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国外医学（脑血管疾病分册） 1996年第2期4卷 104-108页

作者： hacke w 王宏毅

总结急性缺血性卒中重症监护治疗的一些问题,特别强调急性缺血性卒中时颅内压增高的处理,溶栓治疗及一般处理程序,如血压控制与代谢监测,对有明显占位效应的脑梗塞外科处理的指征,并对其他问题进行讨论。

关键词：急性脑血卒中 ICU 重症脑血管疾病

JAMA:急性缺血性卒中血管内治疗应该选择全身麻醉?

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中国卒中杂志 2017年第7期12卷 624-625页

作者：杨中华 Schonenberger S Uhlmann L hacke w 首都医科大学附属北京天坛医院神经病学中心脑血管病中心神经重症医学科北京100050 不详

几项随机对照研究（randomized controlled trial,RCT）临床试验和meta分析显示前循环大动脉闭塞严重急性缺血性卒中可回收支架取栓术联合标准治疗优于标准治疗（大部分包括静脉溶栓治疗）。目前,国际指南也推荐此治疗策略。血管内治疗... 详细信息

几项随机对照研究（randomized controlled trial,RCT）临床试验和meta分析显示前循环大动脉闭塞严重急性缺血性卒中可回收支架取栓术联合标准治疗优于标准治疗（大部分包括静脉溶栓治疗）。目前,国际指南也推荐此治疗策略。血管内治疗围手术期镇静和气道模式选择的问题一直没有解决,这些选择包括全身麻醉（简称全麻）联合气管插管,轻度镇静（清醒镇静）或局麻无气管插管。

关键词：急性缺血性卒中 JAMA 血管内治疗清醒镇静气管插管静脉溶栓围手术期前循环临床试验 NIHSS

去氨普酶治疗急性缺血性脑卒中的II期试验研究:基于MRI的静脉注射去氨普酶溶栓治疗急性卒中的9h时间窗试验

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世界核心医学期刊文摘（神经病学分册） 2005年第6期1卷 53-54页

作者： hacke w. Albers G. Al- RawiY. 赵正卿 Department of Neurology University of Heidelberg Im Neuenheimer Feld 400 69120 Heidelberg Germany Dr.

Background and Purpose - Most acute ischemic stroke patients arrive after the 3- hour time window for recombinant tissue plasminogen activator (rtPA) administration. The Desmoteplase In Acute Ischemic Stroke trial (DIAS) was a dose- finding randomized trial designed to evaluate the safety and efficacy of intravenous desmoteplase, a highly fibrin- specific and nonneurotoxic thrombolytic agent, administered within 3 to 9 hours of ischemic stroke onset in patients with perfusion/diffusion mismatch on MRI. Methods - DIAS was a placebo- controlled, double- blind, randomized, dose- finding phase II trial. Patients with National Institute of Health Stroke Scale (NIHSS) scores of 4 to 20 and MRI evidence of perfusion/diffusion mismatch were eligible. Of 104 patients, the first 47 (referred to as Part 1) were randomized to fixed doses of desmoteplase (25 mg, 37.5 mg, or 50 mg) or placebo. Because of an excessive rate of symptomatic intracranial hemorrhage (sICH), lower weight- adjusted doses escalating through 62.5 μ g/kg, 90 μ g/kg, and 125 μ g/kg were subsequently investigated in 57 patients (referred to as Part 2). The safety endpoint was the rate of sICH. Efficacy endpoints were the rate of reperfusion on MRI after 4 to 8 hours and clinical outcome as assessed by NIHSS, modified Rankin scale, and Barthel Index at 90 days. Results - Part 1 was terminated prematurely because of high rates of sICH with desmoteplase (26.7% ). In Part 2, the sICH rate was 2.2% . No sICH occurred with placebo in either part. Reperfusion rates up to 71.4% (P=0.0012) were observed with desmoteplase (125 μ g/kg) compared with 19.2% with placebo. Favorable 90- day clinical outcome was found in 22.2% of placebo- treated patients and between 13.3% (62.5 μ g/kg; P=0.757) and 60.0% (125 μ g/kg; P=0.0090) of desmote- plase- treated patients. Early reperfusion correlated favorably with clinical outcome (P=0.0028). Favorable outcome occurred in 52.5% of patients experiencing reperfusion versus 24.6% of p

