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Neural Regeneration Research 2015年第10期10卷 1589-1590页

作者： Dong Hoon hwang hae young Shin Byung Gon Kim Department of Brain Science Ajou University School of Medicine Neuroscience Graduate Program Department of Biomedical Sciences Ajou University Graduate School of Medicine Neurology Ajou University School of Medicine

Traumatic injuries to spinal cord elicit diverse signaling pathways leading to unselective and complex pathological outcomes：death of multiple classes of neural cells,formation of cystic cavities and glial scars,disruption of axonal connections,and demyelination of spared axons,all of which can contribute more or less to debilitating functional impairments found in patients with spinal cord injury.

关键词： NSCs Fortuitous benefits of activity-based rehabilitation in stem cell-based therapy for spinal cord repair enhancing graft survival stem cell

Hydrangea serrata extract exerts tumor inhibitory activity against hepatocellular carcinoma HepG2 cells via inducing p27/CDK2-mediated cell cycle arrest and apoptosis

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Asian Pacific Journal of Tropical Biomedicine 2024年第2期14卷 65-72,I0002-I0005页

作者： Ye-eun Kim Jeonghye hwang Ki-young Kim Graduate School of Biotechnology Kyung Hee UniversitySeocheonGiheungYonginGyeonggi-do 446-701Republic of Korea Department of Genetics and Biotechnology College of Life SciencesKyung Hee UniversitySeocheonGiheungYonginGyeonggi-do 446-701Republic of Korea

Objective:To examine the inhibitory effect of Hydrangea serrata extract against hepatocellular carcinoma HepG2 cells and its underlying ***:The effects of Hydrangea serrata extract on growth inhibition of tumor cells and spheroids were assessed using MTT and 3D culture *** real-time PCR and Western blot analyses were employed to investigate the changes in mRNA and protein expression levels of molecules related to cell cycle and ***:Hydrangea serrata extract effectively inhibited the growth of both tumor cells and *** extract also significantly upregulated p27 mRNA expression and downregulated CDK2 mRNA expression,leading to cell cycle ***,increased BAX/Bcl-2 ratio as well as caspase-9 and-3 were observed after treatment with Hydrangea serrata extract,indicating the induction of tumor cell ***:Hydrangea serrata extract has the potential to alleviate tumors by effectively modulating cell-cycle-related gene expressions and inducing apoptosis,thereby inhibiting tumor growth.

关键词： Hydrangea serrata Hepatocellular carcinoma Liver cancer Anticancer Cell cycle arrest Apoptosis

Lightweight design of 45000r/min spindle using full factorial design and extreme vertices design methods

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Journal of Central South University 2011年第1期18卷 153-158页

作者： PARK Seong-jin LEE Choon-man hwang young-kug Department of Mechanical Design and Manufacturing Engineering Changwon National University

Factors for determining the spindle size are the shaft diameter, positions of bearing and motor, and entire length of the spindle. Then, it is important to find the assembling of the optimal design variables, which satisfy the stiffimss and rotational speed required to the spindle. A general full factorial design method was used to verify some factors that affect the natural frequency of a spindle. It is verified that the shorter shaft length and bearing span length represent the higher natural frequency, and there are some effects according to the change in the levels of factors. The detailed spindle dimension is determined by applying an EVD method, which can define the optimal bearing position through considering the limiting condition. Based on the estimated regression model, the optimal spindle size and bearing distance that can improve the primary natural frequency are obtained, and the influence of design factors on the natural frequency is also analyzed.

