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Short health scale: A valid measure of health-related quality of life in Korean-speaking patients with inflammatory bowel disease

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World Journal of Gastroenterology 2017年第19期23卷 3530-3537页

作者： Soo-Kyung Park Bong Min Ko Hyeon Jeong Goong Jeong Yeon Seo Sang Hyuk Lee hae lim baek Moon Sung Lee Dong Il Park Division of Gastroenterology Department of Internal Medicine Kangbuk Samsung HospitalSungkyunkwan University School of Medicine Digestive Disease Center and Research Institute Department of Internal Medicine Soonchunhyang University School of Medicine

AIM To evaluate the short health scale(SHS),a new,simple,four-part visual analogue scale questionnaire that is designed to assess the impact of inflammatory bowel disease(IBD)on health-related quality of life(HRQOL),in Korean-speaking patients with *** The SHS was completed by 256 patients with Crohn’s disease(CD)and ulcerative colitis(UC).Individual SHS items were correlated with inflammatory bowel disease questionnaire(IBDQ)dimensions and with disease activity to assess ***-retest reliability,responsiveness and patient or disease characteristics with probable association with high SHS scores were *** Of 256 patients with IBD,139(54.3%)had UC and 117(45.7%)had *** correlation coefficients between SHS questions about"symptom burden","activities of daily living",and"disease-related worry"and their corresponding dimensions in the IBDQ ranged from0.62 to 0.71,compared with correlation coefficients ranging from-0.45 to-0.61 for their non-corresponding *** was a stepwise increase in SHS scores,with increasing disease activity in both CD and UC(all P values<0.001).Reliability was confirmed with test-retest correlations ranging from 0.68 to 0.90(all P values<0.001).Responsiveness was confirmed with the patients who remained in *** SHS scores remained unchanged,except for the SHS dimension"disease-related worry".In the multivariate analysis,female sex was associated with worse"general well-being"(OR=2.28,95%CI:1.02-5.08)along with worse disease *** The SHS is a valid and reliable measure of HRQOL in Korean-speaking patients with IBD.

关键词： Quality of life Inflammatory bowel disease Ulcerative colitis Crohn's disease Disease activity

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Effect of Squeeze Cast Process Parameters on Fluidity of Hypereutectic Al-Si Alloy

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Journal of Materials Science & Technology 2008年第1期24卷 7-11页

作者： Jong-Kyu baek hae-Wook Kwon School of Materials Science and Engineering Yeungnam University Gyeongsan 712-749 Korea

The effects of processing variables on the fluidity of hypereutectic Al-Si alloy melt during squeeze casting were *** maximum fluidity of Al-16.0%Si alloy during squeeze casting was obtained under the applied pressure of 30 *** fluidity increased with *** fluidity increased with silicon content in the range from 12.0% to 20.0%.That was decreased respectively by eutectic modification and primary silicon refinement.

关键词： Squeeze casting Al-alloy Fluidity Melt treatment

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Improvement of uniformity in cultivation environment and crop growth rate by hybrid control of air flow devices

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Journal of Central South University 2015年第12期22卷 4702-4708页

作者： baek Min-Seon KWON Sook-Youn lim Jae-Hyun Department of Computer Science and Engineering Kongju National University Green Energy Technology Research Center Kongju National University

A complete control type plant factory has high efficiency in terms of cultivation area by constructing vertical multiple layered cultivation ***,it has a problem of irregular crop growth due to temperature deviation at upper and lower beds and increases in energy consumption by a prolonged cultivation *** this work,air flow rate inside a facility was improved by a hybrid control of air flow devices like air conditioning and air circulation fan with an established wireless sensor network to minimize temperature deviations between upper and lower beds and to promote crop *** performance of proposed system was verified with an experimental environment or Case A wherein air conditioning device was operated without a control algorithm and Case B wherein air conditioning and circulation fans were alternatively operated based on the hybrid control *** planting leafy vegetables under each experimental condition,crops were cultivated for 21 *** a result,Case B wherein AC(air conditioning) and ACF(air-circulation fan) were alternatively operated based on the hybrid control algorithm showed that fresh mass,number of leaves,and leaf length for the crops grown were increased by 40.6%,41.1%,and 11.1%,respectively,compared to Case A.

