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M1-polarized macrophage-derived cellular nanovesicle-coated lipid nanoparticles for enhanced cancer treatment through hybridization of gene therapy and cancer immunotherapy

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Acta Pharmaceutica Sinica B 2024年第7期14卷 3169-3183页

作者： ha eun shin Jun-Hyeok han Seungyong shin Ga-Hyun Bae Boram Son Tae-Hyung Kim Hee Ho Park Chun Gwon Park Wooram Park Department of Integrative Biotechnology Sungkyunkwan University(SKKU)SuwonGyeonggi 16419Republic of Korea Deparment of Inteligent Precision Healthcare Convergence SKKUSuwonGyeonggi 16419Republic of Korea Department of MetaBioHealth SKKU Institute for ConvergenceSKKUSuwonGyeonggi 16419Republic of Korea Department of Bioengineering Hanyang UniversitySeoul 04763Republic of Korea Department of Integrative Engineering Chung-Ang UniversitySeoul 06974Republic of Korea Department of Biomedical Engineering SKKUSuwonGyeonggi 16419Republic of Korea Korea Institute of Science and Technology(KIST) Seoul 02792Republic of Korea

Optimum genetic delivery for modulating target genes to diseased tissue is a major obstacle for profitable gene *** nanoparticles(LNPs),considered a prospective vehicle for nucleic acid delivery,have demonstrated efficacy in human use during the COVID-19 *** study introduces a novel biomaterial-based platform,M1-polarized macrophage-derived cellular nanovesicle-coated LNPs(M1-C-LNPs),specifically engineered for a combined gene-immunotherapy approach against solid *** dual-function system of M1-C-LNPs encapsulates Bcl2-targeting siRNA within LNPs and immune-modulating cytokines within M1 macrophage-derived cellular nanovesicles(M1-NVs),effectively facilitating apoptosis in cancer cells without impacting T and NK cells,which activate the intratumoral immune response to promote granule-mediating killing for solid tumor *** retention within tumor was observed upon intratumoral administration of M1-C-LNPs,owing to the presence of adhesion molecules on M1-NVs,thereby contributing to superior tumor growth *** findings represent a promising strategy for the development of targeted and effective nanoparticle-based cancer genetic-immunotherapy,with significant implications for advancing biomaterial use in cancer therapeutics.

关键词： Genetic-immunotherapy M1 macrophage-derived cellular nanovesicles Lipid nanoparticles(LNPs) Gene therapy siRNA Cancer immunotherapy Solid tumor Tumor microenvironment(TME)

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Sphingosylphosphorylcholine stimulates human monocyte-derived dendritic cell chemotaxis

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Acta Pharmacologica Sinica 2006年第10期27卷 1359-1366页

作者： ha-young LEE~(2,3,4) eun-ha shin~(2,4) Yoe-sik BAE~(2,3,5) ~2Medical Research Center for Cancer Molecular Therapy,College of Medicine,Dong-A University,Busan 602-714,Korea,~3Department of Biochemistry,College of Medicine,Dong-A University,Busan 602-714,Korea Medical Research Center for Cancer Molecular Therapy College of Medicine Dong-A University Busan 602-714 Korea

Aim:To investigate the effects of sphingosylphosphorylcholine(SPC)on humanmonocyte-derived dendritic cell(DC)***:Human DC were gen-erated from peripheral blood monocytes by culturing them with granulocyte mac-rophage-colony stimulating factor and *** effect of SPC on the DCchemotactic migration was measured by chemotaxis *** signalingevent involved in the SPC-induced DC chemotaxis was investigated with severalinhibitors for specific *** expression of the SPC receptors was examinedby reverse transcription polymerase chain ***:We found that SPCinduced chemotactic migration in immature DC(iDC)and mature DC(mDC).Interms of SPC-induced signaling events,mitogen activated protein kinase activa-tion and Akt activation in iDC and mDC were ***-induced chemotaxiswas mediated by extracellular signal-regulated protein kinase and phosphoino-sitide-3-kinase,but not by calcium in both iDC and *** mDC expressovarian cancer G protein-coupled receptor 1,but not G protein-coupled receptor 4,iDC do not express any of these *** examine the involvement of sphin-gosine-1-phosphate(S1P)receptors,we checked the effect of an S1P receptorantagonist(VPC23019)on SPC-induced DC ***23019 did not affectSPC-induced DC ***:The results suggest that SPC may playa role in regulating DC trafficking during phagocytosis and the T cell-stimulatingphase,and the unique SPC receptor,which is different from SIP receptors,isinvolved in SPC-induced chemotaxis.

