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New guaiane-type sesquiterpenoid dimers from Artemisia atrovirens and their antihepatoma activity

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Acta Pharmaceutica Sinica B 2021年第6期11卷 1648-1666页

作者： Lihua Su Xintian Zhang Yunbao Ma Changan Geng xiaoyan huang Jing Hu Tianze Li Shuang Tang Cheng Shen Zhen Gao Xuemei Zhang Ji-Jun Chen State Key Laboratory of Phytochemistry and Plant Resources in West China Kunming Institute of BotanyChinese Academy of SciencesYunnan Key Laboratory of Natural Medicinal ChemistryKunming 650201China University of Chinese Academy of Sciences Beijing 100049China

Leading by cytotoxicity against HepG2 cells,bioactivity-guided fractionation of the EtOAc fraction from Artemisia atrovirens led to the isolation of 18 new guaianolide dimers,artematrolides A-R and lavandiolides A,B,C,H,and *** compounds(1,4,10,12,13,and 19-21) were unambiguously confirmed by the single-crystal X-ray diffraction analyses,and the others were elucidated based on IR,UV,HRESIMS,1 D and 2 D NMR experiments,and comparison of the experimental and calculated ECD ***,all of them were [4+2] Diels-Alder adducts of two monomeric *** isolates were evaluated for their cytotoxicity against three human hepatoma cell lines,and 19 compounds demonstrated cytotoxicity against HepG2,SMMC-7721,and Huh7 cell ***,compounds 1,12,14,and 15 exhibited cytotoxicity with IC50 values of 4.4,3.8,7.6,and 6.7 μmol/L(HepG2),9.6,4.6,6.6,and 6.0 μmol/L(SMMC-7721),and 7.6,4.5,6.9,and 5.6 μmol/L(Huh7),***,compound 12 showed the most promising activity against three human hepatoma cell lines and dose-dependently inhibited cell migration and invasion,induced G2/M cell cycle arrest and cell apoptosis in HepG2 cells,down-regulated the expression of BCL-2 and PARP-1,and activated PARP-1 to up-regulate the expression of cleaved-PARP-1.

关键词： Guaianolide dimers Artematrolides Ae R Artemisia atrovirens Cytotoxicity Cell cycle Apoptosis

免疫检查点抑制剂相关皮肤不良反应管理的证据总结

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护士进修杂志 2024年第3期39卷 289-294页

作者：郝素娟柴春燕黄晓燕杨雪芳谷斌丁欢杨丽红苏州市立医院江苏苏州215000 复旦大学护理学院复旦大学JBI循证护理中心上海200032

目的检索、评价并整合免疫检查点抑制剂(ICIs)相关皮肤不良反应(irAEs)管理的相关证据。方法系统检索循证决策支持系统BMJ Best Practice、JBI图书馆、Cochrane图书馆、英国国家卫生和临床优化研究所、苏格兰校际指南、Web of scienc... 详细信息

目的检索、评价并整合免疫检查点抑制剂(ICIs)相关皮肤不良反应(irAEs)管理的相关证据。方法系统检索循证决策支持系统BMJ Best Practice、JBI图书馆、Cochrane图书馆、英国国家卫生和临床优化研究所、苏格兰校际指南、Web of science、美国国立综合癌症网络等专业学会网站、PubMed、中国生物医学文献数据库、中国知网、万方中关于ICIs irAEs管理的指南、证据总结、专家共识、系统评价,检索时间限定为2013年1月1月-2022年10月31日。对检索的文献进行质量评价后,再对证据进行提取和整合。结果共纳入9篇文献,其中包括4篇指南、1篇证据总结、4篇专家共识。经过阅读、提取和归纳,共总结出14条证据,包括培训、健康教育、评估与监测和治疗4个方面。结论临床医护人员应应用最佳证据对ICIs irAEs进行规范管理,降低irAEs的发生。

关键词：肿瘤治疗方案免疫检查点抑制剂皮肤不良反应证据总结循证护理

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ICU胰岛素静脉输注患者血糖管理审查指标的制定及障碍因素分析