关键词： air flow devices hybrid control cultivation environment uniformity growth rate

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Polysaccharide from Astragalus membranaceus promotes the activation of human peripheral blood and mouse spleen dendritic cells

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Chinese Journal of Natural Medicines 2021年第1期19卷 56-62页

作者： lim Seong-Min Park hae-Bin Jin Jun-O Department of Medical Biotechnology Yeungnam UniversityGyeongsan 38541South Korea Shanghai Public Health Clinical Center Shanghai Medical CollegeFudan UniversityShanghai201508China

Astragalus membranaceus(***)is a widely used traditional herb in China and *** polysaccharides(AMP),which make up a major part of the root extract,have been shown to modulate immune modulations,especially activation of bone marrow-derived dendritic cells(BMDCs)and T ***,the immune stimulatory effect of AMP in the mouse in vivo and human peripheral blood DCs(PBDCs)has not been well *** this study,we found that intravenous(i.v.)injection of AMP in C57 BL/6 mice induced remarkable elevations in co-stimulatory and MHC class I and II molecule levels in the splenic DCs and its *** stimulatory effect of DCs by AMP was elevated 6 h after treatment,which rapidly decreased 18 h after ***,AMP promoted intracellular production of pro-inflammatory cytokines in spleen DC subsets,which contributed elevation of serum cytokine ***,the AMP promoted PBDC ***,these results demonstrate that AMP can be used as an immune stimulatory molecules in human and mouse.

关键词： Astragalus membranaceus polysaccharide Spleen dendritic cell Human peripheral blood dendritic cell

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Comparison of vegetable oils on the uptake of lutein and zeaxanthin by ARPE-19 cells

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 40-46页

作者： Jeonghun baek Chun Wai Mai Wei Meng lim Lai Chun Wong School of Medicine International Medical UniversityKuala Lumpur 57000Malaysia Department of Pharmaceutical Chemistry School of PharmacyInternational Medical UniversityKuala Lumpur 57000Malaysia Department of Pharmaceutical Technology School of PharmacyInternational Medical UniversityKuala Lumpur 57000Malaysia

AIM:To compare the effect of vegetable oils on the uptake of lutein and zeaxanthin by adult retinal pigment epithelial(ARPE)-19 cells in ***:ARPE-19 cells were cultured in Dulbecco’s Modified Eagle Medium-F-12 supplemented with 10%foetal bovine serum and 1%penicillin–streptomycin in a humidified 5%CO_(2) incubator maintained at 37℃.Cells were treated with 247μmol/L lutein,49μmol/L zeaxanthin and 1%(v/v)of either coconut oil,corn oil,peanut oil,olive oil,sunflower oil,soybean oil,castor oil,or linseed oil for *** and zeaxanthin concentration in the cells were quantified by high performance liquid ***:Among the oils tested,the highest lutein and zeaxanthin uptake was observed with coconut oil while the lowest was observed with linseed ***:ARPE-19 uptake of lutein and zeaxanthin are found to be dependent on the type of oils.

关键词： lutein zeaxanthin adult retinal pigment epithelial-19 cells vegetable oil

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Characteristics of environmental factors associated with typhoon Kongrey(1825) over the Eastern Coastal Region of Korea

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Tropical Cyclone Research and Review 2020年第3期9卷 162-171页

作者： So-Ra In baek-Jo Kim hae-Min Kim Chang-Geun Park High Impact Weather Research Center Observation and Forecast Research DivisionNational Institute of Meteorological SciencesKMASouth Korea

In this study,the characteristics of environmental factors associated with typhoon Kongrey were examined using radiosonde,wind-profiler,radar,and Automated Surface Observing System(ASOS)data in Uljin,which is located the eastern coast of *** radiosonde data were obtained from intensive observation between 1500 LST 5 to 0000 LST 7 October *** factors such as Total Precipitable Water(TPW)and Strom Relative Environmental Helicity(SREH)were selected to examine their relations to typhoon-accompanied *** TPW peak with 60.54 mm appeared at 1200 LST 6 October,which is 6 h after the peak of typhoon *** was found that the TPW variation is largely associated with the effect of water vapor supply from the typhoon with nearest proximity to Uljin at 1500 LST 6 *** SREH,which indicates mechanical instability,was 761 m2 s-2 during the period in which typhoon precipitation *** environments would provide a good condition for the development of super-cell storms,causing heavy precipitation associated with *** addition,it was found that the correlation coefficient between SREH and typhoon rainfall is 0.8(p-value=0.02).