关键词： high-speed spindle extreme vertices design natural frequency lightweight design full factorial design

Influence of potassium pyrophosphate in electrolyte on coated layer of AZ91 Mg alloy formed by plasma electrolytic oxidation

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中国有色金属学会会刊：英文版 2009年第4期19卷 824-828页

作者： Jin-young CHO Duck-young hwang Dong-H eon LEE Bongyoung YOO Dong-Hyuk SHIN Department of Metallurgy and Materials Scienc e Hanyang University

The effect of potassium pyrophosphate in the electrolyte on plasma electrolytic oxidation(PEO) process for AZ91 Mg alloy was *** morphologies and chemical compositions of the coating layer on the AZ91 Mg alloy were evaluated and corrosion resistance was also estimated by potentiodynamic polarization *** coating layer on AZ91 Mg alloy coated from the Bath 2 containing 0.03 mol/L of potassium pyrophosphate for 360 s exhibited considerably dense structure and contained 11%-18%(mass fraction) of *** higher content of phosphorous of coating layer coated from Bath 2 could be detected at the bottom of oxide layer,which strongly implied that the phosphorous ion might be concentrated at the barrier *** potential of coating layer of AZ91 Mg alloy increased and corrosion current density decreased with increasing the concentration of potassium *** polarization resistance(Rp) of coating layer of AZ91 Mg alloy coated from Bath 2 was 4.65×107 Ω/cm2,which was higher than that(Rp=3.56×104 Ω/cm2) of the sample coated from electrolyte without potassium *** coating layer coated from Bath 2 containing 0.03 mol/L potassium pyrophosphate exhibited the best corrosion resistance.

关键词： AZ91镁合金合金涂层焦磷酸钾电解氧化等离子体电解质腐蚀电流密度耐腐蚀性

Diagnostic accuracy of administrative database for bile duct cancer by ICD-10 code in a tertiary institute in Korea

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Hepatobiliary & Pancreatic Diseases International 2020年第6期19卷 575-580页

作者： young-Jae hwang Seon Mee Park Soomin Ahn Jongchan Lee young Soo Park Nayoung Kim Department of Internal Medicine Seoul National University Bundang HospitalSeongnamKorea Department of Internal Medicine Chungbuk National University College of Medicine and Medical Research InstituteCheongjuKorea Department of Pathology Seoul National University Bundang HospitalSeoungnamKorea Department of Internal Medicine and Institute of Liver Research Seoul National University College of MedicineSeoulKorea Tumor Microenvironment Global Core Research Center Seoul National UniversitySeoulKorea

Background:Administrative database provides valuable information for large cohort studies,especially when tissue diagnosis is rather difficult such as the diagnosis for bile duct cancer(BDC).The aim of this study was to evaluate the diagnostic accuracy of administrative database for BDC by International Classification of Diseases(ICD)-10 codes in a tertiary ***:BDC and control groups were collected from 2003 to 2016 at Seoul National University Bundang *** of BDC were identified in the National Health Insurance Service(NHIS)database by ICD 10-code supported by V *** control group was selected from cases without ICD-10 codes for BDC.A definite or possible diagnosis was defined according to pathologic *** records,images,and pathology reports were analyzed to evaluate ICD-10 codes for ***,specificity,positive predictive value,and negative predictive value for BDC were analyzed according to diagnostic criteria and cancer ***:A total of 1707 patients with BDC and 1707 controls were *** those with BDC,1320(77.3%)were diagnosed by definite ***(99.4%)of them had *** of definite diagnosis was the highest for ampulla of Vater(88.9%),followed by that for extrahepatic(84.9%)and intrahepatic(68.3%)*** positive cases commonly had hepatocellular *** overall diagnosis of BDC,sensitivity,specificity,positive predictive value,and negative predictive value were 99.94%,98.33%,98.30%,and 99.94%,*** accuracies were similar regardless of diagnostic criteria or tumor ***:Administrative database for BDC collected according to ICD-10 code with V code shows good accuracy.

关键词： National Health Insurance Service Bile duct cancer ICD-10

Surgical perspectives of symptomatic omphalomesenteric duct remnants: Differences between infancy and beyond

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World Journal of Clinical Cases 2021年第36期9卷 11228-11236页

作者： Ayoung Kang Soo-Hong Kim Yong-Hoon Cho hae-young Kim Department of Surgery Pusan National University Yangsan HospitalYangsan 50612South Korea Department of Surgery Pusan National University School of MedicineYangsan 50612South Korea Research Institute for Convergence of Biomedical Science and Technology Pusan National University Yangsan HospitalYangsan 50612South Korea

