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Stevens-Johnson syndrome and concurrent hand foot syndrome during treatment with capecitabine:A case report

World Journal of Clinical Cases 2021年第17期9卷 4279-4284页

作者： ha rim ahn Sang-Kyung Lee Hyun Jo Youn Seok-Kweon Yun Il-Jae Lee Division of Breast and Thyroid Surgery Department of SurgeryJeonbuk National UniversityJeonju 54907South Korea Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital Jeonju 54907South Korea Department of Dermatology Jeonbuk National University Medical SchoolJeonju 54907South Korea

BACKGROUND Capecitabine is used in combination with lapatinib as palliative treatment for human epidermal growth factor receptor 2-positive metastatic breast *** most frequently reported adverse events attributed to capecitabine include diarrhea,hyperbilirubinemia,and hand-foot syndrome(HFS).A number of cutaneous adverse events have been attributed to capecitabine,including Stevens-Johnson syndrome(SJS)as a rare and potentially life-threatening mucocutaneous *** report the first case involving concurrent SJS and HFS after capecitabine and lapatinib *** SUMMARY A 70-year-old woman with a history of breast cancer treatment visited our hospital for evaluation of painful skin *** weeks earlier,she had been prescribed capecitabine plus lapatinib as treatment for metastatic breast *** subsequently developed worsening erythema and bullae on her palms and soles,as well as reddish macules on her back and chest *** evaluation of the chest wall lesions revealed extensive eosinophilic epidermal necrosis and separation of the epidermis from the *** capecitabine plus lapatinib treatment was discontinued immediately and treatment was started using systemic *** treatment resolved most lesions,although the lesions on her palms and soles required Vaseline gauze dressings,which resulted in ***,we determined that the patient had concurrent SJS and *** the dermatological problems resolved,the patient ultimately died because of multiple organ *** Oral capecitabine treatment carries a risk of both HFS and also life-threatening adverse cutaneous drug reactions,such as SJS.

关键词： Stevens-Johnson syndrome hand-Foot syndrome Palliative treatment Capecitabine Breast neoplasms Case report

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Elasto-inertial microfluidic separation of microspheres with submicron resolution at high-throughput

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Microsystems & Nanoengineering 2024年第1期10卷 203-216页

作者： Hyunwoo Jeon Song ha Lee Jongho Shin Kicheol Song Nari ahn Jinsoo Park Department of Mechanical Engineering Chonnam National University77 Yongbong-ro Buk-guGwangju 61186Republic of Korea Analytical Engineering Team Samsung Display Co.Ltd.181 Samsung-roTangjeong-myeonAsan-siChungcheongnam-do 31454Republic of Korea

Elasto-inertial microfluidic separation offers many advantages including high throughput and separation *** though the separation efficiency highly depends on precise control of the flow conditions,no concrete guidelines have been reported yet in elasto-inertial ***,we propose a dimensionless analysis for precise estimation of the microsphere behaviors across the interface of Newtonian and viscoelastic *** number,modified Weissenberg number,and modified elastic number are used to investigate the balance between inertial and elastic lift *** on the findings,we introduce a new dimensionless number defined as the width of the Newtonian fluid stream divided by microsphere *** proposed dimensionless analysis allows us to predict whether the microspheres migrate across the co-flow *** theoretical estimation is found to be in good agreement with the experimental results using 2.1-and 3.2-μm-diameter polystyrene microspheres in a co-flow of water and polyethylene oxide *** on the theoretical estimation,we also realize submicron separation of the microspheres with 2.1 and 2.5μm in diameter at high throughput,high purity(>95%),and high recovery rate(>97%).The applicability of the proposed method was validated by separation of platelets from similar-sized Escherichia coli(***).

