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有危及生命的室性心律失常病史的老年患者中埋藏式除颤器的作用

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世界核心医学期刊文摘（心脏病学分册） 2007年第12期3卷 34-35页

作者： healey j.s. Hallstrom A.P. Kuck K.- H. 赵君 Population Health Research Institute Hamilton Health Sciences-General SiteMcMaster University 237 Barton St. E amilton Hamilton Ont. L8L 2X2 Canada

目的:埋藏式除颤器(ICD)能够降低有危及生命室性心律失常病史患者的心律失常性死亡率以及全因死亡率。然而,在老年患者中非心律失常性死亡的风险同样较高,因此ICD在老年患者中的临床效果尚不确定。方法和结果:汇总来自三项比较ICD与胺... 详细信息

目的:埋藏式除颤器(ICD)能够降低有危及生命室性心律失常病史患者的心律失常性死亡率以及全因死亡率。然而,在老年患者中非心律失常性死亡的风险同样较高,因此ICD在老年患者中的临床效果尚不确定。方法和结果:汇总来自三项比较ICD与胺碘酮的二级预防试验的患者资料。根据年龄将患者分为<75岁和≥75岁两组。报道患者的特征并确定各组中ICD对全因死亡和心律失常性死亡的影响。通过评价交互作用项(年龄与治疗)确定年龄对这些结果的影响。

关键词：室性心律失常埋藏式除颤器老年患者病史生命

Why ecosystem characteristics predicted from remotely sensed data are unbiased and biased at the same time-and how this affects applications

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Forest Ecosystems 2024年第1期11卷 24-31页

作者： Goran ståhl Terje Gobakken svetlana saarela Henrik j.Persson Magnus Ekstrom sean P.healey Zhiqiang Yang johan Holmgren Eva Lindberg Kenneth Nystrom Emanuele Papucci Patrik Ulvdal Hans OleØrka Erik Næsset Zhengyang Hou Håkan Olsson Ronald E.McRoberts Department of Forest Resource Management Swedish University of Agricultural Sciences90183UmeåSweden Faculty of Environmental sciences and Natural Resource Management Norwegian University of Life SciencesÅsNorway UsDA Forest service Rocky Mountain Research StationOgdenUTUSA The Key Laboratory for silviculture and Conservation of Ministry of Education Beijing Forestry UniversityBeijing100083China Department of Forest Resources University of MinnesotaSt.PaulMNUSA

Remotely sensed data are frequently used for predicting and mapping ecosystem characteristics,and spatially explicit wall-to-wall information is sometimes proposed as the best possible source of information for ***,wall-to-wall information typically relies on model-based prediction,and several features of model-based prediction should be understood before extensively relying on this type of *** such feature is that model-based predictors can be considered both unbiased and biased at the same time,which has important implications in several areas of *** this discussion paper,we first describe the conventional model-unbiasedness paradigm that underpins most prediction techniques using remotely sensed(or other)auxiliary *** this point of view,model-based predictors are typically ***,we show that for specific domains,identified based on their true values,the same model-based predictors can be considered biased,and sometimes severely *** suggest distinguishing between conventional model-bias,defined in the statistical literature as the difference between the expected value of a predictor and the expected value of the quantity being predicted,and design-bias of model-based estimators,defined as the difference between the expected value of a model-based estimator and the true value of the quantity being *** show that model-based estimators(or predictors)are typically design-biased,and that there is a trend in the design-bias from overestimating small true values to underestimating large true ***,we give examples of applications where this is important to acknowledge and to potentially make adjustments to correct for the design-bias *** argue that relying entirely on conventional model-unbiasedness may lead to mistakes in several areas of application that use predictions from remotely sensed data.