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中华现代护理杂志 2024年第28期30卷 3859-3865页

作者：俞萍卞红周之音何平周英凤孙芹朱晔黄晓燕无锡市第二人民医院护理部无锡214002 无锡市第二人民医院ICU 无锡214002 复旦大学循证护理中心上海200032

目的了解ICU胰岛素静脉输注患者血糖管理相关证据临床应用现状,分析障碍因素并制订行动策略,为循证证据向临床实践转化提供参考。方法以澳大利亚乔安娜布里格斯研究所(JBI)循证卫生保健中心的临床证据应用模式为理论框架,确定临床护理问... 详细信息

目的了解ICU胰岛素静脉输注患者血糖管理相关证据临床应用现状,分析障碍因素并制订行动策略,为循证证据向临床实践转化提供参考。方法以澳大利亚乔安娜布里格斯研究所(JBI)循证卫生保健中心的临床证据应用模式为理论框架,确定临床护理问题,进行文献检索、评价并汇总证据,制定审查指标及审查方法。采用便利抽样法,于2023年7—8月选取无锡市第二人民医院综合ICU的42名护士、80例胰岛素静脉输注患者为研究对象进行基线审查,根据基线审查结果进行障碍因素的分析和变革策略的制定。结果共引入16条ICU胰岛素静脉输注患者血糖管理证据,制订了19条审查指标,其中13条审查指标的依从率<60%,分析得出18个障碍因素、13个促进因素。根据障碍因素和促进因素制订了16条变革策略。结论ICU胰岛素静脉输注血糖管理证据与临床实践尚存在较大差距,应根据干预策略构建循证实践方案,有效促进证据在临床中的应用。

关键词：重症监护病房胰岛素静脉输注血糖管理审查指标障碍因素循证护理

Effect of Rural Social Pension Insurance on Total Retail Sales of Consumer Goods

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Management Studies 2022年第2期10卷 87-93页

作者： xiaoyan huang Zhiyi Ren Yilin Gao Hunan University ChangshaChina Smith College NorthamptonUSA University of Rochester New YorkUSA

Based on data of 31 provinces of China in 2019 collected from the National Bureau of Statistics,this paper explores the impact of the number of urban employees’endowment insurance on the total retail sales of social consumer goods in different provinces in *** the population,per capita disposable income,per capita life expectancy,and regional per capita GDP of each province as the variables,this paper establishes regression models to do the empirical *** results show that:(1)The increase of the number of urban employees’old-age insurance has a significant positive impact on residents’*** wider the coverage of old-age insurance,the more it can enhance the consumption confidence of the residents.(2)Due to the economic development,the level of urbanization has been greatly improved,leading to an increased birth rate and total population,and thus consumption has been ***,the increase of the total population has a significant positive effect on the increase of the total retail sales of social consumer goods.(3)The increase of per capita disposable income has insignificant impact on the increase of total retail sales of social consumer goods due to residents’debt,the rise of house prices,the rapid widening of income gap between different groups,and the difficulty of meeting the various needs of people.(4)Although the increase of life expectancy per capita will lead to the decrease of total retail sales of social consumer goods,this decrease is not significant.(5)Per capita GDP will lead to a small increase in the total retail sales of social ***,based on the above conclusions,some suggestions to stimulate consumption are given.

关键词： pension insurance total retail sales of consumer goods population amount life expectancy

Temperature-and Strain-Compensated Directional Curvature Sensor Based on Bragg Gratings in Three-Core Fiber with Bridged Waveguides

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中国激光 2024年第18期51卷 1-10页

作者： Wu Zhifang Wei Yefen Lin Jing Wang Hupo huang Ruimin Wang xiaoyan Pu Jixiong Fujian Key Laboratory of Light Propagation and Transformation College of Information Science and Engineering Huaqiao University