BACKGROUND The clinical manifestations of omphalomesenteric duct remnant(OMDR)can vary with the age at diagnosis,from asymptomatic incidental findings to symptoms related to gastrointestinal *** lifelong complication rates are reported as 4%-34%,and complications are more common in patients younger than 2 years of *** authors attempted to identify different clinical features and management for the various pediatric age *** To find surgical perspectives for the pediatric age-related variants of OMDR and make recommendations for optimal *** The medical records of pediatric patients diagnosed with OMDR were reviewed *** patients diagnosed based on incidental findings during other surgeries were *** patients were divided into two groups based on age:12 mo(beyond infancy).We analyzed the demographic characteristics,clinical manifestations,diagnostic tools,surgical procedures,and clinical outcomes of the patients and compared them for the age ***-squared and Fisher's exact tests were used for nominal scales and a Mann-Whitney test was used for ratio *** A total of 35 patients(7 infants,28 children beyond infancy)were finally *** both groups,Meckel's diverticulum(MD)was the most common type of OMDR,while umbilical lesions were more common in the infant group(P=0.006).Hematochezia and abdominal pain were common in the beyond infancy group,while umbilical lesions were the most frequent symptoms in the infant *** diagnostic tools were used,but Meckel's scan was most useful in diagnosing OMDR in patients with painless rectal *** invasive surgery was more commonly performed for children than for infants(P=0.016).Single-incision laparoscopic surgery(SILS)was performed for fifteen patients who underwent laparoscopic *** were only three cases of postoperative complications,and all patients survived in good *** The cli

关键词： Omphalomesenteric duct remnant Age Surgical Meckel's diverticulum Single-incision laparoscopic surgery Children

Electrocatalytic and stoichiometric reactivity of 2D layered siloxene for high-energy-dense lithium-sulfur batteries

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Carbon Energy 2021年第6期3卷 976-990页

作者： Hui-Ju Kang Jae-Woo Park Hyun Jin hwang Heejin Kim Kwang-Suk Jang Xiulei Ji hae Jin Kim Won Bin Im young-Si Jun Department of Advanced Chemicals&Engineering Chonnam National UniversityGwangjuRepublic of Korea Division of Analytical Science Korea Basic Science Institute(KBSI)DaejeonRepublic of Korea Department of Applied Chemistry Hanyang UniversityAnsanGyeonggi-doRepublic of Korea Department of Chemistry Oregon State UniversityCorvallisOregonUSA Division of Materials Science and Engineering Hanyang UniversitySeoulRepublic of Korea

Lithium-sulfur batteries(LSBs)have emerged as promising power sources for high-performance devices such as electric ***,the poor energy density of LSBs owing to polysulfide shuttling and passivation has limited their further market *** mitigate this challenge,two-dimensional(2D)siloxene(2DSi),a Si-based analog of graphene,is utilized as an additive for sulfur *** 2DSi is fabricated on a large scale by simple solvent extraction of calcium disilicide to form a thin-layered structure of Si planes functionalized with vertically aligned hydroxyl groups in the *** stoichiometric reaction of 2DSi with polysulfides generates a thiosulfate redox mediator,secures the intercalation pathway,and reveals Lewis acidic sites within the siloxene *** 2DSi utilizes the corresponding in-situ-formed electrocatalyst,the 2D confinement effect of the layered structure,and the surface affinity based on Lewis acid-base interaction to improve the energy density of 2DSi-based LSB *** with the commercial carbon-based current collector,2DSi-based LSB cells achieve a volumetric energy density of 612 Wh Lcell^(−1) at 1 mA cm^(−2) with minor degradation of 0.17%per cycle,which rivals those of state-of-the-art *** study presents a method for the industrial production of high-energy-dense LSBs.

