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Chinese Chemical Letters 2024年第8期35卷 187-200页

作者： si ha Jiacheng Zhu Hua Xiang Guoshun Luo State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry China Pharmaceutical UniversityNanjing 211198China

Small molecule inhibitors have dominated the pharmaceutical landscape for a long time as the primary therapeutic paradigm targeting pathogenic ***,their efficacy heavily relies on the amino acid composition and spatial constitution of proteins,rendering them susceptible to drug resistance and failing to target undruggable *** recent years,the advent of targeted protein degradation(TPD)technology has captured substantial attention from both industry and *** an event-driven mode,TPD offers a novel approach to eliminate pathogenic proteins by promoting their degrada-tion,thus circumventing the limitations associated with traditional small molecule ***-bic tag tethering degrader(HyTTD)technology represents one such TPD approach that is currently in the burgeoning *** employ endogenous protein degradation systems to induce the degrada-tion of target proteins through the proteasome pathway,which displays significant potential for medical *** this review,we provide a comprehensive overview of the development history and the reported mechanism of action of ***,we delve into the physiological roles,structure-activity re-lationships,and medical implications of HyTTDs targeting various disease-associated ***,we propose insights into the challenges that necessitate resolution for the successful development of HyTTDs,with the ultimate goal of initiating a new age of clinical treatment leveraging the immense po-tential of HyTTDs.

关键词： Targeted protein degradation(TPD) Hydrophobic tag Degrader Hydrophobic tag tethering degrader(HyTTD) Targeted therapy

How Participatory is Participatory Flood Risk Mapping? Voices from the Flood Prone Dharavi Slum in Mumbai

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International Journal of Disaster Risk Science 2022年第2期13卷 230-248页

作者： Subhajyoti Samaddar ha si Xinyu Jiang Junho Choi Hirokazu Tatano Disaster Prevention Research Institute Kyoto UniversityKyoto 6110011Japan School of Management Wuhan University of TechnologyWuhan 430070China Disaster and Safety Management Soongsil UniversitySeoul 06978South Korea

Participatory flood risk mapping(PFRM) is a well-recognized and widely implemented tool for meaningful community involvement in disaster risk reduction(DRR). The effectiveness of PFRM remains anecdotal. The PFRM exercise has rarely been applied identically in two different places by two different organizations, which produces varied and uncertain outcomes. In the absence of any agreed and comprehensive framework for participatory DRR, existing studies struggle to provide a scientific account of how the structure, design, and process of PFRM ensure the effective participation of local *** study, examines what factors and methods make PFRM an effective participatory DRR tool. In this study,we first identified the process-based criteria of participation. Then we briefly introduced a participatory flood risk mapping exercise conducted in a flood-prone informal settlement in Dharavi, Mumbai. The exercise was carefully designed to meet the process criteria of effective participation. Finally, using qualitative research methods, we evaluated the effectiveness of our PFRM from the local community perspective. The findings show that ensuring community livelihood security and true involvement of marginalized groups, preparing an action plan, and incorporating fun and cultural connotations into the facilitation process are critical components that enhance community participation through PFRM in DRR.

关键词： Dharavi Evaluation Mumbai flood Participatory disaster risk reduction Participatory flood risk mapping Process-based criteria of participation

Nitrogen addition increased resistance of resident plant community to Solidago canadensis invasion by altering allelopathic effect

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Journal of Plant Ecology 2024年第2期17卷 110-121页

作者： Jing-Fang Cai Kai Sun Lin Li si-ha A Yi-Luan Shen Hong-Li Li School of Ecology and Nature Conservation Beijing Forestry UniversityBeijing 100083China The Key Laboratory of EcologicalProtection in the Yellow River Basin of National Forestry and Grassland Administration Beijing Forestry UniversityBeijing 100083China

Allelopathy plays an important role in the interaction between invasive and resident *** nitrogen(N)deposition has become a global problem,but it is unclear whether N enrichment affects the interaction between invasive and resident plants by affecting their ***,we performed a greenhouse experiment in which the resident plant community was grown under two levels of invasion by ***(invasion *** invasion)and fully crossed with two levels of allelopathy(with or without adding activated carbon)and two levels of N addition(with or without).The resident plant communities were constructed with eight herbaceous species that often co-occur with *** results showed that both allelopathy of *** and the resident plants had obvious positive effects on their own *** addition had more obvious positive effects on the resident plants under invasion than those that were not ***,N addition also altered the allelopathy of resident ***,N addition improved the allelopathy of resident plants when they were invaded but decreased the allelopathy of resident plants when they grew *** nitrogen addition had no obvious effect on ***,it reduced the allelopathy of *** results suggest that N addition could improve the resistance of resident plants to invasion by improving the allelopathy of resident plants and reducing the allelopathy of *** fndings provide a scientifc basis to manage and control the *** invasion.

