evaluated and compared the efficacy of different regimens among different countries of this ***,we conducted a review to select the best options and provide recommendations for *** treatment in this geographic region.A search through PubMed was carried out to obtain relevant randomized clinical trials published in English language up to *** to the results,among different therapeutic regimens used as the first-line protocols,10-d Bismuth-Furazolidone/Metronidazole quadruple therapy,14-d Clarithromycin-containing hybrid therapy and 14-d quadruple therapy including a proton pump inhibitor +Bismuth+Tetracycline(500 mg QID)+Metronidazole(500 mg TDS)seemed to be appropriate *** second-line therapeutic regimens,Bismuthbased quadruple therapies containing Tetracycline and Furazolidone/Metronidazole,triple therapy containing Amoxicillin and Gatifloxacin and Quadruple therapy including Bismuth+Azithromycin and Ofloxacin seemed to be effective ***-line therapies were not evaluated in West Asia;most guidelines,however,recommend choosing optimal eradication regimen according to the pattern of antibiotic susceptibility of *** we limited our investigation to *** eradication regimens in West Asia,the clinical significance of the results goes beyond the countries situated in this geographic *** fact,the results are transferrable to any region as long as the patterns of resistance are the same.

关键词： Helicobacter pylori Eradication West Asia Resistance Recurrence

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Ecologic study of serum selenium and upper gastrointestinal cancers in Iran

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World Journal of Gastroenterology 2004年第17期10卷 2544-2546页

作者： Mehdi Nouarie Akram Pourshams Farin Kamangar Masood Sotoudeh Mohammad Hossein Derakhshan Mobammad Reza Akbari hafez fakheri Mohammad Javad Zahedi Kathleen Caldwell Christian *** Philip R.Taylor Reza Malekzadeh Sanford M.Dawsey Digestive Disease Research Center Tehran University of Medical SciencesTehranIran National Cancer Institute NIHBethesdaMD20895-8314USA Centers for Disease Control AtlantaGeorgiaUSA

AIM:Both observational and experimental studies have shown that higher selenium status reduces the risk of upper gastrointestinal cancers in selenium deficient populations. Recent cancer registry data have shown very different rates of esophageal cancer(EC)and gastric cancer(GC)in four Provinces of Iran,namely Ardabil,Mazandaran,Golestan, and *** aim of this study was to have a preliminary assessment of the hypothesis that high rates of EC in Golestan and high rates of GC in Ardabil may be partly attributable to selenium deficiency. METHODS:We measured serum selenium in 300 healthy adults from An:labil(n=100),Mazandaran(n=50),Golestan (n=100),and Kerman(n=50),using inductively coupled plasma,with dynamic reaction cell,mass spectrometry(ICP- DRC-MS)at the US Centers for Disease Control(Atlanta, Georgia). RESULTS:The median serum selenium concentrations were very different in the four *** medians(IQR)for selenium in Ardabil,Mazandarn,Golestan,and Kerman were 82(75-94),123(111-132),155(141-173),and 119 (110-128)μg/L,respectively(Pfakheri H,Zahedi MJ,Caldwell K,Abner CC, Taylor PR,Malekzadeh R,Dawsey *** study of serum

关键词： Adult Esophageal Neoplasms Female Humans Incidence Iran Linear Models Male Middle Aged Risk Factors Selenium Stomach Neoplasms

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