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Impacts of statin and metformin on neuropathy in patients with type 2 diabetes mellitus: Korean Health Insurance data

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World Journal of Clinical Cases 2021年第33期9卷 10198-10207页

作者： Hong Ki Min Se Hee kim Jong Han Choi Kyomin Choi hae-rim kim Sang-Heon Lee Department of Internal Medicine Konkuk University Medical CenterSeoul KS013South Korea Department of Neurology Konkuk University Medical CenterSeoul KS013South Korea Division of Rheumatology Department of Internal MedicineKonkuk University School of MedicineSeoul KS013South Korea

BACKGROUND Neuropathy is a common chronic complication in type 2 diabetes mellitus(T2DM).Statin and metformin are commonly used medications in T2DM patients,and some studies showed statin-or metformin-induced *** To evaluate the incidence of neuropathy among patients with T2DM associated with statin and metformin *** Korean Health Insurance Review and Assessment national patient sample data from 2016 and 2017 were *** with T2DM and no complications were divided into statin/metformin/statin+metformin users and *** incidence was defined by International Statistical Classification of Diseases and Related Health Problems,10th revision codes and concomitant prescriptions for anticonvulsants or *** regression analyses were conducted to examine the associations between statin/metformin/statin+metformin therapies and the incidence of *** score(PS)matching was performed on the basis of age,sex and *** Overall,34964 and 35887 patients with T2DM and no complications were included in the Korean Health Insurance Review and Assessment national patient sample datasets from 2016 and 2017,*** therapy was associated with increased risks of neuropathy in 2016 and 2017[PS-matched odds ratio(OR)=1.22,95%confidence interval(CI):1.08-1.38;PS-matched OR=1.17,95%CI:1.03-1.33,respectively].Metformin therapy was associated with reduced risks of neuropathy in 2016 and 2017(PS-matched OR=0.30,95%CI:0.21-0.42;PSmatched OR=0.44,95%CI:0.32-0.60,respectively).Combined statin+metformin therapy was not significantly associated with neuropathy in 2016 or 2017(PSmatched OR=0.85,95%CI:0.61-1.19;PS-matched OR=0.95,95%CI:0.66-1.38,respectively).CONCLUSION Statin therapy was associated with enhanced risk of new-onset neuropathy in patients with T2DM,but metformin therapy showed the opposite association.

关键词： Diabetes mellitus Neuropathies Hydroxymethylglutaryl-CoA reductase inhibitors Metformin

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Driving inward growth of lithium metal in hollow microcapsule hosts by heteroatom‐controlled nucleation

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Carbon Energy 2024年第8期6卷 262-272页

作者： Siwon kim Hong rim Shin Ki Jae kim Min‐Sik Park Jong‐Won Lee Division of Materials Science and Engineering Hanyang UniversitySeoulRepublic of Korea Department of Energy Science and Engineering Daegu Gyeongbuk Institute of Science and Technology(DGIST)DaeguRepublic of Korea Department of Energy Science Sungkyunkwan UniversitySuwonRepublic of Korea Department of Advanced Materials Engineering for Information and Electronics Integrated Education for Frontier Science and Technology(BK21 Four)Kyung Hee UniversityYonginRepublic of Korea

The application of Li metal anodes in rechargeable batteries is impeded by safety issues arising from the severe volume changes and formation of dendritic Li ***‐dimensional hollow carbon is receiving increasing attention as a host material capable of accommodating Li metal inside its cavity;however,uncontrollable and nonuniform deposition of Li remains a *** this study,we synthesize metal–organic framework‐derived carbon microcapsules with heteroatom clusters(Zn and Ag)on the capsule walls and it is demonstrated that Ag‐assisted nucleation of Li metal alters the outward‐to‐inward growth in the microcapsule ***‐incorporated microcapsules are prepared via chemical etching of zeolitic imidazole framework‐8 polyhedra and are subsequently decorated with Ag by a galvanic displacement reaction between Ag^(+)and metallic *** introduced Ag significantly reduces the energy barrier and increases the reaction rate for Li nucleation in the microcapsule host upon Li *** combined electrochemical,microstructural,and computational studies,we verify the beneficial role of Ag‐assisted Li nucleation in facilitating inward growth inside the cavity of the microcapsule host and,in turn,enhancing electrochemical *** study provides new insights into the design of reversible host materials for practical Li metal batteries.

