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儿童食管良性狭窄球囊扩张后导致食管破裂的发生率及治疗

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国际医学放射学杂志 2017年第2期 228-229页

作者： W.Z.Zhou H.Y.Song J.H.park J.H.Shin J.H.Kim Y.C.Cho 刘炜 Department of Radiology and Research Institute of Radiology Asan Medical CenterUniversity of Ulsan College of Medicine

摘要目的本研究目的是探讨儿童食管良性狭窄球囊扩张(FBD)后导致食管破裂的发生率及治疗。方法对62例食管良性狭窄儿童行FBD。食管破裂分为壁内(1型)、透壁

关键词：食管破裂食管疾病球囊扩张发生率儿童

对比增强MR血管成像对阴部附属动脉的术前检出及定位

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国际医学放射学杂志 2012年第3期 272-273页

作者： S.Y.Whang D.J.Sung S.A.Lee B.J.park M.J.Kim S.B.Cho 麻智慧 Departments of Radiology and Urology Anam HospitalKorea UniversityCollege of Medicine5-Ka Anam-dongSungbuk kuSeoul 136-705Korea

目的评价对比剂增强MR血管成像对前列腺癌病人阴部附属动脉(accessory pudendal artery,APA)术前检出和定位的诊断价值。材料与方法这项前瞻性研究得到机构审查委员会的批准,并获得知情同意书。2007年7月—2010

关键词：对比增强 MR 血管成像检出术前动脉阴部定位

超声弹性图与彩色多普勒相结合在区分乳腺良恶性肿块方面对放射诊断医生诊断准确性的影响

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国际医学放射学杂志 2012年第2期 165-166页

作者： N.Cho M.J.Jang C.Y.Lyou J.S.park H.Y.Choi W.K.Moon 尚全良 Department of Radiology Seoul National University College of MedicineSeoul National University Hospital101 DaehangnoJongno-guSeoul 110-744Republic of Korea

目的探讨超声弹性图与彩色多普勒相结合在区分乳腺良恶性肿块方面对放射诊断医生诊断准确性的影响以及其对医生作出在B超引导下行乳腺肿块活检建议的作用。材料与方法本前瞻性研究获得机构审查委员会批准,且

关键词：彩色多普勒弹性力学性能超声良恶性肿块诊断准确性乳腺乳房放射诊断

Second-look endoscopy and factors associated with delayedbleeding after endoscopic submucosal dissection

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World Journal of Gastrointestinal Endoscopy 2016年第3期8卷 173-179页

作者： Su-Jin Kim Cheol-Woong Choi Dae-Hwan Kang Hyung-Wook Kim Su-Bum park Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsan 626-770South Korea

Endoscopic submucosal dissection(ESD) is a widely used procedure as curative treatment for superficial gastric neoplasms, including early gastric cancer without lymph node metastasis. However, ESD requires advanced endoscopic skill and there is a major concern regarding complications from bleeding. So far, extensive efforts have been made to develop strategies to reduce post-ESD bleeding. Use of proton pump inhibitors and coagulating exposed vessels on the ulcer floor after ESD are strategies known to reduce the risk of delayed bleeding. Second-look endoscopy(SLE) is also carried out to reduce delayed bleeding following ESD in many institutions. However, the incidence of bleeding still remains around 5%, and further measures are needed to reduce delayed bleeding after gastric ESD. Recently, three randomized studies indicated that routine SLE was unnecessary. Although routine SLE may not be recommended for all patients after gastric ESD, SLE might be an important tool for the prevention of the delayed bleeding in selected high-risk patients. Thus, the identification of the risk factors, such as large size of resected specimen and treatment with multiple antiplatelet medications, may help to further guide clinicians in deciding whether to perform SLE. Studies carried out on larger cohorts are necessary to clarify the efficacy of SLE after ESD in the prevention of post-ESD bleeding in potentially high-risk patients.