关键词： Typhoon Kongrey Precipitation TPW SREH

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Moderating effect of synthesized docosahexaenoic acid-enriched phosphatidylcholine on production of Th1 and Th2 cytokine in lipopolysaccharide-induced inflammation

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Asian Pacific Journal of Tropical Biomedicine 2018年第7期8卷 340-344页

作者： M.Choi JY.baek I.Park SY.lim Department of Mircrobiology Kosin University College of Medicine Division of Marine Bioscience Korea Maritime and Ocean University

Objective: To evaluate effects of docosahexaenoic acid-enriched phosphatidylcholine(DHAPC) on cytokine production induced by lipopolysaccharide(LPS). Methods: The culture supernatants of splenocytes exposed to DHA-PC along with LPS were harvested to determine the production of Th 1(IFN-kines. Cytokines were m毭 and IL-2) and Th2 [IL-4, IL-5, IL-6 and IL-12/IL-23(p40)] cytoeasured using ELISA. Results: Co-administration of DHAPC with LPS resulted in significantly lower IL-2 expression compared to that observed with administration of only LPS(P<0.01). Treatment with DHA-PC and LPS significantly increased IL-5 expression(P<0.01). Moreover, co-administration of DHA-PC with LPS significantly decreased IL-6 and IL-12/IL-23(p40) expressions compared to that observed with administration of only LPS(P<0.01). Conclusions: Our results suggest that DHA-PC inhibits pro-inflammatory cytokines [IL-2, IL-6 and IL-12/IL-23(p40)] expression on induction of inflammation.

关键词： Docosahexaenoic acid Phosphatidylcholine Cytokines Interleukin-2 Interleukin-6 Interleukin-12/IL-23(p40)

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Multiscale Simulation Starting at the Molecular Level for Adsorption Process Development

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Chinese Journal of Chemical Engineering 2008年第1期16卷 108-111页

作者： hae-Jeong Son Young-il lim Laboratory of Functional Analyses of Complex Systems （FACS） Research Center of Chemical Technology Department of Chemical Engineering Hankyong National University Gyonggi-do Anseong-si Jungangno 167456-749 Korea

This article presents a multiscale simulation approach starting at the molecular level for the adsorption process development. A grand canonical Monte Carlo method is used for the prediction of adsorption isotherms of methanol on an activated carbon at the molecular level. The adsorption isotherms obtained in the linear region （or adsorption constant） are exploited as a model parameter required for the adsorption process simulation. The adsorption process model described by a set of partial differential equations （PDEs） is solved by using the conservation element and solution element method, which produces a fast and an accurate numerical solution to PDEs. The simulation results obtained from the adsorption constant estimated at the molecular level are in good agreement with the experimental results of the pulse response. The systematical multiscale simulation approach addressed in this study may be useful to accelerate the adsorption process development by reducing the number of experiments.

关键词： activated carbon methanol adsorption isotherms molecular simulation grand canonical Monte Carlo (GCMC) method process simulation and development

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Effect of Korean Magnolia obovata Extract on Platelet-Derived Growth Factor-Induced Vascular Smooth Muscle Cells

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Chinese Journal of Integrative Medicine 2020年第9期26卷 677-682页

作者： Hyunjhung Jhun Suji baek Jinwoo Kim Kang-Pa Lee Hun-Young Park Won-Hwan Park Kiwon lim Jisu Kim Technical Assistance Center Korea Food Research InstituteJeonbuk(55365)Republic of Korea Department of Medical Science School of MedicineKonkuk UniversitySeoulRepublic of Korea Department of Bio-Science College of Natural ScienceDongguk UniversityGyeongbuk(38066)Republic of Korea Physical Activity&Performance Institute Konkuk UniversitySeoul(05029)Republic of Korea Department of Diagnostic College of Korean MedicineDongguk University GoyangGyeonggi-do(10326)Republic of Korea

