检索结果-南通市图书馆

CCL5 as a potential immunotherapeutic target in triple-negative breast cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2013年第4期10卷 303-310页

作者： Dandan Lv Yan Zhang ha-jeong kim Lixing Zhang Xiaojing Ma Sheng Yushou Center of Cell Biology and Immunology School of Life Science and Biotechnology Shanghai Jiaotong University Shanghai China Department of Microbiology and Immunology Weill Cornell Medical College New York NY USA

Breast cancer （BC） is a leading cause of mortality among women in the world. To date, a number of molecules have been established as disease status indicators and therapeutic targets. The best known among them are estrogen receptor-α （ER-α）, progesterone receptor （PR） and H ER-2/neu. About 15%-20% BC patients do not respond effectively to thera pies targeting these classes of tumor-promoting factors. Thus, additional targets are strongly and urgently sought after in therapy for human BCs negative for ER, PR and HER-2, the so-called triple-negative BC （TNBC）. Recent clinical work has revealed that CC chemokine ligand 5 （CCL5） is strongly associated with the progression of BC, particularly TNBC. How CCL5 contributes to the development of TN BC is not well understood. Experimental animal studies have begun to address the mechanistic issue. In this article, we will review the clinical and laboratory work in this area that has led to our own hypothesis that targeting CCL5 in TNBCs will have favorable therapeutic outcomes with minimal adverse impact on the general physiology.

关键词： triple negative breast cancer CCL5 myeloid derived suppressor cell immunotherapy

Analytical evaluation and experimental validation on dynamic rocking behavior for shallow foundation considering structural response

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Earthquake Engineering and Engineering Vibration 2022年第1期21卷 37-51页

作者： Kil-Wan Ko jeong-Gon ha Dong-Soo kim Department of Civil and Environmental Engineering UC BerkeleyCalifornia 94720USA Advanced Structures and Seismic Safety Research Division Daejeon 34057Korea Department of Civil and Environmental Engineering KAISTDaejeon 34141Korea

The challenge in the practical application of rocking foundations is the estimation of its performance,particularly the rotation angle,during a strong *** this study,the dynamic rocking behavior for a shallow foundation considering structural response was evaluated through two analytical approaches:the conventional soil-foundation-structure interaction(SFSI)governing equation of a single-degree-of-freedom(SDOF)structure on a rocking shallow foundation,and the Housner rocking model(i.e.,a rocking rigid block on a rigid base).Both approaches were validated with dynamic centrifuge *** test models consisted of a soft soil deposit,a shallow rectangular foundation,and an SDOF structure dominated by a bending behavior.A total of 11 foundation-structure systems and six seismic waves,including recorded earthquake signals and sinusoidal waves,were *** results showed that the conventional SFSI equation well predicted the maximum rotation during strong ***,this method was less accurate regarding the rotational phase information and maximum rotation of the foundation during weak *** the other hand,although the modified Housner′s rocking model required five parameters relevant to a soil-foundation-structure system,it overestimated the maximum rotation of the foundation when compared with the results from dynamic centrifuge tests.

关键词： soil-foundation-structure interaction maximum rotation angle rocking foundation Housner rocking model dynamic centrifuge test

Combined treatment of phacoemulsification and single-port limited pars plana vitrectomy in acute angle-closure glaucoma

在线全文

学校读者我要写书评

暂无评论

International Journal of Ophthalmology(English edition) 2019年第6期12卷 974-979页

作者： ha jeong Noh Seong Taeck kim Department of Ophthalmology Chosun University Hospital

AIM: To evaluate the efficacy of combined treatment of phacoemulsification(PE) and micro-incisional single-port transconjunctival limited pars plana vitrectomy(PPV) in acute angle-closure glaucoma(AACG).METHODS: A retrospective study included 26 patients who underwent PE diagnosed with AACG. Among them, 16 patients(16 eyes) underwent PE alone, 10 patients(10 eyes) underwent combined limited vitrectomy and PE. Then we compared intraocular pressure(IOP), anterior chamber angle, anterior chamber depth, central corneal thickness and corneal endothelial cell count before and after surgery, and effective PE time during cataract ***: Effective PE time was shorter in the combined surgery group than in the single surgery group(P=0.040). There was no statistically significant difference in IOP and best-corrected visual acuity between the two groups postoperatively. At 6 mo postoperatively, there was no difference in the anterior chamber angle, anterior chamber depth, and central corneal thickness between two groups, but corneal endothelial cell count was higher in the combined surgery group than in the single surgery group(P=0.046). No complication such as vitreoretinal disease, endophthalmitis, bullous keratopathy was ***: Combined micro-incisional single-port transconjunctival limited PPV and PE are more effective and safer than PE alone because of less operation time and fewer complications for management of AACG.

