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Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer

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World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： Ruo-Yu Guan Jia-Wei Wu Zi-Yun Yuan Zhi-Yuan Liu Zi-Zhu Liu Zhi-Cong Xiao jing-hui Li Cheng-Zhi Huang Jun-Jiang Wang Xue-Qing Yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina Department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type II diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage III CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage III *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage III CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,P<0.001;OS:HR=2.105,P=0.019;CRR:HR=2.214,P=0.005]and glycosylated hemoglobin levels(DFS:HR=2.344,P=0.006;OS:HR=2.119,P=0.021;CRR:HR=2.449,P=0.009)indicated significantly poor prognosis and high CRR,while T2DM history did not(DFS:HR=1.178,P=0.327;OS:HR=0.933,P=0.739;CRR:HR=0.997,P=0.581).CONCLUSION Increased preoperative fasting plasma glucose and glycosylated hemoglobin levels,but not T2DM history,were identified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage III CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis Type II diabetes mellitus

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Stochastic Resonance for a SQUID with Dichotomous Resistance

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Chinese Physics Letters 2014年第3期31卷 30-33页

作者： LI jing-hui Faculty of Science Ningbo University Ningbo 315211

We investigate the response to the ac current for a superconducting quantum interference device （SQUID） with a dichotomous resistance. It is shown that, for some suitably selected parameters＇ values, stochastic resonance appears for the amplitude of the stationary average voltage of the SQUID versus the correlation time of the dichotomous noise. Our result can provide some useful insights for the investigation of the response of the SQUID （especially for the ones with the nano junctions） to the temporal-periodic signal （including the input ac current, the irradiation microwave, the detected temporal-periodic signal, and the added ac voltage）.

关键词： SUPERCONDUCTING quantum interference devices RESEARCH STOCHASTIC resonance SIGNAL-to-noise ratio -- Research LINEAR systems PHYSICS research

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Nonlinear Effects in Quantum Dynamics of Atom Laser: Mean-Field Approach

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Communications in Theoretical Physics 2002年第8期38卷 163-167页

作者： jing hui Laboratory for Quantum Optics Shanghai Institute of Optics and Fine Machines the Chinese Academy of SciencesBox 800-211 Shanghai 201800 China

Quantum dynamics and statistics of an atom laser with nonlinear binary interactions are investigated inthe framework of mean-field approximation. The linearized effective Hamiltonian of the system is accurately *** is shown that, although the input radio frequency field is in an ordinary Glauber coherent state, the output matterwave will periodically exhibit quadrature squeezing effects purely originated from the nonlinear atom-atom collisions.

关键词： quantum dynamics, atom laser, mean-field approximation

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Strong Minkowski Separation and Co-Drop Property

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Acta Mathematica Sinica,English Series 2007年第12期23卷 2295-2302页

作者： jing hui QIU Department of Mathematics Suzhou University Suzhou 215006 P. R. China

In the framework of topological vector spaces, we give a characterization of strong Minkowski separation, introduced by Cheng, et al., in terms of convex body separation. From this, several results on strong Minkowski separation are deduced. Using the results, we prove a drop theorem involving weakly countably compact sets in locally convex spaces. Moreover, we introduce the notion of the co-drop property and show that every weakly countably compact set has the co-drop property. If the underlying locally convex space is quasi-complete, then a bounded weakly closed set has the co-drop property if and only if it is weakly countably compact.

关键词： drop property co-drop property locally convex space strong Minkowski separation weakly countably compact set

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On Ha's Version of Set-valued Ekeland's Variational Principle

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Acta Mathematica Sinica,English Series 2012年第4期28卷 717-726页

作者： jing hui QIU School of Mathematic Science Soochow University

By using the concept of cone extensions and Dancs-Hegedus-Medvegyev theorem, Ha [Some variants of the Ekeland variational principle for a set-valued map. J. Optim. Theory Appl., 124, 187-206 （2005）] established a new version of Ekeland＇s variational principle for set-valued maps, which is expressed by the existence of strict approximate minimizer for a set-valued optimization problem. In this paper, we give an improvement of Ha＇s version of set-valued Ekeland＇s variational principle. Our proof is direct and it need not use Dancs-Hegedus-Medvegyev theorem. From the improved Ha＇s version, we deduce a Caristi-Kirk＇s fixed point theorem and a Takahashi＇s nonconvex minimization theorem for set-valued maps. Moreover, we prove that the above three theorems are equivalent to each other.