Objective:To investigate the effects of Korean Magnolia obovata crude extract(KME)on plateletderived growth factor(PDGF)-BB-induced proliferation and migration of vascular smooth muscle cells(VSMCs).Methods:KME composition was analyzed by high-performance liquid chromatography(HPLC).VSMCs were isolated from the aorta of a Sprague-Dawley rat,incubated in serum free-Dulbecco's modified Eagle's medium in the presence or absence of KME(10,30,100,and 300(xg/mL),then further treated with PDGF-BB(10 ng/mL).VSMC proliferation was detected using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay and VSMC migration was determined using the Boyden chamber and scratch wound healing *** blot analysis was used to detect phosphorylation of extracellular signal-regulated protein kinases 1 and 2(p-ERK1/2),protein kinase B(p-Akt),and stress-activated protein kinase/c-Jun NH2-terminal kinase(p-SAPK/JNK).The antimigration and proliferation effects of KME were tested using aortic sprout ***:The HPLC analysis identified honokiol(0.45 mg/g)and magnolol(0.34 mg/g)as the major components of ***(30,100,and 300μg/m L)significantly decreased the proliferation and migration of PDGF-BB-stimulated(10 ng/mL)VSMCs and the PDGF-BB-induced phosphorylation of EKR1/2,Akt,and SAPK/JNK(P<0.05).Furthermore,PDGF-BBinduced VSMCs treated with 300μg/m L of KME showed reduction in aortic sprout ***:KME could inhibit abnormal proliferation and migration of VSMCs by down-regulating the phosphorylation of EKR1/2 and ***,KME might be a functional food for preventing vascular disorders.

关键词： extracellular signal-regulated protein kinases 1 and 2 Akt platelet-derived growth factor-BB smooth muscle cell functional food

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Beta-phase transformation of polyvinylidene fluoride with supersonically sprayed ZnSnO_(3) cuboids for flexible piezoelectric nanogenerators

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Journal of Materials Science & Technology 2024年第10期177卷 103-113页

作者： Bhavana Joshi Taegun Kim Woojin lim Edmund Samue Chanwoo Park Ali Aldalbahi Mohamed El-Newehy hae-Seok Lee Seongpil An Sam S.Yoon School of Mechanical Engineering Korea UniversitySeoul 02841Republic of Korea Core Component Technology Team Samsung Electronics Co Ltd.Mobile R&D CenterSamsung-roSuwon-siGyeonggi-doRepublic of Korea Energy Environment Policy and Technology Graduate School of Energy and Environment(KU-KIST Green School)Korea UniversitySeoul 02841Republic of Korea Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia SKKU Advanced Institute of Nanotechnology(SAINT) Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Nano Science and Technology Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea Department of Nano Engineering Sungkyunkwan University(SKKU)Suwon 16419Republic of Korea

Flexible self-powered electromechanical devices,such as piezoelectric nanogenerators(PENGs),which are used in wearable and implantable devices,are emerging as state-of-the-art clean energy *** this study,a scalable supersonic spraying technique was used to prepare flexible piezocomposite films of polyvinylidene fluoride(PVDF)and hydrothermally synthesized ZnSnO_(3)(ZSO)cubes for *** spectra confirmed that the transformation of the α-phase of PVDF to its β-phase was induced by the shear stress generated between the ZSO particles and PVDF polymer during supersonic *** op-timized sample comprising 0.43 g of ZSO cubes and 1 g of PVDF produced a maximum piezopotential of 41.5 V and a short-circuit current,I_(sc),of 52.5 μA.A maximum power density of 50.6 μW cm-2 was ob-tained at a loading resistance of 0.4 MΩ,which matched the impedance of the ***-term tapping and bending cycles of N_(tap)=4200 and N_(bend)=600 yielded piezopotentials of 40.5 and 1.7 V,*** addition,electrical poling for 2 h increased the piezopotential to 52 V owing to the alignment of the ferroelectric dipoles in the PVDF.

关键词： ZnSnO_(3) PVDF Composite Perovskite Supersonic cold spray Piezoelectric nanogenerator

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