关键词： dendritic cells sphingosylphosphorylcho line chemotaxis pertussis toxin-sensitive G protein extracellular signal regulated protein kinase

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Inhibitory potential of three Yin-tonification herbal formulas on the activities of human major cytochrome P450 and UDP-glucuronosyltransferases isozymes in vitro

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Journal of Traditional Chinese Medicine 2018年第4期38卷 511-522页

作者： Seong eun Jin Hyeun-Kyoo shin Hyekyung ha K-herb Research Center Korea Institute of Oriental Medicine Daejeon 34054 Republic of Korea

OBJECTIVE:To investigate the influence of Yin-tonification herbal formulas Jaeumganghwa-tang(Ziyin Jianghuo Tang,JEGHT),Ssanghwa-tang(Shuanghe Tang,SHT) and Yukmijihwang-tang(Liuwei Di huang Tang,YMJHT) on the activities of human major cytochrome P450(CYP450 s) and UDP-glucuronosyltransferases isozymes(UGTs) in ***:The activities of CYP450 s(CYP1 A2,CYP3 A4,CYP2 B6,CYP2 C9,CYP2 C19,CYP2 D6 and CYP2 E1) and UGTs(UGT1 A1,UGT1 A4 and UGT2 B7)were assessed using in vitro fluorescence-and luminescence-based enzyme assays,*** effects of herbal formulas on the activities of CYP450 s and UGTs were presented as IC50 ***:JEGHT showed the potent inhibition of the CYP2 D6 activity,with weak inhibition on the activities of CYP1 A2,CYP2 B6,CYP2 C9,CYP2 C19,CYP2 E1,CYP3 A4,UGT1 A1,UGT1 A4 and UGT2 *** inhibited the activities of CYP1 A2 and CYP2 E1,whereas the negligible inhibition of the activities of CYP2 B6,CYP2 C9,CYP2 C19,CYP2 D6,CYP3 A4,UGT1 A1,UGT1 A4 and UGT2 B7 through SHT was *** inhibited CYP2 E1 activity,with a negligible inhibition on the activities of CYP1 A2,CYP2 B6,CYP2 C9,CYP2 C19,CYP2 D6,CYP3 A4,UGT1 A1,UGT1 A4 and UGT2 ***:These findings provide information about the potential interactions between three Yin-tonification herbal formulas and conventional drugs.

关键词： Yin reinforcing agents CytochromeP-450 enzyme system Uridine diphosphate gluc-uronic acid Transferases Herb-drug interactions

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Effects of Traditional Herbal Formulae on Human CYP450 Isozymes

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Chinese Journal of Integrative Medicine 2017年第1期23卷 62-69页

作者： Seong eun Jin Hyekyung ha Hyeun-Kyoo shin K-Herb Research Center Korea Institute of Oriental MedicineDaejeon 34054Republic of Korea

Objective：To assess the effects of traditional herbal formulae Sijunzi Decoction（四君子汤,Sagunja-tang,SJZD）,Siwu Decoction（四物汤,Samul-tang,SWD）,Bawu Decoction（八物汤,Palmul-tang,BWD）and Shiquan Dabu Decoction（十全大补汤,Sipjeondaebo-tang,SDD）on the activities of human cytochrome P450（CYP450）,a drug-metabolizing ***：Herbal formula water extracts were filtered and lyophilized after the powder extracts were dissolved in distilled *** activities of major human CYP450isozymes（CYP3A4,CYP2C19,CYP2D6 and CYP2E1）were measured using in vitro fluorescence-based enzyme *** inhibitory effects of the herbal formulas on the activities of CYP450 were characterized as half maximal inhibition concentration（IC50）***：All the tested herbal formulae inhibited CYP2C19activity（IC50：SJZD,83.28μg/m L;SWD,235.54μg/m L;BWD,166.82μg/m L;SDD,178.19μg/m L）;SJZD（IC50=196.46μg/m L）,SWD（IC50=333.42μg/m L）and SDD（IC50=163.42μg/m L）inhibited CYP2E1-mediated metabolism;whereas BWD exhibited comparatively weak inhibition of CYP2E1（IC50=501.78μg/m L）.None of the four herbal formulas significantly affected CYP3A4 or ***：These results suggest that SJZD,SWD,BWD and SDD could potentially inhibit the metabolism of co-administered synthetic drugs whose primary route of elimination is via *** addition,clinically relevant pharmacokinetic interactions could occur when SJZD,SWD or SDD is co-administered with drugs metabolized by *** findings provide information for the safety and effective clinical use of these four classic herbal formulas.