关键词： Bias Model-based inference Design-based inference

Longitudinal bending stiffness does not affect running economy in Nike Vaporfly shoes

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journal of sport and Health science 2022年第3期11卷 285-292页

作者： Laura A.healey Wouter Hoogkamer Integrative Locomotion Laboratory Department of KinesiologyUniversity of MassachusettsAmherstMA 01003-9258USA

Purpose This study aimed to determine the independent effect of the curved carbon-fiber plate in the Nike Vaporfly 4%shoe on running economy and running *** Fifteen healthy male runners completed a metabolic protocol and a biomechanics *** both protocols participants wore 2 different shoes,an intact Nike Vaporfly 4%(VF_(intact))and a cut Nike Vaporfly 4%(VF_(cut)).The VF_(cut) had 6 medio-lateral cuts through the carbon-fiber plate in the forefoot to reduce the effectiveness of the *** the metabolic protocol,participants ran at 14 km/h for 5 min,twice with each shoe,on a force-measuring treadmill while we measured metabolic *** the biomechanics protocol,participants ran across a runway with embedded force plates at 14 km/*** calculated running economy,kinetics,and lower limb joint *** Running economy did not significantly differ between shoe conditions(on average,0.55%±1.77%(mean±sD))worse in the VF_(cut) compared to the VF_(intact);95%confidence interval(-1.44%to 0.40%).Biomechanical differences were only found in the metatarsophalangeal(MTP)joint with increased MTP dorsiflexion angle,angular velocity,and negative power in the VF_(cut).Contact time was 1%longer in the VF_(intact).Conclusion Cutting the carbon-fiber plate and reducing the longitudinal bending stiffness did not have a significant effect on the energy savings in the Nike Vaporfly 4%.This suggests that the plate's stiffening effect on the MTP joint plays a limited role in the reported energy savings,and instead savings are likely from a combination and interaction of the foam,geometry,and plate.

关键词： Biomechanics Footwear Mechanical doping Metabolic rate Performance

The national forest inventory in China:history-results-international context

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Forest Ecosystems 2015年第4期2卷 288-303页

作者： Wei sheng Zeng Erkki Tomppo sean P.healey Klaus V.Gadow Academy of Forest Inventory and Planning State Forestry Administration Natural Resources Institute Finland Forest service United States Department of Agriculture University of G?ttingen Beijing Forestry University Department of Forestry and Wood Technology University of Stellenbosch

Background： National forest resource assessments Inventories （NFI＇s）, constitute an important nationa and monitoring, commonly known as National Forest information infrastructure in many countries. Methods： This study presents details about developments of the NFI in China, including sampling and plot design and the uses of alternative data sources, and specifically · reviews the evolution of the national forest inventory in China through the 20th and 21st centuries, with some reference to Europe and the Us; · highlights the emergence of some common international themes： consistency of measurement; sampling designs; implementation of improved technology; expansion of the variables monitored more efficient scientific transparency;· presents an example of how China＇s expanding NFI exemplifies these global trends. Results： Main results and important changes in China＇s NFI are documented, both to support continued trend analysis and to provide data users with historical perspective. Conclusions： New technologies and data needs ensure that the Chinese NFI, like the national inventories in other countries, will continue to evolve. Within the context of historical change and current conditions, likely directions for this evolution are suggested.

关键词： China Europe UsA National forest inventories Forest inventory and analysis

Prevalence and methodologies for detection,characterization and subtyping of Listeria monocytogenes and *** in foods and environmental sources

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Food science and Human Wellness 2017年第3期6卷 97-120页

作者： jin-Qiang Chena Patrick Regan Pongpan Laksanalamai stephanie healey Zonglin Hua Winchester Engineering Analytical Center(WEAC)HFR-NE460Office of Regulatory AffairsUS Food and Drug Administration109 Holton StreetWinchesterMA 01890USA MD DHMH Laboratories Administration Division of MicrobiologyRoom 5281770 Ashland Ave.BaltimoreMD 21205USA

