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牡丹皮炭质量标准研究

中国民族民间医药 2024年第3期33卷 30-32页

作者：占丽琴黄晓燕马杰方磊丁野罗艳湖南省药品检验检测研究院湖南长沙410001 湖南省药品质量评价工程技术研究中心湖南长沙410001

目的:对牡丹皮炭进行质量标准研究。方法:建立牡丹皮炭的性状、薄层色谱鉴别方法,并按照《中国药典》2015年版对水分、总灰分、浸出物等项目进行了测定。结果:牡丹皮炭的薄层色谱中,在对照品及对照药材相同的位置显相应的斑点。水分、... 详细信息

目的:对牡丹皮炭进行质量标准研究。方法:建立牡丹皮炭的性状、薄层色谱鉴别方法,并按照《中国药典》2015年版对水分、总灰分、浸出物等项目进行了测定。结果:牡丹皮炭的薄层色谱中,在对照品及对照药材相同的位置显相应的斑点。水分、总灰分、浸出物的范围分别为1.44%~6.84%、3.05%~5.36%、31.28%~45.89%。结论:该研究可为牡丹皮炭质量控制提供依据。

关键词：牡丹皮炭质量标准薄层色谱法

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上海市级医院静脉血栓栓塞症信息监测平台建设实践

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中国卫生质量管理 2024年第6期31卷 5-8页

作者：黄晓燕许媛媛周帅陆勇余松轩侯冷晨上海交通大学医学院附属瑞金医院卢湾分院上海200020 上海市肺栓塞和深静脉血栓形成防治联盟上海200020 上海市医事团体联合管理发展中心上海200000 上海市医院协会上海200000 上海交通大学医学院附属瑞金医院上海200020 上海交通大学医学院上海200000 上海申康医院发展中心上海200041

为了提高医院内VTE规范化防治管理效能,上海申康医院发展中心基于医疗质量安全信息监管平台,建立VTE信息监测平台,通过制订统一的标准、流程和核心管理策略,统筹37家市级医院住院患者的VTE质控指标,实现了与多中心VTE信息互联互通,有效... 详细信息

为了提高医院内VTE规范化防治管理效能,上海申康医院发展中心基于医疗质量安全信息监管平台,建立VTE信息监测平台,通过制订统一的标准、流程和核心管理策略,统筹37家市级医院住院患者的VTE质控指标,实现了与多中心VTE信息互联互通,有效提升了VTE规范化防治水平。

关键词：静脉血栓栓塞症信息化平台建设上海市级医院

糖尿病性心肌病患者血清PDK4,DECR1和MMP1表达水平及临床价值研究

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现代检验医学杂志 2024年第5期39卷 130-134页

作者：马美娟宋荟琴张国安黄晓燕陕西省人民医院西院体检中心西安710068 陕西省人民医院心外科西安710068 陕西省人民医院陕西省感染与免疫疾病重点实验室西安710068 铜川矿务局中心医院检验科陕西铜川727000

目的探讨血清丙酮酸脱氢酶激酶同工酶4(pyruvate dehydrogenase kinase isoenzyme 4,PDK4),2,4-二烯酰辅酶A还原酶1(2,4-dienoyl coenzyme A reductase 1,DECR1)及基质金属蛋白酶1(matrix metalloproteinase 1,MMP1)的联合检测在糖尿病性心肌病(diabetic cardiomyopathy,DCM)诊断、临床分级和病情预后中的应用价值。方法选取2021年10月~2023年10月陕西省人民医院收治的126例糖尿病性心肌病(DCM组)患者及120例单纯糖尿病非心肌病患者(对照组),采用酶联免疫吸附法(ELISA)测定血清中PDK4,DECR1及MMP1蛋白表达水平,评估这三个检测指标在DCM中的诊断、临床分级和病情预后中的应用价值。结果DCM组患者血清PDK4(131.38±10.20 pg/ml),DECR1(152.06±12.57 pg/ml)及MMP1(40.27±4.02μg/ml)蛋白表达水平与对照组(82.69±8.17 pg/ml,86.14±9.55 pg/ml,17.77±0.98μg/ml)相比均明显升高,差异具有统计学意义(t=36.24,47.63,12.29,均P<0.001)。DCM组患者血清PDK4,DECR1及MMP1蛋白表达水平与NYHA心功能分级相关,随等级升高其蛋白表达水平均明显升高,差异具有统计学意义(F=24.12,30.04,12.66,均P<0.001);DCM组中重度组患者与轻度组患者比较,血清PDK4(164.92±1.35pg/ml vs 122.48±8.78pg/ml),DECR1(192.17±9.11pg/ml vs124.36±10.83pg/ml)及MMP1(84.44±7.38μg/ml vs 39.41±3.05μg/ml)蛋白表达水平均显著增高,差异具有统计学意义(t=26.33,47.12,15.41,均P<0.001)。血清PDK4,DECR1及MMP1三项联合检测DCM准确度(χ^(2)=18.23,21.37,22.07)、特异度(χ^(2)=9.72,13.43,15.12)、灵敏度(χ^(2)=12.07,16.07,17.55)与单项检测对比均明显升高,差异具有统计学意义(均P<0.05),且ROC曲线分析结果显示联合检测的AUC高达0.955,明显高于单项检测(Z=16.67,17.09,20.44,均P<0.05)。结论血清PDK4,DECR1及MMP1与DCM诊断、临床分级及病情预后有一定关联,三者联合检测有助于DCM的鉴别诊断。