关键词： II MRI 急性卒中试验研究安慰剂对照缺血性脑卒中巴塞尔指数弥散障碍静脉给药量效关系

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中风病人的溶栓治疗

德国医学 1999年第3期16卷 133-135页

作者： H.C.Diener w.hacke 施琪嘉 Klinik und Poliklinik für Neurologie der Universitt Hufelandstr.55 D-45122 EssenGermany 同济医科大学附属同济医院

急性心肌梗塞病人的溶栓治疗临床上已很成熟,该方法临床运用时的危险性、适应证和禁忌证已众所周知。而对缺血性卒中的病人作溶栓治疗则处于开始阶段。本文将要介绍在急性缺血性梗塞时所常用的几个溶栓制剂。急性缺血性梗塞使用溶栓... 详细信息

急性心肌梗塞病人的溶栓治疗临床上已很成熟,该方法临床运用时的危险性、适应证和禁忌证已众所周知。而对缺血性卒中的病人作溶栓治疗则处于开始阶段。本文将要介绍在急性缺血性梗塞时所常用的几个溶栓制剂。急性缺血性梗塞使用溶栓治疗的目的在于尽早恢复脑血流,以减少由缺血引起的脑组织损害。

关键词：中风溶栓疗法疗效

氯吡格雷联合阿司匹林与单用阿司匹林预防动脉粥样硬化血栓性事件的比较

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世界核心医学期刊文摘（心脏病学分册） 2006年第7期2卷 6-7页

作者： Bhatt D.L. Fox K.A.A. hacke w. E.J. Topol 罗亮 Department of Genetics Case Western Reserve University BRB 724 10900 Euclid Ave. Cleveland OH 44106-4955 United States Dr.

BACKGROUND: Dual antiplatelet therapy with clopidogrel plus low-dose aspirin has not been studied in a broad population of patients at high risk for atherothrombotic events. METHODS: we randomly assigned 15,603 patients with either clinically evident cardiovascular disease or multiple risk factors to receive clopidogrel(75 mg per day) plus low-dose aspirin(75 to 162 mg per day) or placebo plus low-dose aspirin and followed them for a median of 28 months. The primary efficacy end point was a composite of myocardial infarction, stroke, or death from cardiovascular causes. RESULTS: The rate of the primary efficacy end point was 6.8 percent with clopidogrel plus aspirin and 7.3 percent with placebo plus aspirin(relative risk, 0.93; 95 percent confidence interval, 0.83 to 1.05; P=0.22). The respective rate of the principal secondary efficacy end point, which included hospitalizations for ischemic events, was 16.7 percent and 17.9 percent(relative risk, 0.92; 95 percent confidence interval, 0.86 to 0.995; P=0.04), and the rate of severe bleeding was 1.7 percent and 1.3 percent(relative risk, 1.25; 95 percent confidence interval, 0.97 to 1.61 percent; P=0.09). The rate of the primary end point among patients with multiple risk factors was 6.6 percent with clopidogrel and 5.5 percent with placebo(relative risk, 1.2; 95 percent confidence interval, 0.91 to 1.59; P=0.20) and the rate of death from cardiovascular causes also was higher with clopidogrel(3.9 percent vs. 2.2 percent, P=0.01). In the subgroup with clinically evident atherothrombosis, the rate was 6.9 percent with clopidogrel and 7.9 percent with placebo(relative risk, 0.88; 95 percent confidence interval, 0.77 to 0.998; P=0.046). CONCLUSIONS: In this trial, there was a suggestion of benefit with clopidogrel treatment in patients with symptomatic atherothrombosis and a suggestion of harm in patients with multiple risk factors. Overall, clopidogrel plus aspirin was not significantly more effective than aspirin alone

关键词：血栓性疾病联合终点联合小剂量心血管疾病安慰剂死亡发生率亚组高危人群出血发生率随机分

CHARISMA试验:阿司匹林与氯吡格雷联合阿司匹林预防动脉粥样硬化事件的对照研究

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中国现代神经疾病杂志 2009年第1期9卷 102-102页