关键词： hollow carbon hosts lithium metal batteries lithium plating metal-organic frameworks nucleation

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Anomaly Detection Using Data Rate of Change on Medical Data

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Computers, Materials & Continua 2024年第9期80卷 3903-3916页

作者： Kwang-Cheol rim Young-Min Yoon Sung-Uk kim Jeong-In kim AI Convergence Research Institute Chosun UniversityGwangju61452Republic of Korea Interdisciplinary Program of Architectural Studies Chonnam UniversityGwangju61186Republic of Korea AINTCHAIN SOFT Co. Ltd.Mokpo-si58750Republic of Korea BK21 Human Resources Development Project Group Chosun UniversityGwangju61452Republic of Korea

The identification and mitigation of anomaly data,characterized by deviations from normal patterns or singularities,stand as critical endeavors in modern technological landscapes,spanning domains such as Non-Fungible Tokens(NFTs),cyber-security,and the burgeoning *** paper presents a novel proposal aimed at refining anomaly detection methodologies,with a particular focus on continuous data *** essence of the proposed approach lies in analyzing the rate of change within such data streams,leveraging this dynamic aspect to discern anomalies with heightened precision and *** empirical evaluation,our method demonstrates a marked improvement over existing techniques,showcasing more nuanced and sophisticated result ***,we envision a trajectory of continuous research and development,wherein iterative refinement and supplementation will tailor our approach to various anomaly detection scenarios,ensuring adaptability and robustness in real-world applications.

关键词： Anomaly data anomaly detection medical anomaly data cyber security rate of change

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Nanozyme‑Engineered Hydrogels for Anti‑Inflammation and Skin Regeneration

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Nano-Micro Letters 2024年第6期16卷 127-179页

作者： Amal George Kurian Rajendra K.Singh Varsha Sagar Jung‑Hwan Lee hae‑Won kim Institute of Tissue Regeneration Engineering(ITREN) Dankook UniversityCheonan 31116Republic of Korea Department of Nanobiomedical Science&BK21 NBM Global Research Center for Regenerative Medicine Dankook UniversityCheonan 31116Republic of Korea Department of Biomaterials Science School of DentistryDankook UniversityCheonan 31116Republic of Korea UCL Eastman‑Korea Dental Medicine Innovation Centre Dankook UniversityCheonan 31116Republic of Korea Cell and Matter Institute Dankook UniversityCheonan 31116Republic of Korea Mechanobiology Dental Medicine Research Center Dankook UniversityCheonan 31116Republic of Korea

Inflammatory skin disorders can cause chronic scarring and functional impairments,posing a significant burden on patients and the healthcare *** therapies,such as corticosteroids and nonsteroidal anti-inflammatory drugs,are limited in efficacy and associated with adverse ***,nanozyme(NZ)-based hydrogels have shown great promise in addressing these ***-based hydrogels possess unique therapeutic abilities by combining the therapeutic benefits of redox nanomaterials with enzymatic activity and the water-retaining capacity of *** multifaceted therapeutic effects of these hydrogels include scavenging reactive oxygen species and other inflammatory mediators modulating immune responses toward a pro-regenerative environment and enhancing regenerative potential by triggering cell migration and *** review highlights the current state of the art in NZ-engineered hydrogels(NZ@hydrogels)for anti-inflammatory and skin regeneration *** also discusses the underlying chemo-mechano-biological mechanisms behind their ***,the challenges and future directions in this ground,particularly their clinical translation,are *** insights provided in this review can aid in the design and engineering of novel NZ-based hydrogels,offering new possibilities for targeted and personalized skin-care therapies.

关键词： Nanozymes Hydrogels ROS scavenging Anti-inflammation Skin regeneration

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Do brood parasitic Common Cuckoos develop brood patches during the breeding season?