关键词： limited vitrectomy phacoemulsification acute angle-closure glaucoma

Crystal structure of Arabidopsis thaliana RabA_(1a)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Integrative Plant Biology 2019年第2期61卷 93-109页

作者： Ji-Sook Yun Sung Chul ha Shinae kim Yeon-Gil kim Hyeran kim jeong Ho Chang Department of Biology Education Kyungpook National University Beamline Science Division Pohang Accelerator Laboratory Department of Biological Sciences Kangwon National University

RabGTPase is a member of the Ras superfamily of small GTPases, which share a GTP-binding pocket containing highly conserved motifs that promote GTP hydrolysis. In Arabidopsis, the RabA group, which corresponds to the Rab_(11) group in animals, functions in the recycling of endosomes that control docking and fusion during vesicle transport. However, their molecular mechanisms remain unknown. In this study, we determined the crystal structures of the GDP-bound inactive form and both GppNHp-and GTP-bound active forms of RabA1a, at resolutions of 2.8, 2.6, and 2.6 A?,respectively. A bound sulfate ion in the active site of the GDP-bound structure stabilized Switch Ⅱ by bridging the interaction between a magnesium ion and *** of the two states of RabA1a with Rab_(11) proteins revealed clear differences in the Switch Ⅰ and Ⅱ loops. These results suggested that conformational change of the Switch regions of RabA1a, derived by GTP or GDP binding, could maintain subcellular membrane traffic through the specific interaction of effector molecules.

关键词： GDP Crystal structure of Arabidopsis thaliana RabA Figure

Metastasis of hepatocellular carcinoma to the small bowel manifested by intussusception

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2006年第12期12卷 1969-1971页

作者： Hyun Soo kim Jung WooShin In Du jeong Sung-Jo Bang Do ha kim Neung Hwa Park Gyu Yeol kim Young Min kim Hee jeong Cha Yoong Ki jeong Division of Gastroenterology Department of Internal MedicineUniversity of Ulsan College of MedicineUlsan University HospitalUlsanKorea Department of Surgery University of Ulsan College of MedicineUlsan University HospitalUlsanKorea Department of Pathology University of Ulsan College of MedicineUlsan University HospitalUlsanKorea Department of Radiology University of Ulsan College of MedicineUlsan University HospitalUlsanKorea

Hepatocellular carcinoma （HCC） is a so highly invasive tumor that metastasizes hematogenously and lymphogenously to distant site. Frequent sites are lung, regional lymph node, bone, and adrenal gland. But metastasis to the gastrointestinal （GI） tract is rare, and most common site is stomach. Metastasis to the small intestine is extremely rare. Moreover, metastatic HCC of the small bowel causing intussusception has not been reported until now. Here, we report a case of metastasis of HCC to the small bowel manifested by intussusception.

关键词： Hepatocelluar carcinoma Small bowel metastasis Intussusception

Prediction of effluent concentration in a wastewater treatment plant using machine learning models

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2015年第6期27卷 90-101页

作者： Hong Guo Kwanho jeong Jiyeon Lim jeongwon Jo Young Mo kim Jong-pyo Park Joon ha kim Kyung Hwa Cho School of Environmental Science and Engineering Gwangju Institute of Science and Technology (GIST) School of Urban and Environmental Engineering Ulsan National Institute of Science and Technology HECOREA. INC