关键词： cytochrome P450 Sijunzi Decoction Siwu decoction Bawu Decoction Shiquan Dabu Decoction,herb-drug interactions

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Tensor based non-photo realistic rendering for Korean architectural images

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Journal of Central South University 2014年第10期21卷 3805-3810页

作者： Do Kyung shin eun Young Ahn Deprtment of Computer Science and Engineering Hanyang University Deprtment of Communication Infromation & Computer Engineering Hanbat National University

Existing pen and ink sketch technologies can be applied to general images, but they could not produce optimal output for images of traditional architecture, because most images consist of exquisite straight lined patterns in traditional architecture, such as root tiles and window bars. The lines of roofs and eaves need to be described delicately to express pen and ink sketch most effectively. Therefore, by proposing a method to create white noise for light and shade of input images, to extract input vector directions from the white noise, and to determine the direction and length of stroke, a new expression technique is proposed for pen and ink sketch that could best reflect the characteristics of traditional architecture.

关键词： non-photo realistic rendering pen and ink sketch tensor

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Implementation of Turbulent Mixing over a Stratocumulus-Topped Boundary Layer and Its Impact in a GCM

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Advances in Atmospheric Sciences 2009年第5期26卷 995-1004页

作者： Sun-Hee shin Kyung-Ja ha Division of Earth Environmental System Pusan National University

The effect of a vertical diffusion scheme over a stratocumulus topped boundary layer （STBL） was investigated using the YONU AGCM （Yonsei University Atmospheric General Circulation Model）. To consider the impact of clouds on the turbulence production, the turbulence mixing term, driven by radiative cooling at the cloud top, is implemented as an extended non-local diffusion scheme. In the model with this new scheme, the STBL parameterization significantly influences the lower atmosphere over the tropical and subtropical regions. Consideration of the turbulent mixing within the cloud layer leads to continuous stratocumulus formation. The cloud-top radiative cooling tends to favor more rapid entrainment and produces top-down turbulent mixing. This cooling develops a mixed layer without initiation of deep convection by surface fluxes. Variations in thermodynamical and dynamical features are produced by planetary boundary layer （PBL） cloud development. The simulated stratocumulus induces more mixing of heat and moisture due to the cloud forcing. Over STBL regions, the lower boundary layer becomes warmer and drier. It also weakens vertical motion and zonal trade winds in the eastern Pacific, which indicates that stratocumulus cloud cover plays a role in weakening the Walker circulation; that is, cloud cover damps the tropical circulation.

关键词： stratocumulus topped boundary layer non-local diffusion scheme tropical circulation general circulation model

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Association of fluoride exposure with disease burden and neurodevelopment outcomes in children in South Korea

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World Journal of Pediatrics 2024年第10期20卷 1029-1042页