关键词： 2D confinement effects Lewis acid-base interactions lithium-sulfur batteries siloxenes thiosulfate-polythionate redox couple

Crushing behavior of lightmass structural member

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中国有色金属学会会刊：英文版 2009年第B09期19卷 276-279页

作者： Kil-Sung LEE Yong-June YANG Woo-Chae hwang In-young YANG Department of Mechatronics Chosun University of Science and Technology Department of Advanced Part and Materials Engineering Chosun University Department of Mechanical Design Engineering Chosun University

Carbon fiber reinforced plastic (CFRP) of the advanced composite materials is widely used in lightmass structural materials of air planes, ship and automobiles because of high strength and stiffness. In this study, experimental investigation was performed for each specimen. The square section members consist of aluminum, CFRP and hybrid (aluminum/CFRP) member, and hat-shaped section members consist of CFRP and hybrid (aluminum/CFRP) members specimen. Based on the collapse characteristics of aluminum square section member, the collapse characteristics and energy absorption capability of hat-shaped section members were analyzed. The axial static collapse tests were carried out for each section member. The collapse modes and the energy absorption capability of the members were analyzed. In the lightmass design aspect, the collapse characteristics and energy absorption capability of the members were compared.

关键词：碳纤维增强复合材料碳纤维复合材料能量吸收能力行为构件破碎航空飞机 CFRP

Prediction of mechanical properties of Al alloys with change of cooling rate

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China Foundry 2012年第4期9卷 381-386页

作者： Quan-Zhi Dong young-Sire Choi Jun-Ho Hong Ho-young hwang Dept.of Virtual Engineering University of Science and TechnologyIncheon 406-840Korea e-Design Center Korea Institute of Industrial TechnologyIncheon 406-840Korea

The solidification process significantly affects the mechanical properties and there are lots of factors that affect the solidification *** progress has been made in the research on the effect of solidification on mechanical *** them,the PF(Phase Field) model and CA(Cellular Automata) model are widely used as simulation methods which can predict nucleation and its growth,and the size and morphology of the grains during *** they can give accurate calculation results,it needs too much computational memory and calculation *** it is difficult to apply the simulation to the real production *** this study,a more practical simulation approach which can predict the mechanical properties of real aluminum alloys is proposed,by identifying through experiment the relationship between cooling rate and SDAS(Secondary Dendrite Arm Spacing) and mechanical *** experimentally measured values and the values predicted by simulation have relatively small differences and the mechanical properties of a variety of Al alloys are expected to be predicted before casting through use of the simulation.

关键词： mechanical properties dendrite structure aluminum alloy cooling rate solidification castingsimulation

Quasiparticle interference and impurity resonances on WTe2

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Nano Research 2020年第9期13卷 2534-2540页

作者： Hyeokshin Kwon Taehwan Jeong Samudrala Appalakondaiah youngtek Oh Insu Jeon Hongki Min Seongjun Park young Jae Song Euyheon hwang Sungwoo hwang Samsung Advanced Institute of Technology Samsung Electronics Co.Suwon 16678Republic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwon 16419Republic of Korea Department of Nano Engineering Sungkyunkwan UniversitySuwon 16419Republic of Korea Department of Physics and Astronomy Seoul National UniversitySeoul 08826Republic of Korea Department of Physics Sungkyunkwan UniversitySuwon 16419Republic of Korea Center for Integrated Nanostructure Physics(CINAP) Institute for Basic Science(IBS)Sungkyunkwan UniversitySuwon 16419Republic of Korea

Using scanning tunneling microscopy/spectroscopy(STM/STS),we examine quasiparticle scattering and interference properties at the surface of ***2,layered transition metal dichalcogenide,is predicted to be a type-ll Weyl *** Weyl fermion states in WTe2 emerge as topologically protected touching points of electron and hole pockets,and Fermi arcs connecting them can be visible in the spectral function on the *** probe the properties of surface states,we have conducted low-temperature STM/STS(at 2.7 K)on the surfaces of WTe2 single *** visualize the surface states of WTe2 with atomic scale *** surface states emerging from the bulk electron pocket have been identified and their connection with the bulk electronic states shows good agreement with *** show the interesting double resonance peaks in the local density of states appearing at localized *** low-energy resonant peak occurs near the Weyl point above the Fermi energy and it may be mixed with the surface state of Weyl points,which makes it difficult to observe the topological nature of the Weyl semimetal WTe2.

关键词： WTe2 Weyl semimetal quasi-particle interference scanning tunneling microscopy/spectroscopy