作者： Bhatt DL Fox KA hacke w 王蔚不详南京医科大学第一附属医院神经内科 210029

CHARISMA（Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events）试验旨在比较阿司匹林单药治疗与阿司匹林和氯吡格雷联合治疗预防动脉粥样硬化事件的疗效。有26个国家参与了该项研究，共纳... 详细信息

CHARISMA（Clopidogrel and Aspirin versus Aspirin Alone for the Prevention of Atherothrombotic Events）试验旨在比较阿司匹林单药治疗与阿司匹林和氯吡格雷联合治疗预防动脉粥样硬化事件的疗效。有26个国家参与了该项研究，共纳入15603例≥45岁受试者，均符合下列条件：具有动脉粥样硬化多种危险因素，或具有明确的冠心病、脑血管疾病及症状性外周动脉疾病。

关键词：动脉粥样硬化阿司匹林氯吡格雷预防试验 Prevention Aspirin 外周动脉疾病

A novel method for clustering cellular data to improve classification

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Neural Regeneration Research 2025年第9期20卷 2697-2705页

作者： Diek w.wheeler Giorgio A.Ascoli Center for Neural Informatics Structures&PlasticityKrasnow Institute for Advanced Study Bioengineering Department Volgenau School of Engineering George Mason University FairfaxVAUSA

Many fields,such as neuroscience,are experiencing the vast prolife ration of cellular data,underscoring the need fo r organizing and interpreting large datasets.A popular approach partitions data into manageable subsets via hierarchical clustering,but objective methods to determine the appropriate classification granularity are *** recently introduced a technique to systematically identify when to stop subdividing clusters based on the fundamental principle that cells must differ more between than within *** we present the corresponding protocol to classify cellular datasets by combining datadriven unsupervised hierarchical clustering with statistical *** general-purpose functions are applicable to any cellular dataset that can be organized as two-dimensional matrices of numerical values,including molecula r,physiological,and anatomical *** demonstrate the protocol using cellular data from the Janelia MouseLight project to chara cterize morphological aspects of neurons.

关键词： cellular data clustering dendrogram data classification Levene's one-tailed statistical test unsupervised hierarchical clustering

Genistein:a possible solution for the treatment of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2903-2905页

作者： Karolina Pierzynowska Bartosz Karaszewski Grzegorz węgrzyn Department of Molecular Biology University of GdanskGdanskPoland Gdansk Polandand Department of Adult NeurologyFaculty of MedicineMedical University of GdanskGdanskPoland

Neurodegenerative diseases are defined as disorders resulting from the slow and progressive loss of function and eventual death of neural cells that result from the primary pathology of nervous *** can lead to severe nervous system dysfunction,eventually affecting multiple organs and *** hundred neurodegenerative diseases have been described,and owing to their prevalence,severity.

关键词： organs Alzheimer death

血管造影工作流程的一项随机试验:SIESTA试验的验后分析

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国际医学放射学杂志 2018年第3期 348-348页

作者： J.A.R.Pfaff S.Sch?nenberger S.Nagel P.A.Ringleb w.hacke M.Bendszus 吕晓虹 Departments of Neuroradiology and Neurology Heidelberg University Hospital

摘要目的对近期的血管内治疗脑卒中的镇静与插管研究(SIESTA)进行随机对照验后分析,评估对于该类病人,选择哪种镇静模式[清醒镇静(CS)与全身麻醉(GA)]更有助

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Glia-to-neuron reprogramming to the rescue?

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Neural Regeneration Research 2025年第5期20卷 1395-1396页

作者： Jack w.Hickmott Cindi M.Morshead Department of Surgery University of TorontoTorontoONCanada Donnelly Centre for Cellular and Biomolecular Research TorontoONCanada Institute of Biomedical Engineering University of TorontoTorontoONCanada The KITE Research Institute Toronto Rehabilitation InstituteUniversity Health NetworkTorontoONCanada

Over the last two decades,the dogma that cell fate is immutable has been increasingly challenged,with important implications for regenerative *** brea kth rough discovery that induced pluripotent stem cells could be generated from adult mouse fibroblasts is powerful proof that cell fate can be *** exciting extension of the discovery of cell fate impermanence is the direct cellular reprogram ming hypothesis-that terminally differentiated cells can be reprogrammed into other adult cell fates without first passing through a stem cell state.

关键词： programming passing proof