关键词： Ekeland's variational principle set-valued map locally convex space Caristi-Kirk's fixedpoint theorem Takahashi's nonconvex minimization theorem

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Generalized Gerstewitz's Functions and Vector Variational Principle for-Efficient Solutions in the Sense of Németh

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Acta Mathematica Sinica,English Series 2019年第3期35卷 297-320页

作者： jing hui QIU School of Mathematical Sciences Soochow University

In this paper, we first generalize Gerstewitz's functions from a single positive vector to a subset of the positive cone. Then, we establish a partial order principle, which is indeed a variant of the pre-order principle [Qiu, J. H.: A pre-order principle and set-valued Ekeland variational principle.J. Math. Anal. Appl., 419, 904–937(2014)]. By using the generalized Gerstewitz's functions and the partial order principle, we obtain a vector EVP for-efficient solutions in the sense of N′emeth, which essentially improves the earlier results by completely removing a usual assumption for boundedness of the objective function. From this, we also deduce several special vector EVPs, which improve and generalize the related known results.

关键词： Ekeland variational principle partial order principle -efficient solutions in the sense of N'emeth Gerstewitz's function convex cone

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A Revised Pre-Order Principle and Set-Valued Ekeland Variational Principles with Generalized Distances

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Acta Mathematica Sinica,English Series 2017年第6期33卷 775-792页

作者： jing hui QIU School of Mathematical Sciences Soochow University Suzhou 215006 P. R. China

In my former paper ＂A pre-order principle and set-valued Ekeland variational principle＂（see [J. Math. Anal. Applo, 419, 904 937 （2014）]）, we established a general pre-order principle. From the pre-order principle, we deduced most of the known set-valued Ekeland variational principles （denoted by EVPs） in set containing forms and their improvements. But the pre-order principle could not imply Khanh and Quy＇s EVP in [On generalized Ekeland＇s variational principle and equivalent formulations for set-valued mappings, J. Glob. Optim., 49, 381-396 （2011）], where the perturbation contains a weak T-function, a certain type of generalized distances. In this paper, we give a revised version of the pre-order principle. This revised version not only implies the original pre-order principle, but also can be applied to obtain the above Khanh and Quy＇s EVP. In particular, we give several new set-valued EVPs, where the perturbations contain convex subsets of the ordering cone and various types of generalized distances.

关键词： Pre-order principle Ekeland variational principle set-valued map perturbation locallyconvex space vector optimization

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Henig Proper Efficient Points and Generalized Henig Proper Efficient Points

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Acta Mathematica Sinica,English Series 2009年第3期25卷 445-454页

作者： jing hui QIU Department of Mathematics Suzhou University Suzhou 215006 P. R. China

Applying the theory of locally convex spaces to vector optimization, we investigate the relationship between Henig proper efficient points and generalized Henig proper efficient points. In particular, we obtain a sufficient and necessary condition for generalized Henig proper efficient points to be Henig proper efficient points. From this, we derive several convenient criteria for judging Henig proper efficient points.

关键词： locally convex space base of a cone Henig proper efficient point generalized Henig properefficient point

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Two Stochastic Resonances Induced by Two Different Multiplicative Telegraphic Noises for an Electric System

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Communications in Theoretical Physics 2008年第11期50卷 1159-1164页

作者： LI jing-hui Faculty of Science P.O. Box 58 Ningbo University Ningbo 315211 China

In this paper,an electric system with two dichotomous resistors is *** is shown that thissystem can display two stochastic resonances,which are the amplitude of the periodic response as the functions of thetwo dichotomous resistors strengthes *** the limits of Gaussian white noise and shot white noise(i.e.,thetwo noises are both Gaussian white noise or shot white noise),no phenomena of resonance *** further study,we find that when the system is with three or more multiplicative telegraphic noises,there are three or more stochasticresonances.

关键词： stochastic resonance noise

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Stochastic Resonance of Single (Independent of Each Other) Protein Motor System with Fluctuating Potential Barrier

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Communications in Theoretical Physics 2008年第4期49卷 945-950页

作者： LI jing-hui P.O. Box 58 Faculty of Science Ningbo University Ningbo 315211 China

A single （independent of each other） protein motor system with fluctuating potential barrier and subject to sine electric field is investigated. We first derive the approximate Langevin equation of this system with fluctuating potential barrier. Then from this approximate Langevin equation, we calculate the signal-to-noise ratio （SNR） in the adiabatic limit. The phenomenon of stochastic resonance is found for this protein motor system with fluctuating potential barrier.

关键词： stochastic resonance protein motor fluctuating potential barrier

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