关键词：糖尿病性心肌病丙酮酸脱氢酶激酶同工酶4 2,4-二烯酰辅酶A还原酶1 基质金属蛋白酶1

Calculation of Interaction Parameters from Immiscible Phase Diagram of Alkali Metal or Alkali Earth Metal-Halide System by Means of Subregular Solution Model

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Journal of Materials Science & Technology 2000年第3期16卷 354-356页

作者： Zhaochun ZHANG, Deliang CUI, Baibiao huang, xiaoyan QIN and Minhua JIANG (Institute of Crystal Materials, Shandong University, Jinan 250100, China) Institute of Crystal Materials Shandong University Jinan 250100 China

In this paper, the interaction parameters in the subregular solution model, λ1 and λ2, are regarded as a linear function of temperature, T. Therefore, the molar excess Gibbs energy of A-B binary system may be reexpressed as follows:Gm^E=xAxB[(λ11+λ12T)+(λ21+λ22T)xB]The calculation of the model parameters, λ11, λ12, λ21and λ22, was carried out numerically from the phase diagrams for 11 alkali metal-alkali halide or alkali earth metal-halide systems. In addition, artificial neural network trained by known data has been used to predict the values of these model parameters. The predicted results are in good agreement with the .calculated ones. The applicability of the subregular solution model to the alkali metal-alkali halide or alkali earth metal-halide systems were tested by comparing the available experimental composition along the boundary of miscibility gap with the calculated ones which were obtained by using genetic algorithm. The good agreement between the calculated and experimental results across the entire liquidus is valid evidence in support of the model.

关键词： In Calculation of Interaction Parameters from Immiscible Phase Diagram of Alkali Metal or Alkali Earth Metal-Halide System by Means of Subregular Solution Model

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基于地形图数据的煤矿塌陷区域研究

测绘与空间地理信息 2024年第3期47卷 215-217页

作者：杨萍张增场黄晓艳张博余运涛董斌中煤航测遥感集团有限公司陕西西安710100

地面塌陷是地下矿产采空区常见的一种地质灾害,由矿山开采引起的地面塌陷往往形成洼地、槽谷或负地形,并伴随有不规则的开裂和地形起伏,对人类生产活动造成极大的危害。本文以陕西某矿区为例,根据其2011年高精度地形图数据和2021年高精... 详细信息

地面塌陷是地下矿产采空区常见的一种地质灾害,由矿山开采引起的地面塌陷往往形成洼地、槽谷或负地形,并伴随有不规则的开裂和地形起伏,对人类生产活动造成极大的危害。本文以陕西某矿区为例,根据其2011年高精度地形图数据和2021年高精度地形图数据,提取其高程点、等高线数据,在ArcGIS平台下生成高精度DEM数据,对比两期DEM数据,分析得出塌陷区域,并且套和其采掘平面工程图进行验证,为更合理地规划人类生产生活活动以及防治自然灾害提供强有力的支撑。

关键词：地面塌陷地形图数据 DEM 自然灾害

Heptamethine cyanines in bioorthogonal chemistry

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Chinese Chemical Letters 2024年第2期35卷 131-137页

作者： Yuanyuan Liao Yuting Liang Yurou huang xiaoyan Zeng Tian He Jun Yin National Key Laboratory of Green Pesticide International Joint Research Center for Intelligent Biosensor Technology and HealthCollege of ChemistryCentral China Normal UniversityWuhan 430079China

Due to their excellent fluorescence properties and biological function,cyanine dyes have been widely applied in biological *** cyanine(Cy7)dyes,as a type of classic near-infrared(NIR)fluorescent dyes,are considered as one of the effective fluorescent tools in the living organisms due to their good biocompatibility and very low background *** reactions performed in living cells and tissues have developed by leaps and bounds in recent *** NIR fluorescent labeling technique involving cyanine has attracted widespread *** review summarizes their recent application in the field of bioorthogonal imaging,mainly concluding Cy7-type dyes,labeling strategy,bioimaging application,*** expect this work can provide some helps for the studies of NIR bioorthogonal reaction in vivo.