关键词： Endoscopic submucosal dissection Secondlookendoscopy Early gastric cancer

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MR扩散加权成像在壶腹癌诊断中的附加价值

国际医学放射学杂志 2013年第2期 171-172页

作者： K.M. Jang S.H. Kim S.J. Lee H.J. park D. Choi J. Hwang 郭凌飞 Department of Radiology and Center for Imaging Science Samsung Medical Center Sungkyunkwan University School of Medicine 50 Ilwon-dong Gangnam-gu Seoul 135-710 Korea

目的评估在常规MR成像中扩散加权成像对壶腹癌诊断的附加价值。材料与方法该项回顾性研究获得了机构伦理委员会批准并免签知情同意书。纳入恶性壶腹部梗阻病人23例、良性壶腹部梗阻病人39例。根据所见的十二指肠乳头或其预估的位置进行... 详细信息

目的评估在常规MR成像中扩散加权成像对壶腹癌诊断的附加价值。材料与方法该项回顾性研究获得了机构伦理委员会批准并免签知情同意书。纳入恶性壶腹部梗阻病人23例、良性壶腹部梗阻病人39例。根据所见的十二指肠乳头或其预估的位置进行定性（信号强度,强化类型）或定量[表观扩散系数（ADC）]分析。两名观察者独立地对常规MR成像和随后的常规与扩散加权联合的影像进行评估。采用五点评估法对壶腹癌的可能性进行评估。使用Fisher确切概率法和Mann-WhitneyU检验对两组间进行比较。对诊断性能（受试者操作特征曲线）、精确度、敏感度、特异度、阳性预测值（PPV）、阴性预测值（NPV）进行评估。结果在常规MR成像中,良性组内可见的或预计的十二指肠乳头所在区域表现为等信号（39例中有27;8例,占69%;7%）,增强类型与正常十二指肠壁（39例中有27例,占69%）相似。上述表现良性组比恶性组（23例中有7;8例,占30%;8%）和常规MR成像组（23例中检出了3例,占13%）更常见。在扩散加权成像中,23例中有21例（91%）壶腹癌显示为高信号,而全部良性病例与正常十二指肠壁比较均表现为等信号（P<0.001）。壶腹癌的平均ADC值（1.23×10-3mm2/s）显著低于良性组（1.69×10-3mm2/s）(P<0.001)。两位观察者的诊断能力[ROC曲线下面积（Az）]在增加了扩散加权成像后显著提高。观察者1的Az提高至0.923;.992（P=0.029）,观察者2的Az提高至0.910;.992（P=0.025）。此外,联合应用常规MRI与扩散加权成像的诊断精确度、敏感度、特异度、阳性预测值（PPV）、阴性预测值（NPV）显著高于单独应用常规MRI。结论与常规的MRI比较,常规MRI与扩散加权成像联合应用可以显著提高壶腹癌的检测率。

关键词：壶腹癌常规 MR 加权成像附加价值

Characterization of two alkyl hydroperoxide reductase C homologs alkyl hydroperoxide reductase C_H1 and alkyl hydroperoxide reductase C_H2 in Bacillus subtilis

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World Journal of Biological Chemistry 2015年第3期6卷 249-264页

作者： Mee-kyung Cha Yoo-Jeen Bae Kyu-Jeong Kim Byung-Joon park Il-Han Kim Department of Life Science and Technology Daeduk Valley Campus Paichai University