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Avian Research 2024年第3期15卷 363-368页

作者： Jun-Seo Go hae-Ni kim Sue-Jeong Jin Myeong-Chan Cha Heesoo Lee Jin-Won Lee Korea Institute of Ornithology&Department of Biology Kyung Hee University02447SeoulRepublic of Korea Bird Research SaeZiP 12504YangpyeongRepublic of Korea

Many birds develop brood patches on their ventral apterium under hormonal regulation to effectively transmit body heat to eggs during *** developed patch has several characteristics,including de-feathering,vascularization,and ***,little is known about whether avian brood parasites that do not incubate their eggs exhibit brood patch development during the breeding *** this study,we measured the size of the ventral apterium in 114 Common Cuckoos(Cuculus canorus)captured in the field throughout the breeding season and examined the appearance of the ventral apterium to confirm the development of brood *** also examined whether morphological traits and various factors correlated with the size of the ventral apterium(sternal apterium and abdominal apterium)and how it changed during the breeding *** found no clear signs of brood patch development in Common Cuckoos captured throughout the breeding season,indicating that they likely did not develop brood patches on the ventral apterium during this *** also found that ventral apterium size was positively correlated with wing length and body *** addition,Common Cuckoos with newly growing feathers on the boundary of the ventral apterium with pteryla were frequently observed as seasons progressed to the *** conclusion,Common Cuckoos exhibit neither brood patch development nor the vestigial characteristics of ancestral brood patches,except for the growth of feathers on boundary the ventral *** studies examining brood patches across different groups of avian brood parasites are valuable for enhancing our understanding of the developmental and physiological adaptations of avian brood parasites.

关键词： Brood parasitism Brood patch Common Cuckoo Pterylosis Re-feathering Ventral apterium

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Peroxisome proliferator-activated receptor-delta agonist ameliorated inflammasome activation in nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2015年第45期21卷 12787-12799页

作者： Hyun Jung Lee Jong Eun Yeon Eun Jung Ko Eileen L Yoon Sang Jun Suh Keunhee Kang hae rim kim Seoung Hee Kang Yang Jae Yoo Jihye Je Beom Jae Lee Ji Hoon kim Yeon Seok Seo Hyung Joon Yim Kwan Soo Byun Department of Internal Medicine Korea University College of Medicine

AIM: To evaluate the inflammasome activation and the effect of peroxisome proliferator-activated receptors(PPAR)-δ agonist treatment in nonalcoholic fatty liver disease(NAFLD) ***: Male C57BL/6J mice were classified according to control or high fat diet(HFD) with or without PPAR-δ agonist(GW) over period of 12 wk [control, HFD, HFD + lipopolysaccharide(LPS), HFD + LPS + GW group]. Hep G2 cells were exposed to palmitic acid(PA) and/or LPS in the absence or presence of ***: HFD caused glucose intolerance and hepatic steatosis. In mice fed an HFD with LPS, caspase-1 and interleukin(IL)-1β in the liver were significantly increased. Treatment with GW ameliorated the steatosis and inhibited overexpression of pro-inflammatory cytokines. In Hep G2 cells, PA and LPS treatment markedly increased m RNA of several nucleotide-binding andoligomerization domain-like receptor family members(NLRP3, NLRP6, and NLRP10), caspase-1 and IL-1β. PA and LPS also exaggerated reactive oxygen species production. All of the above effects of PA and LPS were reduced by GW. GW also enhanced the phosphorylation of AMPK-α.CONCLUSION: PPAR-δ agonist reduces fatty acidinduced inflammation and steatosis by suppressing inflammasome activation. Targeting the inflammasome by the PPAR-δ agonist may have therapeutic implication for NAFLD.