作者： Won Seok Lee Ju Hee Kim Boeun han Gi Chun Lee Hye Ri Jung Ye Jin shin eun Kyo ha eun Lee Soonchul Lee Man Yong han Department of Pediatrics CHA Ilsan Medical CenterCHA University School of MedicineGoyangRepublic of Korea Department of Pediatrics Kyung Hee University HospitalKyung Hee University College of MedicineSeoulRepublic of Korea Department of Pediatrics CHA Bundang Medical CenterCHA University School of Medicine59 Yatap-RoBundang-GuSeongnam-siGyeonggi-do13496Republic of Korea Multi-Omics Research Center CHA Future Medicine Research InstituteSeongnamRepublic of Korea Department of Computer Science and Engineering Konkuk UniversitySeoulRepublic of Korea School of Medicine CHA UniversityPocheonRepublic of Korea Department of Pediatrics Hallym University Kangnam Sacred Heart HospitalHallym University College of MedicineSeoulRepublic of Korea Department of Pediatrics Chonnam National University HospitalChonnam National University Medical SchoolGwangjuRepublic of Korea Department of Orthopaedic Surgery CHA Bundang Medical CenterCHA University School of Medicine59 Yatap-RoBundang-GuSeongnam-siGyeonggi-do13496Republic of Korea

Background Community water fluoridation is an effective public health strategy for preventing dental caries,*** exist about potential health *** study explores associations between tap water fluoride levels and pediatric disease burden,as well as neurodevelopmental outcomes at 6 years of *** This nationwide population-based cohort study included children born in Korean cities with and without tap water fluoridation projects,between 2006 and 2012,aiming for a fluoride concentration of 0.8±0.2 mg/L in treated tap *** from the National Health Insurance Service were used,spanning from birth to *** relationship between exposure to fluoridated tap water and incidence of 16 childhood diseases that were previously identified as potentially linked to fluoride exposure were ***,we evaluated the neurodevelopmental outcomes across various domains,including gross motor,fine motor,cognition,language,social skills,and self-help *** assessments were performed using data from a comprehensive national health screening program for children aged six *** A fluoride-unexposed group included 22,881 children,whereas a fluoride-exposed group comprised 29,991 children(52%males).Children in the fluoride-exposed group had a decreased risk of dental caries and bone fractures[hazard ratio(95%confidence interval,CI),0.76(0.63–0.93)and 0.89(0.82–0.93),respectively]and increased risk of hepatic failures[1.85,(1.14–2.98)]compared to those in the unexposed ***,the risk ratio of abnormal neurodevelopmental screening outcomes increased by 9%,but this was statistically uncertain(95%CI,0.95–1.26).Conclusions Fluoridated tap water was associated with an increased risk of hepatic failure but a decreased risk of bone fractures in *** association between fluoridated tap water and neurodevelopmental screening outcomes at 6 years remains unclear,highlighting the need for further studies to clarify this associ

关键词： Children-Fluoride.Hepatic failure.Neurodevelopment

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Defect engineering of water-dispersible g-C_(3)N_(4) photocatalysts by chemical oxidative etching of bulk g-C_(3)N_(4) prepared in different calcination atmospheres

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Journal of Materials Science & Technology 2022年第8期103卷 232-243页

作者： Thi Kim Anh Nguyen Thanh-Truc Pham Bolormaa Gendensuren eun-Suok Oh eun Woo shin School of Chemical Engineering University of UlsanDaehakro 93Ulsan 44610South Korea Department of Material Technology Faculty of Applied ScienceHo Chi Minh City University of Technology and Education(HCMUTE)No.1 Vo Van Ngan StreetLinh Chieu WardThu Duc DistrictHo Chi Minh City 700000Viet Nam

In this study,water-dispersible graphitic carbon nitride(g-C_(3)N_(4))photocatalysts were successively prepared through the chemically oxidative etching of bulk g-C_(3)N_(4) that was polymerized thermally in different calcination atmospheres such as air,CO_(2),and N_(2).The different calcination atmospheres directly influenced the physicochemical and optical properties of both bulk and water-dispersible g-C_(3)N_(4),changing the photocatalytic degradation behavior of methylene blue(MB)and tetracycline hydrochloride(TCHCl)for water-dispersible g-C_(3)N_(4).The bubble-burst process in the thermal polymerization of thiourea produced defective edges containing C=O groups that preferred substituting the C-NHx groups over bulk g-C_(3)N_(4).In the oxygen-free N_(2) atmosphere among the different calcination atmospheres,more C=O functional groups were generated on the defective edges of bulk g-C_(3)N_(4),resulting in the highest N vacancy of the tri-s-triazine *** the successive chemical oxidation,S-or O-containing functional groups were introduced onto water-dispersible g-C_(3)N_(4).The water-dispersible g-C_(3)N_(4) photocatalyst from the oxygen-free N_(2) atmosphere(NTw)contained the most O-and S-functional groups on the g-C_(3)N_(4) ***,NTw exhibited the highest photocatalytic activity in the MB and TC-HCl photodegradation because of its slowest recombination process,which was ascribed to the unique surface properties of NTw such as abundant functional groups on the defective edges and N-deficient property.