Fiber-based curvature sensors, especially those capable of discerning the direction of curvature, have attracted more and more interest due to their promising applications in structural health monitoring, high-precision measurement, medical and biological diagnosis-treat instruments, and so on. Here, we propose and demonstrate a compact directional curvature sensor that comprises two bridged waveguides and three Bragg gratings in a section of three-core fiber（TCF）. Both the waveguides and gratings are integrated by femtosecond laser micromachining method. The waveguides, connecting the TCF outer cores to the lead-in single-mode fiber core, function as beam couplers to realize simultaneous interrogation of all three gratings without any separate fan-in/out component. Owing to the spatial specificity, the outer-core gratings exhibit high and direction-dependent sensitivity to curvature, whereas the central-core grating is nearly insensitive to curvature but shows similar sensitivities to ambient temperature and axial strain as the outer-core gratings. It can be used to compensate the cross impact of temperature and strain when the outer-core gratings are applied for curvature detection. Moreover, the wavelength interval between two outer-core gratings is also proposed as an indicator for curvature sensing. It features with a much higher sensitivity to curvature and reduced sensitivities to temperature and axial strain. The corresponding maximum sensitivity to curvature is as high as 191.89 pm/m-1, while the sensitivities to temperature and strain are only 0.3 pm/℃ and 0.0218 pm/με, respectively. Therefore, our proposed device provides a compact and robust all-infiber solution for directional curvature sensing. It not only offers high sensitivity and accuracy but also immunity to temperature and axial strain fluctuations, making it a promising tool for a wide range of applications.

关键词： directional curvature sensing femtosecond laser micromachining fiber Bragg grating fiber optics waveguide integration

Enhancing single-molecule conductance of platinum (Ⅱ) complexes through synergistic aromaticity-assisted structural asymmetry

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Science China Chemistry 2020年第4期63卷 467-474页

作者： Ping Duan Junyang Liu Jin-Yun Wang Kai Qu Shuning Cai Fei Wang Lichuan Chen xiaoyan huang Ruihao Li Jia Shi Qian-Chong Zhang Wenjing Hong Zhong-Ning Chen State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China State Key Laboratory of Physical Chemistry of Solid Surfaces Collaborative Innovation Center of Chemistry for Energy Materials(iChEM)NELCollege of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China

Seeking the strategies of designing highly conductive molecular structures is one of the core researches in molecular *** asymmetric structure has manifested feasible properties in comprehensive fields, we introduce the structures of asymmetric platinum(Ⅱ) complexes into the charge transport study at single-molecule scale for the first time. The single-molecule conductance measurement results reveal that, in platinum(Ⅱ)-aryloligoynyl structures, the conductance of asymmetrically coordinated complexes is obviously higher than that of the symmetric isomers with the same molecular length, while the conductance is almost identical in symmetric and asymmetric platinum(Ⅱ)-oligoynyl complexes. Theoretical study uncovers that, upon connecting to the oligoynyl structure, the aromatic group effectively extends the π-system of the whole conductive backbone and gathers the HOMO population mainly on the longer oligoynyl ligand, which reduces the energy barrier in electron transport and enhances the conductance through HOMO energy lifting. This result provides feasible strategy for achieving high conductive molecular devices.

关键词： single-molecule conductance organometallic asymmetry conductance enhancement

Identification and Characteristics of a Novel E1 Like Gene nUBE1l in Human test

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Acta Biochimica et Biophysica Sinica 2004年第3期36卷 227-234页

作者： Hui ZHU,ZuoMin ZHOU,Ran HUO,xiaoyan huang,Li LU,Min LIN,LiRong WANG, YaDong ZHOU,JianMin Ll,and JiaHao SHA*LaboratoeProductivedicine, Naliingdical Universl,Na109angsu002China Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing Jiangsu 210029 China

A gene,Presumably involved in sPermatogenesis,was identified and characterized byusing cDNA *** intensity was 2.13 fold higher in adult testis than that in fetal *** full length of this gene was 4288 bP and it encoded a 578 amino acid *** structureand amino acid sequence analysis revealed that the Protein contained 1 Thif-domain,2 UBACT-domains,and a functional active site cysteine lay uPstream of UBACT domain,all ofthem also existed in ubiquitin-activating enzyme EI and El like Proteins.50 we named this gene as a novel ubiquitin一activatingenZyme EIlike gene(nUBEjL).ExPression Profile showed that nUBEIL was Predominantly exPressed in *** of the exPression ofnUBEIL in different develoPmental stages oftestis indicated that it washighly exPressed in adult *** conclusion,nUBEjL 15 a novel human El like gene highly exPressed inadult testis,which Plays key role in ubiquitin system,and accordingly influences sPermatogenesis and malefertility·