AIM: To identify alkyl hydroperoxide reductase subunit C(AhpC) homologs in Bacillus subtilis(B. subtilis) and to characterize their structural and biochemical properties. AhpC is responsible for the detoxification of reactive oxygen species in ***: Two AhpC homologs(AhpC_H1 and AhpC_H2) were identified by searching the B. subtilis database; these were then cloned and expressed in Escherichia coli. AhpC mutants carrying substitutions of catalytically important Cys residues(C37S, C47 S, C166 S, C37/47 S, C37/166 S, C47/166 S, and C37/47/166 S for AhpC_H1; C52 S, C169 S, and C52/169 S for AhpC_H2) were obtained by site-directed mutagenesis and purified, and their structure-function relationship was analyzed. The B. subtilis ahp C genes were disrupted by the short flanking homology method, and the phenotypes of the resulting AhpC-deficient bacteria were ***: Comparative characterization of AhpC homologs indicates that AhpC_H1 contains an extra C37, which forms a disulfide bond with the peroxidatic C47, and behaves like an atypical 2-Cys AhpC, while AhpC_H2 functions like a typical 2-Cys AhpC. Tryptic digestion analysis demonstrated the presence of intramolecular Cys37-Cys47 linkage, which could be reduced by thioredoxin, resulting in the association of the dimer into higher-molecular-mass complexes. Peroxidase activity analysis of Cys→Ser mutants indicated that three Cys residues were involved in the catalysis. AhpC_H1 was resistant to inactivation by peroxide substrates, but had lower activity at physiological H2O2 concentrations compared to AhpC_H2, suggesting that in B. subtilis, the enzymes may be physiologically functional at different substrate concentrations. The exposure to organic peroxides induced AhpC_H1 expression, while AhpC_H1-deficient mutants exhibited growth retardation in the stationary phase, suggesting the role of AhpC_H1 as an antioxidant scavenger of lipid hydroperoxides and a stress-response factor in B. subtilis. CONCLUS

关键词： Cysteine-dependent peroxidase Thioredoxin Thiol peroxidase Peroxiredoxin Alkyl hydroperoxide Ortholog Bacil us subtilis Oxidative stress

球囊扩张治疗结核性支气管狭窄:单中心17年113例病人的经验

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国际医学放射学杂志 2015年第6期 591-592页

作者： Y.C.Cho J.H.Kim J.H.park J.H.Shin H.K.Ko H.Y.Song 于静 Department of Radiology and Research Institute of Radiology Asan Medical CenterUniversity of Ulsan College of Medicine

摘要目的评估单中心113例结核性支气管狭窄(TTBS)病人采用球囊扩张治疗的安全性及有效性。方法本研究获得机构伦理委员会批准,免除了获得知情同意的要

关键词：结核性支气管狭窄球囊扩张病人

空腹和非空腹测低密度脂蛋白胆固醇的准确性比较

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中华高血压杂志 2017年第11期25卷 1099-1099页

作者： Sathiyakumar V park J Golozar A Lazo M Quispe R Guallar E Blumenthal RS Jones SR Martin SS 黄洁叶鹏

近期研究表明，非空腹测血脂可能影响低密度脂蛋白胆固醇（10w—density lipoprotein—cholesterol，LDL-C）的评估。LDDC新的评估方法（the novelmethod of LDL—Cestimation，LDL—CN）使用一个较灵活的方法来导出患者特异的三酰甘油... 详细信息

近期研究表明，非空腹测血脂可能影响低密度脂蛋白胆固醇（10w—density lipoprotein—cholesterol，LDL-C）的评估。LDDC新的评估方法（the novelmethod of LDL—Cestimation，LDL—CN）使用一个较灵活的方法来导出患者特异的三酰甘油与极低密度脂蛋白胆固醇（verylow—density lipoprotein—cholesterol，VLDL）的比值。

关键词：极低密度脂蛋白胆固醇非空腹评估方法三酰甘油 LDL

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易于代替过滤器的水的净化器

水处理信息报导 2007年第3期 39-39页

作者： park, Jin U. Ntec Co. Ltd.S.Korea

本文提供了一种易于代替过滤器的水的净化器用于自来水和喷泉水净化和消毒，减少了后期的处理时间。该水的净化器包括一个主体和至少一个过滤器用于净化水，该主体包括机械部分和电子部分，主体被一个壳体和一个前面板封闭，前面板有一... 详细信息

本文提供了一种易于代替过滤器的水的净化器用于自来水和喷泉水净化和消毒，减少了后期的处理时间。该水的净化器包括一个主体和至少一个过滤器用于净化水，该主体包括机械部分和电子部分，主体被一个壳体和一个前面板封闭，前面板有一个一级前面板和一个二级前面板，过滤器既可以安装在一级前面板后侧也可安装自二级前面板后侧，纵向具有支撑轨道的控电板既可以安装在一级前面板后侧也可安装在二级前面板后侧，导轨安装在壳体内侧。

关键词：过滤器水净化净化器前面板安装自来水净化水部分和