关键词： g-C_(3)N_(4) Water-dispersible photocatalyst Calcination atmosphere Charge separation Chemically oxidative etching Defect edges

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Nitric-oxide enriched plasma-activated water inactivates 229E coronavirus and alters antiviral response genes in human lung host cells

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Bioactive Materials 2023年第1期19卷 569-580页

作者： Nagendra Kumar Kaushik Pradeep Bhartiya Neha Kaushik Yungoh shin Linh Nhat Nguyen Jang Sick Park Doyoung Kim eun ha Choi Department of Electrical and Biological Physics Plasma Bioscience Research CenterKwangwoon UniversitySeoul01897Republic of Korea Department of Biotechnology College of EngineeringThe University of SuwonHwaseong-si18323Republic of Korea

The ongoing pandemic caused by the novel coronavirus,SARS-CoV-2,is influencing global ***,there is a major threat of future coronaviruses affecting the entire world in a similar,or even more dreadful,***,effective and biocompatible therapeutic options against coronaviruses are urgently *** address this challenge,medical specialists require a well-informed and safe approach to treating human coronaviruses(HCoVs).Herein,an environmental friendly approach for viral inactivation,based on plasma technology,was considered.A microwave plasma system was employed for the generation of the high amount of gaseous nitric oxide to prepare nitric oxide enriched plasma-activated water(NO-PAW),the effects of which on coronaviruses,have not been reported to *** determine these effects,alpha-HCoV-229E was used in an experimental *** found that NO-PAW treatment effectively inhibited coronavirus infection in host lung cells,visualized by evaluating the cytopathic effect and expression level of spike ***,NO-PAW showed minimal toxicity towards lung host cells,suggesting its potential for therapeutic ***,this new approach resulted in viral inactivation and greatly improved the gene levels involved in host antiviral ***,our findings provide evidence of an initiation point for further progress toward the clinical development of antiviral treatments,including such coronaviruses.

关键词： Nitric oxide enriched plasma-activated water Microwave plasma Coronavirus Virus inactivation Gene expression

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Easy calibration method of vision system for in-situ measurement of strain of thin films

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中国有色金属学会会刊：英文版 2009年第B09期19卷 243-249页

作者： Jun-Hyub PARK Dong-Joong KANG Myung-Soo shin Sung-Jo LIM Son-Cheol YU Kwang-Soo LEE Jong-eun ha Sung-Hoon CHOA Department of Mechatronics Engineering Tongmyong University School of Mechanical Engineering Pusan National University Department of Automotive Engineering Hoseo University Department of Automotive Engineering Seoul National University of Technology Department of Nano/IT Engineering Seoul N ational University of Technology

An easy calibration method was presented for in-situ measurement of displacement in the order of nanometer during micro-tensile test for thin films by using CCD camera as a sensing device. The calibration of the sensing camera in the system is a central element part to measure displacement in the order of nanometer using images taken with the camera. This was accomplished by modeling the optical projection through the camera lens and relative locations between the object and camera in 3D space. A set of known 3D points on a plane where the film is located on is projected to an image plane as input data. These points, known as a calibration points, are then used to estimate the projection parameters of the camera. In the measurement system of the micro-scale by CCD camera, the calibration data acquisition and one-to-one matching steps between the image and 3D planes need precise data extraction procedures and repetitive user's operation to calibrate the measuring devices. The lack of the robust image feature extraction and easy matching prevent the practical use of these methods. A data selection method was proposed to overcome these limitations and offer an easy and convenient calibration of a vision system that has the CCD camera and the 3D reference plane with calibration marks of circular type on the surface of the plane. The method minimizes the user's intervention such as the fine tuning of illumination system and provides an efficient calibration method of the vision system for in-situ axial displacement measurement of the micro-tensile materials.

关键词：标定方法视觉系统原位测试应变薄膜松

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