关键词： solution. separation estimation

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Surface engineering of ZnO electrocatalyst by N doping towards electrochemical CO_(2) reduction

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Journal of Energy Chemistry 2024年第1期88卷 71-81,I0002页

作者： Rohini Subhash Kanase Getasew Mulualem Zewdie Maheswari Arunachalam Jyoti Badiger Suzan Abdelfattah Sayed Kwang-Soon ahn Jun-Seok ha Uk Sim Hyeyoung Shin Soon Hyung Kang Department of Interdisciplinary Program for Photonic Engineering Chonnam National UniversityGwangju 61186Republic of Korea Graduate School of Energy Science and Technology(GEST) Chungnam National University99 Daehak-roYuseong-guDaejeon 34134Republic of Korea Department of Chemistry Education and Optoelectronic Convergence Research Center Chonnam National UniversityGwangju 61186Republic of Korea Department of Advanced Chemicals and Engineering Chonnam National UniversityGwangju 61186Republic of Korea School of Chemical Engineering Yeungnam UniversityGyeongsan 38541Republic of Korea Department of Energy Engineering Korea Institute of Energy Technology(KENTECH)Naju 58217Republic of Korea

The discovery of efficient,selective,and stable electrocatalysts can be a key point to produce the largescale chemical fuels via electrochemical CO_(2) reduction(ECR).In this study,an earth-abundant and nontoxic ZnO-based electrocatalyst was developed for use in gas-diffusion electrodes(GDE),and the effect of nitrogen(N)doping on the ECR activity of ZnO electrocatalysts was ***,a ZnO nanosheet was prepared via the hydrothermal method,and nitridation was performed at different times to control the N-doping *** an increase in the N-doping content,the morphological properties of the nanosheet changed significantly,namely,the 2D nanosheets transformed into irregularly shaped ***,the ECR performance of Zn O electrocatalysts with different N-doping content was assessed in 1.0 M KHCO_(3) electrolyte using a gas-diffusion electrode-based ECR *** the ECR activity increased after a small amount of N doping,it decreased for higher N doping *** them,the N:ZnO-1 h electrocatalysts showed the best CO selectivity,with a faradaic efficiency(FE_(CO))of 92.7%at-0.73 V *** hydrogen electrode(RHE),which was greater than that of an undoped Zn O electrocatalyst(FE_(CO)of 63.4%at-0.78 V_(RHE)).Also,the N:ZnO-1 h electrocatalyst exhibited outstanding durability for 16 h,with a partial current density of-92.1 mA cm^(-2).This improvement of N:ZnO-1 h electrocatalyst can be explained by density functional theory calculations,demonstrating that this improvement of N:ZnO-1 h electrocatalyst comes from(ⅰ)the optimized active sites lowering the free energy barrier for the rate-determining step(RDS),and(ⅱ)the modification of electronic structure enhancing the electron transfer rate by N doping.

关键词： ZnO N-doped ZnO Gas-diffusion electrode CO Selectivity Electrochemical CO_(2)reduction

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Predicting Concrete Compressive Strength Using Deep Convolutional Neural Network Based on Image Characteristics

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Computers, Materials & Continua 2020年第10期65卷 1-17页

作者： Sanghyo Lee Yonghan ahn ha Young Kim Division of Architecture and Civil Engineering Kangwon National UniversitySamcheok-si25913Korea School of Architecture and Architectural Engineering Hanyang University ERICAAnsan-si15588Korea Graduate School of Information Yonsei UniversitySeoul03722Korea

In this study,we examined the efficacy of a deep convolutional neural network(DCNN)in recognizing concrete surface images and predicting the compressive strength of concrete.A digital single-lens reflex(DSLR)camera and microscope were simultaneously used to obtain concrete surface images used as the input data for the ***,training,validation,and testing of the DCNNs were performed based on the DSLR camera and microscope image *** of the analysis indicated that the DCNN employing DSLR image data achieved a relatively higher *** accuracy of the DSLR-derived image data was attributed to the relatively wider range of the DSLR camera,which was beneficial for extracting a larger number of ***,the DSLR camera procured more realistic images than the ***,when the compressive strength of concrete was evaluated using the DCNN employing a DSLR camera,time and cost were reduced,whereas the usefulness ***,an indirect comparison of the accuracy of the DCNN with that of existing non-destructive methods for evaluating the strength of concrete proved the reliability of DCNN-derived concrete strength *** addition,it was determined that the DCNN used for concrete strength evaluations in this study can be further expanded to detect and evaluate various deteriorative factors that affect the durability of structures,such as salt damage,carbonation,sulfation,corrosion,and freezing-thawing.