Of growing amount of food waste, the integrated food waste and waste water treatment was regarded as one of the efficient modeling method. However, the load of food waste to the conventional waste treatment process might lead to the high concentration of total nitrogen（T-N） impact on the effluent water quality. The objective of this study is to establish two machine learning models-artificial neural networks（ANNs） and support vector machines（SVMs）, in order to predict 1-day interval T-N concentration of effluent from a wastewater treatment plant in Ulsan, Korea. Daily water quality data and meteorological data were used and the performance of both models was evaluated in terms of the coefficient of determination（R^2）, Nash-Sutcliff efficiency（NSE）, relative efficiency criteria（d rel）. Additionally, Latin-Hypercube one-factor-at-a-time（LH-OAT） and a pattern search algorithm were applied to sensitivity analysis and model parameter optimization, respectively. Results showed that both models could be effectively applied to the 1-day interval prediction of T-N concentration of effluent. SVM model showed a higher prediction accuracy in the training stage and similar result in the validation ***, the sensitivity analysis demonstrated that the ANN model was a superior model for 1-day interval T-N concentration prediction in terms of the cause-and-effect relationship between T-N concentration and modeling input values to integrated food waste and waste water treatment. This study suggested the efficient and robust nonlinear time-series modeling method for an early prediction of the water quality of integrated food waste and waste water treatment process.

关键词： Artificial neural network Support vector machine Effluent concentration Prediction accuracy Sensitivity analysis

Pharmacologic treatment of depression in patients with myocardial infarction

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2011年第2期8卷 121-126页

作者： jeong-Hoon ha Cheuk-Kit Wong Department of Cardiology Dunedin School of Medicine Dunedin Public Hospital University of Otago Dunedin 9001 New Zealand

Depression is a common medical problem and is more prevalent among patients with coronary artery disease. Whether early detection and treatment of depression will enhance cardiovascular outcome is uncertain. Obviously, the safety and efficacy of the anti-depression drugs is an important link. This article reviews the patho-physiologic and behavioural links between depression and cardiovascular disease progression, the treatment of depression, and the potential benefits of anti-depressants in patients with coronary disease.

关键词： depression coronary disease pharmacologic treatment

Real time shear wave elastography in chronic liver diseases:Accuracy for predicting liver fibrosis,in comparison with serum markers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第38期20卷 13920-13929页

作者： Jae Yoon jeong Tae Yeob kim Joo Hyun Sohn Yongsoo kim Woo Kyoung jeong Young-ha Oh Kyo-Sang Yoo Department of Gastroenterology Hanyang University College of Medicine Department of Internal Medicine Hanyang Univesity Guri Hospital Department of Radiology Hanyang University College of Medicine Department of Radiology Samsung Medical CenterSungkyunkwan University School of Medicine Department of Pathology Hanyang University College of Medicine

AIM: To evaluate the correlation between liver stiffness measurement (LSM) by real-time shear wave elastography (SWE) and liver fibrosis stage and the accuracy of LSM for predicting significant and advanced fibrosis, ... 详细信息

关键词： Elastography Liver fibrosis Liver stiffness Liver biopsy Serum markers

Nanoparticle Exsolution on Perovskite Oxides:Insights into Mechanism,Characteristics and Novel Strategies

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第2期16卷 312-346页

作者： Yo han kim Hyeongwon jeong Bo‑Ram Won Hyejin Jeon Chan‑ho Park Dayoung Park Yeeun kim Somi Lee Jae‑ha Myung Department of Materials Science and Engineering Incheon National UniversityIncheon 22012Republic of Korea

Supported nanoparticles have attracted considerable attention as a promising catalyst for achieving unique properties in numerous applications,including fuel cells,chemical conversion,and *** demonstrate high activity by expanding the number of active sites,but they also intensify deactivation issues,such as agglomeration and poisoning,*** for bottomup synthesis of supported nanoparticles has emerged as a breakthrough technique to overcome limitations associated with conventional *** are uniformly exsolved from perovskite oxide supports and socketed into the oxide support by a one-step reduction *** uniformity and stability,resulting from the socketed structure,play a crucial role in the development of novel ***,tremendous research efforts have been dedicated to further controlling exsolution *** effectively address exsolution at a more precise level,understanding the underlying mechanism is *** review presents a comprehensive overview of the exsolution mechanism,with a focus on its driving force,processes,properties,and synergetic strategies,as well as new pathways for optimizing nanocatalysts in diverse applications.

关键词： Supported nanoparticle Exsolution In situ growth Mechanism Perovskite oxide Catalyst