With a constantly increasing incidence,cutaneous melanoma has raised the need for a better understanding of its complex microenvironment that may further guide therapeutic *** is a model tumor in *** represents an imp...
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With a constantly increasing incidence,cutaneous melanoma has raised the need for a better understanding of its complex microenvironment that may further guide therapeutic *** is a model tumor in *** represents an important hallmark of cancer capable of inducing and sustaining tumor *** inflammatory process also orchestrates the adaptative immunosuppression of tumor cells that helps them to evade immune *** its role in proliferation,angiogenesis,and apoptosis,cyclooxygenase-2(COX-2)is a well-known promoter of immune suppression in ***-2 inhibitors are closely involved in this *** review attempts to answer two controversial questions:is COX-2 a valuable prognostic factor?Among all COX-2 inhibitors,is celecoxib a suitable adjuvant in melanoma therapy?
Rat snakes(genus Ptyas)include 13 large Asian species with sizes reaching 3.8 *** more than 100 years,no new species have been discovered in this ***,we describe a new Ptyas from central Vietnam based on morphological...
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Rat snakes(genus Ptyas)include 13 large Asian species with sizes reaching 3.8 *** more than 100 years,no new species have been discovered in this ***,we describe a new Ptyas from central Vietnam based on morphological data and nucleotide sequences from the MT-CYB *** bachmaensis *** diagnosed by the following morphological characters:large-sized snake(largest total length 2401 mm in adult male);body scale rows in even numbers,16-16-14 rows;two medial vertebral scale rows distinct;two and two or four medial scale rows keeled on middle and posterior parts of body,respectively;ventrals 194-199;subcaudals 132-138;supralabials 8,fourth and fifth entering orbit;maxillary teeth 28 or 29;hemipenis spinose and unforked,reaching 12th subcaudal;cloacal plate divided;lateral side of tail black,without a bright *** new species forms an independent clade on the phylogenetic tree and differs from its congeners by an uncorrected p-distance in MTCYB sequences of at least 5.7%.
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