关键词： Nonalcoholic fatty liver disease Nonalcoholic stea

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Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon kim So-Young Park Chulhwan Kwak Yoonji Lee Dae-Geun Song Jae Woo Jung haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun hae Lee Wonsik kim Soyeon kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-Woo Rhee Kwang-Hyeon Liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

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Discovering High-Quality Threaded Discussions in Online Forums

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Journal of Computer Science & Technology 2014年第3期29卷 519-531页

作者： Jung-Tae Lee Min-Chul Yang hae-Chang rim Department of Computer and Radio Communications Engineering Korea UniversitySeoul 136-713Korea

Archives of threaded discussions generated by users in online forums and discussion boards contain valuable knowledge on various topics. However, not all threads are useful because of deliberate abuses, such as trolling and flaming, that are commonly observed in online conversations. The existence of various users with different levels of expertise also makes it difficult to assume that every discussion thread stored online contains high-quality contents. Although finding high-quality threads automatically can help both users and search engines sift through a huge amount of thread archives and make use of these potentially useful resources effectively, no previous work to our knowledge has performed a study on such task. In this paper, we propose an automatic method for distinguishing high-quality threads from low-quality ones in online discussion sites. We first suggest four different artificial measures for inducing overall quality of a thread based on ratings of its posts. We then propose two tasks involving prediction of thread quality without using post rating information. We adopt a popular machine learning framework to solve the two prediction tasks. Experimental results on a real world forum archive demonstrate that our method can significantly improve the prediction performance across all four measures of thread quality on both tasks. We also compare how different types of features derived from various aspects of threads contribute to the overall performance and investigate key features that play a crucial role in discovering high-quality threads in online discussion sites.

关键词： online forum discussion board thread quality

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Left or Right Hand Classification from Fingerprint Images Using a Deep Neural Network

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Computers, Materials & Continua 2020年第4期63卷 17-30页

作者： Junseob kim Beanbonyka rim Nak-Jun Sung Min Hong Department of Computer Science Soonchunhyang University31538AsanKorea Department of Computer Software Engineering Soonchunhyang University31538AsanKorea

Fingerprint security technology has attracted a great deal of attention in recent years because of its unique biometric information that does not change over an individual’s lifetime and is a highly reliable and secure way to identify a certain ***(Automated Fingerprint Identification System)is a system used by Korean police for identifying a specific person by *** AFIS system,however,only selects a list of possible candidates through fingerprints,the exact individual must be found by fingerprint *** this paper,we designed a deep learning system using deep convolution network to categorize fingerprints as coming from either the left or right *** this paper,we applied the Classic CNN(Convolutional Neural Network),AlexNet,Resnet50(Residual Network),VGG-16,and YOLO(You Only Look Once)networks to this problem,these are deep learning architectures that have been widely used in image analysis *** used total 9,080 fingerprint images for training and 1,000 fingerprint to test the performance of the proposed *** a result of our tests,we found the ResNet50 network performed the best at determining if an input fingerprint image came from the left or right hand with an accuracy of 96.80%.

关键词： Deep Learning convolution neural network fingerprint classification

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Dynamic observation of dendrite growth on lithium metal anode during battery charging/discharging cycles

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npj Computational Materials 2022年第1期8卷 960-972页

作者： hae Gon Lee Se Young kim Joon Sang Lee Next Generation Battery Research Center Korea Electrotechnology Research Institute(KERI)12Jeongiui-gilSeongsan-guChangwon-siGyeongsangnam-do51543Republic of Korea Department of Mechanical Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul03722Republic of Korea

Lithium metal is considered one of the most promising anode materials for application in next-generation ***,despite decades of research,practical application of lithium metal batteries has not yet been achieved because the fundamental interfacial mechanism of lithium dendrite growth is not yet fully *** this study,a series of reactive molecular dynamics (MD) simulations was performed to investigate the electrochemical dynamic reactions at the electrode/electrolyte *** allows quantitative characterization of morphological phenomena and real-time interfacial visualization of the dynamic growth of dead lithium and dendrites during repeated *** computational protocol was utilized to investigate the dendrite mitigation mechanism when an electrolyte additive (hydrogen fluoride) is dissolved in an organic ethylene carbonate (EC) electrolyte *** was confirmed that beneficial decomposition reactions between electrolyte components form a protective film on the anode surface,suppressing large interphase volume changes and unnecessary degradation reactions.

关键词： battery lithium electrolyte

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