关键词： allelochemicals biological invasion nutrient input nitrogen addition resident plants Solidago canadensis

Research Progress of Polysemous Disambiguation

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Research Progress of Polysemous Disambiguation

Nitrogen addition frequency and propagule pressure influence Solidago canadensis invasion into native plant community

作者： Chao han ha si College of Computer Science and Technology Inner Mongolia Normal University

Linguistic ambiguity is a common phenomenon in human language *** natural language,when a word in a sentence has more than one meaning,ambiguity may *** sense disambiguation is an important research topic in the field of natural language *** disambiguation effect has a significant impact on machine translation,information retrieval,information extraction and text mining,speech recognition and other aspects,so word meaning disambiguation has important theoretical research and practical application *** author analyzes,compares,and summarizes Knowledge-based Methods,Supervised Methods,and Unsupervised Methods,and analyzes the future trends of word sense disambiguation.

关键词： Mongolian Natural language processing Word sense disambiguation Semantic category

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Ecosystem Health and Sustainability 2022年第1期8卷 342-351页

作者： Xuan-Shao Liu Jing-Fang Cai Lin Liu Kai Sun Fan Jiang Yi-Luan Shen si-ha A Hong-Li Li The Key Laboratory of Ecological Protection in the Yellow River Basin of National Forestry and Grassland Administration School of Ecology and Nature ConservationBeijing Forestry UniversityBeijingChina

Introduction:Propagule pressure(i.e.,the number of propagules)has long been recognized to play an essential role in plant *** it is not clear whether propagule pressure influences the invasion of exotic plants into native plant communities when different frequencies of nitrogen are ***:We established an experiment with three plant communities that included native plant communities alone(four grasses,two legumes and two forbs)or native plant communities with one or five invasive plants,Solidago canadensis,under three frequencies of nitrogen addition(no addition or low or high addition with the same amount).Results:High propagule pressure significantly enhanced the biomass and relative dominance index of ***,high propagule pressure only decreased the total and aboveground biomass of the ***,the competitive effect between *** and the native community and biomass of the whole native community varied according to different ***:Overall,high propagule pressure encouraged invasion by ***,while alow nitrogen frequency was advantageous for the native community to resist invasion in this *** results provide a scientific basis to manage and control the invasion of ***.

关键词： clonal plants invasiveness nitrogen addition level propagule number

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城市效应对呼和浩特市气候的影响

气候与环境研究 2000年第2期5卷 228-232页

作者：哈斯内蒙古气象局气候中心呼和浩特010051

利用呼和浩特市探空资料和邻近站的地面观测资料 ,分析了城市效应对呼和浩特市气候的影响 ,发现呼和浩特市热岛现象明显 ,每 10年增温 0 2 2～ 0 4 2℃。另外 ,呼和浩特市雷暴日数、雾日数增加了。

关键词：城市效应呼和浩特市气候条件热岛现象多雷多雾效应日照时数

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不同放牧率对草甸植被特征的影响

干旱区资源与环境 2008年第4期22卷 170-174页

作者：白哈斯山东省潍坊学院生物系潍坊261061

通过对羊草+苔草草甸进行受控放牧实验,定量研究了草地植被结构对不同放牧率条件下的反应特征。结果表明:所有不同放牧小区的四种牧草牧前高度远远低于对照小区,而且留茬高度差异不大。各种牧草放牧后的高度受草地群落生物量和牧草本身... 详细信息