Listeria monocytogenes,one of the most important foodborne pathogens,can cause listeriosis,a lethal disease for ***,which is closely related to ***,is also widely distributed in nature and infects mainly warm-blooded ruminants,causing economic ***,there are high priority needs for methodologies for rapid,specific,cost-effective and accurate detection,characterization and subtyping of *** and *** in foods and environmental *** this review,we(A)described *** and ***,world-wide incidence of listeriosis,and prevalence of various *** strains in food and environmental sources;(B)comprehensively reviewed different types of traditional and newly developed methodologies,including culture-based,antigen/antibody-based,LOOP-mediated isothermal amplification,matrix-assisted laser desorption ionization-time of flight-mass spectrometry,DNA microarray,and genomic sequencing for detection and characterization of *** in foods and environmental sources;(C)comprehensively summarized different subtyping methodologies,including pulsed-field gel electrophoresis,multi-locus sequence typing,ribotyping,and phage-typing,and whole genomic sequencing *** subtyping of *** strains from food and environmental sources;and(D)described the applications of these methodologies in detection and subtyping of *** in foods and food processing facilities.

关键词： Foodborne pathogens Listeria monocytogenes Listeria ivanovii Molecular characterization subtyping

How to Heat a Planet? Impact of Anthropogenic Landscapes on Earth’s Albedo and Temperature

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International journal of Geosciences 2020年第6期11卷 420-457页

作者： Mark healey Lindfield Australia

Today anthropogenic climate change is underway and predicted future global temperatures vary significantly. However, the drivers of current climate change and their links to Earth’s natural glacial cycle have yet to be fully resolved. Currently, many on a local level understand, and are exposed to, the heat energy generated by what’s referred to as the urban heat island effect (UHI), whereby natural flora with higher albedos span>span>isspan>span> replaced by manmade urban areas with lower albedos. This heat effect is not constrained to these regions and all anthropogenic surfaces with lower albedos need to be studied and quantified as the accumulated additional heat energy (infrared energy) is trapped within Earth’s atmosphere and could affect the Earth on a planetary level. Deployed satellites have detected critical changes to Earth’s albedo to lower levels, however the cause and impact of these changes have yet to be fully understood and incorporated into Global Circulation models (GCMs). Here it’s shown that industrialization of anthropogenic landscape practices of the past century has displaced millions of square kilometres of naturally high albedo grasslands with lower albedo agricultural landscapes. Utilising a fundamental Energy Balance Model, (EBM) it’s demonstrated these specific changes have generated vast amounts of additional heat energy which is trapped by the atmosphere, transferred and stored within the oceans of the Earth as shown in span>span>Figure 1span>span>span styl

关键词： Earth Albedo Anthropogenic Landscape Changes Heat Fluxes Earth’s Energy Budget Glacial Cycle Gaia Links

Non-uremic calciphylaxis associated with alcoholic hepatitis: A case report

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World journal of Hepatology 2019年第1期11卷 127-132页

作者： Yasser M sammour Haitham M saleh Mohamed M Gad Brayden healey Melissa Piliang Heart and Vascular Institute Cleveland Clinic Department of Dermatology Ain Shams University College of Osteopathic Medicine of the Pacific-Northwest Western University of Health Sciences Department of Dermatology Cleveland Clinic

BACKGROUND Calciphylaxis is a form of vascular calcification more commonly associated with renal disease. While the exact mechanism of calciphylaxis is poorly understood,most cases are due to end stage kidney disease. However, it can also be found in patients without kidney disease and in such cases is termed non-uremic calciphylaxis for which have multiple proposed *** sUMMARY We describe a case of a thirty-year-old morbidly obese Caucasian female who had a positive history of alcoholic hepatitis and presented with painful calciphylaxis wounds of the abdomen, hips, and thighs. The hypercoagulability panel showed low levels of Protein C and normal Protein s, low Antithrombin Ⅲ and positive lupus anticoagulant and negative anticardiolipin. Wound biopsy confirmed the diagnosis of non-uremic calciphylaxis in the setting of alcoholic liver disease. The calciphylaxis wounds did not improve when sodium Thiosulfate was used alone. The patient underwent a series of bedside and surgical debridement. Broad spectrum antibiotics were also used for secondary wound bacterial infections. The patient passed away shortly after due to sepsis and multiorgan *** Non-uremic Calciphylaxis can occur in the setting of alcoholic liver disease. The treatment of choice is still unknown.