关键词： Deep convolutional neural network(DCNN) non-destructive testing(NDT) concrete compressive strength digital single-lens reflex(DSLR)camera microscope

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应用剪切波离散成像斜率值预测移植肾急性排异反应

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国际医学放射学杂志 2024年第5期 620-621页

作者： T.M.Kim H.ahn J.Y.Cho A.han S.I .Min J.ha 郑永利

目的评价剪切波离散成像斜率值预测移植肾功能不全的价值。方法回顾性分析2022年11月—2023年2月期间行肾移植的128例受试者资料[中位年龄，55(43～62)

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Panax ginseng induces the expression of CatSper genes and sperm hyperactivation

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Asian Journal of Andrology 2014年第6期16卷 845-851页

作者： Eun Hwa Park Do rim Kim ha Young Kim Seong Kyu Park Mun Seog Chang Department of Prescriptionology College of Korean Medicine Kyung Hee Unversity Seoul Korea.

The cation channel of sperm （CatSper） protein family plays important roles in male reproduction and infertility. The four members of this family are expressed exclusively in the testis and are localized differently in sperm. To investigate the effects of Panax ginseng treatment on the expression of CatSper genes and sperm hyperactivation in male mice, sperm motility and CatSper gene expression were assessed using a computer-assisted semen analysis system, a Fluoroskan Ascent microplate fluorometer to assess Ca2＊ influx, *** polymerase chain reaction, Western blotting and immunofluorescence. The results suggested that the Ca2＊ levels of sperm cells treated with P. ginseng were increased significantly compared with the normal group. The P. ginseng-treated groups showed increased sperm motility parameters, such as the curvilinear velocity and amplitude of lateral head displacement. Taken together, the data suggest that CatSper messenger ribonucleic acid levels were increased significantly in mouse testes in the P. ginseng-treated group, as was the protein level, with the exception of CatSper2. In conclusion, P. ginseng plays an important role in improving sperm hyperactivation via CatSper gene expression.

关键词： Ca2+ CatSper hyperactivation panax Einseng

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Digital Vision Based Concrete Compressive Strength Evaluating Model Using Deep Convolutional Neural Network

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Computers, Materials & Continua 2019年第9期61卷 911-928页

作者： Hyun Kyu Shin Yong han ahn Sang Hyo Lee ha Young Kim Architectural Engineering Hanyang UniversityERICAAnsan-si15588Korea School of Architecture and Architectural Engineering Hanyang UniversityERICAAnsan-si15588Korea Division of Architecture and Civil Engineering Kangwon National UniversitySamcheok-si25913Korea Graduate School of Information Yonsei UniversitySeoul-si03722Korea.

Compressive strength of concrete is a significant factor to assess building structure health and ***,various methods have been developed to evaluate the compressive strength of concrete ***,previous methods have several challenges in costly,time-consuming,and *** address these drawbacks,this paper proposed a digital vision based concrete compressive strength evaluating model using deep convolutional neural network(DCNN).The proposed model presented an alternative approach to evaluating the concrete strength and contributed to improving efficiency and *** model was developed with 4,000 digital images and 61,996 images extracted from video recordings collected from concrete *** experimental results indicated a root mean square error(RMSE)value of 3.56(MPa),demonstrating a strong feasibility that the proposed model can be utilized to predict the concrete strength with digital images of their surfaces and advantages to overcome the previous *** experiment contributed to provide the basis that could be extended to future research with image analysis technique and artificial neural network in the diagnosis of concrete building structures.

关键词： Concrete compressive strength deep learning deep convolutional neural network image-based evaluation building maintenance and management

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Derivation of Regression Coefficients for Sea Surface Temperature Retrieval over East Asia

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Advances in Atmospheric Sciences 2006年第3期23卷 474-486页

作者： Myoung-Hwan ahn Eun-ha SOHN Byong-Jun HWANG Chu-Yong CHUNG Xiangqian WU Remote Sensing Research Laboratory/Meteorological Research Institute Seoul Korea Office of Research and Applications National Environmental Satellite Data and Information Service National Oceanic and Atmospheric Administration

Among the regression-based algorithms for deriving SST from satellite measurements, regionally optimized algorithms normally perform better than the corresponding global algorithm. In this paper, three algorithms are considered for SST retrieval over the East Asia region （15°-55°N, 105°-170°E）, including the multi-channel algorithm （MCSST）, the quadratic algorithm （QSST）, and the Pathfinder algorithm （PFSST）. All algorithms are derived and validated using collocated buoy and Geostationary Meteorological Satellite （GMS-5） observations from 1997 to 2001. An important part of the derivation and validation of the algorithms is the quality control procedure for the buoy SST data and an improved cloud screening method for the satellite brightness temperature measurements. The regionally optimized MCSST algorithm shows an overall improvement over the global algorithm, removing the bias of about -0.13℃ and reducing the root-mean-square difference （rmsd） from 1.36℃ to 1.26℃. The QSST is only slightly better than the MCSST. For both algorithms, a seasonal dependence of the remaining error statistics is still evident. The Pathfinder approach for deriving a season-specific set of coefficients, one for August to October and one for the rest of the year, provides the smallest rmsd overall that is also stable over time.