通过对羊草+苔草草甸进行受控放牧实验,定量研究了草地植被结构对不同放牧率条件下的反应特征。结果表明:所有不同放牧小区的四种牧草牧前高度远远低于对照小区,而且留茬高度差异不大。各种牧草放牧后的高度受草地群落生物量和牧草本身适口性的影响,适口性越高,降低程度越大。在整个生长季内,羊草+苔草草甸群落地上部分生物量一直处于不断增加的状态,其中苔草和芦苇地上生物量于6月份达到峰值;羊草于7月份达到峰值;香茅在整个生长季内不断增加,于8月份达到最大值。各放牧小区群落生物量均明显低于对照小区。随着放牧率的提高,多样性指数先增高后降低,即适度放牧有利于多样性的维持。

关键词：放牧率草甸留茬高度地上生物量多样性指数

不同放牧率对羊草+苔草低地草甸草地再生和净初级生产力的影响

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干旱区研究 2007年第6期24卷 826-829页

作者：白哈斯山东省潍坊学院生物系山东潍坊261061

在羊草＋苔草低地草甸,通过小区围栏放牧,定量研究了不同放牧率对低地草甸牧草再生性能和地上净初级生产力的影响。结果表明：在不同放牧率下各再生期间的再生草量存在着明显的季节性差异,其最大值出现在5-6月份,为136.6 g/m^2。适宜的... 详细信息

在羊草＋苔草低地草甸,通过小区围栏放牧,定量研究了不同放牧率对低地草甸牧草再生性能和地上净初级生产力的影响。结果表明：在不同放牧率下各再生期间的再生草量存在着明显的季节性差异,其最大值出现在5-6月份,为136.6 g/m^2。适宜的放牧率有利于增加草地的再生草量,各放牧小区的相对生长速率均大于对照小区的相对生长速率,放牧率较低的P2小区相对生长速率最大。各放牧小区地上净初级生产力均小于对照小区地上净初级生产力,即不存在超补偿性生长现象。

关键词：放牧率草甸牧草再生净初级生产力羊草+苔草通辽内蒙古

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复合加固木柱抗侧性能的试验研究

工程力学 2023年第12期40卷 212-221页

作者：阿斯哈周长东内蒙古工业大学土木工程学院内蒙古呼和浩特010051 北京交通大学土木建筑工程学院北京100044

为了探究内嵌钢筋外包碳纤维(CFRP)布复合加固圆形木柱的抗震性能,并提出加固木柱的抗侧性能计算方法,以内嵌钢筋数量和CFRP布加固量为变量,开展了5根复合加固木柱的低周往复荷载试验。试验结果表明:复合加固方法能够延缓木柱损伤破坏... 详细信息

为了探究内嵌钢筋外包碳纤维(CFRP)布复合加固圆形木柱的抗震性能,并提出加固木柱的抗侧性能计算方法,以内嵌钢筋数量和CFRP布加固量为变量,开展了5根复合加固木柱的低周往复荷载试验。试验结果表明:复合加固方法能够延缓木柱损伤破坏的进程,加固木柱均表现为试件底部受拉侧木材纤维的断裂,脆性破坏特征显著。复合加固木柱的承载和变形能力提升明显,随着CFRP布加固量的增加,试件的峰值荷载和延性均呈上升趋势,内嵌钢筋的布设位置会影响木柱的抗侧承载力。钢筋和CFRP布的应变-位移滞回曲线与木材的相应曲线分布形态相近,加固材料可以与木材协调变形、共同工作,进而提升木柱的滞回性能。采用条带法对试件截面进行受力分析,通过理论计算与试验数据的对比,验证了截面内力计算方法的可靠性。基于材料力学基本理论,提出了复合加固木柱抗侧性能计算方法,理论计算与试验结果对应良好。

关键词：圆形木柱复合加固抗震性能往复荷载试验水平承载力

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基于区域优势产业分析的内蒙古村镇银行发展研究

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科学管理研究 2013年第6期31卷 79-82页

作者：哈斯薛桐北京交通大学经济管理学院北京100044

通过与比较优势理论和竞争优势理论的对比,分析了区域优势产业的内涵,并对其区域优势产业特征、表现以及与金融业的关系进行了探讨,指出农牧业是内蒙古自治区潜在的区域优势产业,据此提出内蒙古自治区村镇银行的发展路径。

关键词：区域优势产业村镇银行农牧产业内蒙古