关键词： ubiquitinactivating enzyme EI ubiquitin sPermatogenesis

Impact of ozonation on disinfection byproducts formation from phenylalanine during chlorination

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Journal of Environmental Sciences 2024年第10期144卷 199-211页

作者： Sinong huang Hongwei Liu Kunming Wei Liang Zhang xiaoyan Ma Qingsong Li Xueyan Li Andrea M.Dietrich College of Civil Engineering Zhejiang Key Laboratory of Civil Engineering Structures&Disaster Prevention and Mitigation TechnologyZhejiang University of TechnologyHangzhou 310023China Water Resources and Environmental Institute Xiamen University of TechnologyXiamen 361005China School of Environmental Science and Engineering Suzhou University of Science and TechnologySuzhou 215009China Civil and Environmental Engineering Virginia Polytechnic Institute and State UniversityBlackburgVA 24061USA

As a strong oxidizing agent,ozone is used in some water treatment facilities for disinfection,taste and odor control,and removal of organic ***(Phe)was used as the target amino acid to comprehensively investigate variability of disinfection byproducts(DBPs)formation during chlorine disinfection and residual chlorine conditions subsequent to *** results showed that subsequent to ozonation,the typical regulated and unregulated DBPs formation potential(DBPsFP),including trichloromethane(TCM),dichloroacetonitrile(DCAN),chloral hydrate(CH),dichloroacetic acid(DCAA),trichloroacetic acid(TCAA),and trichloroacetamide(TCAcAm)increased substantially,by 2.4,3.3,5.6,1.2,2.5,and 6.0 times,respectively,compared with only *** also significantly increased the DBPs yield under a 2 day simulated residual chlorine condition that mimicked the water distribution *** formations followed pseudo first order *** formation rates of DBPs in the first 6 hr were higher for TCM(0.214 hr^(−1)),DCAN(0.244 hr^(−1)),CH(0.105 hr^(−1)),TCAcAm(0.234 hr^(−1)),DCAA(0.375 hr^(−1))and TCAA(0.190 hr^(−1))than *** peak DBPsFP of TCM,DCAN,CH,TCAcAm,DCAA,and TCAA were obtained when that ozonation time was set at 5–15 *** times>30 min increased the mineralization of Phe and decreased the formation of DBPs upon *** bromine ion(Br^(−1))concentration increased production of bromine-DBPs and decreased chlorine-DBPs formation by 59.3%–92.2%.Higher ozone dosages and slight alkaline favored to reduce DBP formation and *** ozonation conditions should be optimized for all application purposes including DBPs reduction.

关键词： Ozone Amino acids Chlorination Disinfection by-products

Adaptive gradient-based source and mask co-optimization with process awareness

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Chinese Optics Letters 2019年第12期17卷 32-37页

作者： Yijiang Shen Fei Peng xiaoyan huang Zhenrong Zhang School of Automation Guangdong University of TechnologyMega Education Center SouthGuangzhou 510006China Guangxi Key Laboratory of Multimedia Communications and Network Technology School of ComputerElectronics and InformationGuangxi UniversityNanning 530004China

We develop a source and mask co-optimization framework incorporating the minimization of edge placement error(EPE)and process variability band(PV Band)into the cost function to compensate simultaneously for the image distortion and the increasingly pronounced lithographic process *** differentiable functions of the EPE and the PV Band are presented,and adaptive gradient methods are applied to break symmetry to escape suboptimal local *** on the initial mask conditions is also *** results demonstrate the efficacy of the proposed source and mask optimization approach in pattern fidelity improvement,process robustness enhancement,and almost unaffected performance with random initial masks.

关键词： optimization process gradient