关键词： Calciphylaxis Alcoholic hepatitis Vascular calcification sodium thiosulfate Debridement Case report

Understandings of Logic sublated by the Dialectic

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journal of Philosophy study 2014年第1期4卷 41-54页

作者： Paul M. healey Independent scholar

Empirical, formal, and speculative understandings of logic as identified by Hegel will be formalized. Being formalized the propositions will be deduced from how probabilities can be used to make decisions by appropriating Hegel＇s concept of being two-sided for inferences. This will work for what I will call grounded as opposed to ungrounded probability functions. The domain of their values will be decided by a three-valued modal relation of the binomial probability function. Keynes （1920, Ch. IV ~17） and Popper＇s （1959, Ch. 59） solution to the problem of unknown proportions will be challenged by an understanding of logic that puts the content of what the axioms mean for making rational decisions before their mere being. What is true for the different types inferences will then work for the principle of the dialectic in contrast to the two proposed by Hume and the one proposed by David Lewis. In this way, it will be demonstrated that Hegel＇s understanding of logic is still more advanced than one that fails to recognize it falls within the scope of the dialectic. Dialectic as such will be a principle where the different understandings of a predicated logic will have a modal value within a higher standpoint of system.

关键词： empirical formal speculative binomial probability function and principle

sC切石英晶体谐振器在甚高频低噪声振荡器中的应用

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宇航计测技术 1983年第S1期 132-141页

作者： D.j.healey s.Y.Kwan 谢蔚文

晶体控制的甚高频振荡器广泛应用于具有优良短期频率稳定度和低相位噪声的信号发生器中。这种振荡器均采用工作在泛音模的 AT 切晶体。由于 AT 切晶体谐振器的幅频效应,使相位噪声难以进一步减小。双旋转切晶体(例如 sC 切晶体)的幅频... 详细信息

晶体控制的甚高频振荡器广泛应用于具有优良短期频率稳定度和低相位噪声的信号发生器中。这种振荡器均采用工作在泛音模的 AT 切晶体。由于 AT 切晶体谐振器的幅频效应,使相位噪声难以进一步减小。双旋转切晶体(例如 sC 切晶体)的幅频效应较 AT 切的小得多。因此,可使 sC 切晶体工作在较 AT 切晶体所允许的更大的激励电流上。如果能使振荡器固有的相位起伏不随晶体电流的增大而显著增大,则采用 sC 切晶体元件可以改善晶体控制甚高频信号发生器的短期频率稳定度和噪声。曾用三次泛音 sC 切晶体(而不是用五次泛音 AT 切晶体)进行过100MHz 低噪声振荡器的实际可行性试验。对 sC 切和 AT 切晶体元件的相频特性进行了测量。测量结果表明,晶体元件的功耗能够比使用 AT 切晶体增加6-10dB。对用双极结型晶体管振荡器的噪声源的检查表明,二次及三次失真是造成实际振荡器呈现显著相位闪变的原因。从解凡得堡(微分)方程中出现的频率校正项可了解到减小频率闪变的要求。桥式 T 形振荡器适合于作 sC 切甚高频晶体振荡维持电路。曾研究过这种电路的噪声源(包括调幅闪变噪声的幅相变换),并得到了对上述振荡器所预期的 L(f)的估算值。对相同的一对振荡器进行了测量,预计的 L(f)和所测得的 L(f)很一致。结果表明,和 AT 切甚高频晶体控制振荡器相比较,sC 切晶体控制的甚高频振荡器的L(f)得到了显著改善。

关键词：振荡器晶体相位噪声电子设备晶体谐振器二次谐波电流闪变噪声甚高频 sC