关键词： Fluorescent probes Heptamethine cyanines Bioorthogonal reaction Imaging Cell

Drainage of paddy terraces impacts structures and soil properties in the globally important agricultural heritage of Hani Paddy Terraces,China

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International Soil and Water Conservation Research 2024年第1期12卷 64-76页

作者： Ming Wang Li Rong Yanbo Li Jiangcheng huang Yuanmei Jiao xiaoyan Wei Institute of International Rivers and Eco-Security Kunming650500China Yunnan Key Laboratory of International Rivers and Transboundary Eco-Security Kunming650500China Power China Kunming Engineering Corporation Limited Kunming650051China Department of Geography Yunnan Normal UniversityKunming650500China Yunnan Provincial Archives of Surveying and Mapping(Yunnan Provincial Geomatics Centre) Kunming650032China

Marginalization and abandonment of paddy terraces are widespread,but their effects on the sustainability of subsequent agricultural production are still *** Paddy Terraces,included in Globally Important Agriculture Heritage Systems,are threatened by paddy fields ***,changes in terrace structure,the productivity of topsoil(0-20 cm),and soil water holding capacity at 0-70 cm depth were determined in a case study of Hani Paddy Terraces in Amengkong River Basin in Yuanyang County in Southwestern China,which had been converted into dryland terraces for 2-14 *** results showed that:(1)The degree of terrace structures degradation exhibited a U-shaped curve with increasing time since draining,with those drained for 5-9 years having the best structure;(2)Soil productivity index decreased first and then increased with time after conversion;(3)Maximum water holding capacity at 0-70 cm soil depth dramatically decreased after conversion and such trend became increasingly obvious with increasing time since *** study revealed that drainage of paddy terraces along with associated changes in crop and field management led to an increase in soil productivity,but degradation of terrace structures and a decrease in water holding capacity will inhibit restoration to paddy *** findings enhance the understanding of the biophysical changes due to marginalization in paddy terraces.

关键词： Hani paddy terraces Terraces marginalization Terrace structure degradation Soil productivity Water holding capacity

Clinical observation of rh-endostatin combined with chemotherapy as first line treatment for metastatic colorectal cancer

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Oncology and Translational Medicine 2016年第6期2卷 279-284页

作者： Wenwu Wang Shanshan huang xiaoyan huang Yan Zhang xiaoyan Qi Department of Oncology Nanjing Military Command Fuzhou General Hospital Department of Oncology Central Hospital of Zibo

Objective To analyze the efficacy and safety of Rh-endostatin combined with chemotherapy in the treatment of metastatic colorectal *** All 60 metastatic colorectal cancer patients were divided into the test group(n = 30) and the control group(n = 30). The control group was treated with chemotherapy regime FOLFOX4(Oxaliplatin + Fluorouracil + Calcium Levofolinate), the test group was treated by Endostar combined with FOLFOX4 *** The response rates were 53.3% in test group and 36.7% in control group respectively(P 0.05). The major toxicities were myelosuppression, gastrointestinal symptoms, neurotoxicity, most in grade I-II. After chemotherapy, quality of life(QOL) of patients were more improved than before treatment. After treatment the carcino embryonie antigen(CEA) and caner antigent 199(CA199) levels decreased obviously, furthermore, the test group decreased more obviously than the control group. Conclusion Rh-endostatin combined with chemotherapy in the treatment of metastatic colorectal cancer is safer and effective, and also improves PFS.

关键词： rh-endostatin FOLFOX4 regimen metastatic colorectal cancer

NOTE ON THE STABILITY PROPERTY OF THE VANISHING EQUILIBRIUM POINT OF AN ECOLOGICAL SYSTEM CONSISTING OF A PREDATOR AND STAGE STRUCTURE PREY

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Annals of Applied Mathematics 2019年第2期35卷 139-144页

作者： xiaoyan huang Fengde Chen College of Math.and Computer Science Fuzhou University

We revisit the stability property of an ecological system consisting of a predator and stage structure prey which was proposed by Raid Kamel Naji and Salam Jasim Majeed. By constructing some suitable Lyapunov function and applying the differential inequality theory, we show that the conditions which ensure the local stability of the vanishing point are enough to ensure its global stability. Our result supplements and complements some known results.

关键词： stage structure predator-prey global stability