关键词： Regional SST algorithm GMS-5 Data quality control cloud detection

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Arduino-based low-cost electrical load tracking system with a long-range mesh network

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Advances in Manufacturing 2021年第1期9卷 47-63页

作者： Xin-Lin Wang Bora ha Frank Andrew Manongi Woo-Kyun Jung Yusufu Abeid Chande Jande Sung-Hoon ahn Department of Mechanical and Aerospace Engineering Seoul National UniversitySeoulSouth Korea School of Materials Energy Water and Environment and Environmental Sciences Nelson Mandela African Institution of Science and TechnologyArushaTanzania Water Infrastructure and Sustainable Energy Futures Centre Nelson Mandela African Institution of Science and TechnologyArushaTanzania Institute of Advanced Machinery and Design Seoul National UniversitySeoulSouth Korea

A system that combines the advantage of the long-range(LoRa)communication method and the structural characteristics of a mesh network for an LoRa mesh network-based wireless electrical load tracking system is *** system demonstrates considerable potential in reducing data loss due to environmental factors in farfield wireless energy *** proposed system can automatically control the function of each node by confirming the data source and eventually adjust the system structure according to real-time monitoring data without manual *** further improve the sustainability of the system in outdoor environments,a standby equipment is designed to automatically ensure the normal operation of the system when the hardware of the base station *** system is based on the Arduino board,which lowers the production cost and provides a simple manufacturing *** conducting a long-term monitoring of a near-field smart manufacturing process in South Korea and the far-field energy consumption of rural households in Tanzania,we have proven that the system can be implemented in most regions,neither confined to a specific geographic location nor limited by the development of local *** system comprises a smart framework that improves the quality of energy ***,the proposed big-data-technology-based power supply policy offers a new approach for prolonging the power supply time of off-grid power plants,thereby providing a guideline for more rural areas with limited power sources to utilize uninterrupted electricity.

关键词： Mesh network Wireless electrical load tracking system Sustainability Off-grid power plant

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Review of simulation model for education of point-of-care ultrasound using easy-to-make tools

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World Journal of Clinical Cases 2020年第19期8卷 4286-4302页

作者： Kyu Chul Shi Young Rock ha Seong-Joon Lee Jung Hwan ahn Department of Emergency Medicine Ajou University School of MedicineSuwon 16499Gyeonggi-doSouth Korea Department of Emergency Medicine Bundang Jesaeng HospitalSeongnam-si 13590South Korea Department of Neurology Ajou University School of MedicineSuwon 16499Gyeonggi-doSouth Korea

Point-of-care ultrasound(POCUS)is a powerful diagnostic tool and provides treatment guidelines in acute critical ***,the limitation of using POCUS is operator *** and validated training for acquiring and using skills in practice must be conducted before using POCUS in clinical settings in order to keep patients *** education models have been introduced as a way to solve and overcome these ***,the commercial simulator with sufficiently secured fidelity is expensive and not always *** review focused on the inexpensive and easily made simulators for education on POCUS in critical specific situations related to the airway,breathing,circulation,and *** introduced the simulators that used non-infectious materials,with easily transportable features,and that had a sonographic appearance reproducibility similar to human *** also introduced the recipe of each simulator in two parts:Materials surrounding disease simulators(surrounding materials)and specific disease simulators themselves(target simulators).This review article covered the following:endotracheal or oesophageal intubation,lung(A-lines,B-lines,lung sliding,and pleural effusions such as hemothorax),central vein access,pericardial fluid(cardiac tamponade),the structure related to the eyes,soft tissue abscess,nerve(regional nerve block),and skull fracture simulators.

关键词： Critical care Education Emergency medicine Simulation training Point-of care Ultrasonography

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